The Experts below are selected from a list of 1809 Experts worldwide ranked by ideXlab platform
Carmelo Protopapa - One of the best experts on this subject based on the ideXlab platform.
-
in vitro and in vivo Biocompatibility Evaluation of a polyalkylimide hydrogel for soft tissue augmentation
Journal of Biomedical Materials Research Part B, 2005Co-Authors: Piera Angela Ramires, Maria Antonietta Miccoli, Elisa Panzarini, Luciana Dini, Carmelo ProtopapaAbstract:Injectable fillers are commonly used in Plastic and Reconstructive Surgery to correct serious and slight aesthetic defects due to their low invasiveness and an easy implant technique procedure. Synthetic hydrogels are proposed as filler materials for their similarity with soft tissue and to avoid many disadvantages of naturally derived materials such as short persistence, allergenicity, and immunogenicity. Our studies are focused on the Biocompatibility Evaluation of a polyacrylic hydrogel containing alkylimide-amide groups and pyrogen free water (96%) (Bio-Alcamid®) by means of the in vitro cytotoxicity and mutagenicity assays and the in vivo skin irritation, sensitization test, and subcutaneous implant. All tests conducted on Bio-Alcamid® showed no toxicity. It is a substance easy to inject and remove; it does not migrate, and its safety allows it to be a suitable filler for the correction of slight and also very serious aesthetic defects. © 2004 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 72B: 230–238, 2005
-
in vitro and in vivo Biocompatibility Evaluation of a polyalkylimide hydrogel for soft tissue augmentation
Journal of Biomedical Materials Research, 2005Co-Authors: Piera Angela Ramires, Maria Antonietta Miccoli, Elisa Panzarini, Luciana Dini, Carmelo ProtopapaAbstract:Injectable fillers are commonly used in Plastic and Reconstructive Surgery to correct serious and slight aesthetic defects due to their low invasiveness and an easy implant technique procedure. Synthetic hydrogels are proposed as filler materials for their similarity with soft tissue and to avoid many disadvantages of naturally derived materials such as short persistence, allergenicity, and immunogenicity. Our studies are focused on the Biocompatibility Evaluation of a polyacrylic hydrogel containing alkylimide-amide groups and pyrogen free water (96%) (Bio-Alcamid®) by means of the in vitro cytotoxicity and mutagenicity assays and the in vivo skin irritation, sensitization test, and subcutaneous implant. All tests conducted on Bio-Alcamid® showed no toxicity. It is a substance easy to inject and remove; it does not migrate, and its safety allows it to be a suitable filler for the correction of slight and also very serious aesthetic defects.
J. A. Jansen - One of the best experts on this subject based on the ideXlab platform.
-
Biocompatibility Evaluation of sol-gel coatings for subcutaneously implantable glucose sensors
Biomaterials, 2000Co-Authors: Marinel Gerritsen, V. Sprakel, Jos A. Lutterman, Alexander Kros, Roeland J M Nolte, J. A. JansenAbstract:The objective of the current investigation is to determine the soft- tissue Biocompatibility of sol-gel matrices which can be used to optimize the properties of implantable glucose sensors. The Biocompatibility of sol-gel matrices with heparin, dextran sulphate, Nafion®, polyethylene glycol, and polystyrene sulphonate was examined in vitro in simulated body fluid and with cell culture experiments using human dermal fibroblasts. Finally, an in vivo study was performed. Therefore, sol-gel coated polystyrene discs were inserted subcutaneously in the back of rabbits. After 4 and 12 weeks, the implants with surrounding tissue were retrieved and processed histologically. In simulated body fluid, the formation of a granular calcium phosphate precipitate was observed. Cell proliferation on polyethylene glycol, Nafion®, and heparin coated substrates was comparable to control samples and significantly higher than on dextran sulphate and polystyrene sulphate coated substrates. Light microscopic Evaluation of the retrieved in vivo samples showed a fair tissue reaction to all materials. Histomorphometric analysis demonstrated that there were no differences in tissue response to the different sol-gel coatings. In conclusion, sol-gel matrices exhibit a fair Biocompatibility both in vitro and in vivo. These results will form the basis for further research into the real merits of sol-gel coatings in optimizing the properties of subcutaneously implantable glucose sensors.
