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Kinga Suwinska - One of the best experts on this subject based on the ideXlab platform.
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study of β cyclodextrin inclusion complexes with volatile molecules geraniol and α Terpineol enantiomers in solid state and in solution
Chemical Physics Letters, 2015Co-Authors: Magdalena Ceborska, Kamila Szwed, Monika Asztemborska, Malgorzata Wszelakarylik, Ewa Kicinska, Kinga SuwinskaAbstract:Abstract Geraniol and α-Terpineol are insoluble in water volatile compounds. α-Terpineol is a potentially important agent for medical applications. Formation of molecular complexes with β-cyclodextrin would lead to the increase of water solubility and bioavailability. β-Cyclodextrin forms 2:2 inclusion complexes with both enantiomers of α-Terpineol and their precursor geraniol. Solid state complexes are thoroughly characterized by single X-ray crystallography and their stability over vast range of temperatures is proven by TG analysis. Intermolecular host–guest, host–host and guest–guest interactions give good insight into the nature of formed inclusion complexes. Stability constants of the complexes in solution are determined by HPLC.
Mahsa Moghimi - One of the best experts on this subject based on the ideXlab platform.
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Role of l-arginine/SNAP/NO/cGMP/KATP channel signalling pathway in antinociceptive effect of α-Terpineol in mice.
The Journal of pharmacy and pharmacology, 2018Co-Authors: Sara Safaripour, Yasaman Nemati, Siavash Parvardeh, Shiva Ghafghazi, Anahita Fouladzadeh, Mahsa MoghimiAbstract:OBJECTIVES The main purpose of this study was to assess the role of l-arginine/SNAP/NO/cGMP/KATP channel pathway in analgesic effects of α-Terpineol in mice. METHODS Male NMRI mice were pretreated intraperitoneally with NO precursor (l-arginine, 100 mg/kg), NO synthase inhibitor (l-NAME, 30 mg/kg), NO donor (SNAP, 1 mg/kg), guanylyl cyclase inhibitor (methylene blue, 20 mg/kg), PDE inhibitor (sildenafil, 0.5 mg/kg), KATP channel blocker (glibenclamide, 10 mg/kg) and naloxone (2 mg/kg) 20 min before the administration of α-Terpineol. The formalin test was performed 20 min after the administration of α-Terpineol, and nociceptive responses of mice were recorded during 30 min. KEY FINDINGS A significant and dose-dependent antinociception was produced by α-Terpineol (40 and 80 mg/kg) in both the phases of formalin test. The antinociceptive effect of α-Terpineol was significantly potentiated by l-arginine in the second phase while significantly antagonized by l-NAME in both phases of formalin test. Also, SNAP and sildenafil non-significantly enhanced-while methylene blue significantly diminished-the antinociceptive effect of α-Terpineol in both phases of formalin test. Glibenclamide significantly reversed the α-Terpineol-induced antinociception, indicating the involvement of KATP channels in antinociceptive effect of α-Terpineol. CONCLUSIONS These results indicate that the antinociceptive effect of α-Terpineol is mediated through l-arginine/SNAP/NO/cGMP/KATP channel pathway.
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protective effect of α Terpineol against impairment of hippocampal synaptic plasticity and spatial memory following transient cerebral ischemia in rats
Iranian Journal of Basic Medical Sciences, 2016Co-Authors: Mahsa Moghimi, Siavash Parvardeh, Taraneh Moini Zanjani, Shiva GhafghaziAbstract:Objective(s): Cerebral ischemia is often associated with cognitive impairment. Oxidative stress has a crucial role in the memory deficit following ischemia/reperfusion injury. α-Terpineol is a monoterpenoid with anti-inflammatory and antioxidant effects. This study was carried out to investigate the effect of α-Terpineol against memory impairment following cerebral ischemia in rats. Materials and Methods: Cerebral ischemia was induced by transient bilateral common carotid artery occlusion in male Wistar rats. The rats were allocated to sham, ischemia, and α-Terpineol-treated groups. α-Terpineol was given at doses of 50, 100, and 200 mg/kg, IP once daily for 7 days post ischemia. Morris water maze (MWM) test was used to assess spatial memory and in vivo extracellular recording of long-term potentiation (LTP) in the hippocampal dentate gyrus was carried out to evaluate synaptic plasticity. Malondialdehyde (MDA) was measured to assess the extent of lipid peroxidation in the hippocampus. Results: In MWM test, α-Terpineol (100 mg/kg, IP) significantly decreased the escape latency during training trials (P<0.01). In addition, α-Terpineol increased the number of crossings over the platform location and decreased average proximity to the target in probe trial (P<0.05). In electrophysiological recording, α-Terpineol (100 mg/kg) facilitated the induction of LTP in the hippocampus which was persistent over 2 hr. α-Terpineol (100 and 200 mg/kg) also significantly lowered hippocampal MDA levels in rats subjected to cerebral ischemia. Conclusion: These findings indicate that α-Terpineol improves cerebral ischemia-related memory impairment in rats through the facilitation of LTP and suppression of lipid peroxidation in the hippocampus.
