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Mohammad Naushad Emmambux - One of the best experts on this subject based on the ideXlab platform.
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Storage stability of encapsulated Ascorbyl Palmitate in normal and high amylose maize starches during pasting and spray dryin.
Carbohydrate polymers, 2019Co-Authors: O.p. Bamidele, Mohammad Naushad EmmambuxAbstract:Abstract This study determines storage stability and release of encapsulated Ascorbyl Palmitate in normal and high amylose maize starch by pasting and spray drying. The amount of Ascorbyl Palmitate released was analysed in the stored samples (dark cupboard, and under UV light at a temperature of 40 °C for 12 weeks) and their antioxidant activity determined. Storage of encapsulated Ascorbyl Palmitate at 40 °C under both dark and UV light conditions did not affect the amount release and the ability to scavenge the free radical (ABTS+). However, the antioxidant activity of free Ascorbyl Palmitate exponentially decreased at 40 °C under UV light condition. The analysed residues after α-amylase digestion of encapsulated Ascorbyl Palmitate showed some endothermic peaks, suggesting that amylose-lipids complexes formed were resistant to α-amylase digestion. Encapsulation of Ascorbyl Palmitate in maize starch may improve its storage stability under light (UV) conditions.
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Encapsulation and antioxidant activity of Ascorbyl Palmitate with normal and high amylose maize starch by spray drying
Food Hydrocolloids, 2019Co-Authors: O.p. Bamidele, Kwaku G. Duodu, Mohammad Naushad EmmambuxAbstract:Abstract Amylose-lipid complexes can be formed by interaction between amylose and lipid as ligands. This study determines the effects of Ascorbyl Palmitate (0, 15, 50, 100, and 200 mg/g starch) on the functional properties of maize starches (normal and high amylose maize starch), amount of Ascorbyl Palmitate bound, release of Ascorbyl Palmitate after enzymatic hydrolysis and Ascorbyl Palmitate antioxidant activity after spray drying. Spray drying of starches (normal maize starch and high amylose maize starch) with Ascorbyl Palmitate at 185 °C resulted in the formation of type I amylose-lipid complexes. Entrapment of Ascorbyl Palmitate in the starch matrix also occurred during spray drying, and this was observed with confocal laser scanning microscopy (CLSM) micrographs. As expected, more Ascorbyl Palmitate bound with high amylose maize starch than normal maize starch. Less than 40% of the bound Ascorbyl Palmitate to high amylose maize starch was released during pancreatic α-amylase hydrolysis suggesting that some of the complexes were indigestible and can be fermented in the large intestine. The antioxidant activities of the Ascorbyl Palmitate highly correlated (R = 0.97) to the amount released during enzymatic hydrolysis. It can be concluded that spray drying of maize starches can be used to encapsulate Ascorbyl Palmitate to form amylose-lipid complexes with a higher amount of Ascorbyl Palmitate bound with maize starches when spray dried compared to pasting method as previously reported.
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Encapsulation and antioxidant activity of Ascorbyl Palmitate with maize starch during pasting.
Carbohydrate polymers, 2017Co-Authors: O.p. Bamidele, Kwaku G. Duodu, Mohammad Naushad EmmambuxAbstract:Ascorbyl Palmitate can interact with amylose to form amylose-lipid complexes. This study determined the effects of Ascorbyl Palmitate (0, 15 and 50mg/g starch) on the pasting properties of maize starch, amount of Ascorbyl Palmitate bound in the starch paste, release of Ascorbyl Palmitate after enzymatic hydrolysis and its antioxidant activity. Pasting of starch with Ascorbyl Palmitate at 91°C for 120min resulted in the formation of type II amylose-lipid complexes as shown by DSC melting enthalpies. About 93% and 66% of Ascorbyl Palmitate were encapsulated when 15mg and 50mg was respectively added to maize starch during pasting. Less than 50% of the bound Ascorbyl Palmitate was released during pancreatic α-amylase hydrolysis suggesting that some of the complexes were not hydrolysed to release the ligand. The antioxidant activities of the Ascorbyl Palmitate correlated (R=0.937) to the amount released during enzymatic hydrolysis. It can be concluded that pasting of maize starch can be used to encapsulate Ascorbyl Palmitate by possibly forming amylose-lipid complexes.
O.p. Bamidele - One of the best experts on this subject based on the ideXlab platform.
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Storage stability of encapsulated Ascorbyl Palmitate in normal and high amylose maize starches during pasting and spray dryin.
