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Resit Canbeyli - One of the best experts on this subject based on the ideXlab platform.
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low cognitive competence as a vulnerability factor for Behavioral Despair in rats
Behavioural Processes, 2020Co-Authors: Nilay Atesyakar, Resit Canbeyli, Gunes UnalAbstract:Abstract Elucidating the multi-faceted relationship between cognitive competence and affective states is a major pursuit in Behavioral sciences. Mood disorders constitute a good research model for this question, as cognitive impairment may accompany clinical depression and persist after full remission. This suggests cognitive dysfunction as an etiological factor of depression, rather than an epiphenomenon. Complementing clinical studies, animal models utilizing well-controlled, systematic paradigms are essential to elucidate the complex relationship between cognitive competence and affective states. In current set of experiments, we investigated the extent to which cognitive competence determines the stress response in Wistar rats by utilizing two well-established spatial memory paradigms with different degrees of complexity together with the forced swim test. We revealed that rats with low cognitive competence as assessed by learning performance in the Y-Maze, but not in the radial arm maze, were significantly more vulnerable to Behavioral Despair. In contrast, rats with high cognitive competence were resilient to the negative effects of the forced swim test, irrespective of the spatial memory task used. These results point to a nonlinear relationship between spatial memory performance and Behavioral Despair, suggesting that different types of cognitive functioning may have differential effects on affective processes.
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oral ketamine alleviates Behavioral Despair without cognitive impairment in wistar rats
Behavioural Brain Research, 2019Co-Authors: Alev Ecevitoglu, Resit Canbeyli, Gunes UnalAbstract:Abstract Ketamine is a non-competitive NMDA receptor antagonist used as a major anesthetic agent, especially in children. It has also been shown that at sub-anesthetic concentrations, ketamine has acute antidepressant properties. The rapid-onset nature of this effect makes it a promising alternative for classical antidepressants targeting the monoaminergic system. However, ketamine can lead to various cognitive side effects depending on the user/subject as well as its concentration and administration method, and it is still questionable whether this drug can be utilized as a reliable antidepressant. Here, we test the effects of continuous low dose oral ketamine on Behavioral Despair and spatial working memory in male Wistar rats. We found that 0.4 mg/day, but not 0.2 mg/day, ketamine in 30 ml juice has an antidepressant effect emerging in just 10 consecutive days as measured by means of forced swim tests without impairing spatial working memory performance in the Y-maze for as long as 30 days. These results suggest that, once clinically optimized, long-term use of low dose oral ketamine can produce antidepressant effects.
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head turning asymmetry a novel lateralization in rats predicts susceptibility to Behavioral Despair
Behavioural Brain Research, 2018Co-Authors: Efe Soyman, Guzin Duygu Yilmaz, Resit CanbeyliAbstract:Abstract Behavioral markers of laterality reflecting underlying neurobiological asymmetries between the cerebral hemispheres are related to differential susceptibility to mood disorders. In the present study, we investigated the strength and consistency of a novel Behavioral lateralization, head-turning asymmetry, and its relation to Behavioral Despair in adult female Wistar rats. Head-turning biases were determined in a test where water-deprived rats had to turn their head to right or left to gain access to a water dispenser. This procedure was administered 4 times over 8 days. Four days after the head-turning test, rats were subjected to two forced swim tests separated by 24 h to examine the relationship between head-turning asymmetry and Behavioral Despair. Rats were administered one more head-turning test session after the second swim test to determine whether Behavioral Despair induction altered head-turning direction preferences. Results revealed significant correlations among head-turning test sessions indicating head-turning direction preference as measured with our method is a consistent Behavioral lateralization. Although most rats were strongly lateralized, there was no bias in either direction at the population level. Importantly, we found that while rats with a left head-turning bias showed a significant increase in the duration of immobility from the first to the second swim test, right-biased rats performed similarly in the two swim tests. Behavioral Despair induction did not change head-turning direction preferences. The present findings show that head-turning asymmetries are predictive of mood disorders in rats and may serve as the basis to elucidate the mechanisms relating hemispheric asymmetries to depression in humans.