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α-Terpineol attenuates morphine-induced physical dependence and tolerance in mice: role of nitric oxide.
Iranian journal of basic medical sciences, 2016Co-Authors: Siavash Parvardeh, Mahsa Moghimi, Pegah Eslami, Alireza MasoudiAbstract:Objective(s):Dependence and tolerance to opioid analgesics are major problems limiting their clinical application. a-Terpineol is a monoterpenoid alcohol with neuroprotective effects which is found in several medicinal plants such as Myrtus communis, Laurus nobilis, and Stachys byzantina. It has been shown that some of these medicinal plants such as S. byzantina attenuate dependence and tolerance to morphine. Since a-Terpineol is one of the bioactive phytochemical constituent of these medicinal plants, the present study was conducted to investigate the effects of a-Terpineol on morphine-induced dependence and tolerance in mice. Materials and Methods: The mice were rendered dependent or tolerant to morphine by a 3-day administration schedule. The hot-plate test and naloxone-induced withdrawal syndrome were used to evaluate tolerance and dependence on morphine, respectively. To investigate a possible role for nitric oxide (NO) in the protective effect of a-Terpineol, the NO synthase inhibitor, L-N(G)-nitroarginine methyl ester (L-NAME) and NO precursor, L-arginine, were used. Results: Administration of a-Terpineol (5, 10, and 20 mg/kg, IP) significantly decreased the number of jumps in morphine dependent animals. Moreover, a-Terpineol (20 and 40 mg/kg, IP) attenuated tolerance to the analgesic effect of morphine. The inhibitory effects of a-Terpineol on morphine-induced dependence and tolerance were enhanced by pretreatment with L-NAME (10 mg/kg, IP). However, L-arginine (300 mg/kg, IP) antagonized the protective effects of a-Terpineol on dependence and tolerance to morphine. Conclusion: These findings indicate that a-Terpineol prevents the development of dependence and tolerance to morphine probably through the influence on NO production.
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Protective effect of α-Terpineol against impairment of hippocampal synaptic plasticity and spatial memory following transient cerebral ischemia in rats.
Iranian journal of basic medical sciences, 2016Co-Authors: Mahsa Moghimi, Siavash Parvardeh, Taraneh Moini Zanjani, Shiva GhafghaziAbstract:Objective(s): Cerebral ischemia is often associated with cognitive impairment. Oxidative stress has a crucial role in the memory deficit following ischemia/reperfusion injury. α-Terpineol is a monoterpenoid with anti-inflammatory and antioxidant effects. This study was carried out to investigate the effect of α-Terpineol against memory impairment following cerebral ischemia in rats. Materials and Methods: Cerebral ischemia was induced by transient bilateral common carotid artery occlusion in male Wistar rats. The rats were allocated to sham, ischemia, and α-Terpineol-treated groups. α-Terpineol was given at doses of 50, 100, and 200 mg/kg, IP once daily for 7 days post ischemia. Morris water maze (MWM) test was used to assess spatial memory and in vivo extracellular recording of long-term potentiation (LTP) in the hippocampal dentate gyrus was carried out to evaluate synaptic plasticity. Malondialdehyde (MDA) was measured to assess the extent of lipid peroxidation in the hippocampus. Results: In MWM test, α-Terpineol (100 mg/kg, IP) significantly decreased the escape latency during training trials (P
Shiva Ghafghazi - One of the best experts on this subject based on the ideXlab platform.
