The Experts below are selected from a list of 18414 Experts worldwide ranked by ideXlab platform
Yu Liu - One of the best experts on this subject based on the ideXlab platform.
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a supramolecular vesicle based on the complexation of p sulfonatocalixarene with protamine and its trypsin triggered controllable release properties
Chemistry: A European Journal, 2016Co-Authors: Kui Wang, Dongsheng Guo, Mengyao Zhao, Yu LiuAbstract:Enzyme-responsive assembly represents one of the increasingly significant topics in Biomaterials Research and finds feasible applications to the controlled release of therapeutic agents at specific sites at which the target en- zymes are located. In this work, based on the concept of host-guest chemistry, a trypsin-responsive supramolecular vesicle using p-sulfonatocalix(4)arene as the macrocyclic host and natural serine protease trypsin-cleavable cationic protein protamine as the guest molecule, is reported. The complexation of p-sulfonatocalix(4)arene with protamine di- rects the formation of a supramolecular binary vesicle, which is dissipated by trypsin with high selectivity. Therefore, the present system represents a principle-of-concept to build a controlled-release carrier at trypsin-overexpressed sites.
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cholinesterase responsive supramolecular vesicle
Journal of the American Chemical Society, 2012Co-Authors: Dongsheng Guo, Kui Wang, Yixuan Wang, Yu LiuAbstract:Enzyme-responsive, amphiphilic self-assembly represents one of the increasingly significant topics in Biomaterials Research and finds feasible applications to the controlled release of therapeutic agents at specific sites where the target enzyme is located. The supramolecular approach, using “superamphiphiles”, provides a smart way to fabricate drug delivery systems responsive to enzymatic catalysis. In this work based on the concept of supramolecular chemistry, we report an enzyme-responsive vesicle using p-sulfonatocalix[4]arene as the macrocyclic host and natural enzyme-cleavable myristoylcholine as the guest molecule. The complexation of p-sulfonatocalix[4]arene with myristoylcholine directs the formation of a supramolecular binary vesicle, which is dissipated by cholinesterase with high specificity and efficiency. Cholinesterase is a key protein overexpressed in Alzheimer’s disease, and therefore, the present system may have potential for the delivery of Alzheimer’s disease drugs.
Kui Wang - One of the best experts on this subject based on the ideXlab platform.
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a supramolecular vesicle based on the complexation of p sulfonatocalixarene with protamine and its trypsin triggered controllable release properties
Chemistry: A European Journal, 2016Co-Authors: Kui Wang, Dongsheng Guo, Mengyao Zhao, Yu LiuAbstract:Enzyme-responsive assembly represents one of the increasingly significant topics in Biomaterials Research and finds feasible applications to the controlled release of therapeutic agents at specific sites at which the target en- zymes are located. In this work, based on the concept of host-guest chemistry, a trypsin-responsive supramolecular vesicle using p-sulfonatocalix(4)arene as the macrocyclic host and natural serine protease trypsin-cleavable cationic protein protamine as the guest molecule, is reported. The complexation of p-sulfonatocalix(4)arene with protamine di- rects the formation of a supramolecular binary vesicle, which is dissipated by trypsin with high selectivity. Therefore, the present system represents a principle-of-concept to build a controlled-release carrier at trypsin-overexpressed sites.
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cholinesterase responsive supramolecular vesicle
Journal of the American Chemical Society, 2012Co-Authors: Dongsheng Guo, Kui Wang, Yixuan Wang, Yu LiuAbstract:Enzyme-responsive, amphiphilic self-assembly represents one of the increasingly significant topics in Biomaterials Research and finds feasible applications to the controlled release of therapeutic agents at specific sites where the target enzyme is located. The supramolecular approach, using “superamphiphiles”, provides a smart way to fabricate drug delivery systems responsive to enzymatic catalysis. In this work based on the concept of supramolecular chemistry, we report an enzyme-responsive vesicle using p-sulfonatocalix[4]arene as the macrocyclic host and natural enzyme-cleavable myristoylcholine as the guest molecule. The complexation of p-sulfonatocalix[4]arene with myristoylcholine directs the formation of a supramolecular binary vesicle, which is dissipated by cholinesterase with high specificity and efficiency. Cholinesterase is a key protein overexpressed in Alzheimer’s disease, and therefore, the present system may have potential for the delivery of Alzheimer’s disease drugs.