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blue but not red light stimulation in the dark has antidepressant effect in Behavioral Despair
Behavioural Brain Research, 2009Co-Authors: Onur Iyilikci, E Aydin, Resit CanbeyliAbstract:Abstract The present study investigated potential antidepressant effect of light exposure in the dark phase of a 12:12 L/D cycle on Behavioral Despair. In Exp.1, male Wistar rats were administered a single, 10 min broadband light pulse (1300 lx) either 3 h (ZT15) or 9 h (ZT21) after dark onset (ZT12) and tested in two consecutive swim tests separated by 24 h. Photic stimulation at ZT21 but not ZT15 significantly reduced immobility in the second swim test relative to the first test compared to controls that were treated similarly except for light pulse administration ( p p
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Behavioral Despair is differentially affected by the length and timing of photic stimulation in the dark phase of an l d cycle
Progress in Neuro-psychopharmacology & Biological Psychiatry, 2008Co-Authors: Daniela Schulz, Ayla Aksoy, Resit CanbeyliAbstract:Abstract The effect of varying the length and timing of photic stimulation in the dark phase of an L/D lighting cycle on Behavioral Despair was investigated in female Wistar rats. Animals were kept in a vivarium on an L/D 12 h:12 h light cycle (lights on at 0700 h) except for a single day of light exposure in an insulated chamber in the dark phase of the L/D schedule. Light pulses provided by an incandescent lamp (15- and 25-W, for Exps. 1 and 2, respectively) either 2-h (Exp. 1) or 30-min in length (Exp. 2) were administered to independent groups of rats ( n = 8 each) either in the early, middle or late hours of the dark phase of the L/D cycle in the insulated chamber. Light pulses were delivered beginning 2 1/2, 5 1/2 or 7 1/2 h (Exp. 1) or 3 1/4, 6 1/4 and 8 1/4 h (Exp. 2) after dark onset. Control animals were treated similarly except for photic stimulation. In each experiment, an additional group received a light pulse of the appropriate length both in the early and late portion of the dark phase (double double-pulse groups): beginning 2 1/2 and 7 1/2 h (Exp. 1) or 3 1/4 and 8 1/4 h (Exp. 2) after dark onset. All animals then underwent two forced swim tests separated by 24 h with the first test occurring in the light (starting at 1500 h) following the dark phase when photic stimulation was administered. Total duration of immobility in the second swim test was measured to gauge Behavioral Despair. In Exp. 1, the 2-h double double-pulse group showed significantly shorter immobility compared to controls ( p p
Roger D Porsolt - One of the best experts on this subject based on the ideXlab platform.
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use of latency to immobility improves detection of antidepressant like activity in the Behavioral Despair test in the mouse
European Journal of Pharmacology, 2009Co-Authors: Vincent Castagne, Roger D Porsolt, Paul MoserAbstract:The Behavioral Despair test (BDT), also called the forced swim test, is an economic, reliable and sensitive test for the detection of potential antidepressant-like activity of new test substances. The vast majority of clinically active antidepressants are active in the BDT, although substances specifically acting on serotonin transmission are generally reported to be less easily detected. Substances active in the BDT decrease the duration of immobility at doses considered as relatively high. In contrast, some psychostimulants are considered as potential false positives since they are also active in the BDT although they are not recognized as clinically active antidepressants. In the present study we have evaluated the usefulness of latency to the first immobility period as an additional parameter in the BDT to further evaluate the effects of antidepressants and psychostimulants administered intraperitoneally in the mouse. The results show that this measure increases the sensitivity of the test for detecting the effects of tricyclic antidepressants (imipramine, desipramine) and selective serotonin/norepinephrine reuptake inhibitors (duloxetine and venlafaxine) but not of serotonin reuptake inhibitors (fluoxetine and escitalopram). In contrast with previous reports, psychostimulants (amphetamine and modafinil) did not affect the duration or the latency to immobility in the BDT. The mouse strain used in the BDT seems to be an important parameter to discriminate between antidepressants and psychostimulants. These results suggest that the measure of the latency to the first immobility improves the predictive validity of the BDT.