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analgesic effect of α Terpineol on neuropathic pain induced by chronic constriction injury in rat sciatic nerve involvement of spinal microglial cells and inflammatory cytokines
Iranian Journal of Basic Medical Sciences, 2019Co-Authors: Mohsen Soleimani, Shiva Ghafghazi, Mohammad Abbas Sheikholeslami, Ramin Pouriran, Siavash ParvardehAbstract:Objective(s): Neuropathic pain is a prevalent and debilitating neurological disorder. Ample evidence indicates that microglial cells and inflammatory cytokines are involved in the pathogenesis of neuropathic pain. Alpha-Terpineol is a monoterpenoid alcohol with inhibitory effect on inflammatory cytokines. The main purpose of this study was to evaluate the effect of α-Terpineol on neuropathic pain in rats.Materials and Methods: Chronic constriction injury (CCI) model was utilized to induce neuropathic pain in male Wistar rats. The rats were randomly divided into control, sham, α-Terpineol, and gabapentin groups. Normal saline, α-Terpineol (25, 50, and 100 mg/kg), and gabapentin (100 mg/kg) were administered intraperitoneally in the above-mentioned groups once daily for 14 days post-CCI. Behavioral tests, including Von Frey, acetone, and Hargreaves were used to assess mechanical allodynia, cold allodynia, and hyperalgesia in rats. Iba1 immunostaining and ELISA procedures were used to assess the activation of microglial cells and inflammatory cytokines level. Results: The results showed that α-Terpineol (50 and 100 mg/kg) significantly attenuated mechanical allodynia, cold allodynia, and hyperalgesia in the neuropathic rats. The analgesic effect of α-Terpineol (100 mg/kg) was comparable with that of gabapentin as a standard antineuropathic pain drug. In addition, α-Terpineol (25, 50 and 100 mg/kg) significantly decreased the number of Iba1-positive cells and diminished the concentration of IL-1β and TNF-α in the spinal tissue. Conclusion: It was ultimately attained that α-Terpineol attenuates neuropathic pain through the suppression of the microglial cells and reduction of inflammatory cytokine levels in the spinal cord of rats.
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Role of l-arginine/SNAP/NO/cGMP/KATP channel signalling pathway in antinociceptive effect of α-Terpineol in mice.
The Journal of pharmacy and pharmacology, 2018Co-Authors: Sara Safaripour, Yasaman Nemati, Siavash Parvardeh, Shiva Ghafghazi, Anahita Fouladzadeh, Mahsa MoghimiAbstract:OBJECTIVES The main purpose of this study was to assess the role of l-arginine/SNAP/NO/cGMP/KATP channel pathway in analgesic effects of α-Terpineol in mice. METHODS Male NMRI mice were pretreated intraperitoneally with NO precursor (l-arginine, 100 mg/kg), NO synthase inhibitor (l-NAME, 30 mg/kg), NO donor (SNAP, 1 mg/kg), guanylyl cyclase inhibitor (methylene blue, 20 mg/kg), PDE inhibitor (sildenafil, 0.5 mg/kg), KATP channel blocker (glibenclamide, 10 mg/kg) and naloxone (2 mg/kg) 20 min before the administration of α-Terpineol. The formalin test was performed 20 min after the administration of α-Terpineol, and nociceptive responses of mice were recorded during 30 min. KEY FINDINGS A significant and dose-dependent antinociception was produced by α-Terpineol (40 and 80 mg/kg) in both the phases of formalin test. The antinociceptive effect of α-Terpineol was significantly potentiated by l-arginine in the second phase while significantly antagonized by l-NAME in both phases of formalin test. Also, SNAP and sildenafil non-significantly enhanced-while methylene blue significantly diminished-the antinociceptive effect of α-Terpineol in both phases of formalin test. Glibenclamide significantly reversed the α-Terpineol-induced antinociception, indicating the involvement of KATP channels in antinociceptive effect of α-Terpineol. CONCLUSIONS These results indicate that the antinociceptive effect of α-Terpineol is mediated through l-arginine/SNAP/NO/cGMP/KATP channel pathway.
