The Experts below are selected from a list of 25365 Experts worldwide ranked by ideXlab platform
Julia L. Newton - One of the best experts on this subject based on the ideXlab platform.
-
Symptoms of Autonomic Dysfunction in chronic fatigue syndrome
QJM : monthly journal of the Association of Physicians, 2007Co-Authors: Julia L. Newton, Oc Okonkwo, Katy Sutcliffe, A. Seth, J. Shin, Dej JonesAbstract:Background: Chronic fatigue syndrome (CFS) is common and its cause is unknown. Aim: To study the prevalence of Autonomic Dysfunction in CFS, and to develop diagnostic criteria. Design: Cross-sectional study with independent derivation and validation phases. Methods: Symptoms of Autonomic Dysfunction were assessed using the Composite Autonomic Symptom Scale (COMPASS). Fatigue was assessed using the Fatigue Impact Scale (FIS). Subjects were studied in two groups: phase 1 (derivation phase), 40 CFS patients and 40 age- and sex-matched controls; phase 2 (validation phase), 30 CFS patients, 37 normal controls and 60 patients with primary biliary cirrhosis. Results: Symptoms of Autonomic Dysfunction were strongly and reproducibly associated with the presence of CFS or primary biliary cirrhosis (PBC), and correlated with severity of fatigue. Total COMPASS score >32.5 was identified in phase 1 as a diagnostic criterion for Autonomic Dysfunction in CFS patients, and was shown in phase 2 to have a positive predictive value of 0.96 (95%CI 0.86–0.99) and a negative predictive value of 0.84 (0.70–0.93) for the diagnosis of CFS. Discussion: Autonomic Dysfunction is strongly associated with fatigue in some, but not all, CFS and PBC patients. We postulate the existence of a ‘cross-cutting’ aetiological process of dysautonomia-associated fatigue (DAF). COMPASS >32.5 is a valid diagnostic criterion for Autonomic Dysfunction in CFS and PBC, and can be used to identify patients for targeted intervention studies.
-
Autonomic Dysfunction in primary biliary cirrhosis correlates with fatigue severity.
European journal of gastroenterology & hepatology, 2007Co-Authors: Julia L. Newton, Adrian Davidson, Simon Kerr, N Bhala, Jessie Pairman, Jennifer Burt, David JonesAbstract:Background and aimsAutonomic Dysfunction has previously been described in primary biliary cirrhosis patients. In nonhepatic diseases, fatigue is associated with Autonomic Dysfunction and impaired baroreflex sensitivity. Here, we investigate the prevalence of Autonomic Dysfunction using highly sensit
-
Population prevalence and symptom associations of Autonomic Dysfunction in primary biliary cirrhosis.
Hepatology (Baltimore Md.), 2007Co-Authors: Julia L. Newton, Jessie Pairman, Jennifer Burt, Mark Hudson, Phaedra Tachtatzis, Kathryn Sutcliffe, David JonesAbstract:Patients with primary biliary cirrhosis (PBC) frequently experience significant fatigue thought to result from as-yet-unidentified central nervous system (CNS)-mediated processes. Pilot studies have suggested that Autonomic Dysfunction is a frequent occurrence in PBC and may contribute to the pathogenesis of this fatigue. The degree to which Autonomic Dysfunction affects the PBC population as a whole, and its interrelationship with other symptoms experienced by PBC patients remains unstudied. In this study, we used a geographically defined, fully representative PBC patient cohort to study the prevalence of symptoms of Autonomic Dysfunction and its relationship with other symptoms of PBC. Symptoms of cardiovascular Autonomic Dysfunction (as assessed using the Orthostatic Grading Scale [OGS]) were significantly more frequently reported and significantly more severe in PBC patients than in both matched normal controls (40% versus 6% with moderate or worse orthostasis (P 4 (moderate severity and worse) had significant abnormality in Autonomic regulation of blood pressure, which was identified on dynamic testing. Conclusion: Symptoms suggestive of Autonomic Dysfunction frequently occur in PBC patients and reflect dysregulation of actual blood pressure. Autonomic Dysfunction is independently associated with both fatigue and, importantly, symptoms of cognitive Dysfunction, suggesting the potential for significant organic sequelae. (HEPATOLOGY 2007;45:1496–1505.)
David Jones - One of the best experts on this subject based on the ideXlab platform.
-
Autonomic Dysfunction in primary biliary cirrhosis correlates with fatigue severity.
