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Michael H Antoni - One of the best experts on this subject based on the ideXlab platform.

  • differential psychological effects of cognitive Behavioral Stress management among breast cancer patients with high and low initial cancer specific diStress
    Journal of Psychosomatic Research, 2018
    Co-Authors: Ashley Weiting Wang, Laura C. Bouchard, Lisa M. Gudenkauf, Devika R. Jutagir, Bonnie B Blomberg, Charles S Carver, Suzanne C Lechner, Hannah M Fisher, Jamie M Jacobs, Michael H Antoni
    Abstract:

    Abstract Objective Cognitive-Behavioral Stress management (CBSM) improves adaptation to primary treatment for breast cancer (BCa), evidenced as reductions in diStress and increases in positive affect. Because not all BCa patients may need psychosocial intervention, identifying those most likely to benefit is important. A secondary analysis of a previous randomized trial tested whether baseline level of cancer-specific diStress moderated CBSM effects on adaptation over 12 months. We hypothesized that patients experiencing the greatest cancer-specific diStress in the weeks after surgery would show the greatest CBSM-related effects on diStress and affect. Methods Stages 0-III BCa patients (N = 240) were enrolled 2–8 weeks after surgery and randomized to either a 10-week group CBSM intervention or a 1-day psychoeducational (PE) control group. They completed the Impact of Event Scale (IES) and Affect Balance Scale (ABS) at study entry, and at 6- and 12- month follow-ups. Results Latent Growth Curve Modeling across the 12-month interval showed that CBSM interacted with initial cancer-related diStress to influence diStress and affect. Follow-up analyses showed that those with higher initial diStress were significantly improved by CBSM compared to control treatment. No differential improvement in affect or intrusive thoughts occurred among low-diStress women. Conclusion CBSM decreased negative affect and intrusive thoughts and increases positive affect among post-surgical BCa patients presenting with elevated cancer-specific diStress after surgery, but did not show similar effects in women with low levels of cancer-specific diStress. Identifying patients most in need of intervention in the period after surgery may optimize cost-effective cancer care.

  • Study design and protocol for a culturally adapted cognitive Behavioral Stress and self-management intervention for localized prostate cancer: The Encuentros de Salud study.
    Contemporary clinical trials, 2018
    Co-Authors: Frank J Penedo, Lara Traeger, Michael H Antoni, Jason R. Dahn, Patricia I. Moreno, Dolores Perdomo, Greg Miller, Steve W. Cole, Julian Orjuela, Edgar Pizarro
    Abstract:

    Abstract Almost 2.8 million men in the U.S. are living with prostate cancer (PC), accounting for 40% of all male cancer survivors. Men diagnosed with prostate cancer may experience chronic and debilitating treatment side effects, including sexual and urinary dysfunction, pain and fatigue. Side effects can be Stressful and can also lead to poor psychosocial functioning. Prior trials reveal that group-based cognitive Behavioral Stress and self-management (CBSM) is effective in reducing Stress and mitigating some of these symptoms, yet little is known about the effects of culturally-translated CBSM among Spanish-speaking men with PC. This manuscript describes the rationale and study design of a multi-site, randomized controlled trial to determine whether participation in a culturally adapted cognitive Behavioral Stress management (C-CBSM) intervention leads to significantly greater reductions in symptom burden and improvements in health-related quality of life relative to participation in a non-culturally adapted cognitive Behavioral Stress management (CBSM) intervention. Participants (N = 260) will be Spanish-speaking Hispanic/Latino men randomized to the standard, non-culturally adapted CBSM intervention (e.g., cognitive Behavioral strategies, Stress management, and health maintenance) or the culturally adapted C-CBSM intervention (e.g., content adapted to be compatible with Hispanic/Latino cultural patterns and belief systems, meanings, values and social context) for 10 weeks. Primary outcomes (i.e., disease-specific symptom burden and health-related quality of life) will be assessed across time. We hypothesize that a culturally adapted C-CBSM intervention will be more efficacious in reducing symptom burden and improving health-related quality of life among Hispanic/Latino men when compared to a non-culturally adapted CBSM intervention.