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protective effect of α Terpineol against impairment of hippocampal synaptic plasticity and spatial memory following transient cerebral ischemia in rats
Iranian Journal of Basic Medical Sciences, 2016Co-Authors: Mahsa Moghimi, Siavash Parvardeh, Taraneh Moini Zanjani, Shiva GhafghaziAbstract:Objective(s): Cerebral ischemia is often associated with cognitive impairment. Oxidative stress has a crucial role in the memory deficit following ischemia/reperfusion injury. α-Terpineol is a monoterpenoid with anti-inflammatory and antioxidant effects. This study was carried out to investigate the effect of α-Terpineol against memory impairment following cerebral ischemia in rats. Materials and Methods: Cerebral ischemia was induced by transient bilateral common carotid artery occlusion in male Wistar rats. The rats were allocated to sham, ischemia, and α-Terpineol-treated groups. α-Terpineol was given at doses of 50, 100, and 200 mg/kg, IP once daily for 7 days post ischemia. Morris water maze (MWM) test was used to assess spatial memory and in vivo extracellular recording of long-term potentiation (LTP) in the hippocampal dentate gyrus was carried out to evaluate synaptic plasticity. Malondialdehyde (MDA) was measured to assess the extent of lipid peroxidation in the hippocampus. Results: In MWM test, α-Terpineol (100 mg/kg, IP) significantly decreased the escape latency during training trials (P<0.01). In addition, α-Terpineol increased the number of crossings over the platform location and decreased average proximity to the target in probe trial (P<0.05). In electrophysiological recording, α-Terpineol (100 mg/kg) facilitated the induction of LTP in the hippocampus which was persistent over 2 hr. α-Terpineol (100 and 200 mg/kg) also significantly lowered hippocampal MDA levels in rats subjected to cerebral ischemia. Conclusion: These findings indicate that α-Terpineol improves cerebral ischemia-related memory impairment in rats through the facilitation of LTP and suppression of lipid peroxidation in the hippocampus.
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Protective effect of α-Terpineol against impairment of hippocampal synaptic plasticity and spatial memory following transient cerebral ischemia in rats.
Iranian journal of basic medical sciences, 2016Co-Authors: Mahsa Moghimi, Siavash Parvardeh, Taraneh Moini Zanjani, Shiva GhafghaziAbstract:Objective(s): Cerebral ischemia is often associated with cognitive impairment. Oxidative stress has a crucial role in the memory deficit following ischemia/reperfusion injury. α-Terpineol is a monoterpenoid with anti-inflammatory and antioxidant effects. This study was carried out to investigate the effect of α-Terpineol against memory impairment following cerebral ischemia in rats. Materials and Methods: Cerebral ischemia was induced by transient bilateral common carotid artery occlusion in male Wistar rats. The rats were allocated to sham, ischemia, and α-Terpineol-treated groups. α-Terpineol was given at doses of 50, 100, and 200 mg/kg, IP once daily for 7 days post ischemia. Morris water maze (MWM) test was used to assess spatial memory and in vivo extracellular recording of long-term potentiation (LTP) in the hippocampal dentate gyrus was carried out to evaluate synaptic plasticity. Malondialdehyde (MDA) was measured to assess the extent of lipid peroxidation in the hippocampus. Results: In MWM test, α-Terpineol (100 mg/kg, IP) significantly decreased the escape latency during training trials (P
Siavash Parvardeh - One of the best experts on this subject based on the ideXlab platform.
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analgesic effect of α Terpineol on neuropathic pain induced by chronic constriction injury in rat sciatic nerve involvement of spinal microglial cells and inflammatory cytokines
Iranian Journal of Basic Medical Sciences, 2019Co-Authors: Mohsen Soleimani, Shiva Ghafghazi, Mohammad Abbas Sheikholeslami, Ramin Pouriran, Siavash ParvardehAbstract:Objective(s): Neuropathic pain is a prevalent and debilitating neurological disorder. Ample evidence indicates that microglial cells and inflammatory cytokines are involved in the pathogenesis of neuropathic pain. Alpha-Terpineol is a monoterpenoid alcohol with inhibitory effect on inflammatory cytokines. The main purpose of this study was to evaluate the effect of α-Terpineol on neuropathic pain in rats.Materials and Methods: Chronic constriction injury (CCI) model was utilized to induce neuropathic pain in male Wistar rats. The rats were randomly divided into control, sham, α-Terpineol, and gabapentin groups. Normal saline, α-Terpineol (25, 50, and 100 mg/kg), and gabapentin (100 mg/kg) were administered intraperitoneally in the above-mentioned groups once daily for 14 days post-CCI. Behavioral tests, including Von Frey, acetone, and Hargreaves were used to assess mechanical allodynia, cold allodynia, and hyperalgesia in rats. Iba1 immunostaining and ELISA procedures were used to assess the activation of microglial cells and inflammatory cytokines level. Results: The results showed that α-Terpineol (50 and 100 mg/kg) significantly attenuated mechanical allodynia, cold allodynia, and hyperalgesia in the neuropathic rats. The analgesic effect of α-Terpineol (100 mg/kg) was comparable with that of gabapentin as a standard antineuropathic pain drug. In addition, α-Terpineol (25, 50 and 100 mg/kg) significantly decreased the number of Iba1-positive cells and diminished the concentration of IL-1β and TNF-α in the spinal tissue. Conclusion: It was ultimately attained that α-Terpineol attenuates neuropathic pain through the suppression of the microglial cells and reduction of inflammatory cytokine levels in the spinal cord of rats.