-
Biocompatibility Evaluation of sol gel coatings for subcutaneously implantable glucose sensors
Biomaterials, 2000Co-Authors: Marinel Gerritsen, V. Sprakel, Jos A. Lutterman, Alexander Kros, Roeland J M Nolte, J. A. JansenAbstract:The objective of the current investigation is to determine the soft-tissue Biocompatibility of sol}gel matrices which can be used to optimize the properties of implantable glucose sensors. The Biocompatibility of sol}gel matrices with heparin, dextran sulphate, Na"ont, polyethylene glycol, and polystyrene sulphonate was examined in vitro in simulated body #uid and with cell culture experiments using human dermal "broblasts. Finally, an in vivo study was performed. Therefore, sol}gel coated polystyrene discs were inserted subcutaneously in the back of rabbits. After 4 and 12 weeks, the implants with surrounding tissue were retrieved and processed histologically. In simulated body #uid, the formation of a granular calcium phosphate precipitate was observed. Cell proliferation on polyethylene glycol, Na"ont, and heparin coated substrates was comparable to control samples and signi"cantly higher than on dextran sulphate and polystyrene sulphate coated substrates. Light microscopic Evaluation of the retrieved in vivo samples showed a fair tissue reaction to all materials. Histomorphometric analysis demonstrated that there were no di!erences in tissue response to the di!erent sol}gel coatings. In conclusion, sol}gel matrices exhibit a fair Biocompatibility both in vitro and in vivo. These results will form the basis for further research into the real merits of sol}gel coatings in optimizing the properties of subcutaneously implantable glucose sensors. ( 1999 Elsevier Science Ltd. All rights reserved.
Piera Angela Ramires - One of the best experts on this subject based on the ideXlab platform.
-
in vitro and in vivo Biocompatibility Evaluation of a polyalkylimide hydrogel for soft tissue augmentation
Journal of Biomedical Materials Research Part B, 2005Co-Authors: Piera Angela Ramires, Maria Antonietta Miccoli, Elisa Panzarini, Luciana Dini, Carmelo ProtopapaAbstract:Injectable fillers are commonly used in Plastic and Reconstructive Surgery to correct serious and slight aesthetic defects due to their low invasiveness and an easy implant technique procedure. Synthetic hydrogels are proposed as filler materials for their similarity with soft tissue and to avoid many disadvantages of naturally derived materials such as short persistence, allergenicity, and immunogenicity. Our studies are focused on the Biocompatibility Evaluation of a polyacrylic hydrogel containing alkylimide-amide groups and pyrogen free water (96%) (Bio-Alcamid®) by means of the in vitro cytotoxicity and mutagenicity assays and the in vivo skin irritation, sensitization test, and subcutaneous implant. All tests conducted on Bio-Alcamid® showed no toxicity. It is a substance easy to inject and remove; it does not migrate, and its safety allows it to be a suitable filler for the correction of slight and also very serious aesthetic defects. © 2004 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 72B: 230–238, 2005
-
in vitro and in vivo Biocompatibility Evaluation of a polyalkylimide hydrogel for soft tissue augmentation
Journal of Biomedical Materials Research, 2005Co-Authors: Piera Angela Ramires, Maria Antonietta Miccoli, Elisa Panzarini, Luciana Dini, Carmelo ProtopapaAbstract:Injectable fillers are commonly used in Plastic and Reconstructive Surgery to correct serious and slight aesthetic defects due to their low invasiveness and an easy implant technique procedure. Synthetic hydrogels are proposed as filler materials for their similarity with soft tissue and to avoid many disadvantages of naturally derived materials such as short persistence, allergenicity, and immunogenicity. Our studies are focused on the Biocompatibility Evaluation of a polyacrylic hydrogel containing alkylimide-amide groups and pyrogen free water (96%) (Bio-Alcamid®) by means of the in vitro cytotoxicity and mutagenicity assays and the in vivo skin irritation, sensitization test, and subcutaneous implant. All tests conducted on Bio-Alcamid® showed no toxicity. It is a substance easy to inject and remove; it does not migrate, and its safety allows it to be a suitable filler for the correction of slight and also very serious aesthetic defects.
Marinel Gerritsen - One of the best experts on this subject based on the ideXlab platform.
-
Biocompatibility Evaluation of sol-gel coatings for subcutaneously implantable glucose sensors
Biomaterials, 2000Co-Authors: Marinel Gerritsen, V. Sprakel, Jos A. Lutterman, Alexander Kros, Roeland J M Nolte, J. A. JansenAbstract:The objective of the current investigation is to determine the soft- tissue Biocompatibility of sol-gel matrices which can be used to optimize the properties of implantable glucose sensors. The Biocompatibility of sol-gel matrices with heparin, dextran sulphate, Nafion®, polyethylene glycol, and polystyrene sulphonate was examined in vitro in simulated body fluid and with cell culture experiments using human dermal fibroblasts. Finally, an in vivo study was performed. Therefore, sol-gel coated polystyrene discs were inserted subcutaneously in the back of rabbits. After 4 and 12 weeks, the implants with surrounding tissue were retrieved and processed histologically. In simulated body fluid, the formation of a granular calcium phosphate precipitate was observed. Cell proliferation on polyethylene glycol, Nafion®, and heparin coated substrates was comparable to control samples and significantly higher than on dextran sulphate and polystyrene sulphate coated substrates. Light microscopic Evaluation of the retrieved in vivo samples showed a fair tissue reaction to all materials. Histomorphometric analysis demonstrated that there were no differences in tissue response to the different sol-gel coatings. In conclusion, sol-gel matrices exhibit a fair Biocompatibility both in vitro and in vivo. These results will form the basis for further research into the real merits of sol-gel coatings in optimizing the properties of subcutaneously implantable glucose sensors.
