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Kohei Soga – 1st expert on this subject based on the ideXlab platform

  • Application of Ceramic Nanoparticles for Near Infrared Bioimaging
    Proceedings of the IV Advanced Ceramics and Applications Conference, 2017
    Co-Authors: Kohei Soga, Masao Kamimura


    Bioimaging is an inevitable technique for biological studies and medical diagnosis. As for the fluorescence Bioimaging, only wavelength up to 1000 nm has been used. However, by extend it to be over-1000-nm near infrared, the fluorescence Bioimaging with ten times deeper, several centimeters, observation depth can be achieved in comparison with that with a currently used wavelength. The authors have developed both materials and system for the over-1000 nm near infrared Bioimaging. The paper will review the development by using rare-earth doped ceramic nanoparticles.

  • inorganic nanoparticles for optical Bioimaging
    Advances in Optics and Photonics, 2016
    Co-Authors: D Jaque, Kohei Soga, Cyrille Richard, Bruno Viana, Jose Garcia Sole


    The tremendous progress in the synthesis of different inorganic nanoparticles with pretailored size, shape, structural, compositional, and surface properties has significantly raised their potential applications in biomedicine. Optically active inorganic nanoparticles are those that, based on inorganic materials, can produce fluorescence or scattered light under suitable optical excitation. These outgoing radiations can be conveniently used for Bioimaging purposes. In this work, the different types of optically active inorganic nanoparticles that are being used for optical Bioimaging are reviewed in detail. Special attention is paid to fluorescent and inorganic persistent luminescence nanoparticles and how their different excitation mechanisms (no-photon, one-photon, or multiphoton excited fluorescence) and working spectral ranges can be conveniently applied for in vitro and in vivo high-contrast optical Bioimaging.

  • Upconverting and NIR emitting rare earth based nanostructures for NIR-Bioimaging
    Nanoscale, 2013
    Co-Authors: Eva Hemmer, Natarajan Venkatachalam, Hiroshi Hyodo, Akito Hattori, Yoshie Ebina, Hidehiro Kishimoto, Kohei Soga


    In recent years, significant progress was achieved in the field of nanomedicine and Bioimaging, but the development of new biomarkers for reliable detection of diseases at an early stage, molecular imaging, targeting and therapy remains crucial. The disadvantages of commonly used organic dyes include photobleaching, autofluorescence, phototoxicity and scattering when UV (ultraviolet) or visible light is used for excitation. The limited penetration depth of the excitation light and the visible emission into and from the biological tissue is a further drawback with regard to in vivo Bioimaging. Lanthanide containing inorganic nanostructures emitting in the near-infrared (NIR) range under NIR excitation may overcome those problems. Due to the outstanding optical and magnetic properties of lanthanide ions (Ln(3+)), nanoscopic host materials doped with Ln(3+), e.g. Y2O3:Er(3+),Yb(3+), are promising candidates for NIR-NIR Bioimaging. Ln(3+)-doped gadolinium-based inorganic nanostructures, such as Gd2O3:Er(3+),Yb(3+), have a high potential as opto-magnetic markers allowing the combination of time-resolved optical imaging and magnetic resonance imaging (MRI) of high spatial resolution. Recent progress in our research on over-1000 nm NIR fluorescent nanoprobes for in vivo NIR-NIR Bioimaging will be discussed in this review.

Fuyou Li – 2nd expert on this subject based on the ideXlab platform

  • Near‐Infrared Upconversion Luminescence and Bioimaging In Vivo Based on Quantum Dots
    Advanced Science, 2019
    Co-Authors: Xianlong Su, Wei Feng, Ming Xu, Wei Yuan, Fuyou Li


    : Recently, upconversion luminescence (UCL) has been widely applied in Bioimaging due to its low autofluorescence and high contrast. However, a relatively high power density is still needed in conventional UCL Bioimaging. In the present study, an ultralow power density light, as low as 0.06 mW cm-2, is applied as an excitation source for UCL Bioimaging with PbS/CdS/ZnS quantum dots (UCL-QDs) as probes. The speculated UCL mechanism is a phonon-assisted single-photon process, and the relative quantum yield is up to 4.6%. As determined by continuous irradiation with a 980 nm laser, the UCL-QDs show excellent photostability. Furthermore, UCL-QDs-based probe is applied in tumor, blood vessel, and lymph node Bioimaging excited with an eye-safe low-power light-emitting diode light in a nude mouse with few heat effects.