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rodent models of depression forced swim and tail suspension Behavioral Despair tests in rats and mice
Current protocols in pharmacology, 2007Co-Authors: Vincent Castagne, Paul Moser, Sylvain Roux, Roger D PorsoltAbstract:The development of antidepressants requires simple rodent Behavioral tests for initial screening before undertaking more complex preclinical tests and clinical evaluation. Presented in the unit are two widely used screening tests used for antidepressants, the forced swim (also termed Behavioral Despair) test in the rat and mouse, and the tail suspension test in the mouse. These tests have good predictive validity and allow rapid and economical detection of substances with potential antidepressant-like activity. The Behavioral Despair and the tail suspension tests are based on the same principle: measurement of the duration of immobility when rodents are exposed to an inescapable situation. The majority of clinically used antidepressants decrease the duration of immobility. Antidepressants also increase the latency to immobility, and this additional measure can increase the sensitivity of the Behavioral Despair test in the mouse for certain classes of antidepressant. Testing of new substances in the Behavioral Despair and tail suspension tests allows a simple assessment of their potential antidepressant activity by the measurement of their effect on immobility.
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animal models of depression utility for transgenic research
Reviews in The Neurosciences, 2000Co-Authors: Roger D PorsoltAbstract:The utility of available animal models of depression for transgenic research is reviewed. Criteria for usefulness are non-dependence on a mechanism of action, pharmacological validity, existence of genetic determinants, availability of a mouse version, procedural simplicity, and reproducibility. The following models are reviewed: Behavioral Despair, tail suspension, learned helplessness, chronic mild stress, olfactory bulbectomy, DRL behavior and conditioned place preference. It is concluded that the Behavioral Despair and tail suspension models satisfy the criteria most closely. On the other hand, despite its procedural complexity and poor reproducibility, the chronic mild stress model shows high promise for the future.
Urs Albrecht - One of the best experts on this subject based on the ideXlab platform.
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light affects Behavioral Despair involving the clock gene period 1
PLOS Genetics, 2021Co-Authors: Iwona Olejniczak, Juergen Ripperger, Federica Sandrelli, Anna Schnell, Ka Yi Hui, Andrea Brenna, Laureen Mansencalstrittmatter, Katrin Wendrich, Naila Ben Fredj, Urs AlbrechtAbstract:Light at night has strong effects on physiology and behavior of mammals. It affects mood in humans, which is exploited as light therapy, and has been shown to reset the circadian clock in the suprachiasmatic nuclei (SCN). This resetting is paramount to align physiological and biochemical timing to the environmental light-dark cycle. Here we provide evidence that light at zeitgeber time (ZT) 22 affects mood-related behaviors also in mice by activating the clock gene Period1 (Per1) in the lateral habenula (LHb), a brain region known to modulate mood-related behaviors. We show that complete deletion of Per1 in mice led to depressive-like behavior and loss of the beneficial effects of light on this behavior. In contrast, specific deletion of Per1 in the region of the LHb did not affect mood-related behavior, but suppressed the beneficial effects of light. RNA sequence analysis in the mesolimbic dopaminergic system revealed profound changes of gene expression after a light pulse at ZT22. In the nucleus accumbens (NAc), sensory perception of smell and G-protein coupled receptor signaling were affected the most. Interestingly, most of these genes were not affected in Per1 knock-out animals, indicating that induction of Per1 by light serves as a filter for light-mediated gene expression in the brain. Taken together we show that light affects mood-related behavior in mice at least in part via induction of Per1 in the LHb with consequences on mood-related behavior and signaling mechanisms in the mesolimbic dopaminergic system.
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Light affects Behavioral Despair involving the clock gene Period 1
2020Co-Authors: Iwona Olejniczak, Juergen Ripperger, Federica Sandrelli, Anna Schnell, Laureen Mansencal-strittmatter, Ka Yi Hui, Andrea Brenna, Naila Benfredj, Urs AlbrechtAbstract:Light at night has strong effects on physiology and behavior of mammals. It affects mood in humans, which is exploited as light therapy, and has been shown to reset the circadian clock in the suprachiasmatic nuclei (SCN). This resetting is paramount to align physiological and biochemical timing to the environmental light-dark cycle. Here we provide evidence that light affects mood-related behaviors also in mice by activating the clock gene Period1 (Per1) in the lateral habenula (LHb), a brain region known to modulate mood-related behaviors. A light pulse given at ZT22 to wild type mice caused profound changes of gene expression in the mesolimbic dopaminergic system including the nucleus accumbens (NAc). Sensory perception of smell and G-protein coupled receptor signaling was affected the most in this brain region. Interestingly, most of these genes were not affected in Per1 knock-out animals, indicating that induction of Per1 by light serves as a filter for light-mediated gene induction in the brain. Taken together we show that light affects mood-related behavior in mice at least in part via induction of Per1 in the LHb with consequences on signaling mechanisms in the mesolimbic dopaminergic system.