  • long term psychological benefits of cognitive Behavioral Stress management for women with breast cancer 11 year follow up of a randomized controlled trial
    Cancer, 2015
    Co-Authors: Jamie M. Stagl, Laura C. Bouchard, Lisa M. Gudenkauf, Devika R. Jutagir, Bonnie B Blomberg, Charles S Carver, Suzanne C Lechner, Stefan Gluck, Robert P Derhagopian, Michael H Antoni
    Abstract:

    BACKGROUND Breast cancer survivors experience long-term physical and psychological sequelae after their primary treatment that negatively influence their quality of life (QOL) and increase depressive symptoms. Group-based cognitive-Behavioral Stress management (CBSM) delivered after surgery for early-stage breast cancer was previously associated with better QOL over a 12-month follow-up and with fewer depressive symptoms up to 5 years after study enrollment. This 8- to 15-year follow-up (median, 11 years) of a previously conducted trial (NCT01422551) evaluated whether women in this cohort receiving CBSM had fewer depressive symptoms and better QOL than controls at an 8- to 15-year follow-up. METHODS Women with stage 0 to IIIb breast cancer were initially recruited 2 to 10 weeks after surgery and randomized to a 10-week CBSM intervention or a 1-day psychoeducational control group. One hundred women (51 CBSM patients and 49 controls) were recontacted 8 to 15 years after study enrollment to participate in a follow-up assessment. The Center for Epidemiologic Studies–Depression (CES-D) scale and the Functional Assessment of Cancer Therapy–Breast (FACT-B) were self-administered. Multiple regression was employed to evaluate group differences on the CES-D scale and FACT-B over and above effects of confounding variables. RESULTS Participants assigned to CBSM reported significantly lower depressive symptoms (d, 0.63; 95% confidence interval [CI], 0.56-0.70) and better QOL (d, 0.58; 95% CI, 0.52-0.65) above the effects of the covariates. CONCLUSIONS Women who received CBSM after surgery for early-stage breast cancer reported lower depressive symptoms and better QOL than the control group up to 15 years later. Early implementation of cognitive-Behavioral interventions may influence long-term psychosocial functioning in breast cancer survivors. Cancer 2015;121:1873–1881. © 2015 American Cancer Society.

  • cognitive Behavioral Stress management reverses anxiety related leukocyte transcriptional dynamics
    Biological Psychiatry, 2012
    Co-Authors: Michael H Antoni, Jamie M. Stagl, Alain Diaz, Susan K. Lutgendorf, Bonnie B Blomberg, Charles S Carver, Suzanne C Lechner, Jesusa M G Arevalo, Steven W Cole
    Abstract:

    Background Chronic threat and anxiety are associated with pro-inflammatory transcriptional profiles in circulating leukocytes, but the causal direction of that relationship has not been established. This study tested whether a cognitive-Behavioral Stress management (CBSM) intervention targeting negative affect and cognition might counteract anxiety-related transcriptional alterations in people confronting a major medical threat. Methods One hundred ninety-nine women undergoing primary treatment of stage 0–III breast cancer were randomized to a 10-week CBSM protocol or an active control condition. Seventy-nine provided peripheral blood leukocyte samples for genome-wide transcriptional profiling and bioinformatic analyses at baseline, 6-month, and 12-month follow-ups. Results Baseline negative affect was associated with >50% differential expression of 201 leukocyte transcripts, including upregulated expression of pro-inflammatory and metastasis-related genes. CBSM altered leukocyte expression of 91 genes by >50% at follow-up (group × time interaction), including downregulation of pro-inflammatory and metastasis-related genes and upregulation of type I interferon response genes. Promoter-based bioinformatic analyses implicated decreased activity of NF-κB/Rel and GATA family transcription factors and increased activity of interferon response factors and the glucocorticoid receptor as potential mediators of CBSM-induced transcriptional alterations. Conclusions In early-stage breast cancer patients, a 10-week CBSM intervention can reverse anxiety-related upregulation of pro-inflammatory gene expression in circulating leukocytes. These findings clarify the molecular signaling pathways by which Behavioral interventions can influence physical health and alter peripheral inflammatory processes that may reciprocally affect brain affective and cognitive processes.

  • cognitive Behavioral Stress management effects on psychosocial and physiological adaptation in women undergoing treatment for breast cancer
    Brain Behavior and Immunity, 2009
    Co-Authors: Michael H Antoni, Alain Diaz, Charles S Carver, Suzanne C Lechner, Bonnie A Mcgregor, Sara Vargas, Heather Holley, Kristin M Phillips, Bonnie B Blomberg
    Abstract:

    Abstract Background A diagnosis of breast cancer and treatment are psychologically Stressful events, particularly over the first year after diagnosis. Women undergo many demanding and anxiety-arousing treatments such as surgery, radiation and chemotherapy. Psychosocial interventions that promote psychosocial adaptation to these challenges may modulate physiological processes (neuroendocrine and immune) that are relevant for health outcomes in breast cancer patients. Methods Women with Stages 1–3 breast cancer recruited 4–8 weeks after surgery were randomized to either a 10-week group-based cognitive Behavioral Stress management (CBSM) intervention or a 1-day psychoeducational control group and completed questionnaires and late afternoon blood samples at study entry and 6 and 12 months after assignment to experimental condition. Results Of 128 women initially providing psychosocial questionnaire and blood samples at study entry, 97 provided complete data for anxiety measures and cortisol analysis at all time points, and immune assays were run on a subset of 85 of these women. Those assigned to a 10-week group-based CBSM intervention evidenced better psychosocial adaptation (lower reported cancer-specific anxiety and interviewer-rated general anxiety symptoms) and physiological adaptation (lower cortisol, greater Th1 cytokine [interleukin-2 and interferon-γ] production and IL-2:IL-4 ratio) after their adjuvant treatment compared to those in the control group. Effects on psychosocial adaptation indicators and cortisol appeared to hold across the entire 12-month observation period. Th1 cytokine regulation changes held only over the initial 6-month period. Conclusions This intervention may have facilitated a “recovery or maintenance” of Th1 cytokine regulation during or after the adjuvant therapy period. Behavioral interventions that address dysregulated neuroendocrine function could play a clinically significant role in optimizing host immunologic resistance during a vulnerable period.

Neil Schneiderman - One of the best experts on this subject based on the ideXlab platform.

  • A randomized clinical trial of group-based cognitive-Behavioral Stress management in localized prostate cancer: Development of Stress management skills improves quality of life and benefit finding
    Annals of behavioral medicine : a publication of the Society of Behavioral Medicine, 2006
    Co-Authors: Frank J Penedo, Scott Siegel, Dave Kinsinger, Biing-jiun Shen, Lara Traeger, Ivan Molton, Neil Schneiderman, Jason R. Dahn, Michael Antoni
    Abstract:

    BACKGROUND: Recent literature has indicated that a significant percentage of oncology patients describe finding some benefit (e.g., improved personal growth, sense of meaning, and enhanced interpersonal relationships) in the cancer experience. However, few studies have investigated the role of group-based psychosocial interventions in improving benefit finding (BF), and virtually none have investigated these constructs in men. PURPOSE: This study examined whether a cognitive-Behavioral Stress management (CBSM) intervention improves BF and quality of life (QoL) in men recovering from treatment for localized prostate cancer. METHODS: Participants in this study were 191 men (M age = 65.1) treated with radiation or radical prostatectomy for clinically localized (i.e., Stage I or II) prostate cancer. Participants were primarily non-Hispanic White (40%) or Hispanic (41%), followed by Black (18%) and other ethnicity (1%), were an average of 65.1 years old (SD = 7.7), and earned an average of 47,800 US dollars annually (SD = 41,000 US dollars). Participants were randomized to either a 10-week group-based cognitive-Behavioral Stress management intervention or a half-day educational seminar as a control condition. All participants provided demographic information and completed the Positive Contributions Scale-Cancer to assess BF, the Functional Assessment of Cancer Therapy to measure quality of life, and a measure of perceived Stress management skills. Structural equation modeling was utilized for all analyses. RESULTS: Results indicated that the CBSM condition led to increases in BF and QoL and that these changes were mediated by the development of Stress management skills. CONCLUSIONS: Results support the use of group-based cognitive-Behavioral interventions in promoting QoL and BF in this population.

  • Cognitive Behavioral Stress management effects on mood, social support, and a marker of antiviral immunity are maintained up to 1 year in HIV-infected gay men
    International journal of behavioral medicine, 2005
    Co-Authors: Adam W. Carrico, Nancy Klimas, S C Lechner, Mary Ann Fletcher, Michael H Antoni, D. Pereira, Neil Schneiderman
    Abstract:

    Numerous herpesvirus infections are associated with clinically relevant outcomes as well as an accelerated HIV replication rate and subsequent disease progression. Stress management interventions may improve markers of cellular immune control over latent herpesvirus infections and these changes appear to be mediated by perceptions of increased social support availability. We examined the effects of a group-based cognitive Behavioral Stress management (CBSM) intervention on diStress, dysphoria, perceived social support, and herpesvirus immunoglobulin G (IgG) antibody titers during the 6 to 12 months following the intervention. Of those who were initially randomized, 49 HIV-infected men were followed during the 6- to 12-month period after randomization to either a 10-week CBSM intervention (n = 31) or a modified wait-list control condition (n = 18). Measures of diStress, dysphoria, social support, and blood samples for herpesvirus IgG titers were taken at baseline, immediately following CBSM and at 6- to 12-month follow-up. Men in CBSM displayed maintenance of previously observed intervention effects on dysphoria, reliable alliance support, and herpesvirus IgG antibody titers (i.e., Epstein-Barr virus capsid antigen; EBV-VCA). Intervention-related changes in EBV-VCA were unrelated to changes in lymphocyte subsets (i.e., CD4+, CD8+, and CD4+:CD8+) or changes in measures of dysphoria and social support during the investigation period. Data indicate that HIV-infected men participating in a CBSM intervention maintain better psychosocial status and immunologic control of latent EBV infection up to 1 year after its conclusion.

  • Changes in mood and depressive symptoms and related change processes during cognitive-Behavioral Stress management in HIV-infected men
    Cognitive Therapy and Research, 2002
    Co-Authors: Stacy Cruess, Mary Ann Fletcher, Adele Hayes, Frank Penedo, Susan K. Lutgendorf, Michael H Antoni, Gail Ironson, Neil Schneiderman
    Abstract:

    This study examined the effects of a cognitive-Behavioral Stress management (CBSM) intervention vs. a no-treatment control group in 100 HIV-infected gay men. CBSM participants showed significant decreases in mood disturbance and depressive symptoms as well as changes in coping, perceptions of social support, self-efficacy, and dysfunctional attitudes. Stepwise regression analyses were conducted to determine which of these changes were most important for reductions in mood disturbance and depressive symptoms. Although increases in self-efficacy emerged as a significant predictor of reduction in both mood disturbance and depressive symptoms, improvements in Behavioral coping strategies were most closely tied to lowered overall mood disturbance whereas improvements in cognitive coping strategies and reduction in dysfunctional attitudes were more closely associated with decreases in depressive symptoms. These results support the use of multimodal CBSM interventions for HIV-infected men as a way to modify many different types of processes independently associated with different indicators of psychological adjustment.

  • Cognitive-Behavioral Stress management increases free testosterone and decreases psychological diStress in HIV-seropositive men
    Health Psychology, 2000
    Co-Authors: Dean G. Cruess, Philip Mccabe, Stacy E. Cruess, Nancy Klimas, Jesus B Fernandez, Michael H Antoni, Gail Ironson, Neil Schneiderman, Mahendra Kumar
    Abstract:

    The effects of a 10-week group-based cognitive-Behavioral Stress management (CBSM) intervention on psychological diStress and plasma free testosterone in symptomatic, HIV-seropositive men were examined. Participants were randomized to either CBSM (n = 42) or a wait-list control group (n = 23). Men in the CBSM intervention showed significant increases in testosterone, whereas control participants showed significant decreases. Those participating in CBSM had significant diStress reductions, whereas controls showed no such change. Alterations in free testosterone were inversely related to changes in diStress states over time, independent of any changes in cortisol. These findings demonstrate that a short-term CBSM intervention increases free testosterone levels among symptomatic, HIV-seropositive men, and alterations in free testosterone are associated with changes in psychological diStress observed during CBSM.

  • Reductions in herpes simplex virus type 2 antibody titers after cognitive Behavioral Stress management and relationships with neuroendocrine function, relaxation skills, and social support in HIV-positive men.
    Psychosomatic medicine, 2000
    Co-Authors: Stacy Cruess, Susan K. Lutgendorf, Dean G. Cruess, Michael H Antoni, Gail Ironson, Mahendra Kumar, Nancy G. Klimas, Mary A Fletcher, Adele M. Hayes, Neil Schneiderman
    Abstract:

    ObjectiveCoinfection with herpes simplex virus type 2 (HSV-2) is common in individuals infected with human immunodeficiency virus (HIV) and may have health implications. This study examined the effect of a 10-week cognitive Behavioral Stress management (CBSM) intervention on immunoglobulin G (IgG) a

Mahendra Kumar - One of the best experts on this subject based on the ideXlab platform.