Carbohydrate polymers, 2019Co-Authors: O.p. Bamidele, Mohammad Naushad EmmambuxAbstract:Abstract This study determines storage stability and release of encapsulated Ascorbyl Palmitate in normal and high amylose maize starch by pasting and spray drying. The amount of Ascorbyl Palmitate released was analysed in the stored samples (dark cupboard, and under UV light at a temperature of 40 °C for 12 weeks) and their antioxidant activity determined. Storage of encapsulated Ascorbyl Palmitate at 40 °C under both dark and UV light conditions did not affect the amount release and the ability to scavenge the free radical (ABTS+). However, the antioxidant activity of free Ascorbyl Palmitate exponentially decreased at 40 °C under UV light condition. The analysed residues after α-amylase digestion of encapsulated Ascorbyl Palmitate showed some endothermic peaks, suggesting that amylose-lipids complexes formed were resistant to α-amylase digestion. Encapsulation of Ascorbyl Palmitate in maize starch may improve its storage stability under light (UV) conditions.
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Encapsulation and antioxidant activity of Ascorbyl Palmitate with normal and high amylose maize starch by spray drying
Food Hydrocolloids, 2019Co-Authors: O.p. Bamidele, Kwaku G. Duodu, Mohammad Naushad EmmambuxAbstract:Abstract Amylose-lipid complexes can be formed by interaction between amylose and lipid as ligands. This study determines the effects of Ascorbyl Palmitate (0, 15, 50, 100, and 200 mg/g starch) on the functional properties of maize starches (normal and high amylose maize starch), amount of Ascorbyl Palmitate bound, release of Ascorbyl Palmitate after enzymatic hydrolysis and Ascorbyl Palmitate antioxidant activity after spray drying. Spray drying of starches (normal maize starch and high amylose maize starch) with Ascorbyl Palmitate at 185 °C resulted in the formation of type I amylose-lipid complexes. Entrapment of Ascorbyl Palmitate in the starch matrix also occurred during spray drying, and this was observed with confocal laser scanning microscopy (CLSM) micrographs. As expected, more Ascorbyl Palmitate bound with high amylose maize starch than normal maize starch. Less than 40% of the bound Ascorbyl Palmitate to high amylose maize starch was released during pancreatic α-amylase hydrolysis suggesting that some of the complexes were indigestible and can be fermented in the large intestine. The antioxidant activities of the Ascorbyl Palmitate highly correlated (R = 0.97) to the amount released during enzymatic hydrolysis. It can be concluded that spray drying of maize starches can be used to encapsulate Ascorbyl Palmitate to form amylose-lipid complexes with a higher amount of Ascorbyl Palmitate bound with maize starches when spray dried compared to pasting method as previously reported.
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Encapsulation and antioxidant activity of Ascorbyl Palmitate with maize starch during pasting.
Carbohydrate polymers, 2017Co-Authors: O.p. Bamidele, Kwaku G. Duodu, Mohammad Naushad EmmambuxAbstract:Ascorbyl Palmitate can interact with amylose to form amylose-lipid complexes. This study determined the effects of Ascorbyl Palmitate (0, 15 and 50mg/g starch) on the pasting properties of maize starch, amount of Ascorbyl Palmitate bound in the starch paste, release of Ascorbyl Palmitate after enzymatic hydrolysis and its antioxidant activity. Pasting of starch with Ascorbyl Palmitate at 91°C for 120min resulted in the formation of type II amylose-lipid complexes as shown by DSC melting enthalpies. About 93% and 66% of Ascorbyl Palmitate were encapsulated when 15mg and 50mg was respectively added to maize starch during pasting. Less than 50% of the bound Ascorbyl Palmitate was released during pancreatic α-amylase hydrolysis suggesting that some of the complexes were not hydrolysed to release the ligand. The antioxidant activities of the Ascorbyl Palmitate correlated (R=0.937) to the amount released during enzymatic hydrolysis. It can be concluded that pasting of maize starch can be used to encapsulate Ascorbyl Palmitate by possibly forming amylose-lipid complexes.
Vojko Kmetec - One of the best experts on this subject based on the ideXlab platform.
