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Bo Chen - One of the best experts on this subject based on the ideXlab platform.

  • effect of enamel matrix derivative and parathyroid hormone on bone formation in standardized osseous defects an experimental study in minipigs
    Journal of Periodontology, 2011
    Co-Authors: Bo Chen, Simon Storgard Jensen, Michael M Bornstein, Dieter D Bosshardt, Daniel Buser
    Abstract:

    Background: Previous experimental studies have indicated that locally administered enamel matrix derivative (EMD) and parathyroid hormone (PTH) may have a stimulatory effect on bone formation. However, it is not clear if the positive effect of EMD is related to its effect on the periodontium as a whole or directly on the bone-forming cells. In addition, it is not known if the presentation of PTH by adding the amino acid sequence Arg-Gly-Asp (RGD) is essential for its osteopromotive effect. Local delivery of a Bioactive Substance at the right time and in the right concentration often constitutes a major challenge. Polyethylene glycol–based hydrogel (PEG) is a degradable vehicle developed for delivery of Bioactive proteins. To enhance the mechanical stability of the PEG-Bioactive Substance complex, an osteoconductive bone substitute material is often needed.Methods: Three standard diameter monocortical bone defects were prepared bilaterally in the mandibles of 18 Gottingen minipigs. The six defects of each ...

  • Effect of enamel matrix derivative and parathyroid hormone on bone formation in standardized osseous defects: an experimental study in minipigs
    'American Academy of Periodontology (AAP)', 2011
    Co-Authors: Jensen, Simon S, Bo Chen, Bornstein, Michael M, Bosshardt Dieter, Buser Daniel
    Abstract:

    Previous experimental studies have indicated that locally administered enamel matrix derivative (EMD) and parathyroid hormone (PTH) may have a stimulatory effect on bone formation. However, it is not clear if the positive effect of EMD is related to its effect on the periodontium as a whole or directly on the bone-forming cells. In addition, it is not known if the presentation of PTH by adding the amino acid sequence Arg-Gly-Asp (RGD) is essential for its osteopromotive effect. Local delivery of a Bioactive Substance at the right time and in the right concentration often constitutes a major challenge. Polyethylene glycol-based hydrogel (PEG) is a degradable vehicle developed for delivery of Bioactive proteins. To enhance the mechanical stability of the PEG-Bioactive Substance complex, an osteoconductive bone substitute material is often needed

  • Effect of enamel matrix derivative and parathyroid hormone on bone formation in standardized osseous defects: An experimental study in minipigs
    'American Academy of Periodontology (AAP)', 2011
    Co-Authors: Bosshardt, Dieter D., Jensen, Simon S, Bo Chen, Bornstein, Michael M, Buser Daniel
    Abstract:

    Background: Previous experimental studies have indicated that locally administered enamel matrix derivative (EMD) and parathyroid hormone (PTH) may have a stimulatory effect on bone formation. However, it is not clear if the positive effect of EMD is related to its effect on the periodontium as a whole or directly on the bone-forming cells. In addition, it is not known if the presentation of PTH by adding the amino acid sequence Arg-Gly-Asp (RGD) is essential for its osteopromotive effect. Local delivery of a Bioactive Substance at the right time and in the right concentration often constitutes a major challenge. Polyethylene glycol-based hydrogel (PEG) is a degradable vehicle developed for delivery of Bioactive proteins. To enhance the mechanical stability of the PEG-Bioactive Substance complex, an osteoconductive bone substitute material is often needed. Methods: Three standard diameter monocortical bone defects were prepared bilaterally in the mandibles of 18 Göttingen minipigs. The six defects of each animal were grafted with 1) autogenous bone chips, 2) biphasic calcium phosphate bone substitute (BCP), 3) PEG + BCP, 4) EMD + PEG + BCP, 5) PTH + PEG + BCP, or 6) PTH-RGD + PEG + BCP. A non-resorbable barrier membrane was used to cover the defects. Three groups of six animals healed for 2, 4, and 8 weeks, respectively. Results: There was no statistically significant effect of EMD, PTH, and PTH + RGDonbone formationcompared to BCP and BCP + PEG. Particulated autografts showed the highest amount of new bone formation at all observation periods. Conclusion: The present study fails to demonstrate any stimulatory effect of EMD, PTH, or PTH + RGD in combination with an experimental PEG hydrogel and BCP on bone formation.Link_to_subscribed_fulltex