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Role of l-arginine/SNAP/NO/cGMP/KATP channel signalling pathway in antinociceptive effect of α-Terpineol in mice.
The Journal of pharmacy and pharmacology, 2018Co-Authors: Sara Safaripour, Yasaman Nemati, Siavash Parvardeh, Shiva Ghafghazi, Anahita Fouladzadeh, Mahsa MoghimiAbstract:OBJECTIVES The main purpose of this study was to assess the role of l-arginine/SNAP/NO/cGMP/KATP channel pathway in analgesic effects of α-Terpineol in mice. METHODS Male NMRI mice were pretreated intraperitoneally with NO precursor (l-arginine, 100 mg/kg), NO synthase inhibitor (l-NAME, 30 mg/kg), NO donor (SNAP, 1 mg/kg), guanylyl cyclase inhibitor (methylene blue, 20 mg/kg), PDE inhibitor (sildenafil, 0.5 mg/kg), KATP channel blocker (glibenclamide, 10 mg/kg) and naloxone (2 mg/kg) 20 min before the administration of α-Terpineol. The formalin test was performed 20 min after the administration of α-Terpineol, and nociceptive responses of mice were recorded during 30 min. KEY FINDINGS A significant and dose-dependent antinociception was produced by α-Terpineol (40 and 80 mg/kg) in both the phases of formalin test. The antinociceptive effect of α-Terpineol was significantly potentiated by l-arginine in the second phase while significantly antagonized by l-NAME in both phases of formalin test. Also, SNAP and sildenafil non-significantly enhanced-while methylene blue significantly diminished-the antinociceptive effect of α-Terpineol in both phases of formalin test. Glibenclamide significantly reversed the α-Terpineol-induced antinociception, indicating the involvement of KATP channels in antinociceptive effect of α-Terpineol. CONCLUSIONS These results indicate that the antinociceptive effect of α-Terpineol is mediated through l-arginine/SNAP/NO/cGMP/KATP channel pathway.
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protective effect of α Terpineol against impairment of hippocampal synaptic plasticity and spatial memory following transient cerebral ischemia in rats
Iranian Journal of Basic Medical Sciences, 2016Co-Authors: Mahsa Moghimi, Siavash Parvardeh, Taraneh Moini Zanjani, Shiva GhafghaziAbstract:Objective(s): Cerebral ischemia is often associated with cognitive impairment. Oxidative stress has a crucial role in the memory deficit following ischemia/reperfusion injury. α-Terpineol is a monoterpenoid with anti-inflammatory and antioxidant effects. This study was carried out to investigate the effect of α-Terpineol against memory impairment following cerebral ischemia in rats. Materials and Methods: Cerebral ischemia was induced by transient bilateral common carotid artery occlusion in male Wistar rats. The rats were allocated to sham, ischemia, and α-Terpineol-treated groups. α-Terpineol was given at doses of 50, 100, and 200 mg/kg, IP once daily for 7 days post ischemia. Morris water maze (MWM) test was used to assess spatial memory and in vivo extracellular recording of long-term potentiation (LTP) in the hippocampal dentate gyrus was carried out to evaluate synaptic plasticity. Malondialdehyde (MDA) was measured to assess the extent of lipid peroxidation in the hippocampus. Results: In MWM test, α-Terpineol (100 mg/kg, IP) significantly decreased the escape latency during training trials (P<0.01). In addition, α-Terpineol increased the number of crossings over the platform location and decreased average proximity to the target in probe trial (P<0.05). In electrophysiological recording, α-Terpineol (100 mg/kg) facilitated the induction of LTP in the hippocampus which was persistent over 2 hr. α-Terpineol (100 and 200 mg/kg) also significantly lowered hippocampal MDA levels in rats subjected to cerebral ischemia. Conclusion: These findings indicate that α-Terpineol improves cerebral ischemia-related memory impairment in rats through the facilitation of LTP and suppression of lipid peroxidation in the hippocampus.
