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Ozcan Erel - One of the best experts on this subject based on the ideXlab platform.
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decreased paraoxonase and Arylesterase activities in the pathogenesis of future atherosclerotic heart disease in women with gestational diabetes mellitus
Journal of Womens Health, 2009Co-Authors: Hakan Camuzcuoglu, Harun Toy, Hale Cakir, Hakim Celik, Ozcan ErelAbstract:Abstract Objective: The aim of this study was to investigate serum paraoxonase, arlyesterase activities, and lipid hydroperoxide (LOOH) levels in patients with gestational diabetes mellitus (GDM). Methods: Paraoxonase and Arylesterase activities, and LOOH levels were assessed for GDM cases (n = 55) and controls (n = 59). Serum basal and salt-stimulated paraoxonase and Arylesterase activities were measured spectrophotometrically. LOOH levels were measured by ferrous oxidation with a xylenol orange assay. Results: Basal and salt-stimulated paraoxonase and Arylesterase activities were significantly lower (p = 0.002, p = 0.004; and p = 0.013, respectively) in patients with GDM compared to controls, while LOOH levels were significantly higher (p < 0.001). Among gestational diabetes patients, serum paraoxonase and Arylesterase activities were inversely correlated with LOOH levels (r = − 0.390, p = 0.003; and r = − 0.287, p = 0.034, respectively). Conclusions: Findings of the present study have shown that serum ...
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Assessment of serum paraoxonase and Arylesterase activities in early pregnancy failure.
Swiss medical weekly, 2009Co-Authors: Harun Toy, Hakan Camuzcuoglu, Hakim Celik, Ozcan Erel, Nurten AksoyAbstract:Paraoxonase-1 (PON1) is an HDL-bound enzyme system which plays a key role in the protection of LDL and HDL from oxidation by hydrolysing activated phospholipids and lipid peroxide products. Oxidative stress has been involved in the pathogenesis of many complications of human pregnancy, including early pregnancy failure (EPF), preeclampsia and preterm labour. The purpose of this study was to determine serum paraoxonase/Arylesterase activities and lipid hydroperoxide (LOOH) levels as an oxidative stress indicator in women with EPF. Paraoxonase/Arylesterase activities and LOOH levels were assessed in women with EPF (n = 40) and healthy continuum pregnant women without EPF (n = 38) before 12 weeks' gestation. Serum basal and salt-stimulated paraoxonase/Arylesterase activities were measured spectrophotometrically. LOOH levels were measured by ferrous oxidation with a xylenol orange assay. Student's t-test and the Pearson correlation were used for statistical analysis. We found that basal and salt-stimulated paraoxonase/Arylesterase activities were significantly lower in women with EPF than in women without EPF (all p <0.05), while LOOH levels were significantly higher (p = 0.009). Our study showed that decreased paraoxonase/Arylesterase activities and increased LOOH levels may play a role in ethiopathogenesis through increased susceptibility to lipid peroxidation in women with EPF.
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assessment of serum paraoxonase and Arylesterase activities in early pregnancy failure
Swiss Medical Weekly, 2009Co-Authors: Harun Toy, Hakan Camuzcuoglu, Hakim Celik, Ozcan Erel, Nurten AksoyAbstract:Questions under study: Paraoxonase-1 (PON1) is an HDL-bound enzyme system which plays a key role in the protection of LDL and HDL from oxidation by hydrolysing activated phospholipids and lipid peroxide products. Oxidative stress has been involved in the pathogenesis of many complications of human pregnancy, including early pregnancy failure (EPF), preeclampsia and preterm labour. The purpose of this study was to determine serum paraoxonase/Arylesterase activities and lipid hydroperoxide (LOOH) levels as an oxidative stress indicator in women with EPF. Method: Paraoxonase/Arylesterase activities and LOOH levels were assessed in women with EPF (n = 40) and healthy continuum pregnant women without EPF (n = 38) before 12 weeks’ gestation. Serum basal and salt-stimulated paraoxonase/Arylesterase activities were measured spectrophotometrically. LOOH levels were measured by ferrous oxidation with a xylenol orange assay. Student’s t-test and the Pearson correlation were used for statistical analysis Results: We found that basal and salt-stimulated paraoxonase/Arylesterase activities were significantly lower in women with EPF than in women without EPF (all p <0.05), while LOOH levels were significantly higher ( p = 0.009). Conclusion: Our study showed that decreased paraoxonase/Arylesterase activities and increased LOOH levels may play a role in ethiopathogenesis through increased susceptibility to lipid peroxidation in women with EPF. Summary
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Assessment of serum paraoxonase and Arylesterase activities in early pregnancy failure.
