The Experts below are selected from a list of 27174 Experts worldwide ranked by ideXlab platform
Kohei Soga - One of the best experts on this subject based on the ideXlab platform.
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Application of Ceramic Nanoparticles for Near Infrared Bioimaging
Proceedings of the IV Advanced Ceramics and Applications Conference, 2017Co-Authors: Kohei Soga, Masao KamimuraAbstract:Bioimaging is an inevitable technique for biological studies and medical diagnosis. As for the fluorescence Bioimaging, only wavelength up to 1000 nm has been used. However, by extend it to be over-1000-nm near infrared, the fluorescence Bioimaging with ten times deeper, several centimeters, observation depth can be achieved in comparison with that with a currently used wavelength. The authors have developed both materials and system for the over-1000 nm near infrared Bioimaging. The paper will review the development by using rare-earth doped ceramic nanoparticles.
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inorganic nanoparticles for optical Bioimaging
Advances in Optics and Photonics, 2016Co-Authors: D Jaque, Kohei Soga, Cyrille Richard, Bruno Viana, Jose Garcia SoleAbstract:The tremendous progress in the synthesis of different inorganic nanoparticles with pretailored size, shape, structural, compositional, and surface properties has significantly raised their potential applications in biomedicine. Optically active inorganic nanoparticles are those that, based on inorganic materials, can produce fluorescence or scattered light under suitable optical excitation. These outgoing radiations can be conveniently used for Bioimaging purposes. In this work, the different types of optically active inorganic nanoparticles that are being used for optical Bioimaging are reviewed in detail. Special attention is paid to fluorescent and inorganic persistent luminescence nanoparticles and how their different excitation mechanisms (no-photon, one-photon, or multiphoton excited fluorescence) and working spectral ranges can be conveniently applied for in vitro and in vivo high-contrast optical Bioimaging.
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Upconverting and NIR emitting rare earth based nanostructures for NIR-Bioimaging
Nanoscale, 2013Co-Authors: Eva Hemmer, Natarajan Venkatachalam, Akito Hattori, Yoshie Ebina, Hidehiro Kishimoto, Hiroshi Hyodo, Kohei SogaAbstract:In recent years, significant progress was achieved in the field of nanomedicine and Bioimaging, but the development of new biomarkers for reliable detection of diseases at an early stage, molecular imaging, targeting and therapy remains crucial. The disadvantages of commonly used organic dyes include photobleaching, autofluorescence, phototoxicity and scattering when UV (ultraviolet) or visible light is used for excitation. The limited penetration depth of the excitation light and the visible emission into and from the biological tissue is a further drawback with regard to in vivo Bioimaging. Lanthanide containing inorganic nanostructures emitting in the near-infrared (NIR) range under NIR excitation may overcome those problems. Due to the outstanding optical and magnetic properties of lanthanide ions (Ln(3+)), nanoscopic host materials doped with Ln(3+), e.g. Y2O3:Er(3+),Yb(3+), are promising candidates for NIR-NIR Bioimaging. Ln(3+)-doped gadolinium-based inorganic nanostructures, such as Gd2O3:Er(3+),Yb(3+), have a high potential as opto-magnetic markers allowing the combination of time-resolved optical imaging and magnetic resonance imaging (MRI) of high spatial resolution. Recent progress in our research on over-1000 nm NIR fluorescent nanoprobes for in vivo NIR-NIR Bioimaging will be discussed in this review.
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Development of NIR Bioimaging Systems
Journal of Physics: Conference Series, 2008Co-Authors: Kohei Soga, Takashi Tsuji, Fumio Tashiro, Joe Chiba, Motoi Oishi, Keitaro Yoshimoto, Yukio Nagasaki, Katsuhisa Kitano, Satoshi HamaguchiAbstract:Fluorescence Bioimaging is one of the most important technologies in the biomedical field. The most serious issue concerning current fluorescence Bioimaging systems is the use of short wavelength light, UV or VIS, for the excitation of phosphors such as fluorescent proteins or quantum dots. The authors propose a fluorescence Bioimaging system excited by near infrared light using rare-earth doped ceramic nanophosphors. The requirements for the nanophosphors are a designed emission scheme under the near infrared excitation, a controlled size between 10 and 200 nm and surface modification of the particles with a bio- functional polymer, which prevents particle agglomeration and non-specific interaction to non- targeting substances and gives them a specific interaction for the targeted objects. The preparation of the Bioimaging probe and demonstrative imaging work are reported.
Fuyou Li - One of the best experts on this subject based on the ideXlab platform.
