The Experts below are selected from a list of 8214 Experts worldwide ranked by ideXlab platform
R Jayakumar - One of the best experts on this subject based on the ideXlab platform.
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retraction of flexible and microporous chitosan hydrogel nano zno composite Bandages for wound dressing in vitro and in vivo evaluation
ACS Applied Materials & Interfaces, 2019Co-Authors: P Sudheesh T Kumar, Vinothkumar Lakshmanan, Shantikumar V Nair, T V Anilkumar, C Ramya, P Reshmi, A G Unnikrishnan, R JayakumarAbstract:Current wound dressings have disadvantages such as less flexibility, poor mechanical strength, lack of porosity, and a tendency for dressings to adhere onto the wound surface; in addition, a majority of the dressings did not possess antibacterial activity. Hydrogel-based wound dressings would be helpful to provide a cooling sensation and a moisture environment, as well as act as a barrier to microbes. To overcome these hassles, we have developed flexible and microporous chitosan hydrogel/nano zinc oxide composite Bandages (CZBs) via the incorporation of zinc oxide nanoparticles (nZnO) into chitosan hydrogel. The prepared nanocomposite Bandages were characterized using Fourier transform infrared spectroscopy (FT-IR), X-ray diffractometry (XRD), and scanning electron microscopy (SEM). In addition, swelling, degradation, blood clotting, antibacterial, cytocompatibility, cell attachment on the material, and cell infiltration into the composite Bandages were evaluated. The nanocomposite Bandage showed enhanced...
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exploration of alginate hydrogel nano zinc oxide composite Bandages for infected wounds
International Journal of Nanomedicine, 2015Co-Authors: Annapoorna Mohandas, Biswas Raja, Vinothkumar Lakshmanan, R JayakumarAbstract:Alginate hydrogel/zinc oxide nanoparticles (nZnO) composite Bandage was developed by freeze-dry method from the mixture of nZnO and alginate hydrogel. The developed composite Bandage was porous with porosity at a range of 60%-70%. The swelling ratios of the Bandages decreased with increasing concentrations of nZnO. The composite Bandages with nZnO incorporation showed controlled degradation profile and faster blood clotting ability when compared to the KALTOSTAT® and control Bandages without nZnO. The prepared composite Bandages exhibited excellent antimicrobial activity against Escherichia coli, Staphylococcus aureus, Candida albicans, and methicillin resistant S. aureus (MRSA). Cytocompatibility evaluation of the prepared composite Bandages done on human dermal fibroblast cells by Alamar assay and infiltration studies proved that the Bandages have a non-toxic nature at lower concentrations of nZnO whereas slight reduction in viability was seen with increasing nZnO concentrations. The qualitative analysis of ex-vivo re-epithelialization on porcine skin revealed keratinocyte infiltration toward wound area for nZnO alginate Bandages.
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flexible micro porous chitosan gelatin hydrogel nanofibrin composite Bandages for treating burn wounds
RSC Advances, 2014Co-Authors: P Sudheesh T Kumar, Mincy Raj, G Praveen, K P Chennazhi, R JayakumarAbstract:We developed chitosan–gelatin hydrogel/nanofibrin ternary composite Bandages for the treatment of burn wounds and characterized the material by SEM. The spherical nanofibrin moieties (229 ± 3 nm in size) were prepared using an emulsification method and were distributed within the chitosan–gelatin matrix. The presence of the fibrin component within the matrix was confirmed by SEM and phosphotungstic acid-hematoxylin staining. The swelling, biodegradation, porosity, whole-blood clotting, platelet activation, cell viability, cell attachment and cell infiltration properties of the nanocomposite Bandages were evaluated. The nanocomposite Bandages were flexible, degradable and showed enhanced blood clotting and platelet activity compared with control samples. The nanocomposite Bandages showed adequate swelling ability when immersed in water and phosphate-buffered saline. Cell viability studies on normal human dermal fibroblast and human umbilical cord vein endothelial cells proved the non-toxic nature of the composite Bandages. Cell attachment and infiltration studies showed that the human dermal fibroblast and human umbilical cord vein endothelial cells attached to the Bandage. Enhanced collagen deposition and re-epithelialization with the formation of intact mature epidermis was noted in the animal groups treated with the nanocomposite Bandages compared with the experimental controls. These results show that these ternary nanocomposite Bandages are ideal candidates for burn wound dressings.