Swiss Medical Weekly, 2009Co-Authors: Harun Toy, Hakan Camuzcuoglu, Hakim Celik, Ozcan Erel, Nurten AksoyAbstract:Questions under study: Paraoxonase-1 (PON1) is an HDL-bound enzyme system which plays a key role in the protection of LDL and HDL from oxidation by hydrolysing activated phospholipids and lipid peroxide products. Oxidative stress has been involved in the pathogenesis of many complications of human pregnancy, including early pregnancy failure (EPF), preeclampsia and preterm labour. The purpose of this study was to determine serum paraoxonase/Arylesterase activities and lipid hydroperoxide (LOOH) levels as an oxidative stress indicator in women with EPF. Method: Paraoxonase/Arylesterase activities and LOOH levels were assessed in women with EPF (n = 40) and healthy continuum pregnant women without EPF (n = 38) before 12 weeks’ gestation. Serum basal and salt-stimulated paraoxonase/Arylesterase activities were measured spectrophotometrically. LOOH levels were measured by ferrous oxidation with a xylenol orange assay. Student’s t-test and the Pearson correlation were used for statistical analysis Results: We found that basal and salt-stimulated paraoxonase/Arylesterase activities were significantly lower in women with EPF than in women without EPF (all p
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Decreased paraoxonase and Arylesterase activities in the pathogenesis of future atherosclerotic heart disease in women with gestational diabetes mellitus.
Journal of women's health (2002), 2009Co-Authors: Hakan Camuzcuoglu, Harun Toy, Hale Cakir, Hakim Celik, Ozcan ErelAbstract:Abstract Objective: The aim of this study was to investigate serum paraoxonase, arlyesterase activities, and lipid hydroperoxide (LOOH) levels in patients with gestational diabetes mellitus (GDM). Methods: Paraoxonase and Arylesterase activities, and LOOH levels were assessed for GDM cases (n = 55) and controls (n = 59). Serum basal and salt-stimulated paraoxonase and Arylesterase activities were measured spectrophotometrically. LOOH levels were measured by ferrous oxidation with a xylenol orange assay. Results: Basal and salt-stimulated paraoxonase and Arylesterase activities were significantly lower (p = 0.002, p = 0.004; and p = 0.013, respectively) in patients with GDM compared to controls, while LOOH levels were significantly higher (p
Nurten Aksoy - One of the best experts on this subject based on the ideXlab platform.
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An evaluation of serum paraoxonase together with Arylesterase activities and oxidative stress in children with intractable epilepsy: A cross-sectional study
Epilepsy research, 2014Co-Authors: Mustafa Calik, Nurten Aksoy, Elif Oguz, Suna Sarikaya, Özcan Kocatürk, Bülent Koca, Hatice Eke Gungor, Tahir Kurtuluş Yoldaş, Akin IscanAbstract:Epilepsy is the most common chronic neurological illness in childhood and adolescence. The aim of this study was to investigate paraoxonase and Arylesterase activities along with oxidative status parameters in children with intractable epilepsy. The study comprised 42 subjects with intractable epilepsy and a control group of 35 healthy subjects. Serum paraoxonase and Arylesterase activities, and lipid hydroperoxide levels were determined. All paraoxonase and Arylesterase activities were significantly lower in the intractable epilepsy subjects than in the controls (P
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The activity of paraoxonase and Arylesterase in patients with osteomyelitis.
Scandinavian journal of clinical and laboratory investigation, 2012Co-Authors: Suda Tekin Koruk, Nurten Aksoy, Melek Hamidanoglu, Hasan Karsen, Sebnem Unlu, Hasan BilincAbstract:Background. The aim of this study was to evaluate oxidative stress and to determine the activity of paraoxonase and Arylesterase in patients with osteomyelitis compared to healthy controls. Method. In total, 30 patients diagnosed with osteomyelitis and 30 healthy volunteers were enrolled in the study. Paraoxonase and Arylesterase activities were measured spectrophotometrically. Serum lipid hydroperoxide (LOOH) concentrations were measured by ferrous oxidation with xylenol orange (FOX) assay as markers of oxidative stress. Results. Serum paraoxonase and Arylesterase activities were significantly lower in patients with osteomyelitis compared to control individuals (all p < 0.05). Serum LOOH concentrations were significantly higher in patients with osteomyelitis than those in controls (p < 0.05). Arylesterase activity was inversely correlated with triglyceride (r =− 0.49; p = 0.005) and cholesterol concentrations (r =− 0.41; p = 0.025). Conclusion. In light of the findings obtained from the present study, it...
