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Beta Eudesmol

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Yu-chang Su – One of the best experts on this subject based on the ideXlab platform.

  • Composition and antifungal activities of the leaf essential oil of Neolitsea parvigemma from Taiwan.
    Natural Product Communications, 2020
    Co-Authors: Chen-lung Ho, Pei-chun Liao, Eugene I-chen Wang, Yu-chang Su

    Abstract:

    : The hydrodistillated leaf essential oil of Neolitsea parvigemma was analyzed to determine its composition and yield. Sixty-two compounds were identified, the main components being Beta-caryophyllene (14.2%), Beta–Eudesmol (12.9%), alpha-cadinol (10.2%) and tau-cadinol (8.8%). Oxygenated sesquiterpenes (48.9%) and sesquiterpene hydrocarbons (48.8%) were the predominant groups of compounds. The antifungal indexes of the leaf oil against the 7 fungi, Aspergillus clavatus, A. niger, Chaetomium globosum, Cladosporium cladosporioides, Myrothecium verrucaria, Penicillium citrinum and Trichoderma viride, were 100.0, 72.3, 100.0, 100.0, 100.0, 75.8 and 88.6% at a 1 mg/mL concentration, respectively. The oil also exhibited anti-wood-decay-fungi activity against Trametes versicolor, Phaneochaete chrysosporium, Phaeolus schweintizii, and Lenzites sulphureu with MIC values of 50, 50, 25 and 25 microg/mL, respectively. For the antifungal and anti-wood-decay fungal activities of the oil, the active source compounds were determined to be alpha-cadinol, Beta–Eudesmol and tau-cadinol.

  • Composition and antimicrobial activity of the leaf and twig oils of Litsea mushaensis and L. linii from Taiwan.
    Natural Product Communications, 2020
    Co-Authors: Chen-lung Ho, Pei-chun Liao, Eugene I-chen Wang, Yen-hsueh Tseng, Ju-ching Chou, Yu-chang Su

    Abstract:

    : The hydrodistilled essential oils of the leaves and twigs of Litsea mushaensis and L. linii were analyzed. Sixty-nine and ninety compounds were identified in the leaf and twig oils, respectively, of L. mushaensis. The main components of the leaf oil were Beta–Eudesmol (24.2%), tau-cadinol (10.2%), alpha-humulene (10.1%), alpha-pinene (9.7%), and trans-Beta-ocimene (6.5%), whereas the main components of the twig oil were trans-Beta-ocimene (19.5%), alpha-pinene (12.8%) and cis-Beta-ocimene (7.7%). With L. linii, 72 and 78 compounds were respectively identified in the leaf and twig oils. The main components of the leaf oil were Beta-selinene (15.7%), alpha-selinene (15.5%), Beta-caryophyllene (12.2%), alpha-humulene (7.2%), and delta-cadinene (5.6%), and of the twig oil trans-Beta-ocimene (20.8%), Beta-selinene (11.4%), alpha-cadinol (6.0%), delta-cadinene (5.8%), tau-cadinol (5.4%) and Beta–Eudesmol (5.2%). L. mushaensis leaf oil was shown to have excellent antimicrobial and anti-wood-decay fungal activity, superior to the other oils.

  • Composition and antimicrobial activity of the leaf essential oil of Litsea kostermansii from Taiwan.
    Natural product communications, 2020
    Co-Authors: Chen-lung Ho, Eugene I-chen Wang, Yu-chang Su

    Abstract:

    The hydrodistillated leaf essential oil of Litsea kostermansii was analyzed to determine its composition and yield. Seventy-three compounds were identified, the main components being Beta–Eudesmol (22.5%), gamma-Eudesmol (18.6%), delta-selinene (8.5%), alpha-Eudesmol (6.0%), and gamma-muurolene (4.7%). Oxygenated sesquiterpenes (66.2%) and sesquiterpene hydrocarbons (32.8%) were the predominant groups of compounds. The leaf oil exhibited excellent antimicrobial activities.

Masayasu Kimura – One of the best experts on this subject based on the ideXlab platform.

  • Noncontractile acetylcholine receptor-operated Ca++ mobilization: suppression of activation by open channel blockers and acceleration of desensitization by closed channel blockers in mouse diaphragm muscle.
    Journal of Pharmacology and Experimental Therapeutics, 1991
    Co-Authors: Masayasu Kimura, I Kimura, T Kondoh, H Tsuneki

    Abstract:

    The effects of various blockers of the nicotinic acetylcholine receptor-activated ionic channel on noncontractile slow Ca++ mobilization were investigated at the neuromuscular synapse of aequorin-injected diaphragm muscles of mice. Intracellular Ca++ mobilization (Ca++ transients) was evoked in the presence of neostigmine (0.3 microM) by nerve stimulation. Bupivacaine, an open channel blocker, decreased the peak amplitude, whereas chlorpromazine, a closed channel blocker, shortened the duration. Phencyclidine, an open and closed channel blocker, decreased both peak amplitude and duration. Beta–Eudesmol, a compound of Atractylodes lancea, clearly and specifically shortened the duration but had little effect on peak amplitude. All the above channel blockers, when given in the same concentration ranges, also blocked the total amount of contractile Ca++ transients. The effects of bupivacaine, chlorpromazine and phencyclidine on noncontractile Ca++ transients were not affected by 5 mM [Ca++]o, whereas the effect of Beta–Eudesmol was enhanced. Geographutoxin II (0.3 microM), a skeletal muscle Na+ channel blocker, selectively and partly reversibly blocked contractile Ca++ transients without affecting noncontractile ones. These results suggest that: 1) the activation of noncontractile Ca++ mobilization is suppressed by open channel blockers, whereas its desensitization is accelerated by closed channel blockers and 2) activation of the muscle Na+ channel and subsequent release of Ca++ from sarcoplasmic reticulum is not involved in the mechanism of noncontractile Ca++ mobilization. It may reflect the steps of the desensitization process.