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α-Terpineol attenuates morphine-induced physical dependence and tolerance in mice: role of nitric oxide.
Iranian journal of basic medical sciences, 2016Co-Authors: Siavash Parvardeh, Mahsa Moghimi, Pegah Eslami, Alireza MasoudiAbstract:Objective(s):Dependence and tolerance to opioid analgesics are major problems limiting their clinical application. a-Terpineol is a monoterpenoid alcohol with neuroprotective effects which is found in several medicinal plants such as Myrtus communis, Laurus nobilis, and Stachys byzantina. It has been shown that some of these medicinal plants such as S. byzantina attenuate dependence and tolerance to morphine. Since a-Terpineol is one of the bioactive phytochemical constituent of these medicinal plants, the present study was conducted to investigate the effects of a-Terpineol on morphine-induced dependence and tolerance in mice. Materials and Methods: The mice were rendered dependent or tolerant to morphine by a 3-day administration schedule. The hot-plate test and naloxone-induced withdrawal syndrome were used to evaluate tolerance and dependence on morphine, respectively. To investigate a possible role for nitric oxide (NO) in the protective effect of a-Terpineol, the NO synthase inhibitor, L-N(G)-nitroarginine methyl ester (L-NAME) and NO precursor, L-arginine, were used. Results: Administration of a-Terpineol (5, 10, and 20 mg/kg, IP) significantly decreased the number of jumps in morphine dependent animals. Moreover, a-Terpineol (20 and 40 mg/kg, IP) attenuated tolerance to the analgesic effect of morphine. The inhibitory effects of a-Terpineol on morphine-induced dependence and tolerance were enhanced by pretreatment with L-NAME (10 mg/kg, IP). However, L-arginine (300 mg/kg, IP) antagonized the protective effects of a-Terpineol on dependence and tolerance to morphine. Conclusion: These findings indicate that a-Terpineol prevents the development of dependence and tolerance to morphine probably through the influence on NO production.
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Protective effect of α-Terpineol against impairment of hippocampal synaptic plasticity and spatial memory following transient cerebral ischemia in rats.
Iranian journal of basic medical sciences, 2016Co-Authors: Mahsa Moghimi, Siavash Parvardeh, Taraneh Moini Zanjani, Shiva GhafghaziAbstract:Objective(s): Cerebral ischemia is often associated with cognitive impairment. Oxidative stress has a crucial role in the memory deficit following ischemia/reperfusion injury. α-Terpineol is a monoterpenoid with anti-inflammatory and antioxidant effects. This study was carried out to investigate the effect of α-Terpineol against memory impairment following cerebral ischemia in rats. Materials and Methods: Cerebral ischemia was induced by transient bilateral common carotid artery occlusion in male Wistar rats. The rats were allocated to sham, ischemia, and α-Terpineol-treated groups. α-Terpineol was given at doses of 50, 100, and 200 mg/kg, IP once daily for 7 days post ischemia. Morris water maze (MWM) test was used to assess spatial memory and in vivo extracellular recording of long-term potentiation (LTP) in the hippocampal dentate gyrus was carried out to evaluate synaptic plasticity. Malondialdehyde (MDA) was measured to assess the extent of lipid peroxidation in the hippocampus. Results: In MWM test, α-Terpineol (100 mg/kg, IP) significantly decreased the escape latency during training trials (P
Magdalena Ceborska - One of the best experts on this subject based on the ideXlab platform.
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study of β cyclodextrin inclusion complexes with volatile molecules geraniol and α Terpineol enantiomers in solid state and in solution
Chemical Physics Letters, 2015Co-Authors: Magdalena Ceborska, Kamila Szwed, Monika Asztemborska, Malgorzata Wszelakarylik, Ewa Kicinska, Kinga SuwinskaAbstract:Abstract Geraniol and α-Terpineol are insoluble in water volatile compounds. α-Terpineol is a potentially important agent for medical applications. Formation of molecular complexes with β-cyclodextrin would lead to the increase of water solubility and bioavailability. β-Cyclodextrin forms 2:2 inclusion complexes with both enantiomers of α-Terpineol and their precursor geraniol. Solid state complexes are thoroughly characterized by single X-ray crystallography and their stability over vast range of temperatures is proven by TG analysis. Intermolecular host–guest, host–host and guest–guest interactions give good insight into the nature of formed inclusion complexes. Stability constants of the complexes in solution are determined by HPLC.