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paraoxonase and Arylesterase activity and total oxidative anti oxidative status in patients with chronic adenotonsillitis
International Journal of Pediatric Otorhinolaryngology, 2011Co-Authors: Sema Koc, Nurten Aksoy, Hasan Bilinc, Fazilet Duygu, İsmail Önder Uysal, Adnan EkinciAbstract:Abstract Objectives The aim of this study was to investigate serum paraoxonase, Arylesterase activities along with determination of oxidative status via measurement of total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI) in children with recurrent adenotonsillitis during pre- and post-adenotonsillectomy period and to compare results with data from healthy subjects. Methods We performed a prospective controlled trial on adenoidectomy and/or tonsillectomy patients. A total of 47 subjects, including 22 patients with recurrent adenotonsillitis and 25 healthy controls were enrolled in this study. Peripheral venous blood samples were taken from patients before adenotonsillectomy and a second sample was obtained in first month postoperatively. In the control group, blood samples from healthy volunteers were collected for one time only. Serum paraoxonase, Arylesterase activities, TOS, TAS and OSI levels were measured. Results Paraoxonase, Arylesterase activity, TAS and TOS levels were significantly higher in preoperative group compared to control group (P Conclusions Based on data obtained from this study, we may state that paraoxonase, Arylesterase activities with TAS, TOS and OSI levels of patients with chronic adenotonsillitis shows alterations due to oxidant/antioxidant imbalance induced by frequent infections.
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Serum paraoxonase and Arylesterase activities in various forms of hepatitis B virus infection.
Journal of clinical laboratory analysis, 2011Co-Authors: Fazilet Duygu, Suda Tekin Koruk, Nurten AksoyAbstract:The aim of this study was to determine and evaluate the activity of paraoxonase and Arylesterase enzymes in various clinical forms of hepatitis B infection and to investigate the correlation between these parameters and chronic disease course/fibrosis. Overall, 40 patients diagnosed as hepatitis B carriers (CIHBV), 40 chronic active hepatitis B (CAHBV) patients, and 40 healthy adults (control group) between 18 and 65 years of age were enrolled the study. Serum paraoxonase and Arylesterase activities were measured spectrophotometrically. Their activities were significantly lower in patients with CAHBV compared with CIHBV patients or with control group patients (P 0.05). The histology activity index of CAHBV patients did not correlate with paraoxonase and Arylesterase activities (P>0.05). In light of these findings, it may be assumed that during the progression of an inactive hepatitis B carrier to being actively infected, reduced paraoxonase and Arylesterase activities may be observed. J. Clin. Lab. Anal. 25:311–316, 2011. © 2011 Wiley-Liss, Inc.
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Paraoxonase and Arylesterase activity and total oxidative/anti-oxidative status in patients with chronic adenotonsillitis.
International journal of pediatric otorhinolaryngology, 2011Co-Authors: Sema Koc, Nurten Aksoy, Hasan Bilinc, Fazilet Duygu, İsmail Önder Uysal, Adnan EkinciAbstract:Abstract Objectives The aim of this study was to investigate serum paraoxonase, Arylesterase activities along with determination of oxidative status via measurement of total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI) in children with recurrent adenotonsillitis during pre- and post-adenotonsillectomy period and to compare results with data from healthy subjects. Methods We performed a prospective controlled trial on adenoidectomy and/or tonsillectomy patients. A total of 47 subjects, including 22 patients with recurrent adenotonsillitis and 25 healthy controls were enrolled in this study. Peripheral venous blood samples were taken from patients before adenotonsillectomy and a second sample was obtained in first month postoperatively. In the control group, blood samples from healthy volunteers were collected for one time only. Serum paraoxonase, Arylesterase activities, TOS, TAS and OSI levels were measured. Results Paraoxonase, Arylesterase activity, TAS and TOS levels were significantly higher in preoperative group compared to control group (P Conclusions Based on data obtained from this study, we may state that paraoxonase, Arylesterase activities with TAS, TOS and OSI levels of patients with chronic adenotonsillitis shows alterations due to oxidant/antioxidant imbalance induced by frequent infections.
Mehmet Aslan - One of the best experts on this subject based on the ideXlab platform.
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Decreased serum paraoxonase and Arylesterase activities in patients with rosacea.
Journal of the European Academy of Dermatology and Venereology : JEADV, 2014Co-Authors: Zennure Takci, Sahbettin Selek, S. G. Bilgili, Ayse Serap Karadag, M.e. Kucukoglu, Mehmet AslanAbstract:Background Recent evidence suggests that oxidative stress may be an important phenomenon in the pathophysiology of rosacea. Paraoxonase-1 (PON1) is an antioxidant enzyme with three activities: paraoxonase, Arylesterase and dyazoxonase. In this study, we evaluated serum paraoxonase and Arylesterase activities, and serum lipid hydroperoxide (LOOH) levels in patients with rosacea in comparison to healthy controls. Material and method The study included 39 rosacea patients and healthy controls, consisting of 40 age- and sex-matched healthy volunteers. Serum paraoxonase and Arylesterase activities were measured using paraoxon and phenylacetate substrates. Serum LOOH levels were measured with the ferrous ion oxidation-xylenol orange assay. Results In rosacea group mean serum paraoxonase and Arylesterase activities were 74.54 ± 38.30 U L−1 and 141.29 ± 22.27 kU L−1 respectively, which were significantly lower than controls (P = 0.010, 0.005; respectively). Mean serum LOOH level of rosacea group was 8.17 ± 1.91 μmol L−1 which was significantly higher than controls (P = 0.009). There were no statistically significant differences between the clinical subtypes of the disease, menopause situation or ocular involvement with the respect to the serum paraoxonase and Arylesterase activities and LOOH levels (all; P > 0.05). Conclusions Serum PON1 enzyme activities have decreased significantly in rosacea. These findings support that decreased PON1 activity and increased oxidative stress may play a role in the pathogenesis of rosacea. Further studies are needed to elucidate the role of PON1 activity in the pathophysiology of rosacea.