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Near‐Infrared Upconversion Luminescence and Bioimaging In Vivo Based on Quantum Dots
Advanced Science, 2019Co-Authors: Xianlong Su, Wei Feng, Ming Xu, Wei Yuan, Fuyou LiAbstract:: Recently, upconversion luminescence (UCL) has been widely applied in Bioimaging due to its low autofluorescence and high contrast. However, a relatively high power density is still needed in conventional UCL Bioimaging. In the present study, an ultralow power density light, as low as 0.06 mW cm-2, is applied as an excitation source for UCL Bioimaging with PbS/CdS/ZnS quantum dots (UCL-QDs) as probes. The speculated UCL mechanism is a phonon-assisted single-photon process, and the relative quantum yield is up to 4.6%. As determined by continuous irradiation with a 980 nm laser, the UCL-QDs show excellent photostability. Furthermore, UCL-QDs-based probe is applied in tumor, blood vessel, and lymph node Bioimaging excited with an eye-safe low-power light-emitting diode light in a nude mouse with few heat effects.
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Phosphorescent Iridium(III) Complexes for Bioimaging
Luminescent and Photoactive Transition Metal Complexes as Biomolecular Probes and Cellular Reagents, 2014Co-Authors: Kenneth Yin Zhang, Fuyou Li, Qiang Zhao, Wei HuangAbstract:Phosphorescent iridium(III) complexes have received increasing attention in Bioimaging applications owing to their advantageous photophysical properties and efficient internalization into live cells. In this chapter, we summarize the recent design of Bioimaging reagents based on phosphorescent iridium(III) complexes. The utilizations of cationic, neutral, and zwitterionic phosphorescent iridium(III) complexes in Bioimaging applications have been described first. Complexes showing aggregation-induced phosphorescence have also been included considering the absence of the commonly observed aggregation-caused quenching. Then we discuss the functionalization of iridium(III) complexes with biological substrates and reactive groups, which allows non-covalent and covalent interaction, respectively, with intracellular biomolecules. As the photophysical properties of iridium(III) complexes are very sensitive toward their surrounding ligands and microenvironment, the use of these complexes as intracellular sensors for gas molecules, ions, and amino acids has been summarized. Additionally, the incorporation of iridium(III) complexes into dendrimer, polymer, and nanoparticle systems providing attractive functionalities has been discussed. Furthermore, various strategies, including the use of near-infrared-emitting and two-photon excitable complexes, upconversion nanoparticles, and lifetime-based microscopy techniques, to enhance signal-to-noise ratios in Bioimaging have been discussed. At last, the design of reagents for multi-mode imaging techniques involving phosphorescence and magnetic resonance imaging has been described.
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Water-soluble lanthanide upconversion nanophosphors: Synthesis and Bioimaging applications in vivo
Coordination Chemistry Reviews, 2014Co-Authors: Wei Feng, Fuyou LiAbstract:Abstract Lanthanide-based upconversion nanophosphors are able to convert lower-energy near-infrared photons to higher-energy ones as emission. This anti-Stokes photoluminescence process will result in low background noise, large tissue penetration depth, and low photo-damage in Bioimaging applications. Due to their special photoluminescent properties, upconversion nanophosphors have been considered as the next generation of photoluminescent probes for sensing and Bioimaging, operating in the near-infrared range. This review summarizes recent advances in the synthesis of water-soluble lanthanide upconversion nanophosphors and their application in functional Bioimaging (including lymphatic imaging, multimodality Bioimaging, ion monitoring in vivo , targeted tumor imaging) that have been developed by our group in the past five years. In addition, the set-up for laser scanning upconversion luminescence confocal microscope and the in vivo imaging system developed by our group are also included in this review. Finally, we discuss the challenges and opportunities in the development of lanthanide upconversion nanophosphors for Bioimaging.
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phosphorescent heavy metal complexes for Bioimaging
Chemical Society Reviews, 2011Co-Authors: Qiang Zhao, Chunhui Huang, Fuyou LiAbstract:The application of phosphorescent heavy-metal complexes with d6, d8 and d10 electron configurations for Bioimaging is a new and promising research field and has been attracting increasing interest. In this critical review, we systematically evaluate the advantages of phosphorescent heavy-metal complexes as Bioimaging probes, including their photophysical properties, cytotoxicity and cellular uptake mechanisms. The progress of research into the use of phosphorescent heavy-metal complexes for staining different compartments of cells, monitoring intracellular functional species, providing targeted Bioimaging, two-photon Bioimaging, small-animal Bioimaging, multimodal Bioimaging and time-resolved Bioimaging is summarized. In addition, several possible future directions in this field are also discussed (133 references).
Brij M Moudgil - One of the best experts on this subject based on the ideXlab platform.