R. Stevens - One of the best experts on this subject based on the ideXlab platform.
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A synthesis route to nanoparticle dicalcium silicate for Biomaterials Research
Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2011Co-Authors: W. Booncharoen, Angkhana Jaroenworaluck, R. StevensAbstract:Dicalcium silicate (Ca(2)SiO(4)) has been reported as an interesting candidate for Biomaterials use due to its attractive bioactive properties. Here, we report on how dicalcium silicate was prepared by a sol-gel route using calcium nitrate tetrahydrate and tetraorthosilicate as the precursors chemicals for CaO and SiO(2), respectively. The synthesized powders were characterized using thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), Brunauer-Emmett-Teller (BET) method, scanning electron microscopy (SEM), and transmission electron microscopy (TEM). High purity dicalcium silicate at a CaO/SiO(2) molar ratio of 2: 1 could be formed by the sol-gel method without a washing process and was then calcined at 800 degrees C. The effects of the molar ratio of CaO/SiO(2), the washing process, and the calcination temperature have been shown to affect the purity, the formation, and the particle size of the nanoparticles, which have been investigated and discussed
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A synthesis route to nanoparticle dicalcium silicate for Biomaterials Research
Journal of Biomedical Materials Research Part B, 2011Co-Authors: W. Booncharoen, Angkhana Jaroenworaluck, R. StevensAbstract:Dicalcium silicate (Ca2SiO4) has been reported as an interesting candidate for Biomaterials use due to its attractive bioactive properties. Here, we report on how dicalcium silicate was prepared by a sol–gel route using calcium nitrate tetrahydrate and tetraorthosilicate as the precursors chemicals for CaO and SiO2, respectively. The synthesized powders were characterized using thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), Brunauer-Emmett-Teller (BET) method, scanning electron microscopy (SEM), and transmission electron microscopy (TEM). High purity dicalcium silicate at a CaO/SiO2 molar ratio of 2:1 could be formed by the sol–gel method without a washing process and was then calcined at 800°C. The effects of the molar ratio of CaO/SiO2, the washing process, and the calcination temperature have been shown to affect the purity, the formation, and the particle size of the nanoparticles, which have been investigated and discussed. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2011.
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A synthesis route to nanoparticle dicalcium silicate for Biomaterials Research.
Journal of biomedical materials research. Part B Applied biomaterials, 2011Co-Authors: W. Booncharoen, Angkhana Jaroenworaluck, R. StevensAbstract:Dicalcium silicate (Ca₂ SiO₄) has been reported as an interesting candidate for Biomaterials use due to its attractive bioactive properties. Here, we report on how dicalcium silicate was prepared by a sol-gel route using calcium nitrate tetrahydrate and tetraorthosilicate as the precursors chemicals for CaO and SiO₂ , respectively. The synthesized powders were characterized using thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), Brunauer-Emmett-Teller (BET) method, scanning electron microscopy (SEM), and transmission electron microscopy (TEM). High purity dicalcium silicate at a CaO/SiO₂ molar ratio of 2:1 could be formed by the sol-gel method without a washing process and was then calcined at 800°C. The effects of the molar ratio of CaO/SiO₂ , the washing process, and the calcination temperature have been shown to affect the purity, the formation, and the particle size of the nanoparticles, which have been investigated and discussed.
Thomas J. Webster - One of the best experts on this subject based on the ideXlab platform.
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a hierarchical integration pyramid to increase translation of Biomaterials based on recent successes in multiscale synthetic Biomaterials Research
Current Opinion in Biomedical Engineering, 2019Co-Authors: Aandrew D Jones, Zelong Xie, Thomas J. WebsterAbstract:Abstract The success of science and engineering in increasing life span and quality of life has generated difficult challenges to sustaining health span. Aging populations and poor health patterns have increased the need for replacement organs, tissues, and limbs that must do more, longer. To meet this need, advanced synthetic Biomaterials that mimic or encourage native tissue regrowth are needed. We highlight recent advances in tissue engineering and regenerative medicine for bone, skin, and cardio scaffolds, grafts, and replacements. Recognizing the complexity of multiscale development and testing, we use these as case studies to propose a hierarchical integration pyramid to assist the rapid translation of these developments from benchtop to bedside.