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evaluation of wound healing potential of β chitin hydrogel nano zinc oxide composite Bandage
Pharmaceutical Research, 2013Co-Authors: P Sudheesh T Kumar, Vinothkumar Lakshmanan, Raja Biswas, Tamura Hiroshi, Shantikumar V Nair, R JayakumarAbstract:Purpose β-chitin hydrogel/nZnO composite Bandage was fabricated and evaluated in detail as an alternative to existing Bandages.
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evaluation of wound healing potential of β chitin hydrogel nano zinc oxide composite Bandage
Pharmaceutical Research, 2013Co-Authors: P Sudheesh T Kumar, Vinothkumar Lakshmanan, Raja Biswas, Tamura Hiroshi, Shantikumar V Nair, Mincy Raj, R JayakumarAbstract:β-chitin hydrogel/nZnO composite Bandage was fabricated and evaluated in detail as an alternative to existing Bandages. β-chitin hydrogel was synthesized by dissolving β-chitin powder in Methanol/CaCl2 solvent, followed by the addition of distilled water. ZnO nanoparticles were added to the β-chitin hydrogel and stirred for homogenized distribution. The resultant slurry was frozen at 0°C for 12 h. The frozen samples were lyophilized for 24 h to obtain porous composite Bandages. The Bandages showed controlled swelling and degradation. The composite Bandages showed blood clotting ability as well as platelet activation, which was higher when compared to the control. The antibacterial activity of the Bandages were proven against Staphylococcus aureus (S. aureus) and Escherichia coli (E.coli). Cytocompatibility of the composite Bandages were assessed using human dermal fibroblast cells (HDF) and these cells on the composite Bandages were viable similar to the Kaltostat control Bandages and bare β-chitin hydrogel based Bandages. The viability was reduced to 50–60% in Bandages with higher concentration of zinc oxide nanoparticles (nZnO) and showed 80–90% viability with lower concentration of nZnO. In vivo evaluation in Sprague Dawley rats (S.D. rats) showed faster healing and higher collagen deposition ability of composite Bandages when compared to the control. The prepared Bandages can be used on various types of infected wounds with large volume of exudates.
P Sudheesh T Kumar - One of the best experts on this subject based on the ideXlab platform.
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retraction of flexible and microporous chitosan hydrogel nano zno composite Bandages for wound dressing in vitro and in vivo evaluation
ACS Applied Materials & Interfaces, 2019Co-Authors: P Sudheesh T Kumar, Vinothkumar Lakshmanan, Shantikumar V Nair, T V Anilkumar, C Ramya, P Reshmi, A G Unnikrishnan, R JayakumarAbstract:Current wound dressings have disadvantages such as less flexibility, poor mechanical strength, lack of porosity, and a tendency for dressings to adhere onto the wound surface; in addition, a majority of the dressings did not possess antibacterial activity. Hydrogel-based wound dressings would be helpful to provide a cooling sensation and a moisture environment, as well as act as a barrier to microbes. To overcome these hassles, we have developed flexible and microporous chitosan hydrogel/nano zinc oxide composite Bandages (CZBs) via the incorporation of zinc oxide nanoparticles (nZnO) into chitosan hydrogel. The prepared nanocomposite Bandages were characterized using Fourier transform infrared spectroscopy (FT-IR), X-ray diffractometry (XRD), and scanning electron microscopy (SEM). In addition, swelling, degradation, blood clotting, antibacterial, cytocompatibility, cell attachment on the material, and cell infiltration into the composite Bandages were evaluated. The nanocomposite Bandage showed enhanced...
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flexible micro porous chitosan gelatin hydrogel nanofibrin composite Bandages for treating burn wounds
RSC Advances, 2014Co-Authors: P Sudheesh T Kumar, Mincy Raj, G Praveen, K P Chennazhi, R JayakumarAbstract:We developed chitosan–gelatin hydrogel/nanofibrin ternary composite Bandages for the treatment of burn wounds and characterized the material by SEM. The spherical nanofibrin moieties (229 ± 3 nm in size) were prepared using an emulsification method and were distributed within the chitosan–gelatin matrix. The presence of the fibrin component within the matrix was confirmed by SEM and phosphotungstic acid-hematoxylin staining. The swelling, biodegradation, porosity, whole-blood clotting, platelet activation, cell viability, cell attachment and cell infiltration properties of the nanocomposite Bandages were evaluated. The nanocomposite Bandages were flexible, degradable and showed enhanced blood clotting and platelet activity compared with control samples. The nanocomposite Bandages showed adequate swelling ability when immersed in water and phosphate-buffered saline. Cell viability studies on normal human dermal fibroblast and human umbilical cord vein endothelial cells proved the non-toxic nature of the composite Bandages. Cell attachment and infiltration studies showed that the human dermal fibroblast and human umbilical cord vein endothelial cells attached to the Bandage. Enhanced collagen deposition and re-epithelialization with the formation of intact mature epidermis was noted in the animal groups treated with the nanocomposite Bandages compared with the experimental controls. These results show that these ternary nanocomposite Bandages are ideal candidates for burn wound dressings.