  • Effect of Enamel Matrix Derivative and Parathyroid Hormone on Bone Formation in Standardized Osseous Defects: An Experimental Study in Minipigs
    journal of periodontology, 2011
    Co-Authors: Jensen, Simon S, Bo Chen, Bornstein, Michael M, Bosshardt, Dieter D., Buser Daniel
    Abstract:

    Background: Previous experimental studies have indicated that locally administered enamel matrix derivative (EMD) and parathyroid hormone (PTH) may have a stimulatory effect on bone formation. However, it is not clear if the positive effect of EMD is related to its effect on the periodontium as a whole or directly on the bone-forming cells. In addition, it is not known if the presentation of PTH by adding the amino acid sequence Arg-Gly-Asp (RGD) is essential for its osteopromotive effect. Local delivery of a Bioactive Substance at the right time and in the right concentration often constitutes a major challenge. Polyethylene glycol-based hydrogel (PEG) is a degradable vehicle developed for delivery of Bioactive proteins. To enhance the mechanical stability of the PEG-Bioactive Substance complex, an osteoconductive bone substitute material is often needed. Methods: Three standard diameter monocortical bone defects were prepared bilaterally in the mandibles of 18 Gottingen minipigs. The six defects of each animal were grafted with 1) autogenous bone chips, 2) biphasic calcium phosphate bone substitute (BCP), 3) PEG + BCP, 4) EMD + PEG + BCP, 5) PTH + PEG + BCP, or 6) PTH-RGD + PEG + BCP. A non-resorbable barrier membrane was used to cover the defects. Three groups of six animals healed for 2, 4, and 8 weeks, respectively. Results: There was no statistically significant effect of EMD, PTH, and PTH + RGD on bone formation compared to BCP and BCP + PEG. Particulated autografts showed the highest amount of new bone formation at all observation periods. Conclusion: The present study fails to demonstrate any stimulatory effect of EMD, PTH, or PTH + RGD in combination with an experimental PEG hydrogel and BCP on bone formation. J Periodontol 2011;82:1197-1205.Dentistry, Oral Surgery & MedicineSCI(E)5ARTICLE81197-12058

Simon Storgard Jensen - One of the best experts on this subject based on the ideXlab platform.

  • effect of enamel matrix derivative and parathyroid hormone on bone formation in standardized osseous defects an experimental study in minipigs
    Journal of Periodontology, 2011
    Co-Authors: Bo Chen, Simon Storgard Jensen, Michael M Bornstein, Dieter D Bosshardt, Daniel Buser
    Abstract:

    Background: Previous experimental studies have indicated that locally administered enamel matrix derivative (EMD) and parathyroid hormone (PTH) may have a stimulatory effect on bone formation. However, it is not clear if the positive effect of EMD is related to its effect on the periodontium as a whole or directly on the bone-forming cells. In addition, it is not known if the presentation of PTH by adding the amino acid sequence Arg-Gly-Asp (RGD) is essential for its osteopromotive effect. Local delivery of a Bioactive Substance at the right time and in the right concentration often constitutes a major challenge. Polyethylene glycol–based hydrogel (PEG) is a degradable vehicle developed for delivery of Bioactive proteins. To enhance the mechanical stability of the PEG-Bioactive Substance complex, an osteoconductive bone substitute material is often needed.Methods: Three standard diameter monocortical bone defects were prepared bilaterally in the mandibles of 18 Gottingen minipigs. The six defects of each ...

Buser Daniel - One of the best experts on this subject based on the ideXlab platform.