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Serum paraoxonase and Arylesterase activities for the evaluation of patients with chronic hepatitis.
International journal of clinical practice, 2008Co-Authors: Mehmet Aslan, Mehmet Horoz, Sahbettin Selek, Yasar Nazligul, Cengiz Bolukbas, Filiz F Bolukbas, Nurten Aksoy, Ozcan ErelAbstract:Summary The sensitivity of standard biochemical tests for liver function is low and insufficient for a reliable determination of the presence or absence of liver disease. The aim of the present study was to investigate serum paraoxonase and Arylesterase activities and lipid hydroperoxide (LOOH) levels, and to find out that whether the measurement of serum paraoxonase and Arylesterase activities would be useful as an index of liver function status in chronic hepatitis (CH). Fourty-four patients with CH (24 CHB and 20 CHC) and 38 controls were enrolled. Serum paraoxonase and Arylesterase activities were detected spectrophotometrically. LOOH levels were measured by the FOX-2 assay. Serum paraoxonase and Arylesterase activities were significantly lower in patients with CH than controls (p
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paraoxonase and Arylesterase activities in untreated dipper and non dipper hypertensive patients
Clinical Biochemistry, 2008Co-Authors: Ali Yildiz, Mehmet Aslan, Recep Demirbag, Mustafa Gur, Remzi Yilmaz, Selahattin Akyol, Ozcan ErelAbstract:Objectives Paraoxonase, a high density lipoprotein (HDL) associated enzyme, was shown to be reduced in patients with cardiovascular diseases. We aimed to examine serum paraoxonase and Arylesterase activities, and oxidative stress markers such as lipid hydroperoxide (LOOH) and total antioxidant status (TAS) in dipper and non-dipper hypertensive patients. Design and methods Forty-six non-dipper hypertensives (NDH group), 40 dipper hypertensives (DH group) and 28 healthy control subjects were included in the study. Clinical and echocardiographic assessment and ambulatory blood pressure monitoring were performed in all subjects. Serum paraoxonase and Arylesterase activities were measured spectrophotometrically. LOOH levels were measured by ferrous oxidation with xylenol orange assay. TAS was determined by using an automated measurement method. Results Paraoxonase and Arylesterase activities and TAS levels were significantly lower in patients with NDH compared to both DH and control groups (p < 0.001, for both). Also, LOOH levels were found at high level in patients with NDH compared to control and DH groups. In NDH group, both paraoxonase and Arylesterase activities were independently correlated with LDL cholesterol, TAS and LOOH levels. In DH group, both paraoxonase and Arylesterase activities were independently correlated with HDL cholesterol and LOOH levels. Conclusions Reduced paraoxonase and Arylesterase activities in NDH might indicate increased oxidative stress, which plays an important role in the development of cardiovascular diseases. Low serum activities of paraoxonase and Arylesterase might be considered as prospective prognostic markers of the development of cardiovascular diseases in dipper and non-dipper hypertensive patients.
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Paraoxonase and Arylesterase activities in untreated dipper and non-dipper hypertensive patients.
Clinical biochemistry, 2008Co-Authors: Ali Yildiz, Mehmet Aslan, Recep Demirbag, Mustafa Gur, Remzi Yilmaz, Selahattin Akyol, Ozcan ErelAbstract:Paraoxonase, a high density lipoprotein (HDL) associated enzyme, was shown to be reduced in patients with cardiovascular diseases. We aimed to examine serum paraoxonase and Arylesterase activities, and oxidative stress markers such as lipid hydroperoxide (LOOH) and total antioxidant status (TAS) in dipper and non-dipper hypertensive patients. Forty-six non-dipper hypertensives (NDH group), 40 dipper hypertensives (DH group) and 28 healthy control subjects were included in the study. Clinical and echocardiographic assessment and ambulatory blood pressure monitoring were performed in all subjects. Serum paraoxonase and Arylesterase activities were measured spectrophotometrically. LOOH levels were measured by ferrous oxidation with xylenol orange assay. TAS was determined by using an automated measurement method. Paraoxonase and Arylesterase activities and TAS levels were significantly lower in patients with NDH compared to both DH and control groups (p<0.001, for both). Also, LOOH levels were found at high level in patients with NDH compared to control and DH groups. In NDH group, both paraoxonase and Arylesterase activities were independently correlated with LDL cholesterol, TAS and LOOH levels. In DH group, both paraoxonase and Arylesterase activities were independently correlated with HDL cholesterol and LOOH levels. Reduced paraoxonase and Arylesterase activities in NDH might indicate increased oxidative stress, which plays an important role in the development of cardiovascular diseases. Low serum activities of paraoxonase and Arylesterase might be considered as prospective prognostic markers of the development of cardiovascular diseases in dipper and non-dipper hypertensive patients.