European journal of gastroenterology & hepatology, 2007Co-Authors: Julia L. Newton, Adrian Davidson, Simon Kerr, N Bhala, Jessie Pairman, Jennifer Burt, David JonesAbstract:Background and aimsAutonomic Dysfunction has previously been described in primary biliary cirrhosis patients. In nonhepatic diseases, fatigue is associated with Autonomic Dysfunction and impaired baroreflex sensitivity. Here, we investigate the prevalence of Autonomic Dysfunction using highly sensit
-
Population prevalence and symptom associations of Autonomic Dysfunction in primary biliary cirrhosis.
Hepatology (Baltimore Md.), 2007Co-Authors: Julia L. Newton, Jessie Pairman, Jennifer Burt, Mark Hudson, Phaedra Tachtatzis, Kathryn Sutcliffe, David JonesAbstract:Patients with primary biliary cirrhosis (PBC) frequently experience significant fatigue thought to result from as-yet-unidentified central nervous system (CNS)-mediated processes. Pilot studies have suggested that Autonomic Dysfunction is a frequent occurrence in PBC and may contribute to the pathogenesis of this fatigue. The degree to which Autonomic Dysfunction affects the PBC population as a whole, and its interrelationship with other symptoms experienced by PBC patients remains unstudied. In this study, we used a geographically defined, fully representative PBC patient cohort to study the prevalence of symptoms of Autonomic Dysfunction and its relationship with other symptoms of PBC. Symptoms of cardiovascular Autonomic Dysfunction (as assessed using the Orthostatic Grading Scale [OGS]) were significantly more frequently reported and significantly more severe in PBC patients than in both matched normal controls (40% versus 6% with moderate or worse orthostasis (P 4 (moderate severity and worse) had significant abnormality in Autonomic regulation of blood pressure, which was identified on dynamic testing. Conclusion: Symptoms suggestive of Autonomic Dysfunction frequently occur in PBC patients and reflect dysregulation of actual blood pressure. Autonomic Dysfunction is independently associated with both fatigue and, importantly, symptoms of cognitive Dysfunction, suggesting the potential for significant organic sequelae. (HEPATOLOGY 2007;45:1496–1505.)
Yukio Ando - One of the best experts on this subject based on the ideXlab platform.
-
Ganglionic Acetylcholine Receptor Antibodies and Autonomic Dysfunction in Autoimmune Rheumatic Diseases.
International Journal of Molecular Sciences, 2020Co-Authors: Michie Imamura, Osamu Higuchi, Akihiro Mukaino, Koutaro Takamatsu, Hidenori Matsuo, Yukio Ando, Hiroto Tsuboi, Hideki Nakamura, Saori Abe, Tadashi NakamuraAbstract:Autonomic neuropathy has been reported in autoimmune rheumatic diseases (ARD) including Sjogren's syndrome, systemic sclerosis, rheumatoid arthritis, and systemic lupus erythematosus. However, the pathophysiological mechanism underlying Autonomic Dysfunction remains unknown to researchers. On the other hand, autoimmune Autonomic ganglionopathy (AAG) is an acquired immune-mediated disorder, which causes dysautonomia that is mediated by autoantibodies against ganglionic acetylcholine receptors (gAChRs). The purpose of this review was to describe the characteristics of Autonomic disturbance through previous case reports and the functional tests used in these studies and address the importance of anti-gAChR antibodies. We have established luciferase immunoprecipitation systems to detect antibodies against gAChR in the past and determined the prevalence of gAChR antibodies in various autoimmune diseases including AAG and rheumatic diseases. Autonomic Dysfunction, which affects lower parasympathetic and higher sympathetic activity, is usually observed in ARD. The anti-gAChR antibodies may play a crucial role in Autonomic Dysfunction observed in ARD. Further studies are necessary to determine whether anti-gAChR antibody levels are correlated with the severity of Autonomic Dysfunction in ARD.
-
Focus on Autonomic Dysfunction in familial amyloidotic polyneuropathy (FAP).
Amyloid, 2012Co-Authors: Konen Obayashi, Yukio AndoAbstract:It is well known that Autonomic Dysfunction in familial amyloidotic polyneuropathy (FAP) is the most serious problem, because it restricts the daily life of these patients. The detail mechanisms of the onset are not well understood in FAP and domino liver transplantation-induced amyloid neuropathy. As Autonomic disturbances play an important role in the symptomatology of FAP, further studies of Autonomic Dysfunction in these patients may lead the pathogenesis of FAP. Autonomic Dysfunction is often observed before sensory and motor nerve Dysfunction in FAP. This can be attributed to the morphological characteristics of the nerves. Unmyelinated, small myelinated, and large myelinated fibers tend to become impaired in that order. Although the reasons of susceptibility to amyloid infiltration and injury are not known, studies of autopsied FAP patients have revealed heavy infiltration of amyloid in Autonomic ganglions. Moreover, spinal ganglion and posterior loot of the spine had severe amyloid deposits than d...