  • Cognitive-Behavioral Stress management increases free testosterone and decreases psychological diStress in HIV-seropositive men
    Health Psychology, 2000
    Co-Authors: Dean G. Cruess, Philip Mccabe, Stacy E. Cruess, Nancy Klimas, Jesus B Fernandez, Michael H Antoni, Gail Ironson, Neil Schneiderman, Mahendra Kumar
    Abstract:

    The effects of a 10-week group-based cognitive-Behavioral Stress management (CBSM) intervention on psychological diStress and plasma free testosterone in symptomatic, HIV-seropositive men were examined. Participants were randomized to either CBSM (n = 42) or a wait-list control group (n = 23). Men in the CBSM intervention showed significant increases in testosterone, whereas control participants showed significant decreases. Those participating in CBSM had significant diStress reductions, whereas controls showed no such change. Alterations in free testosterone were inversely related to changes in diStress states over time, independent of any changes in cortisol. These findings demonstrate that a short-term CBSM intervention increases free testosterone levels among symptomatic, HIV-seropositive men, and alterations in free testosterone are associated with changes in psychological diStress observed during CBSM.

  • Cognitive-Behavioral Stress management reduces serum cortisol by enhancing benefit finding among women being treated for early stage breast cancer.
    Psychosomatic medicine, 2000
    Co-Authors: Dean G. Cruess, A Boyers, S M Alferi, K M Kilbourn, Michael H Antoni, Bruce A. Mcgregor, Charles S Carver, Mahendra Kumar
    Abstract:

    OBJECTIVE: This study examined the effects of a cognitive-Behavioral Stress management (CBSM) group intervention on serum cortisol levels in women being treated for stage I or II breast cancer. METHODS: Participants were randomly assigned to undergo a 10-week intervention (N = 24) within 8 weeks after surgery or were placed on a waiting list (N = 10). Cortisol was assessed by means of a radioimmunoassay of blood samples collected at the same time of day just before the start of the intervention and immediately after its completion. The women also reported the degree to which breast cancer had made positive contributions to their lives. RESULTS: Intervention participants showed increased benefit finding and reduced serum cortisol levels, whereas control subjects experienced neither change. Path analysis suggested that the effect of CBSM on cortisol was mediated by increases in benefit finding. CONCLUSIONS: These findings suggest that positive growth enhanced during a time-limited intervention can influence physiological parameters such as cortisol among women with early stage breast cancer.

  • Cognitive-Behavioral Stress management reduces diStress and 24-hour urinary free cortisol output among symptomatic HIV-infected gay men.
    Annals of behavioral medicine : a publication of the Society of Behavioral Medicine, 2000
    Co-Authors: Michael H Antoni, Stacy Cruess, Susan K. Lutgendorf, Dean G. Cruess, Gail Ironson, Mahendra Kumar, Elizabeth Dettmer, Jessie Williams, Nancy G. Klimas, Mary A Fletcher
    Abstract:

    Background Stress management interventions can reduce symptoms of diStress as well as modulate certain immune system components in persons infected with human immunodeficiency virus (HIV). These effects may occur in parallel with reductions in hypothalamic-pituitary-adrenal (HPA) axis hormones such as cortisol, which has been related in other work to a down-regulation of immune system components relevant to HIV infection. The present study tested the effects of a multimodal cognitive-Behavioral Stress management (CBSM) intervention on 24-hour urinary free cortisol levels and diStressed mood in symptomatic HIV+ gay men.

  • Reductions in herpes simplex virus type 2 antibody titers after cognitive Behavioral Stress management and relationships with neuroendocrine function, relaxation skills, and social support in HIV-positive men.
    Psychosomatic medicine, 2000
    Co-Authors: Stacy Cruess, Susan K. Lutgendorf, Dean G. Cruess, Michael H Antoni, Gail Ironson, Mahendra Kumar, Nancy G. Klimas, Mary A Fletcher, Adele M. Hayes, Neil Schneiderman
    Abstract:

    ObjectiveCoinfection with herpes simplex virus type 2 (HSV-2) is common in individuals infected with human immunodeficiency virus (HIV) and may have health implications. This study examined the effect of a 10-week cognitive Behavioral Stress management (CBSM) intervention on immunoglobulin G (IgG) a

  • Cognitive-Behavioral Stress management decreases dysphoric mood and herpes simplex virus-type 2 antibody titers in symptomatic HIV-seropositive gay men
    Journal of Consulting and Clinical Psychology, 1997
    Co-Authors: Susan K. Lutgendorf, Philip Mccabe, Nancy Klimas, Karen Cleven, Mary Ann Fletcher, Kathleen Starr, Michael H Antoni, Gail Ironson, Mahendra Kumar, Neil Schneiderman
    Abstract:

    This study tested the effects of a 10-week group cognitive-Behavioral Stress management (CBSM) intervention on mood and immunologic parameters in HIV-seropositive gay men whose disease had progressed to a symptomatic stage. Men were randomized to either CBSM or a modified waiting-list control group. The CBSM intervention significantly decreased self-reported dysphoria, anxiety, and total diStress. Individuals who practiced relaxation more consistently had significantly greater drops in dysphoria. The intervention also decreased herpes simplex virus-Type 2 (HSV-2) immunoglobulin G antibody titers. The control group showed no significant changes in either mood or antibody titers. Individual difference analyses revealed that decreases in dysphoria significantly predicted lower HSV-2 antibody titers by the end of the 10-week period. Neither group displayed changes in HSV-Type 1 antibody titers or in CD4+ or CD8+ cell numbers.