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Paraoxonase and Arylesterase activities in untreated dipper and non-dipper hypertensive patients.
Clinical Biochemistry, 2008Co-Authors: Ali Yildiz, Mehmet Aslan, Recep Demirbag, Mustafa Gur, Remzi Yilmaz, Selahattin Akyol, Ozcan ErelAbstract:Objectives Paraoxonase, a high density lipoprotein (HDL) associated enzyme, was shown to be reduced in patients with cardiovascular diseases. We aimed to examine serum paraoxonase and Arylesterase activities, and oxidative stress markers such as lipid hydroperoxide (LOOH) and total antioxidant status (TAS) in dipper and non-dipper hypertensive patients. Design and methods Forty-six non-dipper hypertensives (NDH group), 40 dipper hypertensives (DH group) and 28 healthy control subjects were included in the study. Clinical and echocardiographic assessment and ambulatory blood pressure monitoring were performed in all subjects. Serum paraoxonase and Arylesterase activities were measured spectrophotometrically. LOOH levels were measured by ferrous oxidation with xylenol orange assay. TAS was determined by using an automated measurement method. Results Paraoxonase and Arylesterase activities and TAS levels were significantly lower in patients with NDH compared to both DH and control groups (p
Ali Yildiz - One of the best experts on this subject based on the ideXlab platform.
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Paraoxonase and Arylesterase activities in stent restenosis in bare metal stent.
Coronary artery disease, 2011Co-Authors: Recep Demirbag, Yusuf Sezen, Asuman Biçer Yeşilay, Memduh Bas, Ali Yildiz, Unal Guntekin, Nurten AksoyAbstract:BACKGROUND AND OBJECTIVE The serum paraoxonase and Arylesterase activities are related to coronary artery diseases. However, there are a few data about the association of paraoxonase and Arylesterase activities with in-stent restenosis (ISR). The aim of this study was to evaluate the relationship between paraoxonase and Arylesterase activities and ISR in patients with bare metal stent (BMS). MATERIALS AND METHODS Thirty-one patients with normal coronary artery (group 1) and 60 with BMS were enrolled in this observational study. According to the ISR, the patients were classified as group 2, without the ISR (n=29) and group 3, with the ISR (n=31). Serum paraoxonase and Arylesterase activities were measured spectrophotometrically. RESULTS The paraoxonase and Arylesterase activities were lower in patients with BMS than in the individuals with normal coronary artery (P < 0.001 and P = 0.001, respectively). The enzyme activities were also higher in patients without ISR than with ISR (both of P < 0.001). In bivariate correlation analyses in patients with BMS, ISR shows significant positive correlations with the presence of hypertension and hyperlipidemia, type C lesion, and stent length, but shows negative correlations with type A lesion stent diameter, high-density lipoprotein cholesterol, and paraoxonase and Arylesterase activities. In regression analysis, ISR is independently associated with paraoxonase and Arylesterase activities (β = -0.216, P = 0.038 and β = -0.452, P < 0.001, respectively), type A lesion (β = -0.251, P = 0.013), and stent diameter (β = -0.192, P = 0.024) in patients with BMS. CONCLUSION Our study shows that decreased paraoxonase and Arylesterase activities play a significant role in ethiopathogenesis ISR in patients with BMS.
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paraoxonase and Arylesterase activities in untreated dipper and non dipper hypertensive patients
Clinical Biochemistry, 2008Co-Authors: Ali Yildiz, Mehmet Aslan, Recep Demirbag, Mustafa Gur, Remzi Yilmaz, Selahattin Akyol, Ozcan ErelAbstract:Objectives Paraoxonase, a high density lipoprotein (HDL) associated enzyme, was shown to be reduced in patients with cardiovascular diseases. We aimed to examine serum paraoxonase and Arylesterase activities, and oxidative stress markers such as lipid hydroperoxide (LOOH) and total antioxidant status (TAS) in dipper and non-dipper hypertensive patients. Design and methods Forty-six non-dipper hypertensives (NDH group), 40 dipper hypertensives (DH group) and 28 healthy control subjects were included in the study. Clinical and echocardiographic assessment and ambulatory blood pressure monitoring were performed in all subjects. Serum paraoxonase and Arylesterase activities were measured spectrophotometrically. LOOH levels were measured by ferrous oxidation with xylenol orange assay. TAS was determined by using an automated measurement method. Results Paraoxonase and Arylesterase activities and TAS levels were significantly lower in patients with NDH compared to both DH and control groups (p < 0.001, for both). Also, LOOH levels were found at high level in patients with NDH compared to control and DH groups. In NDH group, both paraoxonase and Arylesterase activities were independently correlated with LDL cholesterol, TAS and LOOH levels. In DH group, both paraoxonase and Arylesterase activities were independently correlated with HDL cholesterol and LOOH levels. Conclusions Reduced paraoxonase and Arylesterase activities in NDH might indicate increased oxidative stress, which plays an important role in the development of cardiovascular diseases. Low serum activities of paraoxonase and Arylesterase might be considered as prospective prognostic markers of the development of cardiovascular diseases in dipper and non-dipper hypertensive patients.