-
Biocompatibility Evaluation of sol gel coatings for subcutaneously implantable glucose sensors
Biomaterials, 2000Co-Authors: Marinel Gerritsen, V. Sprakel, Jos A. Lutterman, Alexander Kros, Roeland J M Nolte, J. A. JansenAbstract:The objective of the current investigation is to determine the soft-tissue Biocompatibility of sol}gel matrices which can be used to optimize the properties of implantable glucose sensors. The Biocompatibility of sol}gel matrices with heparin, dextran sulphate, Na"ont, polyethylene glycol, and polystyrene sulphonate was examined in vitro in simulated body #uid and with cell culture experiments using human dermal "broblasts. Finally, an in vivo study was performed. Therefore, sol}gel coated polystyrene discs were inserted subcutaneously in the back of rabbits. After 4 and 12 weeks, the implants with surrounding tissue were retrieved and processed histologically. In simulated body #uid, the formation of a granular calcium phosphate precipitate was observed. Cell proliferation on polyethylene glycol, Na"ont, and heparin coated substrates was comparable to control samples and signi"cantly higher than on dextran sulphate and polystyrene sulphate coated substrates. Light microscopic Evaluation of the retrieved in vivo samples showed a fair tissue reaction to all materials. Histomorphometric analysis demonstrated that there were no di!erences in tissue response to the di!erent sol}gel coatings. In conclusion, sol}gel matrices exhibit a fair Biocompatibility both in vitro and in vivo. These results will form the basis for further research into the real merits of sol}gel coatings in optimizing the properties of subcutaneously implantable glucose sensors. ( 1999 Elsevier Science Ltd. All rights reserved.
Maria Antonietta Miccoli - One of the best experts on this subject based on the ideXlab platform.
-
in vitro and in vivo Biocompatibility Evaluation of a polyalkylimide hydrogel for soft tissue augmentation
Journal of Biomedical Materials Research Part B, 2005Co-Authors: Piera Angela Ramires, Maria Antonietta Miccoli, Elisa Panzarini, Luciana Dini, Carmelo ProtopapaAbstract:Injectable fillers are commonly used in Plastic and Reconstructive Surgery to correct serious and slight aesthetic defects due to their low invasiveness and an easy implant technique procedure. Synthetic hydrogels are proposed as filler materials for their similarity with soft tissue and to avoid many disadvantages of naturally derived materials such as short persistence, allergenicity, and immunogenicity. Our studies are focused on the Biocompatibility Evaluation of a polyacrylic hydrogel containing alkylimide-amide groups and pyrogen free water (96%) (Bio-Alcamid®) by means of the in vitro cytotoxicity and mutagenicity assays and the in vivo skin irritation, sensitization test, and subcutaneous implant. All tests conducted on Bio-Alcamid® showed no toxicity. It is a substance easy to inject and remove; it does not migrate, and its safety allows it to be a suitable filler for the correction of slight and also very serious aesthetic defects. © 2004 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 72B: 230–238, 2005
-
in vitro and in vivo Biocompatibility Evaluation of a polyalkylimide hydrogel for soft tissue augmentation
Journal of Biomedical Materials Research, 2005Co-Authors: Piera Angela Ramires, Maria Antonietta Miccoli, Elisa Panzarini, Luciana Dini, Carmelo ProtopapaAbstract:Injectable fillers are commonly used in Plastic and Reconstructive Surgery to correct serious and slight aesthetic defects due to their low invasiveness and an easy implant technique procedure. Synthetic hydrogels are proposed as filler materials for their similarity with soft tissue and to avoid many disadvantages of naturally derived materials such as short persistence, allergenicity, and immunogenicity. Our studies are focused on the Biocompatibility Evaluation of a polyacrylic hydrogel containing alkylimide-amide groups and pyrogen free water (96%) (Bio-Alcamid®) by means of the in vitro cytotoxicity and mutagenicity assays and the in vivo skin irritation, sensitization test, and subcutaneous implant. All tests conducted on Bio-Alcamid® showed no toxicity. It is a substance easy to inject and remove; it does not migrate, and its safety allows it to be a suitable filler for the correction of slight and also very serious aesthetic defects.