Gail Ironson - One of the best experts on this subject based on the ideXlab platform.

  • A randomized controlled trial of cognitive-Behavioral Stress management in breast cancer: survival and recurrence at 11-year follow-up
    Breast Cancer Research and Treatment, 2015
    Co-Authors: Jamie M. Stagl, S C Lechner, Qilu Yu, Laura C. Bouchard, Lisa M. Gudenkauf, Alain Diaz, Devika R. Jutagir, Bonnie B Blomberg, Charles S Carver, Gail Ironson
    Abstract:

    Non-metastatic breast cancer patients often experience psychological diStress which may influence disease progression and survival. Cognitive-Behavioral Stress management (CBSM) improves psychological adaptation and lowers diStress during breast cancer treatment and long-term follow-ups. We examined whether breast cancer patients randomized to CBSM had improved survival and recurrence 8-15 years post-enrollment. From 1998 to 2005, women (N = 240) 2-10 weeks post-surgery for non-metastatic Stage 0-IIIb breast cancer were randomized to a 10-week, group-based CBSM intervention (n = 120) or a 1-day psychoeducational seminar control (n = 120). In 2013, 8-15 years post-study enrollment (11-year median), recurrence and survival data were collected. Cox Proportional Hazards Models and Weibull Accelerated Failure Time tests were used to assess group differences in all-cause mortality, breast cancer-specific mortality, and disease-free interval, controlling for biomedical confounders. Relative to the control, the CBSM group was found to have a reduced risk of all-cause mortality (HR = 0.21; 95 % CI [0.05, 0.93]; p = .040). Restricting analyses to women with invasive disease revealed significant effects of CBSM on breast cancer-related mortality (p = .006) and disease-free interval (p = .011). CBSM intervention delivered post-surgery may provide long-term clinical benefit for non-metastatic breast cancer patients in addition to previously established psychological benefits. Results should be interpreted with caution; however, the findings contribute to the limited evidence regarding physical benefits of psychosocial intervention post-surgery for non-metastatic breast cancer. Additional research is necessary to confirm these results and investigate potential explanatory mechanisms, including physiological pathways, health behaviors, and treatment adherence changes.

  • Changes in mood and depressive symptoms and related change processes during cognitive-Behavioral Stress management in HIV-infected men
    Cognitive Therapy and Research, 2002
    Co-Authors: Stacy Cruess, Mary Ann Fletcher, Adele Hayes, Frank Penedo, Susan K. Lutgendorf, Michael H Antoni, Gail Ironson, Neil Schneiderman
    Abstract:

    This study examined the effects of a cognitive-Behavioral Stress management (CBSM) intervention vs. a no-treatment control group in 100 HIV-infected gay men. CBSM participants showed significant decreases in mood disturbance and depressive symptoms as well as changes in coping, perceptions of social support, self-efficacy, and dysfunctional attitudes. Stepwise regression analyses were conducted to determine which of these changes were most important for reductions in mood disturbance and depressive symptoms. Although increases in self-efficacy emerged as a significant predictor of reduction in both mood disturbance and depressive symptoms, improvements in Behavioral coping strategies were most closely tied to lowered overall mood disturbance whereas improvements in cognitive coping strategies and reduction in dysfunctional attitudes were more closely associated with decreases in depressive symptoms. These results support the use of multimodal CBSM interventions for HIV-infected men as a way to modify many different types of processes independently associated with different indicators of psychological adjustment.