-
Focus on Autonomic Dysfunction in familial amyloidotic polyneuropathy (FAP).
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, 2012Co-Authors: Konen Obayashi, Yukio AndoAbstract:It is well known that Autonomic Dysfunction in familial amyloidotic polyneuropathy (FAP) is the most serious problem, because it restricts the daily life of these patients. The detail mechanisms of the onset are not well understood in FAP and domino liver transplantation-induced amyloid neuropathy. As Autonomic disturbances play an important role in the symptomatology of FAP, further studies of Autonomic Dysfunction in these patients may lead the pathogenesis of FAP. Autonomic Dysfunction is often observed before sensory and motor nerve Dysfunction in FAP. This can be attributed to the morphological characteristics of the nerves. Unmyelinated, small myelinated, and large myelinated fibers tend to become impaired in that order. Although the reasons of susceptibility to amyloid infiltration and injury are not known, studies of autopsied FAP patients have revealed heavy infiltration of amyloid in Autonomic ganglions. Moreover, spinal ganglion and posterior loot of the spine had severe amyloid deposits than did the anterior root of the spine or the motor nerves. It is well known that Autonomic Dysfunction is the most serious problem, because it restricts the daily life of FAP patients. However, we have four major questions about Autonomic Dysfunction in clinical. In this manuscript, we discuss about the answers of these questions.
-
Autonomic Dysfunction and anemia in neurologic disorders
Journal of the autonomic nervous system, 1996Co-Authors: Yukio Ando, Konen Obayashi, Keiko Asahara, Ole B. Suhr, Mizue Yonemitsu, Taro Yamashita, Kazuhiro Tashima, Makoto Uchino, Masayuki AndoAbstract:The effect of Autonomic Dysfunctions on anemia in various neurological disorders, such as familial amyloidotic polyneuropathy (FAP) Type I, pandysautonomia, and Shy-Drager syndrome was examined. As a control, hemograms of patients with amyotrophic lateral sclerosis (ALS), which is known to be free from Autonomic Dysfunction, was compared with patients with the above neurological disorders. FAP and pandysautonomia patients showed significant anemia comparable with the severity of the Autonomic Dysfunctions. Shy-Drager patients exhibited mild anemia. However, in ALS patients, no such anemia was recognized at all even in the end stage of this disease. In pandysautonomia patients, hypoplastic bone marrow was recognized, which was quite consistent with the data previously reported in FAP patients. Human recombinant erythropoietin improved orthostatic hypotension as well as anemia in 4 FAP patients. These results suggest that Autonomic Dysfunction may be deeply connected with erythropoiesis.
Ronald F. Pfeiffer - One of the best experts on this subject based on the ideXlab platform.
-
Autonomic Dysfunction in Parkinson’s Disease
Neurotherapeutics, 2020Co-Authors: Ronald F. PfeifferAbstract:Recognition of the importance of nonmotor Dysfunction as a component of Parkinson’s disease has exploded over the past three decades. Autonomic Dysfunction is a frequent and particularly important nonmotor feature because of the broad clinical spectrum it covers. Cardiovascular, gastrointestinal, urinary, sexual, and thermoregulatory abnormalities all can appear in the setting of Parkinson’s disease. Cardiovascular Dysfunction is characterized most prominently by orthostatic hypotension. Gastrointestinal Dysfunction can involve virtually all levels of the gastrointestinal tract. Urinary Dysfunction can entail either too frequent voiding or difficulty voiding. Sexual Dysfunction is frequent and frustrating for both patient and partner. Alterations in sweating and body temperature are not widely recognized but often are present. Autonomic Dysfunction can significantly and deleteriously impact quality of life for individuals with Parkinson’s disease. Because effective treatment for many aspects of Autonomic Dysfunction is available, it is vitally important that assessment of Autonomic Dysfunction be a regular component of the neurologic history and exam and that appropriate treatment be initiated and maintained.