  • Effect of enamel matrix derivative and parathyroid hormone on bone formation in standardized osseous defects: an experimental study in minipigs
    'American Academy of Periodontology (AAP)', 2011
    Co-Authors: Jensen, Simon S, Bo Chen, Bornstein, Michael M, Bosshardt Dieter, Buser Daniel
    Abstract:

    Previous experimental studies have indicated that locally administered enamel matrix derivative (EMD) and parathyroid hormone (PTH) may have a stimulatory effect on bone formation. However, it is not clear if the positive effect of EMD is related to its effect on the periodontium as a whole or directly on the bone-forming cells. In addition, it is not known if the presentation of PTH by adding the amino acid sequence Arg-Gly-Asp (RGD) is essential for its osteopromotive effect. Local delivery of a Bioactive Substance at the right time and in the right concentration often constitutes a major challenge. Polyethylene glycol-based hydrogel (PEG) is a degradable vehicle developed for delivery of Bioactive proteins. To enhance the mechanical stability of the PEG-Bioactive Substance complex, an osteoconductive bone substitute material is often needed

  • Effect of enamel matrix derivative and parathyroid hormone on bone formation in standardized osseous defects: An experimental study in minipigs
    'American Academy of Periodontology (AAP)', 2011
    Co-Authors: Bosshardt, Dieter D., Jensen, Simon S, Bo Chen, Bornstein, Michael M, Buser Daniel
    Abstract:

    Background: Previous experimental studies have indicated that locally administered enamel matrix derivative (EMD) and parathyroid hormone (PTH) may have a stimulatory effect on bone formation. However, it is not clear if the positive effect of EMD is related to its effect on the periodontium as a whole or directly on the bone-forming cells. In addition, it is not known if the presentation of PTH by adding the amino acid sequence Arg-Gly-Asp (RGD) is essential for its osteopromotive effect. Local delivery of a Bioactive Substance at the right time and in the right concentration often constitutes a major challenge. Polyethylene glycol-based hydrogel (PEG) is a degradable vehicle developed for delivery of Bioactive proteins. To enhance the mechanical stability of the PEG-Bioactive Substance complex, an osteoconductive bone substitute material is often needed. Methods: Three standard diameter monocortical bone defects were prepared bilaterally in the mandibles of 18 Göttingen minipigs. The six defects of each animal were grafted with 1) autogenous bone chips, 2) biphasic calcium phosphate bone substitute (BCP), 3) PEG + BCP, 4) EMD + PEG + BCP, 5) PTH + PEG + BCP, or 6) PTH-RGD + PEG + BCP. A non-resorbable barrier membrane was used to cover the defects. Three groups of six animals healed for 2, 4, and 8 weeks, respectively. Results: There was no statistically significant effect of EMD, PTH, and PTH + RGDonbone formationcompared to BCP and BCP + PEG. Particulated autografts showed the highest amount of new bone formation at all observation periods. Conclusion: The present study fails to demonstrate any stimulatory effect of EMD, PTH, or PTH + RGD in combination with an experimental PEG hydrogel and BCP on bone formation.Link_to_subscribed_fulltex

  • Effect of Enamel Matrix Derivative and Parathyroid Hormone on Bone Formation in Standardized Osseous Defects: An Experimental Study in Minipigs
    journal of periodontology, 2011
    Co-Authors: Jensen, Simon S, Bo Chen, Bornstein, Michael M, Bosshardt, Dieter D., Buser Daniel
    Abstract:

    Background: Previous experimental studies have indicated that locally administered enamel matrix derivative (EMD) and parathyroid hormone (PTH) may have a stimulatory effect on bone formation. However, it is not clear if the positive effect of EMD is related to its effect on the periodontium as a whole or directly on the bone-forming cells. In addition, it is not known if the presentation of PTH by adding the amino acid sequence Arg-Gly-Asp (RGD) is essential for its osteopromotive effect. Local delivery of a Bioactive Substance at the right time and in the right concentration often constitutes a major challenge. Polyethylene glycol-based hydrogel (PEG) is a degradable vehicle developed for delivery of Bioactive proteins. To enhance the mechanical stability of the PEG-Bioactive Substance complex, an osteoconductive bone substitute material is often needed. Methods: Three standard diameter monocortical bone defects were prepared bilaterally in the mandibles of 18 Gottingen minipigs. The six defects of each animal were grafted with 1) autogenous bone chips, 2) biphasic calcium phosphate bone substitute (BCP), 3) PEG + BCP, 4) EMD + PEG + BCP, 5) PTH + PEG + BCP, or 6) PTH-RGD + PEG + BCP. A non-resorbable barrier membrane was used to cover the defects. Three groups of six animals healed for 2, 4, and 8 weeks, respectively. Results: There was no statistically significant effect of EMD, PTH, and PTH + RGD on bone formation compared to BCP and BCP + PEG. Particulated autografts showed the highest amount of new bone formation at all observation periods. Conclusion: The present study fails to demonstrate any stimulatory effect of EMD, PTH, or PTH + RGD in combination with an experimental PEG hydrogel and BCP on bone formation. J Periodontol 2011;82:1197-1205.Dentistry, Oral Surgery & MedicineSCI(E)5ARTICLE81197-12058

