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E Mutschler - One of the best experts on this subject based on the ideXlab platform.
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hplc assays to simultaneously determine the angiotensin at1 antagonist losartan as well as its main and active metabolite exp 3174 in Biological Material of humans and rats
Journal of Pharmaceutical and Biomedical Analysis, 1998Co-Authors: Andrea Soldner, Hildegard Spahnlangguth, E MutschlerAbstract:Abstract Novel rapid and sensitive HPLC assays were developed to simultaneously determine losartan and its main active metabolite EXP 3174 in Biological Material of humans and rats following solid–phase or liquid–liquid extraction. The analytes were separated on a 3 μm particle-sized ULTREMEX™ CN column, which was preceeded by a 5 μm particle-sized guard column, using UV-detection at 245 nm. The assays provided high sensitivity with limits of quantification (LoQ) of 5 ng ml−1 for both compounds in human and rat plasma and 10 ng ml−1 in human and rat urine, respectively. In rat blood, bile and various tissues, limits of quantifications were achieved that ranged 10–15 ng per ml and per 100 mg tissue, respectively, for both analytes.
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hplc assays to simultaneously determine the angiotensin at1 antagonist losartan as well as its main and active metabolite exp 3174 in Biological Material of humans and rats
Journal of Pharmaceutical and Biomedical Analysis, 1998Co-Authors: Andrea Soldner, Hildegard Spahnlangguth, E MutschlerAbstract:Novel rapid and sensitive HPLC assays were developed to simultaneously determine losartan and its main active metabolite EXP 3174 in Biological Material of humans and rats following solid-phase or liquid-liquid extraction. The analytes were separated on a 3 microm particle-sized ULTREMEX CN column, which was preceded by a 5 microm particle-sized guard column, using UV-detection at 245 nm. The assays provided high sensitivity with limits of quantification (LoQ) of 5 ng ml(-1) for both compounds in human and rat plasma and 10 ng ml(-1) in human and rat urine, respectively. In rat blood, bile and various tissues, limits of quantifications were achieved that ranged 10-15 ng per ml and per 100 mg tissue, respectively, for both analytes.
Andrea Soldner - One of the best experts on this subject based on the ideXlab platform.
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hplc assays to simultaneously determine the angiotensin at1 antagonist losartan as well as its main and active metabolite exp 3174 in Biological Material of humans and rats
Journal of Pharmaceutical and Biomedical Analysis, 1998Co-Authors: Andrea Soldner, Hildegard Spahnlangguth, E MutschlerAbstract:Abstract Novel rapid and sensitive HPLC assays were developed to simultaneously determine losartan and its main active metabolite EXP 3174 in Biological Material of humans and rats following solid–phase or liquid–liquid extraction. The analytes were separated on a 3 μm particle-sized ULTREMEX™ CN column, which was preceeded by a 5 μm particle-sized guard column, using UV-detection at 245 nm. The assays provided high sensitivity with limits of quantification (LoQ) of 5 ng ml−1 for both compounds in human and rat plasma and 10 ng ml−1 in human and rat urine, respectively. In rat blood, bile and various tissues, limits of quantifications were achieved that ranged 10–15 ng per ml and per 100 mg tissue, respectively, for both analytes.
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hplc assays to simultaneously determine the angiotensin at1 antagonist losartan as well as its main and active metabolite exp 3174 in Biological Material of humans and rats
Journal of Pharmaceutical and Biomedical Analysis, 1998Co-Authors: Andrea Soldner, Hildegard Spahnlangguth, E MutschlerAbstract:Novel rapid and sensitive HPLC assays were developed to simultaneously determine losartan and its main active metabolite EXP 3174 in Biological Material of humans and rats following solid-phase or liquid-liquid extraction. The analytes were separated on a 3 microm particle-sized ULTREMEX CN column, which was preceded by a 5 microm particle-sized guard column, using UV-detection at 245 nm. The assays provided high sensitivity with limits of quantification (LoQ) of 5 ng ml(-1) for both compounds in human and rat plasma and 10 ng ml(-1) in human and rat urine, respectively. In rat blood, bile and various tissues, limits of quantifications were achieved that ranged 10-15 ng per ml and per 100 mg tissue, respectively, for both analytes.
Hildegard Spahnlangguth - One of the best experts on this subject based on the ideXlab platform.