  • Cognitive-Behavioral Stress management increases free testosterone and decreases psychological diStress in HIV-seropositive men
    Health Psychology, 2000
    Co-Authors: Dean G. Cruess, Philip Mccabe, Stacy E. Cruess, Nancy Klimas, Jesus B Fernandez, Michael H Antoni, Gail Ironson, Neil Schneiderman, Mahendra Kumar
    Abstract:

    The effects of a 10-week group-based cognitive-Behavioral Stress management (CBSM) intervention on psychological diStress and plasma free testosterone in symptomatic, HIV-seropositive men were examined. Participants were randomized to either CBSM (n = 42) or a wait-list control group (n = 23). Men in the CBSM intervention showed significant increases in testosterone, whereas control participants showed significant decreases. Those participating in CBSM had significant diStress reductions, whereas controls showed no such change. Alterations in free testosterone were inversely related to changes in diStress states over time, independent of any changes in cortisol. These findings demonstrate that a short-term CBSM intervention increases free testosterone levels among symptomatic, HIV-seropositive men, and alterations in free testosterone are associated with changes in psychological diStress observed during CBSM.

  • Cognitive-Behavioral Stress management reduces diStress and 24-hour urinary free cortisol output among symptomatic HIV-infected gay men.
    Annals of behavioral medicine : a publication of the Society of Behavioral Medicine, 2000
    Co-Authors: Michael H Antoni, Stacy Cruess, Susan K. Lutgendorf, Dean G. Cruess, Gail Ironson, Mahendra Kumar, Elizabeth Dettmer, Jessie Williams, Nancy G. Klimas, Mary A Fletcher
    Abstract:

    Background Stress management interventions can reduce symptoms of diStress as well as modulate certain immune system components in persons infected with human immunodeficiency virus (HIV). These effects may occur in parallel with reductions in hypothalamic-pituitary-adrenal (HPA) axis hormones such as cortisol, which has been related in other work to a down-regulation of immune system components relevant to HIV infection. The present study tested the effects of a multimodal cognitive-Behavioral Stress management (CBSM) intervention on 24-hour urinary free cortisol levels and diStressed mood in symptomatic HIV+ gay men.

  • Reductions in herpes simplex virus type 2 antibody titers after cognitive Behavioral Stress management and relationships with neuroendocrine function, relaxation skills, and social support in HIV-positive men.
    Psychosomatic medicine, 2000
    Co-Authors: Stacy Cruess, Susan K. Lutgendorf, Dean G. Cruess, Michael H Antoni, Gail Ironson, Mahendra Kumar, Nancy G. Klimas, Mary A Fletcher, Adele M. Hayes, Neil Schneiderman
    Abstract:

    ObjectiveCoinfection with herpes simplex virus type 2 (HSV-2) is common in individuals infected with human immunodeficiency virus (HIV) and may have health implications. This study examined the effect of a 10-week cognitive Behavioral Stress management (CBSM) intervention on immunoglobulin G (IgG) a

Susan K. Lutgendorf - One of the best experts on this subject based on the ideXlab platform.

  • cognitive Behavioral Stress management reverses anxiety related leukocyte transcriptional dynamics
    Biological Psychiatry, 2012
    Co-Authors: Michael H Antoni, Jamie M. Stagl, Alain Diaz, Susan K. Lutgendorf, Bonnie B Blomberg, Charles S Carver, Suzanne C Lechner, Jesusa M G Arevalo, Steven W Cole
    Abstract:

    Background Chronic threat and anxiety are associated with pro-inflammatory transcriptional profiles in circulating leukocytes, but the causal direction of that relationship has not been established. This study tested whether a cognitive-Behavioral Stress management (CBSM) intervention targeting negative affect and cognition might counteract anxiety-related transcriptional alterations in people confronting a major medical threat. Methods One hundred ninety-nine women undergoing primary treatment of stage 0–III breast cancer were randomized to a 10-week CBSM protocol or an active control condition. Seventy-nine provided peripheral blood leukocyte samples for genome-wide transcriptional profiling and bioinformatic analyses at baseline, 6-month, and 12-month follow-ups. Results Baseline negative affect was associated with >50% differential expression of 201 leukocyte transcripts, including upregulated expression of pro-inflammatory and metastasis-related genes. CBSM altered leukocyte expression of 91 genes by >50% at follow-up (group × time interaction), including downregulation of pro-inflammatory and metastasis-related genes and upregulation of type I interferon response genes. Promoter-based bioinformatic analyses implicated decreased activity of NF-κB/Rel and GATA family transcription factors and increased activity of interferon response factors and the glucocorticoid receptor as potential mediators of CBSM-induced transcriptional alterations. Conclusions In early-stage breast cancer patients, a 10-week CBSM intervention can reverse anxiety-related upregulation of pro-inflammatory gene expression in circulating leukocytes. These findings clarify the molecular signaling pathways by which Behavioral interventions can influence physical health and alter peripheral inflammatory processes that may reciprocally affect brain affective and cognitive processes.