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Paraoxonase and Arylesterase activities in untreated dipper and non-dipper hypertensive patients.
Clinical biochemistry, 2008Co-Authors: Ali Yildiz, Mehmet Aslan, Recep Demirbag, Mustafa Gur, Remzi Yilmaz, Selahattin Akyol, Ozcan ErelAbstract:Paraoxonase, a high density lipoprotein (HDL) associated enzyme, was shown to be reduced in patients with cardiovascular diseases. We aimed to examine serum paraoxonase and Arylesterase activities, and oxidative stress markers such as lipid hydroperoxide (LOOH) and total antioxidant status (TAS) in dipper and non-dipper hypertensive patients. Forty-six non-dipper hypertensives (NDH group), 40 dipper hypertensives (DH group) and 28 healthy control subjects were included in the study. Clinical and echocardiographic assessment and ambulatory blood pressure monitoring were performed in all subjects. Serum paraoxonase and Arylesterase activities were measured spectrophotometrically. LOOH levels were measured by ferrous oxidation with xylenol orange assay. TAS was determined by using an automated measurement method. Paraoxonase and Arylesterase activities and TAS levels were significantly lower in patients with NDH compared to both DH and control groups (p<0.001, for both). Also, LOOH levels were found at high level in patients with NDH compared to control and DH groups. In NDH group, both paraoxonase and Arylesterase activities were independently correlated with LDL cholesterol, TAS and LOOH levels. In DH group, both paraoxonase and Arylesterase activities were independently correlated with HDL cholesterol and LOOH levels. Reduced paraoxonase and Arylesterase activities in NDH might indicate increased oxidative stress, which plays an important role in the development of cardiovascular diseases. Low serum activities of paraoxonase and Arylesterase might be considered as prospective prognostic markers of the development of cardiovascular diseases in dipper and non-dipper hypertensive patients.
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Paraoxonase and Arylesterase activities in untreated dipper and non-dipper hypertensive patients.
Clinical Biochemistry, 2008Co-Authors: Ali Yildiz, Mehmet Aslan, Recep Demirbag, Mustafa Gur, Remzi Yilmaz, Selahattin Akyol, Ozcan ErelAbstract:Objectives Paraoxonase, a high density lipoprotein (HDL) associated enzyme, was shown to be reduced in patients with cardiovascular diseases. We aimed to examine serum paraoxonase and Arylesterase activities, and oxidative stress markers such as lipid hydroperoxide (LOOH) and total antioxidant status (TAS) in dipper and non-dipper hypertensive patients. Design and methods Forty-six non-dipper hypertensives (NDH group), 40 dipper hypertensives (DH group) and 28 healthy control subjects were included in the study. Clinical and echocardiographic assessment and ambulatory blood pressure monitoring were performed in all subjects. Serum paraoxonase and Arylesterase activities were measured spectrophotometrically. LOOH levels were measured by ferrous oxidation with xylenol orange assay. TAS was determined by using an automated measurement method. Results Paraoxonase and Arylesterase activities and TAS levels were significantly lower in patients with NDH compared to both DH and control groups (p
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paraoxonase and Arylesterase activities in patients with cardiac syndrome x and their relationship with oxidative stress markers
Coronary Artery Disease, 2007Co-Authors: Mustafa Gur, Mehmet Aslan, Recep Demirbag, Ali Yildiz, Remzi Yilmaz, Ibrahim Ozdogru, Ozcan ErelAbstract:OBJECTIVES Paraoxonase-1 is a high-density lipoprotein-associated enzyme with three activities, which are paraoxonase, Arylesterase and dyazoxonase. Paraoxonase-1 was shown to decrease in patients with cardiovascular diseases. We aimed to examine serum paraoxonase and Arylesterase activities, and their relation with oxidative stress markers such as lipid hydroperoxide and total antioxidant status in patients with cardiac syndrome X. METHODS Forty-one consecutive patients with cardiac syndrome X (CSX group), 33 consecutive patients without cardiac syndrome X (non-cardiac syndrome X group) and 20 healthy volunteers as control group were taken into the study. Serum paraoxonase and Arylesterase activities were measured spectrophotometrically. Lipid hydroperoxide levels were measured by ferrous oxidation with xylenol orange assay. Total antioxidant status was determined using an automated measurement method. RESULTS Basal paraoxonase, salt-stimulated paraoxonase and Arylesterase activities were significantly lower in patients with cardiac syndrome X than those of the non-cardiac syndrome X and control groups (P<0.001, for both). Moreover, lipid hydroperoxide was found at high level, and total antioxidant status was found at low level in patients with cardiac syndrome X than control and non-cardiac syndrome X groups (P<0.001, for all). In patients with cardiac syndrome X, in multiple linear regression analysis, both paraoxonase and Arylesterase activities were independently correlated with lipid hydroperoxide levels (P=0.001, P=0.003, respectively), and also Arylesterase activity was independently correlated with magnitude of ST depression (P=0.002). CONCLUSION Reduced paraoxonase and Arylesterase activities and total antioxidant status levels and enhanced lipid hydroperoxide levels in patients with cardiac syndrome X might indicate increased oxidative stress that can play a role in pathogenesis of cardiac syndrome X.