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evaluation of wound healing potential of β chitin hydrogel nano zinc oxide composite Bandage
Pharmaceutical Research, 2013Co-Authors: P Sudheesh T Kumar, Vinothkumar Lakshmanan, Raja Biswas, Tamura Hiroshi, Shantikumar V Nair, R JayakumarAbstract:Purpose β-chitin hydrogel/nZnO composite Bandage was fabricated and evaluated in detail as an alternative to existing Bandages.
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evaluation of wound healing potential of β chitin hydrogel nano zinc oxide composite Bandage
Pharmaceutical Research, 2013Co-Authors: P Sudheesh T Kumar, Vinothkumar Lakshmanan, Raja Biswas, Tamura Hiroshi, Shantikumar V Nair, Mincy Raj, R JayakumarAbstract:β-chitin hydrogel/nZnO composite Bandage was fabricated and evaluated in detail as an alternative to existing Bandages. β-chitin hydrogel was synthesized by dissolving β-chitin powder in Methanol/CaCl2 solvent, followed by the addition of distilled water. ZnO nanoparticles were added to the β-chitin hydrogel and stirred for homogenized distribution. The resultant slurry was frozen at 0°C for 12 h. The frozen samples were lyophilized for 24 h to obtain porous composite Bandages. The Bandages showed controlled swelling and degradation. The composite Bandages showed blood clotting ability as well as platelet activation, which was higher when compared to the control. The antibacterial activity of the Bandages were proven against Staphylococcus aureus (S. aureus) and Escherichia coli (E.coli). Cytocompatibility of the composite Bandages were assessed using human dermal fibroblast cells (HDF) and these cells on the composite Bandages were viable similar to the Kaltostat control Bandages and bare β-chitin hydrogel based Bandages. The viability was reduced to 50–60% in Bandages with higher concentration of zinc oxide nanoparticles (nZnO) and showed 80–90% viability with lower concentration of nZnO. In vivo evaluation in Sprague Dawley rats (S.D. rats) showed faster healing and higher collagen deposition ability of composite Bandages when compared to the control. The prepared Bandages can be used on various types of infected wounds with large volume of exudates.
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flexible and microporous chitosan hydrogel nano zno composite Bandages for wound dressing in vitro and in vivo evaluation
ACS Applied Materials & Interfaces, 2012Co-Authors: P Sudheesh T Kumar, Vinothkumar Lakshmanan, Shantikumar V Nair, T V Anilkumar, C Ramya, P Reshmi, A G Unnikrishnan, R JayakumarAbstract:Current wound dressings have disadvantages such as less flexibility, poor mechanical strength, lack of porosity, and a tendency for dressings to adhere onto the wound surface; in addition, a majority of the dressings did not possess antibacterial activity. Hydrogel-based wound dressings would be helpful to provide a cooling sensation and a moisture environment, as well as act as a barrier to microbes. To overcome these hassles, we have developed flexible and microporous chitosan hydrogel/nano zinc oxide composite Bandages (CZBs) via the incorporation of zinc oxide nanoparticles (nZnO) into chitosan hydrogel. The prepared nanocomposite Bandages were characterized using Fourier transform infrared spectroscopy (FT-IR), X-ray diffractometry (XRD), and scanning electron microscopy (SEM). In addition, swelling, degradation, blood clotting, antibacterial, cytocompatibility, cell attachment on the material, and cell infiltration into the composite Bandages were evaluated. The nanocomposite Bandage showed enhanced...
Vinothkumar Lakshmanan - One of the best experts on this subject based on the ideXlab platform.