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stability of Ascorbyl Palmitate in topical microemulsions
International Journal of Pharmaceutics, 2001Co-Authors: Polona Spiclin, Mirjana Gašperlin, Vojko KmetecAbstract:Abstract Ascorbyl Palmitate and sodium Ascorbyl phosphate are derivatives of ascorbic acid, which differ in stability and hydro-lipophilic properties. They are widely used in cosmetic and pharmaceutical preparations. In the present work the stability of both derivatives was studied in microemulsions for topical use as carrier systems. The microemulsions were of both o/w and w/o types and composed of the same ingredients. The stability of the less stable derivative Ascorbyl Palmitate was tested under different conditions to evaluate the influence of initial concentration, location in microemulsion, dissolved oxygen and storage conditions. High concentrations of Ascorbyl Palmitate reduced the extent of its degradation. The location of Ascorbyl Palmitate in the microemulsion and oxygen dissolved in the system together significantly influence the stability of the compound. Light accelerated the degradation of Ascorbyl Palmitate. In contrast, sodium Ascorbyl phosphate was stable in both types of microemulsions. Sodium Ascorbyl phosphate is shown to be convenient as an active ingredient in topical preparations. In the case of Ascorbyl Palmitate, long-term stability in selected microemulsions was not adequate. To formulate an optimal carrier system for this ingredient other factors influencing the stability have to be considered.
Anne S. Meyer - One of the best experts on this subject based on the ideXlab platform.
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Ascorbyl Palmitate, gamma-tocopherol, and EDTA affect lipid oxidation in fish oil enriched salad dressing differently
Journal of agricultural and food chemistry, 2007Co-Authors: Mette Bruni Let, Charlotte Jacobsen, Anne S. MeyerAbstract:The aim of the study was to investigate the ability of gamma-tocopherol, ethylenediaminetetraacetate (EDTA), and Ascorbyl Palmitate to protect fish oil enriched salad dressing against oxidation during a 6 week storage period at room temperature. The lipid-soluble gamma-tocopherol (220 and 880 microg g-1 of fish oil) reduced lipid oxidation during storage by partly retarding the formation of lipid hydroperoxides (PV) and by decreasing the concentrations of individual volatile oxidation products by 34-39 and 42-66%, respectively. EDTA (10 and 50 microg g-1 of dressing) was the most efficient single antioxidant, and overall peroxide values and volatiles were reduced by approximately 70 and 77-86%, respectively. Conversely, prooxidant effects were observed with a high concentration of Ascorbyl Palmitate (300 microg g-1 of fish oil), whereas a low concentration was slightly antioxidative (50 microg/g of fish oil). Finally, a combination of all three antioxidants completely inhibited oxidation during storage, indicating that the prooxidant effects of Ascorbyl Palmitate were reverted or overshadowed by EDTA and gamma-tocopherol.
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Ascorbyl Palmitate gamma tocopherol and edta affect lipid oxidation in fish oil enriched salad dressing differently
Journal of Agricultural and Food Chemistry, 2007Co-Authors: Charlotte Jacobsen, Anne S. MeyerAbstract:The aim of the study was to investigate the ability of γ-tocopherol, ethylenediaminetetraacetate (EDTA), and Ascorbyl Palmitate to protect fish oil enriched salad dressing against oxidation during a 6 week storage period at room temperature. The lipid-soluble γ-tocopherol (220 and 880 μg g-1 of fish oil) reduced lipid oxidation during storage by partly retarding the formation of lipid hydroperoxides (PV) and by decreasing the concentrations of individual volatile oxidation products by 34−39 and 42−66%, respectively. EDTA (10 and 50 μg g-1 of dressing) was the most efficient single antioxidant, and overall peroxide values and volatiles were reduced by approximately 70 and 77−86%, respectively. Conversely, prooxidant effects were observed with a high concentration of Ascorbyl Palmitate (300 μg g-1 of fish oil), whereas a low concentration was slightly antioxidative (50 μg/g of fish oil). Finally, a combination of all three antioxidants completely inhibited oxidation during storage, indicating that the proox...
Zarqa Nawaz - One of the best experts on this subject based on the ideXlab platform.
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synergistic effects of Ascorbyl Palmitate and sodium Ascorbyl phosphate loaded in multiple emulsions on facial skin melanin and erythema content
Biomedical Research-tokyo, 2016Co-Authors: Hira Salah Ud Din Khan, Naveed Akhtar, Haji Muhammad Shoaib Khan, Atif I Arshad, Muhammad Naeem, Muhammad Sohail, Atif Ali, Fatima Rasool, Zarqa NawazAbstract:Hyperpigmentation, such as melasma, postinflammatory melanoderma and dermatitis caused by increased production and accumulation of melanin are the major problems today. Ascorbyl Palmitate (AP) and Sodium Ascorbyl Phosphate (SAP), derivatives of ascorbic acid, having the inhibitory effect on skin melanin production and also has anti-inflammatory activity. Aim of this study was to investigate the synergistic effects of Ascorbyl Palmitate and sodium Ascorbyl phosphate loaded in three multiple emulsion formulations i.e. ME1, ME2, and ME3 on facial skin melanin and erythema contents of Asian human females over 12-week treatment course. Thirty three female volunteers were enrolled to singleblinded, placebo-controlled, split-face trial, 3 groups of 11 volunteers each were treated with active treatments versus control/placebo for a period of 12 weeks. Evaluation was performed with non-invasive bioengineering techniques. Patch testing showed no side effects. Control multiple emulsion showed insignificant results while active multiple emulsion formulations showed a significant decrease in skin melanin and erythema content after statistically applied ANOVA (p <0.05). Ascorbyl Palmitate and sodium Ascorbyl phosphate are potent antioxidants. Treatments of human skin with active formulations; ME1, ME2, and ME3 containing Ascorbyl Palmitate and sodium Ascorbyl phosphate significantly reduces facial skin melanin and erythema thus could be explored further for the treatment of pigmentation disorders and dermatitis.