  • enhancing effect by nicotinic acetylcholine receptor channel blockers including Beta Eudesmol on succinylcholine induced inhibition of twitch tension and intracellular ca in mouse diaphragm muscle
    Journal of Pharmacology and Experimental Therapeutics, 1991
    Co-Authors: I Kimura, H Tsuneki, T Kondoh, Masayasu Kimura

    Abstract:

    To elucidate the mechanism of neuromuscular block by succinylcholine, nerve-evoked changes in intracellular Ca(++)-aequorin luminescence and twitch tension were measured simultaneously in the presence of several different types of blockers for the nicotinic acetylcholine receptor channel. Mouse diaphragm muscles were pretreated for 30 to 60 min with 3 to 40 microM bupivacaine, chlorpromazine, phencyclidine and Beta–Eudesmol. The effects of these noncompetitive blockers on the succinylcholine-induced response were also compared with those for pancuronium. These channel blockers potentiated (2- to 10-fold) both the blocking effects on intracellular Ca++ and twitch tension of succinylcholine (13-100 microM), but not the pancuronium (0.3-1.1 microM)-induced block. These channel blockers also suppressed succinylcholine (1.3-5 microM)-induced enhancement of evoked Ca++ transients. On the other hand, the channel blockers inhibited the succinylcholine (2.5-100 microM)-induced increase in basal Ca++ transients. These results suggest that neuromuscular block induced by succinylcholine is mainly due to desensitization of the nicotinic acetylcholine receptor.

Chen-lung Ho – One of the best experts on this subject based on the ideXlab platform.

  • Composition and antifungal activities of the leaf essential oil of Neolitsea parvigemma from Taiwan.
    Natural Product Communications, 2020
    Co-Authors: Chen-lung Ho, Pei-chun Liao, Eugene I-chen Wang, Yu-chang Su

    Abstract:

    : The hydrodistillated leaf essential oil of Neolitsea parvigemma was analyzed to determine its composition and yield. Sixty-two compounds were identified, the main components being Beta-caryophyllene (14.2%), Beta–Eudesmol (12.9%), alpha-cadinol (10.2%) and tau-cadinol (8.8%). Oxygenated sesquiterpenes (48.9%) and sesquiterpene hydrocarbons (48.8%) were the predominant groups of compounds. The antifungal indexes of the leaf oil against the 7 fungi, Aspergillus clavatus, A. niger, Chaetomium globosum, Cladosporium cladosporioides, Myrothecium verrucaria, Penicillium citrinum and Trichoderma viride, were 100.0, 72.3, 100.0, 100.0, 100.0, 75.8 and 88.6% at a 1 mg/mL concentration, respectively. The oil also exhibited anti-wood-decay-fungi activity against Trametes versicolor, Phaneochaete chrysosporium, Phaeolus schweintizii, and Lenzites sulphureu with MIC values of 50, 50, 25 and 25 microg/mL, respectively. For the antifungal and anti-wood-decay fungal activities of the oil, the active source compounds were determined to be alpha-cadinol, Beta–Eudesmol and tau-cadinol.

  • Composition and antimicrobial activity of the leaf and twig oils of Litsea mushaensis and L. linii from Taiwan.
    Natural Product Communications, 2020
    Co-Authors: Chen-lung Ho, Pei-chun Liao, Eugene I-chen Wang, Yen-hsueh Tseng, Ju-ching Chou, Yu-chang Su

    Abstract:

    : The hydrodistilled essential oils of the leaves and twigs of Litsea mushaensis and L. linii were analyzed. Sixty-nine and ninety compounds were identified in the leaf and twig oils, respectively, of L. mushaensis. The main components of the leaf oil were Beta–Eudesmol (24.2%), tau-cadinol (10.2%), alpha-humulene (10.1%), alpha-pinene (9.7%), and trans-Beta-ocimene (6.5%), whereas the main components of the twig oil were trans-Beta-ocimene (19.5%), alpha-pinene (12.8%) and cis-Beta-ocimene (7.7%). With L. linii, 72 and 78 compounds were respectively identified in the leaf and twig oils. The main components of the leaf oil were Beta-selinene (15.7%), alpha-selinene (15.5%), Beta-caryophyllene (12.2%), alpha-humulene (7.2%), and delta-cadinene (5.6%), and of the twig oil trans-Beta-ocimene (20.8%), Beta-selinene (11.4%), alpha-cadinol (6.0%), delta-cadinene (5.8%), tau-cadinol (5.4%) and Beta–Eudesmol (5.2%). L. mushaensis leaf oil was shown to have excellent antimicrobial and anti-wood-decay fungal activity, superior to the other oils.

  • Composition and antimicrobial activity of the leaf essential oil of Litsea kostermansii from Taiwan.
    Natural product communications, 2020
    Co-Authors: Chen-lung Ho, Eugene I-chen Wang, Yu-chang Su

    Abstract:

    The hydrodistillated leaf essential oil of Litsea kostermansii was analyzed to determine its composition and yield. Seventy-three compounds were identified, the main components being Beta–Eudesmol (22.5%), gamma-Eudesmol (18.6%), delta-selinene (8.5%), alpha-Eudesmol (6.0%), and gamma-muurolene (4.7%). Oxygenated sesquiterpenes (66.2%) and sesquiterpene hydrocarbons (32.8%) were the predominant groups of compounds. The leaf oil exhibited excellent antimicrobial activities.