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retraction of flexible and microporous chitosan hydrogel nano zno composite Bandages for wound dressing in vitro and in vivo evaluation
ACS Applied Materials & Interfaces, 2019Co-Authors: P Sudheesh T Kumar, Vinothkumar Lakshmanan, Shantikumar V Nair, T V Anilkumar, C Ramya, P Reshmi, A G Unnikrishnan, R JayakumarAbstract:Current wound dressings have disadvantages such as less flexibility, poor mechanical strength, lack of porosity, and a tendency for dressings to adhere onto the wound surface; in addition, a majority of the dressings did not possess antibacterial activity. Hydrogel-based wound dressings would be helpful to provide a cooling sensation and a moisture environment, as well as act as a barrier to microbes. To overcome these hassles, we have developed flexible and microporous chitosan hydrogel/nano zinc oxide composite Bandages (CZBs) via the incorporation of zinc oxide nanoparticles (nZnO) into chitosan hydrogel. The prepared nanocomposite Bandages were characterized using Fourier transform infrared spectroscopy (FT-IR), X-ray diffractometry (XRD), and scanning electron microscopy (SEM). In addition, swelling, degradation, blood clotting, antibacterial, cytocompatibility, cell attachment on the material, and cell infiltration into the composite Bandages were evaluated. The nanocomposite Bandage showed enhanced...
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exploration of alginate hydrogel nano zinc oxide composite Bandages for infected wounds
International Journal of Nanomedicine, 2015Co-Authors: Annapoorna Mohandas, Biswas Raja, Vinothkumar Lakshmanan, R JayakumarAbstract:Alginate hydrogel/zinc oxide nanoparticles (nZnO) composite Bandage was developed by freeze-dry method from the mixture of nZnO and alginate hydrogel. The developed composite Bandage was porous with porosity at a range of 60%-70%. The swelling ratios of the Bandages decreased with increasing concentrations of nZnO. The composite Bandages with nZnO incorporation showed controlled degradation profile and faster blood clotting ability when compared to the KALTOSTAT® and control Bandages without nZnO. The prepared composite Bandages exhibited excellent antimicrobial activity against Escherichia coli, Staphylococcus aureus, Candida albicans, and methicillin resistant S. aureus (MRSA). Cytocompatibility evaluation of the prepared composite Bandages done on human dermal fibroblast cells by Alamar assay and infiltration studies proved that the Bandages have a non-toxic nature at lower concentrations of nZnO whereas slight reduction in viability was seen with increasing nZnO concentrations. The qualitative analysis of ex-vivo re-epithelialization on porcine skin revealed keratinocyte infiltration toward wound area for nZnO alginate Bandages.
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evaluation of wound healing potential of β chitin hydrogel nano zinc oxide composite Bandage
Pharmaceutical Research, 2013Co-Authors: P Sudheesh T Kumar, Vinothkumar Lakshmanan, Raja Biswas, Tamura Hiroshi, Shantikumar V Nair, R JayakumarAbstract:Purpose β-chitin hydrogel/nZnO composite Bandage was fabricated and evaluated in detail as an alternative to existing Bandages.
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evaluation of wound healing potential of β chitin hydrogel nano zinc oxide composite Bandage
Pharmaceutical Research, 2013Co-Authors: P Sudheesh T Kumar, Vinothkumar Lakshmanan, Raja Biswas, Tamura Hiroshi, Shantikumar V Nair, Mincy Raj, R JayakumarAbstract:β-chitin hydrogel/nZnO composite Bandage was fabricated and evaluated in detail as an alternative to existing Bandages. β-chitin hydrogel was synthesized by dissolving β-chitin powder in Methanol/CaCl2 solvent, followed by the addition of distilled water. ZnO nanoparticles were added to the β-chitin hydrogel and stirred for homogenized distribution. The resultant slurry was frozen at 0°C for 12 h. The frozen samples were lyophilized for 24 h to obtain porous composite Bandages. The Bandages showed controlled swelling and degradation. The composite Bandages showed blood clotting ability as well as platelet activation, which was higher when compared to the control. The antibacterial activity of the Bandages were proven against Staphylococcus aureus (S. aureus) and Escherichia coli (E.coli). Cytocompatibility of the composite Bandages were assessed using human dermal fibroblast cells (HDF) and these cells on the composite Bandages were viable similar to the Kaltostat control Bandages and bare β-chitin hydrogel based Bandages. The viability was reduced to 50–60% in Bandages with higher concentration of zinc oxide nanoparticles (nZnO) and showed 80–90% viability with lower concentration of nZnO. In vivo evaluation in Sprague Dawley rats (S.D. rats) showed faster healing and higher collagen deposition ability of composite Bandages when compared to the control. The prepared Bandages can be used on various types of infected wounds with large volume of exudates.