  • Changes in mood and depressive symptoms and related change processes during cognitive-Behavioral Stress management in HIV-infected men
    Cognitive Therapy and Research, 2002
    Co-Authors: Stacy Cruess, Mary Ann Fletcher, Adele Hayes, Frank Penedo, Susan K. Lutgendorf, Michael H Antoni, Gail Ironson, Neil Schneiderman
    Abstract:

    This study examined the effects of a cognitive-Behavioral Stress management (CBSM) intervention vs. a no-treatment control group in 100 HIV-infected gay men. CBSM participants showed significant decreases in mood disturbance and depressive symptoms as well as changes in coping, perceptions of social support, self-efficacy, and dysfunctional attitudes. Stepwise regression analyses were conducted to determine which of these changes were most important for reductions in mood disturbance and depressive symptoms. Although increases in self-efficacy emerged as a significant predictor of reduction in both mood disturbance and depressive symptoms, improvements in Behavioral coping strategies were most closely tied to lowered overall mood disturbance whereas improvements in cognitive coping strategies and reduction in dysfunctional attitudes were more closely associated with decreases in depressive symptoms. These results support the use of multimodal CBSM interventions for HIV-infected men as a way to modify many different types of processes independently associated with different indicators of psychological adjustment.

  • Cognitive-Behavioral Stress management reduces diStress and 24-hour urinary free cortisol output among symptomatic HIV-infected gay men.
    Annals of behavioral medicine : a publication of the Society of Behavioral Medicine, 2000
    Co-Authors: Michael H Antoni, Stacy Cruess, Susan K. Lutgendorf, Dean G. Cruess, Gail Ironson, Mahendra Kumar, Elizabeth Dettmer, Jessie Williams, Nancy G. Klimas, Mary A Fletcher
    Abstract:

    Background Stress management interventions can reduce symptoms of diStress as well as modulate certain immune system components in persons infected with human immunodeficiency virus (HIV). These effects may occur in parallel with reductions in hypothalamic-pituitary-adrenal (HPA) axis hormones such as cortisol, which has been related in other work to a down-regulation of immune system components relevant to HIV infection. The present study tested the effects of a multimodal cognitive-Behavioral Stress management (CBSM) intervention on 24-hour urinary free cortisol levels and diStressed mood in symptomatic HIV+ gay men.

  • Reductions in herpes simplex virus type 2 antibody titers after cognitive Behavioral Stress management and relationships with neuroendocrine function, relaxation skills, and social support in HIV-positive men.
    Psychosomatic medicine, 2000
    Co-Authors: Stacy Cruess, Susan K. Lutgendorf, Dean G. Cruess, Michael H Antoni, Gail Ironson, Mahendra Kumar, Nancy G. Klimas, Mary A Fletcher, Adele M. Hayes, Neil Schneiderman
    Abstract:

    ObjectiveCoinfection with herpes simplex virus type 2 (HSV-2) is common in individuals infected with human immunodeficiency virus (HIV) and may have health implications. This study examined the effect of a 10-week cognitive Behavioral Stress management (CBSM) intervention on immunoglobulin G (IgG) a

  • Cognitive-Behavioral Stress management decreases dysphoric mood and herpes simplex virus-type 2 antibody titers in symptomatic HIV-seropositive gay men
    Journal of Consulting and Clinical Psychology, 1997
    Co-Authors: Susan K. Lutgendorf, Philip Mccabe, Nancy Klimas, Karen Cleven, Mary Ann Fletcher, Kathleen Starr, Michael H Antoni, Gail Ironson, Mahendra Kumar, Neil Schneiderman
    Abstract:

    This study tested the effects of a 10-week group cognitive-Behavioral Stress management (CBSM) intervention on mood and immunologic parameters in HIV-seropositive gay men whose disease had progressed to a symptomatic stage. Men were randomized to either CBSM or a modified waiting-list control group. The CBSM intervention significantly decreased self-reported dysphoria, anxiety, and total diStress. Individuals who practiced relaxation more consistently had significantly greater drops in dysphoria. The intervention also decreased herpes simplex virus-Type 2 (HSV-2) immunoglobulin G antibody titers. The control group showed no significant changes in either mood or antibody titers. Individual difference analyses revealed that decreases in dysphoria significantly predicted lower HSV-2 antibody titers by the end of the 10-week period. Neither group displayed changes in HSV-Type 1 antibody titers or in CD4+ or CD8+ cell numbers.