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hplc assays to simultaneously determine the angiotensin at1 antagonist losartan as well as its main and active metabolite exp 3174 in Biological Material of humans and rats
Journal of Pharmaceutical and Biomedical Analysis, 1998Co-Authors: Andrea Soldner, Hildegard Spahnlangguth, E MutschlerAbstract:Abstract Novel rapid and sensitive HPLC assays were developed to simultaneously determine losartan and its main active metabolite EXP 3174 in Biological Material of humans and rats following solid–phase or liquid–liquid extraction. The analytes were separated on a 3 μm particle-sized ULTREMEX™ CN column, which was preceeded by a 5 μm particle-sized guard column, using UV-detection at 245 nm. The assays provided high sensitivity with limits of quantification (LoQ) of 5 ng ml−1 for both compounds in human and rat plasma and 10 ng ml−1 in human and rat urine, respectively. In rat blood, bile and various tissues, limits of quantifications were achieved that ranged 10–15 ng per ml and per 100 mg tissue, respectively, for both analytes.
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hplc assays to simultaneously determine the angiotensin at1 antagonist losartan as well as its main and active metabolite exp 3174 in Biological Material of humans and rats
Journal of Pharmaceutical and Biomedical Analysis, 1998Co-Authors: Andrea Soldner, Hildegard Spahnlangguth, E MutschlerAbstract:Novel rapid and sensitive HPLC assays were developed to simultaneously determine losartan and its main active metabolite EXP 3174 in Biological Material of humans and rats following solid-phase or liquid-liquid extraction. The analytes were separated on a 3 microm particle-sized ULTREMEX CN column, which was preceded by a 5 microm particle-sized guard column, using UV-detection at 245 nm. The assays provided high sensitivity with limits of quantification (LoQ) of 5 ng ml(-1) for both compounds in human and rat plasma and 10 ng ml(-1) in human and rat urine, respectively. In rat blood, bile and various tissues, limits of quantifications were achieved that ranged 10-15 ng per ml and per 100 mg tissue, respectively, for both analytes.
Tláskalová Anna - One of the best experts on this subject based on the ideXlab platform.
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LC-HRMS analysis of selected antihypertensive drugs in Biological Material for compliance assessment
2018Co-Authors: Tláskalová AnnaAbstract:5 ABSTRACT Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Pharmaceutical Analysis Candidate: Anna Tláskalová Supervisor - specialist: Mgr. Martin Mžik Supervisor: doc. PharmDr. Radim Kučera, Ph.D. Title: LC-HRMS analysis of selected antihypertensive drugs in Biological Material for compliance assessment About 40 % of Czech population between the ages of 25 and 64 suffer from arterial hypertension. Although an array of effective antihypertensives is available nowadays, optimal blood pressure during treatment is reached by mere 30 % of the patients. This is mainly due to the patients' poor adherence to the treatment, who use their medicaments incorrectly or not at all. The adherence of a patient to the treatment, as well as pharmacokinetics, represent the most significant source of variability of the answer to the treatment and notably influences its outcome. The monitoring of plasmatic levels of antihypertensives is one of the methods of modern medicine which enables both an effective supervision of the incorrectly compensated patients, and the adjustment of dosage scheme. This diploma thesis focuses on development and optimisation of extraction procedures for selected antihypertensives (amiloride, amlodipine, betaxolol, bisoprolol, carvedilol, celiprolol,..
