The Experts below are selected from a list of 6546 Experts worldwide ranked by ideXlab platform
Narutoshi Hibino - One of the best experts on this subject based on the ideXlab platform.
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3D bioprinting using stem cells
Pediatric Research, 2018Co-Authors: Pooja Yesantharao, Chen Yu Huang, Gunnar Mattson, Joseph Boktor, Takuma Fukunishi, Huaitao Zhang, Narutoshi HibinoAbstract:Recent advances have allowed for three-dimensional (3D) printing technologies to be applied to biocompatible materials, cells and supporting components, creating a field of 3D bioprinting that holds great promise for Artificial Organ printing and regenerative medicine. At the same time, stem cells, such as human induced pluripotent stem cells, have driven a paradigm shift in tissue regeneration and the modeling of human disease, and represent an unlimited cell source for tissue regeneration and the study of human disease. The ability to reprogram patient-specific cells holds the promise of an enhanced understanding of disease mechanisms and phenotypic variability. 3D bioprinting has been successfully performed using multiple stem cell types of different lineages and potency. The type of 3D bioprinting employed ranged from microextrusion bioprinting, inkjet bioprinting, laser-assisted bioprinting, to newer technologies such as scaffold-free spheroid-based bioprinting. This review discusses the current advances, applications, limitations and future of 3D bioprinting using stem cells, by Organ systems.
Masahiro Saito - One of the best experts on this subject based on the ideXlab platform.
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functional tooth restoration by next generation bio hybrid implant as a bio hybrid Artificial Organ replacement therapy
Scientific Reports, 2015Co-Authors: Masamitsu Oshima, Miho Ogawa, Kaoru Inoue, Kei Nakajima, Tetsuhiko Tachikawa, Hiromichi Yamazaki, Tomohide Isobe, Ayaka Sugawara, Chie Tanaka, Masahiro SaitoAbstract:Bio-hybrid Artificial Organs are an attractive concept to restore Organ function through precise biological cooperation with surrounding tissues in vivo. However, in bio-hybrid Artificial Organs, an Artificial Organ with fibrous connective tissues, including muscles, tendons and ligaments, has not been developed. Here, we have enveloped with embryonic dental follicle tissue around a HA-coated dental implant, and transplanted into the lower first molar region of a murine tooth-loss model. We successfully developed a novel fibrous connected tooth implant using a HA-coated dental implant and dental follicle stem cells as a bio-hybrid Organ. This bio-hybrid implant restored physiological functions, including bone remodelling, regeneration of severe bone-defect and responsiveness to noxious stimuli, through regeneration with periodontal tissues, such as periodontal ligament and cementum. Thus, this study represents the potential for a next-generation bio-hybrid implant for tooth loss as a future bio-hybrid Artificial Organ replacement therapy.
Pooja Yesantharao - One of the best experts on this subject based on the ideXlab platform.
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3D bioprinting using stem cells
Pediatric Research, 2018Co-Authors: Pooja Yesantharao, Chen Yu Huang, Gunnar Mattson, Joseph Boktor, Takuma Fukunishi, Huaitao Zhang, Narutoshi HibinoAbstract:Recent advances have allowed for three-dimensional (3D) printing technologies to be applied to biocompatible materials, cells and supporting components, creating a field of 3D bioprinting that holds great promise for Artificial Organ printing and regenerative medicine. At the same time, stem cells, such as human induced pluripotent stem cells, have driven a paradigm shift in tissue regeneration and the modeling of human disease, and represent an unlimited cell source for tissue regeneration and the study of human disease. The ability to reprogram patient-specific cells holds the promise of an enhanced understanding of disease mechanisms and phenotypic variability. 3D bioprinting has been successfully performed using multiple stem cell types of different lineages and potency. The type of 3D bioprinting employed ranged from microextrusion bioprinting, inkjet bioprinting, laser-assisted bioprinting, to newer technologies such as scaffold-free spheroid-based bioprinting. This review discusses the current advances, applications, limitations and future of 3D bioprinting using stem cells, by Organ systems.
Dong Yun Lee - One of the best experts on this subject based on the ideXlab platform.
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3D Bioprinting for Artificial Pancreas Organ
Advances in experimental medicine and biology, 2018Co-Authors: Seon Jae Lee, Jae Bin Lee, Young Woo Park, Dong Yun LeeAbstract:Type 1 diabetes mellitus (T1DM) results from an autoimmune destruction of insulin-producing beta cells in the islet of the endocrine pancreas. Although islet transplantation has been regarded as an ideal strategy for T1D, transplanted islets are rejected from host immune system. To immunologically protect them, islet encapsulation technology with biocompatible materials is emerged as an immuno-barrier. However, this technology has been limited for clinical trial such as hypoxia in the central core of islet bead, impurity of islet bead and retrievability from the body. Recently, 3D bioprinting has been emerged as an alternative approach to make the Artificial pancreas. It can be used to position live cells in a desired location with real scale of human Organ. Furthermore, constructing a vascularization of the Artificial pancreas is actualized with 3D bioprinting. Therefore, it is possible to create real pancreas-mimic Artificial Organ for clinical application. In conclusion, 3D bioprinting can become a new leader in the development of the Artificial pancreas to overcome the existed islet.
Yukihiko Nosé - One of the best experts on this subject based on the ideXlab platform.
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The Artificial Organ museum in Cleveland (1979-1999) moved to Houston, Texas, and named in 2002 as the ICMT Museum for Artificial Organs.
Artificial organs, 2003Co-Authors: Yukihiko NoséAbstract:: The Artificial Organ museum established in Cleveland, Ohio, in 1979 Organized by the International Center for Artificial Organs and Transplantation (ICAOT), was moved to Houston, Texas, in 1999. The museum with expanded and renewed Artificial Organ exhibits was officially opened on the 8th and 9th of November, 2002, at the Cullen Pavilion of the original Memorial Hermann Hospital. This building is the oldest in the Texas Medical Center, which was built in 1922. The ICMT (International Center for Medical Technologies) Museum for Artificial Organs (Museum) was completed after phase I, II, and III expansions of the exhibit booths, which were made over the last two years. Approximately 250 historically important and currently widely used Artificial Organs are exhibited in the Museum. The official opening of the Museum was coordinated with the “Symposium on Artificial Organs: Past, Present, and Future” during two days in November. There were approximately 225 participants at these events, and approximately 40 pioneers and clinical experts in the development and practice of various types of Artificial Organs contributed. During these programs, a proposal to maintain human resources in addition to Artificial Organ hardware and software was made in addition to the Museum. This new Organization would be called the International Academy of Artificial Organ Pioneers (Academy). All contributors to the symposium were invited to be members of the Academy. The attendants of the symposium accepted this proposal unanimously. An additional 40 individuals, who were recognized as contributors to Artificial Organ technologies, were later added to the original Academy members. Later, the effective utilization of the Museum and Academy was encompassed in the International Faculty for Health and Medical Technologies (Faculty), a new addition to the activities of the ICMT. Dr. Michael DeBakey was elected as Dean of the Faculty. This is considered a “university without walls,” a “university linked to the world,” and a “university providing simultaneous teaching at multiple sites”—a completely new concept in teaching tools for medical technologies. All of these subsidiary Organizations of the ICMT were legally included as nonprofit, nontaxable charity Organizations of the state of Texas.