Recep Demirbag - One of the best experts on this subject based on the ideXlab platform.
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Paraoxonase and Arylesterase activities in stent restenosis in bare metal stent.
Coronary artery disease, 2011Co-Authors: Recep Demirbag, Yusuf Sezen, Asuman Biçer Yeşilay, Memduh Bas, Ali Yildiz, Unal Guntekin, Nurten AksoyAbstract:BACKGROUND AND OBJECTIVE The serum paraoxonase and Arylesterase activities are related to coronary artery diseases. However, there are a few data about the association of paraoxonase and Arylesterase activities with in-stent restenosis (ISR). The aim of this study was to evaluate the relationship between paraoxonase and Arylesterase activities and ISR in patients with bare metal stent (BMS). MATERIALS AND METHODS Thirty-one patients with normal coronary artery (group 1) and 60 with BMS were enrolled in this observational study. According to the ISR, the patients were classified as group 2, without the ISR (n=29) and group 3, with the ISR (n=31). Serum paraoxonase and Arylesterase activities were measured spectrophotometrically. RESULTS The paraoxonase and Arylesterase activities were lower in patients with BMS than in the individuals with normal coronary artery (P < 0.001 and P = 0.001, respectively). The enzyme activities were also higher in patients without ISR than with ISR (both of P < 0.001). In bivariate correlation analyses in patients with BMS, ISR shows significant positive correlations with the presence of hypertension and hyperlipidemia, type C lesion, and stent length, but shows negative correlations with type A lesion stent diameter, high-density lipoprotein cholesterol, and paraoxonase and Arylesterase activities. In regression analysis, ISR is independently associated with paraoxonase and Arylesterase activities (β = -0.216, P = 0.038 and β = -0.452, P < 0.001, respectively), type A lesion (β = -0.251, P = 0.013), and stent diameter (β = -0.192, P = 0.024) in patients with BMS. CONCLUSION Our study shows that decreased paraoxonase and Arylesterase activities play a significant role in ethiopathogenesis ISR in patients with BMS.
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paraoxonase and Arylesterase activities in untreated dipper and non dipper hypertensive patients
Clinical Biochemistry, 2008Co-Authors: Ali Yildiz, Mehmet Aslan, Recep Demirbag, Mustafa Gur, Remzi Yilmaz, Selahattin Akyol, Ozcan ErelAbstract:Objectives Paraoxonase, a high density lipoprotein (HDL) associated enzyme, was shown to be reduced in patients with cardiovascular diseases. We aimed to examine serum paraoxonase and Arylesterase activities, and oxidative stress markers such as lipid hydroperoxide (LOOH) and total antioxidant status (TAS) in dipper and non-dipper hypertensive patients. Design and methods Forty-six non-dipper hypertensives (NDH group), 40 dipper hypertensives (DH group) and 28 healthy control subjects were included in the study. Clinical and echocardiographic assessment and ambulatory blood pressure monitoring were performed in all subjects. Serum paraoxonase and Arylesterase activities were measured spectrophotometrically. LOOH levels were measured by ferrous oxidation with xylenol orange assay. TAS was determined by using an automated measurement method. Results Paraoxonase and Arylesterase activities and TAS levels were significantly lower in patients with NDH compared to both DH and control groups (p < 0.001, for both). Also, LOOH levels were found at high level in patients with NDH compared to control and DH groups. In NDH group, both paraoxonase and Arylesterase activities were independently correlated with LDL cholesterol, TAS and LOOH levels. In DH group, both paraoxonase and Arylesterase activities were independently correlated with HDL cholesterol and LOOH levels. Conclusions Reduced paraoxonase and Arylesterase activities in NDH might indicate increased oxidative stress, which plays an important role in the development of cardiovascular diseases. Low serum activities of paraoxonase and Arylesterase might be considered as prospective prognostic markers of the development of cardiovascular diseases in dipper and non-dipper hypertensive patients.
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Paraoxonase and Arylesterase activities in untreated dipper and non-dipper hypertensive patients.