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Synergistic effects of Ascorbyl Palmitate and sodium Ascorbyl phosphate loaded in multiple emulsions on facial skin melanin and erythema content.
Biomedical Research-tokyo, 2016Co-Authors: Hira Salah Ud Din Khan, Naveed Akhtar, Haji Muhammad Shoaib Khan, Atif I Arshad, Muhammad Naeem, Atif Ali, Fatima Rasool, Muhammad Umar Sohail, Zarqa NawazAbstract:Hyperpigmentation, such as melasma, postinflammatory melanoderma and dermatitis caused by increased production and accumulation of melanin are the major problems today. Ascorbyl Palmitate (AP) and Sodium Ascorbyl Phosphate (SAP), derivatives of ascorbic acid, having the inhibitory effect on skin melanin production and also has anti-inflammatory activity. Aim of this study was to investigate the synergistic effects of Ascorbyl Palmitate and sodium Ascorbyl phosphate loaded in three multiple emulsion formulations i.e. ME1, ME2, and ME3 on facial skin melanin and erythema contents of Asian human females over 12-week treatment course. Thirty three female volunteers were enrolled to singleblinded, placebo-controlled, split-face trial, 3 groups of 11 volunteers each were treated with active treatments versus control/placebo for a period of 12 weeks. Evaluation was performed with non-invasive bioengineering techniques. Patch testing showed no side effects. Control multiple emulsion showed insignificant results while active multiple emulsion formulations showed a significant decrease in skin melanin and erythema content after statistically applied ANOVA (p
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PHYSICAL AND CHEMICAL STABILITY ANALYSIS OF COSMETIC MULTI- PLE EMULSIONS LOADED WITH Ascorbyl Palmitate AND SODIUM Ascorbyl PHOSPHATE SALTS.
Acta poloniae pharmaceutica, 2016Co-Authors: Hira Salah Ud Din Khan, Naveed Akhtar, Haji Muhammad Shoaib Khan, Muhammad Naeem, Atif Ali, Muhammad Umar Sohail, Zarqa NawazAbstract:Stability of hydrophilic and lipophilic vitamin C derivatives for quenching synergistic antioxidant activities and to treat oxidative related diseases is a major issue. This study was aimed to encapsulate hydrophilic and lipophilic vitamin C derivatives (Ascorbyl Palmitate and sodium Ascorbyl phosphate) as functional ingredients in a newly formulated multiple emulsion of the W//W type to attain the synergistic antioxidant effects and the resultant system's long term physical and chemical stability. Several multiple emulsions using the same concentration of emulsifiers but different concentrations of Ascorbyl Palmitate and sodium Ascorbyl phosphate were developed. Three finally selected multiple emulsions (ME₁, ME₂ and ME₃) were evaluated for physical stability in terms of rheology, microscopy, conductivity, pH, and organoleptic characteristics under different storage conditions for 3 months. Chemical stability was determined by HPLC on Sykam GmbH HPLC system (Germany), equipped with a variable UV detector. Results showed that at accelerated storage conditions all the three multiple emulsions had shear thinning behavior of varying shear stress with no influence of location of functional ingredients in a carrier system. Conductivity values increased and pH values remained within the skin pH range for 3 months. Microscopic analysis showed an increase in globule size with the passage of time, especially at higher temperatures while decreased at low temperatures. Centrifugation test did not cause phase separation till the 45th day, but little effects after 2 months. Chemical stability analysis by HPLC at the end of 3 months showed that Ascorbyl Palmitate and sodium Ascorbyl phosphate were almost stable in all multiple emulsions with no influence of their location in a carrier system. Multiple emulsions were found a stable carrier for hydrophilic and lipophilic vitamin C derivatives to enhance their desired effects. Considering that many topical formulations contain simple vitamin C it is suggested that present study may contribute to the development of more stable formulations with a combination of vitamin C derivatives to enhance their cosmetic benefits.