Ayla Aksoy - One of the best experts on this subject based on the ideXlab platform.
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Behavioral Despair is differentially affected by the length and timing of photic stimulation in the dark phase of an l d cycle
Progress in Neuro-psychopharmacology & Biological Psychiatry, 2008Co-Authors: Daniela Schulz, Ayla Aksoy, Resit CanbeyliAbstract:Abstract The effect of varying the length and timing of photic stimulation in the dark phase of an L/D lighting cycle on Behavioral Despair was investigated in female Wistar rats. Animals were kept in a vivarium on an L/D 12 h:12 h light cycle (lights on at 0700 h) except for a single day of light exposure in an insulated chamber in the dark phase of the L/D schedule. Light pulses provided by an incandescent lamp (15- and 25-W, for Exps. 1 and 2, respectively) either 2-h (Exp. 1) or 30-min in length (Exp. 2) were administered to independent groups of rats ( n = 8 each) either in the early, middle or late hours of the dark phase of the L/D cycle in the insulated chamber. Light pulses were delivered beginning 2 1/2, 5 1/2 or 7 1/2 h (Exp. 1) or 3 1/4, 6 1/4 and 8 1/4 h (Exp. 2) after dark onset. Control animals were treated similarly except for photic stimulation. In each experiment, an additional group received a light pulse of the appropriate length both in the early and late portion of the dark phase (double double-pulse groups): beginning 2 1/2 and 7 1/2 h (Exp. 1) or 3 1/4 and 8 1/4 h (Exp. 2) after dark onset. All animals then underwent two forced swim tests separated by 24 h with the first test occurring in the light (starting at 1500 h) following the dark phase when photic stimulation was administered. Total duration of immobility in the second swim test was measured to gauge Behavioral Despair. In Exp. 1, the 2-h double double-pulse group showed significantly shorter immobility compared to controls ( p p
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bnst lesions aggravate Behavioral Despair but do not impair navigational learning in rats
Brain Research Bulletin, 2006Co-Authors: Pinar Pezuk, Ayla Aksoy, Didem Goz, Resit CanbeyliAbstract:The bed nucleus of the stria terminalis (BNST) is a basal forebrain structure involved in many motivational processes closely linked to stress regulation. The present study investigated the effect of bilateral lesions of the BNST in male Wistar rats on Behavioral Despair and navigational learning in the Morris water maze both of which present stressful challenges. Compared to controls, BNST-lesioned animals displayed longer duration of immobility in the second of two forced swim tests used to assess Behavioral Despair but performed similarly in the water maze task. The present results indicate strongly that the BNST is involved in the modulation of Behavioral Despair. Experimentally induced depression by BNST lesions does not impair learning and memory in the water maze suggesting a possible dissociation between BNST-mediated depression and cognitive performance.
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brief communication seasonal variability in Behavioral Despair in female rats
International Journal of Neuroscience, 2004Co-Authors: Ayla Aksoy, Ajda Yilmaz, Daniela Schulz, Resit CanbeyliAbstract:Separate groups of female Wistar rats were tested every three months over a year to assess the extent of seasonal variability in the Behavioral Despair model of depression consisting of 2 swim tests separated by 24 h. There was a significant seasonal variability in the duration of immobility in the swim tests; duration of immobility was shorter in August and November than in February and May. These findings suggest reduced immobility and susceptibility to Behavioral Despair in summer and fall compared to winter and spring.
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a single day of constant light l l provides immunity to Behavioral Despair in female rats maintained on an l d cycle
Progress in Neuro-psychopharmacology & Biological Psychiatry, 2004Co-Authors: Ajda Yilmaz, Ayla Aksoy, Resit CanbeyliAbstract:The present experiment investigated the potentially ameliorative effect of exposure to light in the dark phase of an 12:12 h daily lighting schedule (12L/12D cycle) on Behavioral Despair, an animal model of depression based on two forced swim tests separated by 24 h. Experimental groups of female Wistar rats were maintained on the 12L/12D cycle except for a single exposure to 12 h of light treatment in the dark phase of the 12L/12D cycle. Control animals were treated similarly except for light treatment. Animals then underwent one of two sets of Behavioral tests starting on either the day light (or control) treatment ended (No Delay groups) or 24 h thereafter (Delay groups). The treatment for subgroups of light-treated and control animals tested with or without delay consisted of either two forced swim tests separated by 24 h or testing in the open field and elevated plus maze. Results indicated that a single exposure to a 12-h light treatment has protective effect on Behavioral Despair in groups tested with or without delay as measured by shorter duration of immobility in the second swim test compared to the controls. Light-treated and control animals behaved similarly in the open field and elevated plus-maze tests.