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LC-HRMS analysis of selected antihypertensive drugs in Biological Material for compliance assessment
Univerzita Karlova Farmaceutická fakulta v Hradci Králové, 2018Co-Authors: Tláskalová AnnaAbstract:4 ABSTRAKT Univerzita Karlova Farmaceutická fakulta v Hradci Králové Katedra farmaceutické chemie a farmaceutické analýzy Kandidát: Anna Tláskalová Konzultant: Mgr. Martin Mžik Vedoucí diplomové práce: doc. PharmDr. Radim Kučera, Ph.D. Název diplomové práce: LC-HRMS analýza vybraných antihypertenziv v biologickém materiálu jako průkaz compliance Arteriální hypertenzí trpí ve věku 25 - 64 let kolem 40 % české populace. I když je v současné době k dispozici řada účinných antihypertenziv, optimálního krevního tlaku je při léčbě dosaženo pouze u 30 % pacientů, což je způsobeno především špatnou adherencí pacientů k léčbě, kteří své léky užívají nesprávně nebo vůbec. Adherence pacienta k léčbě, stejně jako farmakokinetika, představuje nejvýznamnější zdroj variability v odpovědi na léčbu a významně ovlivňuje její výsledek. Monitorování plazmatických hladin antihypertenziv je jedním z nástrojů moderní medicíny, který umožňuje jak efektivní kontrolu špatně kompenzovaných pacientů, tak úpravu dávkovacího schématu. Tato diplomová práce se zabývá vývojem a optimalizací extrakční metody pro vybraná antihypertenziva (amilorid, amlodipin, betaxolol, bisoprolol, carvedilol, celiprolol, indapamid, metoprolol, moxonidin, nebivolol, nitrendipin, rilmenidin, urapidil) a následnou validací celé analytické metody pro potřeby...5 ABSTRACT Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Pharmaceutical Analysis Candidate: Anna Tláskalová Supervisor - specialist: Mgr. Martin Mžik Supervisor: doc. PharmDr. Radim Kučera, Ph.D. Title: LC-HRMS analysis of selected antihypertensive drugs in Biological Material for compliance assessment About 40 % of Czech population between the ages of 25 and 64 suffer from arterial hypertension. Although an array of effective antihypertensives is available nowadays, optimal blood pressure during treatment is reached by mere 30 % of the patients. This is mainly due to the patients' poor adherence to the treatment, who use their medicaments incorrectly or not at all. The adherence of a patient to the treatment, as well as pharmacokinetics, represent the most significant source of variability of the answer to the treatment and notably influences its outcome. The monitoring of plasmatic levels of antihypertensives is one of the methods of modern medicine which enables both an effective supervision of the incorrectly compensated patients, and the adjustment of dosage scheme. This diploma thesis focuses on development and optimisation of extraction procedures for selected antihypertensives (amiloride, amlodipine, betaxolol, bisoprolol, carvedilol, celiprolol,...Katedra farmaceutické chemie a farmaceutické analýzyDepartment of Pharmaceutical Chemistry and Pharmaceutical AnalysisFaculty of Pharmacy in Hradec KrálovéFarmaceutická fakulta v Hradci Králov
Mariza Vono Tancredi - One of the best experts on this subject based on the ideXlab platform.
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p3 233 occupational accident with Biological Material in the state of sao paulo 2007 2016
Sexually Transmitted Infections, 2017Co-Authors: A P Volpato, Ana Lucia Carvalho Monteiro, Maria Clara Gianna, M A Silva, Mariza Vono TancrediAbstract:Introduction Occupational accidents with Biological Material are an injury which can largely be prevented. This study describes the notified occupational accidents in the State of Sao Paulo. Methods Descriptive data analysis of the accidents with Biological Material notified by SINAN in the State of Sao Paulo, in the period from 2007 to June 2016. Results During this period 1 25 060 accidents were reported with Biological Material. 77.5% occurred in female health professionals and most frequently in the 20 and 39 years age group, in nurses and lab technicians (53.1%) followed by physicians (10.7%). Regarding the accident circumstances, 17.1% occurred during the administration of medication, inappropriate disposal of syringes and needles (15.5%) and surgical and dental procedures (15.1%). The proportions of accidents by inappropriate disposal over time remained unchanged. The accidents in procedures of realisation of capillary blood glucose test and recapping needles had a proportional decrease of two times. It was observed that 30.2% of professionals who were injured were not using gloves when administering medication, and 15.3% and 14.7%, respectively, did not do so in the procedures of blood collection and laboratory collection. Glove use during accident in surgical and dental procedures occurred in 96.7% and 95.3%, respectively. The outpatient discharge of the injured professionals occurred in 39.6% (49,557) after confirming a negative source for hepatitis B, C and HIV (human immunodeficiency virus), in 22.1% (27,674) after six months of follow-up without serological conversion and in 11.6% due to abandonment of follow-up. In this period there were no cases of conversion to HIV. Conclusion Reporting accidents with Biological Material is a great monitoring tool. Inadequate disposal of needles is an important cause of accidents, and their frequency remains unchanged over the years. The accidents in procedures of realisation of blood test and recapping needles had a decrease. Much more can be done to prevent accidents and improve the follow-up of accidents.