Clinical biochemistry, 2008Co-Authors: Ali Yildiz, Mehmet Aslan, Recep Demirbag, Mustafa Gur, Remzi Yilmaz, Selahattin Akyol, Ozcan ErelAbstract:Paraoxonase, a high density lipoprotein (HDL) associated enzyme, was shown to be reduced in patients with cardiovascular diseases. We aimed to examine serum paraoxonase and Arylesterase activities, and oxidative stress markers such as lipid hydroperoxide (LOOH) and total antioxidant status (TAS) in dipper and non-dipper hypertensive patients. Forty-six non-dipper hypertensives (NDH group), 40 dipper hypertensives (DH group) and 28 healthy control subjects were included in the study. Clinical and echocardiographic assessment and ambulatory blood pressure monitoring were performed in all subjects. Serum paraoxonase and Arylesterase activities were measured spectrophotometrically. LOOH levels were measured by ferrous oxidation with xylenol orange assay. TAS was determined by using an automated measurement method. Paraoxonase and Arylesterase activities and TAS levels were significantly lower in patients with NDH compared to both DH and control groups (p<0.001, for both). Also, LOOH levels were found at high level in patients with NDH compared to control and DH groups. In NDH group, both paraoxonase and Arylesterase activities were independently correlated with LDL cholesterol, TAS and LOOH levels. In DH group, both paraoxonase and Arylesterase activities were independently correlated with HDL cholesterol and LOOH levels. Reduced paraoxonase and Arylesterase activities in NDH might indicate increased oxidative stress, which plays an important role in the development of cardiovascular diseases. Low serum activities of paraoxonase and Arylesterase might be considered as prospective prognostic markers of the development of cardiovascular diseases in dipper and non-dipper hypertensive patients.
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Paraoxonase and Arylesterase activities in untreated dipper and non-dipper hypertensive patients.
Clinical Biochemistry, 2008Co-Authors: Ali Yildiz, Mehmet Aslan, Recep Demirbag, Mustafa Gur, Remzi Yilmaz, Selahattin Akyol, Ozcan ErelAbstract:Objectives Paraoxonase, a high density lipoprotein (HDL) associated enzyme, was shown to be reduced in patients with cardiovascular diseases. We aimed to examine serum paraoxonase and Arylesterase activities, and oxidative stress markers such as lipid hydroperoxide (LOOH) and total antioxidant status (TAS) in dipper and non-dipper hypertensive patients. Design and methods Forty-six non-dipper hypertensives (NDH group), 40 dipper hypertensives (DH group) and 28 healthy control subjects were included in the study. Clinical and echocardiographic assessment and ambulatory blood pressure monitoring were performed in all subjects. Serum paraoxonase and Arylesterase activities were measured spectrophotometrically. LOOH levels were measured by ferrous oxidation with xylenol orange assay. TAS was determined by using an automated measurement method. Results Paraoxonase and Arylesterase activities and TAS levels were significantly lower in patients with NDH compared to both DH and control groups (p
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paraoxonase and Arylesterase activities in patients with cardiac syndrome x and their relationship with oxidative stress markers
Coronary Artery Disease, 2007Co-Authors: Mustafa Gur, Mehmet Aslan, Recep Demirbag, Ali Yildiz, Remzi Yilmaz, Ibrahim Ozdogru, Ozcan ErelAbstract:OBJECTIVES Paraoxonase-1 is a high-density lipoprotein-associated enzyme with three activities, which are paraoxonase, Arylesterase and dyazoxonase. Paraoxonase-1 was shown to decrease in patients with cardiovascular diseases. We aimed to examine serum paraoxonase and Arylesterase activities, and their relation with oxidative stress markers such as lipid hydroperoxide and total antioxidant status in patients with cardiac syndrome X. METHODS Forty-one consecutive patients with cardiac syndrome X (CSX group), 33 consecutive patients without cardiac syndrome X (non-cardiac syndrome X group) and 20 healthy volunteers as control group were taken into the study. Serum paraoxonase and Arylesterase activities were measured spectrophotometrically. Lipid hydroperoxide levels were measured by ferrous oxidation with xylenol orange assay. Total antioxidant status was determined using an automated measurement method. RESULTS Basal paraoxonase, salt-stimulated paraoxonase and Arylesterase activities were significantly lower in patients with cardiac syndrome X than those of the non-cardiac syndrome X and control groups (P<0.001, for both). Moreover, lipid hydroperoxide was found at high level, and total antioxidant status was found at low level in patients with cardiac syndrome X than control and non-cardiac syndrome X groups (P<0.001, for all). In patients with cardiac syndrome X, in multiple linear regression analysis, both paraoxonase and Arylesterase activities were independently correlated with lipid hydroperoxide levels (P=0.001, P=0.003, respectively), and also Arylesterase activity was independently correlated with magnitude of ST depression (P=0.002). CONCLUSION Reduced paraoxonase and Arylesterase activities and total antioxidant status levels and enhanced lipid hydroperoxide levels in patients with cardiac syndrome X might indicate increased oxidative stress that can play a role in pathogenesis of cardiac syndrome X.