  • Phosphorescent Iridium(III) Complexes for Bioimaging
    Luminescent and Photoactive Transition Metal Complexes as Biomolecular Probes and Cellular Reagents, 2014
    Co-Authors: Kenneth Yin Zhang, Qiang Zhao, Fuyou Li, Wei Huang


    Phosphorescent iridium(III) complexes have received increasing attention in Bioimaging applications owing to their advantageous photophysical properties and efficient internalization into live cells. In this chapter, we summarize the recent design of Bioimaging reagents based on phosphorescent iridium(III) complexes. The utilizations of cationic, neutral, and zwitterionic phosphorescent iridium(III) complexes in Bioimaging applications have been described first. Complexes showing aggregation-induced phosphorescence have also been included considering the absence of the commonly observed aggregation-caused quenching. Then we discuss the functionalization of iridium(III) complexes with biological substrates and reactive groups, which allows non-covalent and covalent interaction, respectively, with intracellular biomolecules. As the photophysical properties of iridium(III) complexes are very sensitive toward their surrounding ligands and microenvironment, the use of these complexes as intracellular sensors for gas molecules, ions, and amino acids has been summarized. Additionally, the incorporation of iridium(III) complexes into dendrimer, polymer, and nanoparticle systems providing attractive functionalities has been discussed. Furthermore, various strategies, including the use of near-infrared-emitting and two-photon excitable complexes, upconversion nanoparticles, and lifetime-based microscopy techniques, to enhance signal-to-noise ratios in Bioimaging have been discussed. At last, the design of reagents for multi-mode imaging techniques involving phosphorescence and magnetic resonance imaging has been described.

  • Water-soluble lanthanide upconversion nanophosphors: Synthesis and Bioimaging applications in vivo
    Coordination Chemistry Reviews, 2014
    Co-Authors: Wei Feng, Fuyou Li


    Abstract Lanthanide-based upconversion nanophosphors are able to convert lower-energy near-infrared photons to higher-energy ones as emission. This anti-Stokes photoluminescence process will result in low background noise, large tissue penetration depth, and low photo-damage in Bioimaging applications. Due to their special photoluminescent properties, upconversion nanophosphors have been considered as the next generation of photoluminescent probes for sensing and Bioimaging, operating in the near-infrared range. This review summarizes recent advances in the synthesis of water-soluble lanthanide upconversion nanophosphors and their application in functional Bioimaging (including lymphatic imaging, multimodality Bioimaging, ion monitoring in vivo , targeted tumor imaging) that have been developed by our group in the past five years. In addition, the set-up for laser scanning upconversion luminescence confocal microscope and the in vivo imaging system developed by our group are also included in this review. Finally, we discuss the challenges and opportunities in the development of lanthanide upconversion nanophosphors for Bioimaging.

Brij M Moudgil – 3rd expert on this subject based on the ideXlab platform

  • nanoparticles for Bioimaging
    Advances in Colloid and Interface Science, 2006
    Co-Authors: Parvesh Sharma, Scott C Brown, Glenn A Walter, Swadeshmukul Santra, Brij M Moudgil


    The emergence of synthesis strategies for the fabrication of nanosized contrast agents is anticipated to lead to advancements in understanding biological processes at the molecular level in addition to progress in the development of diagnostic tools and innovative therapies. Imaging agents such as fluorescent dye-doped silica nanoparticles, quantum dots and gold nanoparticles have overcome many of the limitations of conventional contrast agents (organic dyes) such as poor photostability, low quantum yield, insufficient in vitro and in vivo stability, etc. Such particulates are now being developed for absorbance and emission in the near infrared region, which is expected to allow for real time and deep tissue imaging via optical routes. Other efforts to facilitate deep tissue imaging with pre-existing technologies have lead to the development of multimodal nanoparticles which are both optical and MRI active. The main focus of this article is to provide an overview of properties and design of contrast agents such as dye-doped silica nanoparticles, quantum dots and gold nanoparticles for non-invasive Bioimaging.