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flexible and microporous chitosan hydrogel nano zno composite Bandages for wound dressing in vitro and in vivo evaluation
ACS Applied Materials & Interfaces, 2012Co-Authors: P Sudheesh T Kumar, Vinothkumar Lakshmanan, Shantikumar V Nair, T V Anilkumar, C Ramya, P Reshmi, A G Unnikrishnan, R JayakumarAbstract:Current wound dressings have disadvantages such as less flexibility, poor mechanical strength, lack of porosity, and a tendency for dressings to adhere onto the wound surface; in addition, a majority of the dressings did not possess antibacterial activity. Hydrogel-based wound dressings would be helpful to provide a cooling sensation and a moisture environment, as well as act as a barrier to microbes. To overcome these hassles, we have developed flexible and microporous chitosan hydrogel/nano zinc oxide composite Bandages (CZBs) via the incorporation of zinc oxide nanoparticles (nZnO) into chitosan hydrogel. The prepared nanocomposite Bandages were characterized using Fourier transform infrared spectroscopy (FT-IR), X-ray diffractometry (XRD), and scanning electron microscopy (SEM). In addition, swelling, degradation, blood clotting, antibacterial, cytocompatibility, cell attachment on the material, and cell infiltration into the composite Bandages were evaluated. The nanocomposite Bandage showed enhanced...
Shantikumar V Nair - One of the best experts on this subject based on the ideXlab platform.
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retraction of flexible and microporous chitosan hydrogel nano zno composite Bandages for wound dressing in vitro and in vivo evaluation
ACS Applied Materials & Interfaces, 2019Co-Authors: P Sudheesh T Kumar, Vinothkumar Lakshmanan, Shantikumar V Nair, T V Anilkumar, C Ramya, P Reshmi, A G Unnikrishnan, R JayakumarAbstract:Current wound dressings have disadvantages such as less flexibility, poor mechanical strength, lack of porosity, and a tendency for dressings to adhere onto the wound surface; in addition, a majority of the dressings did not possess antibacterial activity. Hydrogel-based wound dressings would be helpful to provide a cooling sensation and a moisture environment, as well as act as a barrier to microbes. To overcome these hassles, we have developed flexible and microporous chitosan hydrogel/nano zinc oxide composite Bandages (CZBs) via the incorporation of zinc oxide nanoparticles (nZnO) into chitosan hydrogel. The prepared nanocomposite Bandages were characterized using Fourier transform infrared spectroscopy (FT-IR), X-ray diffractometry (XRD), and scanning electron microscopy (SEM). In addition, swelling, degradation, blood clotting, antibacterial, cytocompatibility, cell attachment on the material, and cell infiltration into the composite Bandages were evaluated. The nanocomposite Bandage showed enhanced...
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evaluation of wound healing potential of β chitin hydrogel nano zinc oxide composite Bandage
Pharmaceutical Research, 2013Co-Authors: P Sudheesh T Kumar, Vinothkumar Lakshmanan, Raja Biswas, Tamura Hiroshi, Shantikumar V Nair, R JayakumarAbstract:Purpose β-chitin hydrogel/nZnO composite Bandage was fabricated and evaluated in detail as an alternative to existing Bandages.
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evaluation of wound healing potential of β chitin hydrogel nano zinc oxide composite Bandage
Pharmaceutical Research, 2013Co-Authors: P Sudheesh T Kumar, Vinothkumar Lakshmanan, Raja Biswas, Tamura Hiroshi, Shantikumar V Nair, Mincy Raj, R JayakumarAbstract:β-chitin hydrogel/nZnO composite Bandage was fabricated and evaluated in detail as an alternative to existing Bandages. β-chitin hydrogel was synthesized by dissolving β-chitin powder in Methanol/CaCl2 solvent, followed by the addition of distilled water. ZnO nanoparticles were added to the β-chitin hydrogel and stirred for homogenized distribution. The resultant slurry was frozen at 0°C for 12 h. The frozen samples were lyophilized for 24 h to obtain porous composite Bandages. The Bandages showed controlled swelling and degradation. The composite Bandages showed blood clotting ability as well as platelet activation, which was higher when compared to the control. The antibacterial activity of the Bandages were proven against Staphylococcus aureus (S. aureus) and Escherichia coli (E.coli). Cytocompatibility of the composite Bandages were assessed using human dermal fibroblast cells (HDF) and these cells on the composite Bandages were viable similar to the Kaltostat control Bandages and bare β-chitin hydrogel based Bandages. The viability was reduced to 50–60% in Bandages with higher concentration of zinc oxide nanoparticles (nZnO) and showed 80–90% viability with lower concentration of nZnO. In vivo evaluation in Sprague Dawley rats (S.D. rats) showed faster healing and higher collagen deposition ability of composite Bandages when compared to the control. The prepared Bandages can be used on various types of infected wounds with large volume of exudates.