-
Autonomic Dysfunction in Parkinson's Disease.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2020Co-Authors: Ronald F. PfeifferAbstract:Recognition of the importance of nonmotor Dysfunction as a component of Parkinson's disease has exploded over the past three decades. Autonomic Dysfunction is a frequent and particularly important nonmotor feature because of the broad clinical spectrum it covers. Cardiovascular, gastrointestinal, urinary, sexual, and thermoregulatory abnormalities all can appear in the setting of Parkinson's disease. Cardiovascular Dysfunction is characterized most prominently by orthostatic hypotension. Gastrointestinal Dysfunction can involve virtually all levels of the gastrointestinal tract. Urinary Dysfunction can entail either too frequent voiding or difficulty voiding. Sexual Dysfunction is frequent and frustrating for both patient and partner. Alterations in sweating and body temperature are not widely recognized but often are present. Autonomic Dysfunction can significantly and deleteriously impact quality of life for individuals with Parkinson's disease. Because effective treatment for many aspects of Autonomic Dysfunction is available, it is vitally important that assessment of Autonomic Dysfunction be a regular component of the neurologic history and exam and that appropriate treatment be initiated and maintained.
-
Management of Autonomic Dysfunction in Parkinson's Disease.
Seminars in neurology, 2017Co-Authors: Ronald F. PfeifferAbstract:Autonomic Dysfunction is a frequent and important nonmotor feature of Parkinson's disease (PD). Autonomic Dysfunction in PD spans a broad clinical spectrum. Cardiovascular Dysfunction is characterized most prominently by orthostatic hypotension. Gastrointestinal Dysfunction can involve virtually all levels of the gastrointestinal tract. Urinary Dysfunction can entail either too frequent voiding or difficulty voiding. Sexual Dysfunction is frequent and frustrating for both the patient and the partner. Alterations in sweating and body temperature are not widely recognized, but often are present. The presence of effective treatment for at least some aspects of Autonomic Dysfunction makes it vitally important that the assessment of Autonomic Dysfunction be a regular component of the neurologic history and examination for individuals with PD.
-
Autonomic Dysfunction in parkinson s disease a comprehensive symptom survey
Parkinsonism & Related Disorders, 2002Co-Authors: S Rast, M.f Siddiqui, Michael J. Lynn, Alexander P. Auchus, Ronald F. PfeifferAbstract:Background: Autonomic Dysfunction occurs in Parkinson's disease (PD), but few studies have addressed it in a comprehensive manner. Methods: Autonomic symptoms were evaluated by a questionnaire in sixty-eight subjects (44 patients and 24 controls). Results: PD patients experienced higher frequency and severity of Autonomic Dysfunction. When all Autonomic symptoms were pooled into an aggregate score, differences between patients and controls were highly statistically significant (p<0.0001). ‘Increased salivation’, ‘frequency of dysphagia’, decreased ‘BM (bowel movement) frequency’, i.e. constipation, and ‘orthostatic dizziness’ were more frequent in PD patients (p<0.05). A prediction model to determine the predictors of Autonomic Dysfunction was unsuccessful. Conclusion: Differences in the prevalence of Autonomic symptoms in PD and non-parkinsonian controls are apparent from this study.
-
Autonomic Dysfunction in Parkinson's disease: a comprehensive symptom survey.
Parkinsonism & related disorders, 2002Co-Authors: M.f Siddiqui, S Rast, Michael J. Lynn, Alexander P. Auchus, Ronald F. PfeifferAbstract:Background: Autonomic Dysfunction occurs in Parkinson's disease (PD), but few studies have addressed it in a comprehensive manner. Methods: Autonomic symptoms were evaluated by a questionnaire in sixty-eight subjects (44 patients and 24 controls). Results: PD patients experienced higher frequency and severity of Autonomic Dysfunction. When all Autonomic symptoms were pooled into an aggregate score, differences between patients and controls were highly statistically significant (p
Søren Møller - One of the best experts on this subject based on the ideXlab platform.
-
Autonomic Dysfunction in cirrhosis and portal hypertension.
Scandinavian journal of clinical and laboratory investigation, 2008Co-Authors: Christine E Winkler Dümcke, Søren MøllerAbstract:Liver cirrhosis and portal hypertension are frequently associated with signs of circulatory Dysfunction and peripheral polyneuropathy, which includes defects of the Autonomic nervous system. Autonomic Dysfunction, which is seen in both alcoholic and non-alcoholic liver cirrhosis and increases with severity and duration of the liver disease, is associated with a significant increase in mortality. The lack of total resolution after liver transplantation indicates that the Autonomic neuropathy is not exclusively functional. This article highlights some aspects of the Autonomic Dysfunction in chronic liver disease. A description is given of its aetiology and the typical circulatory Dysfunction with characteristic hyperdynamic and hyporeactive circulation and heart failure, and the most important tests of the Autonomic nervous system.