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nanoparticles for Bioimaging
Advances in Colloid and Interface Science, 2006Co-Authors: Parvesh Sharma, Scott C Brown, Glenn A Walter, Swadeshmukul Santra, Brij M MoudgilAbstract:The emergence of synthesis strategies for the fabrication of nanosized contrast agents is anticipated to lead to advancements in understanding biological processes at the molecular level in addition to progress in the development of diagnostic tools and innovative therapies. Imaging agents such as fluorescent dye-doped silica nanoparticles, quantum dots and gold nanoparticles have overcome many of the limitations of conventional contrast agents (organic dyes) such as poor photostability, low quantum yield, insufficient in vitro and in vivo stability, etc. Such particulates are now being developed for absorbance and emission in the near infrared region, which is expected to allow for real time and deep tissue imaging via optical routes. Other efforts to facilitate deep tissue imaging with pre-existing technologies have lead to the development of multimodal nanoparticles which are both optical and MRI active. The main focus of this article is to provide an overview of properties and design of contrast agents such as dye-doped silica nanoparticles, quantum dots and gold nanoparticles for non-invasive Bioimaging.
Parvesh Sharma - One of the best experts on this subject based on the ideXlab platform.
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nanoparticles for Bioimaging
Advances in Colloid and Interface Science, 2006Co-Authors: Parvesh Sharma, Scott C Brown, Glenn A Walter, Swadeshmukul Santra, Brij M MoudgilAbstract:The emergence of synthesis strategies for the fabrication of nanosized contrast agents is anticipated to lead to advancements in understanding biological processes at the molecular level in addition to progress in the development of diagnostic tools and innovative therapies. Imaging agents such as fluorescent dye-doped silica nanoparticles, quantum dots and gold nanoparticles have overcome many of the limitations of conventional contrast agents (organic dyes) such as poor photostability, low quantum yield, insufficient in vitro and in vivo stability, etc. Such particulates are now being developed for absorbance and emission in the near infrared region, which is expected to allow for real time and deep tissue imaging via optical routes. Other efforts to facilitate deep tissue imaging with pre-existing technologies have lead to the development of multimodal nanoparticles which are both optical and MRI active. The main focus of this article is to provide an overview of properties and design of contrast agents such as dye-doped silica nanoparticles, quantum dots and gold nanoparticles for non-invasive Bioimaging.
Peng Wu - One of the best experts on this subject based on the ideXlab platform.
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doped quantum dots for chemo biosensing and Bioimaging
Chemical Society Reviews, 2013Co-Authors: Peng WuAbstract:Quantum dots (QDs) have received great interest for diverse applications due to their distinct advantages, such as narrow and symmetric emission with tunable colors, broad and strong absorption, reasonable stability, and solution processibility. Doped QDs not only potentially retain almost all of the above advantages, but also avoid the self-quenching problem due to their substantial ensemble Stokes shift. Two obvious advantages of doped QDs, especially doped ZnS QDs, over typical CdSe@ZnS and CdTe QDs are longer dopant emission lifetime and potentially lower cytotoxicity. The lifetime of dopant emission from transition-metal ion or lanthanide ion-doped QDs is generally longer than that of the bandgap or defect-related emission of host, and that of biological background fluorescence, providing great opportunities to eliminate background fluorescence for biosensing and Bioimaging. For Bioimaging applications, fluorescent dopants may mitigate toxicity problems by producing visible or infrared emission in nanocrystals made from less-harmful elements than those currently used. In this review, recent advances in utilizing doped QDs for chemo/biosensing and Bioimaging are discussed, and the synthetic routes and optical properties of doped QDs that make them excellent probes for various strategies in chemo/biosensing and Bioimaging are highlighted. Moreover, perspectives on future exploration of doped QDs for chemo/biosensing and Bioimaging are also given.
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Doped quantum dots for chemo/biosensing and Bioimaging
Chemical Society Reviews, 2013Co-Authors: Peng WuAbstract:Quantum dots (QDs) have received great interest for diverse applications due to their distinct advantages, such as narrow and symmetric emission with tunable colors, broad and strong absorption, reasonable stability, and solution processibility. Doped QDs not only potentially retain almost all of the above advantages, but also avoid the self-quenching problem due to their substantial ensemble Stokes shift. Two obvious advantages of doped QDs, especially doped ZnS QDs, over typical CdSe@ZnS and CdTe QDs are longer dopant emission lifetime and potentially lower cytotoxicity. The lifetime of dopant emission from transition-metal ion or lanthanide ion-doped QDs is generally longer than that of the bandgap or defect-related emission of host, and that of biological background fluorescence, providing great opportunities to eliminate background fluorescence for biosensing and Bioimaging. For Bioimaging applications, fluorescent dopants may mitigate toxicity problems by producing visible or infrared emission in nanocrystals made from less-harmful elements than those currently used. In this review, recent advances in utilizing doped QDs for chemo/biosensing and Bioimaging are discussed, and the synthetic routes and optical properties of doped QDs that make them excellent probes for various strategies in chemo/biosensing and Bioimaging are highlighted. Moreover, perspectives on future exploration of doped QDs for chemo/biosensing and Bioimaging are also given.