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Summary of the National Conference on Challenges in Biomaterials Research jointly organized by VIT and CSIR-CECRI
International journal of nanomedicine, 2015Co-Authors: Geetha Manivasagam, Balasubramanian Subramanian, Thomas J. WebsterAbstract:Health care has become one of the highest priority Research fields of this century owing to the dramatic increase in the number of people affected by various diseases. Health care costs and the high demand for Biomaterials have placed tremendous pressure on government funding agencies and Researchers to develop cost-effective, appropriate Biomaterials to treat various diseases and to regenerate diseased and fractured organs. The field of Biomaterials is projected to generate approximately $80 billion by the end of this decade. Thus, various funding organizations have allocated considerable funding for the development of the next generation of Biomaterials. Despite the fact that certain global regions and countries (such as the US, Europe, Australia, Brazil, and the People’s Republic of China) have considerable expertise in the manufacturing of various Biomaterials, India has developed considerable expertise in specifically manufacturing cardiovascular and orthopedic implants over the past 3 decades. There are several Research and development institutes, universities, and colleges in India working toward developing novel Biomaterials and unique characterization methods. Extensive Research in the field of nanoBiomaterials is being pursued all over India, with considerable effort toward generating new Biomaterials with enhanced service and lifetime and superior biocompatibility. In order to provide young Researchers a platform to interact with clinicians, industrialists, and Researchers from and in India, and to showcase their talent to understand the current challenges in this field, a 2-day national conference on “Challenges in Biomaterials Research” was held at VIT University, Vellore, India from December 23–24, 2013. Challenges from the clinical, industrial, and academic Researcher point of view were presented by speakers from numerous international and national universities. Clinicians were present from various medical hospitals, and scientists working in Research labs also contributed toward the discussion. Topics such as problems encountered in surgical procedures, the design of Biomaterials, toxicity of materials, development of orthopedic implants, surface engineering, corrosion and wear, and biocompatibility were presented by both Researchers and students. This supplement issue of the International Journal of Nanomedicine comprehensively presents the peer-reviewed Research presented at this unique conference. As various topics were covered, the papers are categorized under categories: “Novel materials for bone tissue engineering”, “Novel materials for wound healing and nerve applications”, “Novel nanomaterials for antibacterial applications”, “Novel calcium phosphate-based Biomaterials”, “Novel non-calcium phosphate-based Biomaterials”, “Silver-based and calcium-based anti-toxicity studies”, and “Mechanical properties and surface engineering of orthopedic implants”. We hope you enjoy reading this issue and learning about all of the wonderful Research presented at this conference as we continue to forge a path forward developing improved Biomaterials to meet health care challenges in the decades ahead.
Dongsheng Guo - One of the best experts on this subject based on the ideXlab platform.
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a supramolecular vesicle based on the complexation of p sulfonatocalixarene with protamine and its trypsin triggered controllable release properties
Chemistry: A European Journal, 2016Co-Authors: Kui Wang, Dongsheng Guo, Mengyao Zhao, Yu LiuAbstract:Enzyme-responsive assembly represents one of the increasingly significant topics in Biomaterials Research and finds feasible applications to the controlled release of therapeutic agents at specific sites at which the target en- zymes are located. In this work, based on the concept of host-guest chemistry, a trypsin-responsive supramolecular vesicle using p-sulfonatocalix(4)arene as the macrocyclic host and natural serine protease trypsin-cleavable cationic protein protamine as the guest molecule, is reported. The complexation of p-sulfonatocalix(4)arene with protamine di- rects the formation of a supramolecular binary vesicle, which is dissipated by trypsin with high selectivity. Therefore, the present system represents a principle-of-concept to build a controlled-release carrier at trypsin-overexpressed sites.
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cholinesterase responsive supramolecular vesicle
Journal of the American Chemical Society, 2012Co-Authors: Dongsheng Guo, Kui Wang, Yixuan Wang, Yu LiuAbstract:Enzyme-responsive, amphiphilic self-assembly represents one of the increasingly significant topics in Biomaterials Research and finds feasible applications to the controlled release of therapeutic agents at specific sites where the target enzyme is located. The supramolecular approach, using “superamphiphiles”, provides a smart way to fabricate drug delivery systems responsive to enzymatic catalysis. In this work based on the concept of supramolecular chemistry, we report an enzyme-responsive vesicle using p-sulfonatocalix[4]arene as the macrocyclic host and natural enzyme-cleavable myristoylcholine as the guest molecule. The complexation of p-sulfonatocalix[4]arene with myristoylcholine directs the formation of a supramolecular binary vesicle, which is dissipated by cholinesterase with high specificity and efficiency. Cholinesterase is a key protein overexpressed in Alzheimer’s disease, and therefore, the present system may have potential for the delivery of Alzheimer’s disease drugs.