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flexible and microporous chitosan hydrogel nano zno composite Bandages for wound dressing in vitro and in vivo evaluation
ACS Applied Materials & Interfaces, 2012Co-Authors: P Sudheesh T Kumar, Vinothkumar Lakshmanan, Shantikumar V Nair, T V Anilkumar, C Ramya, P Reshmi, A G Unnikrishnan, R JayakumarAbstract:Current wound dressings have disadvantages such as less flexibility, poor mechanical strength, lack of porosity, and a tendency for dressings to adhere onto the wound surface; in addition, a majority of the dressings did not possess antibacterial activity. Hydrogel-based wound dressings would be helpful to provide a cooling sensation and a moisture environment, as well as act as a barrier to microbes. To overcome these hassles, we have developed flexible and microporous chitosan hydrogel/nano zinc oxide composite Bandages (CZBs) via the incorporation of zinc oxide nanoparticles (nZnO) into chitosan hydrogel. The prepared nanocomposite Bandages were characterized using Fourier transform infrared spectroscopy (FT-IR), X-ray diffractometry (XRD), and scanning electron microscopy (SEM). In addition, swelling, degradation, blood clotting, antibacterial, cytocompatibility, cell attachment on the material, and cell infiltration into the composite Bandages were evaluated. The nanocomposite Bandage showed enhanced...
A G Unnikrishnan - One of the best experts on this subject based on the ideXlab platform.
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retraction of flexible and microporous chitosan hydrogel nano zno composite Bandages for wound dressing in vitro and in vivo evaluation
ACS Applied Materials & Interfaces, 2019Co-Authors: P Sudheesh T Kumar, Vinothkumar Lakshmanan, Shantikumar V Nair, T V Anilkumar, C Ramya, P Reshmi, A G Unnikrishnan, R JayakumarAbstract:Current wound dressings have disadvantages such as less flexibility, poor mechanical strength, lack of porosity, and a tendency for dressings to adhere onto the wound surface; in addition, a majority of the dressings did not possess antibacterial activity. Hydrogel-based wound dressings would be helpful to provide a cooling sensation and a moisture environment, as well as act as a barrier to microbes. To overcome these hassles, we have developed flexible and microporous chitosan hydrogel/nano zinc oxide composite Bandages (CZBs) via the incorporation of zinc oxide nanoparticles (nZnO) into chitosan hydrogel. The prepared nanocomposite Bandages were characterized using Fourier transform infrared spectroscopy (FT-IR), X-ray diffractometry (XRD), and scanning electron microscopy (SEM). In addition, swelling, degradation, blood clotting, antibacterial, cytocompatibility, cell attachment on the material, and cell infiltration into the composite Bandages were evaluated. The nanocomposite Bandage showed enhanced...
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flexible and microporous chitosan hydrogel nano zno composite Bandages for wound dressing in vitro and in vivo evaluation
ACS Applied Materials & Interfaces, 2012Co-Authors: P Sudheesh T Kumar, Vinothkumar Lakshmanan, Shantikumar V Nair, T V Anilkumar, C Ramya, P Reshmi, A G Unnikrishnan, R JayakumarAbstract:Current wound dressings have disadvantages such as less flexibility, poor mechanical strength, lack of porosity, and a tendency for dressings to adhere onto the wound surface; in addition, a majority of the dressings did not possess antibacterial activity. Hydrogel-based wound dressings would be helpful to provide a cooling sensation and a moisture environment, as well as act as a barrier to microbes. To overcome these hassles, we have developed flexible and microporous chitosan hydrogel/nano zinc oxide composite Bandages (CZBs) via the incorporation of zinc oxide nanoparticles (nZnO) into chitosan hydrogel. The prepared nanocomposite Bandages were characterized using Fourier transform infrared spectroscopy (FT-IR), X-ray diffractometry (XRD), and scanning electron microscopy (SEM). In addition, swelling, degradation, blood clotting, antibacterial, cytocompatibility, cell attachment on the material, and cell infiltration into the composite Bandages were evaluated. The nanocomposite Bandage showed enhanced...