Leon J. Schurgers - One of the best experts on this subject based on the ideXlab platform.

  • Vitamin K2 Needs an RDI Separate from Vitamin K1.
    Nutrients, 2020
    Co-Authors: Asim Cengiz Akbulut, Angelina Pavlic, Ploingarm Petsophonsakul, Maurice Halder, Katarzyna Maresz, Rafael Kramann, Leon J. Schurgers
    Abstract:

    Vitamin K and its essential role in coagulation (vitamin K [Koagulation]) have been well established and accepted the world over. Many countries have a Recommended Daily Intake (RDI) for vitamin K based on early research, and its necessary role in the activation of vitamin K-dependent coagulation proteins is known. In the past few decades, the role of vitamin K-dependent proteins in processes beyond coagulation has been discovered. Various isoforms of vitamin K have been identified, and vitamin K2 specifically has been highlighted for its long half-life and extrahepatic activity, whereas the dietary form vitamin K1 has a shorter half-life. In this review, we highlight the specific activity of vitamin K2 based upon proposed frameworks necessary for a Bioactive Substance to be recommended for an RDI. Vitamin K2 meets all these criteria and should be considered for a specific dietary recommendation intake.

Huisuk Yun - One of the best experts on this subject based on the ideXlab platform.

  • a simultaneous process of 3d magnesium phosphate scaffold fabrication and Bioactive Substance loading for hard tissue regeneration
    Materials Science and Engineering: C, 2014
    Co-Authors: Jongman Lee, M M Farag, Eui Kyun Park, Jiwon Lim, Huisuk Yun
    Abstract:

    Abstract A novel room temperature process was developed to produce a 3D porous magnesium phosphate (MgP) scaffold with high drug load/release efficiency for use in hard tissue regeneration through a combination of a paste extruding deposition (PED) system and cement chemistry. MgP scaffolds were prepared using a two-step process. The first step was fabrication of the 3D porous scaffold green body to control both the morphology and pore structure using a PED system without hardening. The second step was cementation, which was carried out by immersing the scaffold green body in the binder solution for hardening instead of the typical sintering process in ceramic scaffold fabrication. Separation of the manufacturing process and cement reaction was important to secure enough time to fabricate a 3D scaffold with various sizes and architectures under homogeneous extruding conditions. Because the whole process is carried out at room temperature, the Bioactive molecules, which are easily denatured by heat, may apply to scaffolds during the process. Lysozyme was selected as a model Bioactive Substance to demonstrate the efficiency of this process; this was directly mixed into MgP powder to introduce homogeneous distribution in the scaffold. The extruding paste for the PED system was prepared using the MgP–lysozyme blended powder as starting materials. That is, both 3D scaffold fabrication and functionalization of the scaffold with Bioactive Substances could be carried out simultaneously. This process significantly enhanced both drug loading efficiency and release performance compared to the typical sintering process, where the drug is generally loaded by adsorption after heat treatment. The MgP scaffold developed in this study satisfied the required conditions for scaffolding in hard tissue regeneration in an ideal manner, including 3 dimensionally well-interconnected pore structures, favorable mechanical properties, biodegradability, good cell affinity and in vitro biocompatibility; thus, it has excellent potential for application in the field of biomaterials.