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effect of lesioning the suprachiasmatic nuclei on Behavioral Despair in rats
Brain Research, 2004Co-Authors: Ozgur Tataroglu, Ajda Yilmaz, Ayla Aksoy, Resit CanbeyliAbstract:The suprachiasmatic nucleus (SCN) is involved in regulating many biological rhythms. Several lines of research implicate the SCN in affective behavior. The SCN is directly involved in regulating the daily rhythms of the hypothalamo-pituitary-adrenal (HPA) axis hormones involved in stress. Bilateral lesions of the SCN disrupt both the rhythms and the basal levels of the HPA axis hormones involved in coping with stress. Moreover, stress can affect the biological rhythms regulated by the SCN, and disruption of biological rhythms in turn can cause stress. The present study assessed the effect of bilateral destruction of the SCN on Behavioral Despair, an animal model of depression sensitive to antidepressant treatment. The results indicate that bilateral destruction of the SCN results in reduced immobility in the second forced swimming test (FST) compared to sham controls and animals with incomplete lesions. These results indicate that bilateral destruction of the SCN has a protective effect in the induction of Behavioral Despair which may arise out of disruption of the secretion of the HPA axis hormones and/or of the neural connections between the SCN and the limbic structures that modulate the response to swim stress.
Vincent Castagne - One of the best experts on this subject based on the ideXlab platform.
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use of latency to immobility improves detection of antidepressant like activity in the Behavioral Despair test in the mouse
European Journal of Pharmacology, 2009Co-Authors: Vincent Castagne, Roger D Porsolt, Paul MoserAbstract:The Behavioral Despair test (BDT), also called the forced swim test, is an economic, reliable and sensitive test for the detection of potential antidepressant-like activity of new test substances. The vast majority of clinically active antidepressants are active in the BDT, although substances specifically acting on serotonin transmission are generally reported to be less easily detected. Substances active in the BDT decrease the duration of immobility at doses considered as relatively high. In contrast, some psychostimulants are considered as potential false positives since they are also active in the BDT although they are not recognized as clinically active antidepressants. In the present study we have evaluated the usefulness of latency to the first immobility period as an additional parameter in the BDT to further evaluate the effects of antidepressants and psychostimulants administered intraperitoneally in the mouse. The results show that this measure increases the sensitivity of the test for detecting the effects of tricyclic antidepressants (imipramine, desipramine) and selective serotonin/norepinephrine reuptake inhibitors (duloxetine and venlafaxine) but not of serotonin reuptake inhibitors (fluoxetine and escitalopram). In contrast with previous reports, psychostimulants (amphetamine and modafinil) did not affect the duration or the latency to immobility in the BDT. The mouse strain used in the BDT seems to be an important parameter to discriminate between antidepressants and psychostimulants. These results suggest that the measure of the latency to the first immobility improves the predictive validity of the BDT.
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rodent models of depression forced swim and tail suspension Behavioral Despair tests in rats and mice
Current protocols in pharmacology, 2007Co-Authors: Vincent Castagne, Paul Moser, Sylvain Roux, Roger D PorsoltAbstract:The development of antidepressants requires simple rodent Behavioral tests for initial screening before undertaking more complex preclinical tests and clinical evaluation. Presented in the unit are two widely used screening tests used for antidepressants, the forced swim (also termed Behavioral Despair) test in the rat and mouse, and the tail suspension test in the mouse. These tests have good predictive validity and allow rapid and economical detection of substances with potential antidepressant-like activity. The Behavioral Despair and the tail suspension tests are based on the same principle: measurement of the duration of immobility when rodents are exposed to an inescapable situation. The majority of clinically used antidepressants decrease the duration of immobility. Antidepressants also increase the latency to immobility, and this additional measure can increase the sensitivity of the Behavioral Despair test in the mouse for certain classes of antidepressant. Testing of new substances in the Behavioral Despair and tail suspension tests allows a simple assessment of their potential antidepressant activity by the measurement of their effect on immobility.