The Experts below are selected from a list of 60276 Experts worldwide ranked by ideXlab platform

Svetlana G Vorsanova - One of the best experts on this subject based on the ideXlab platform.

Iolanda Francolini - One of the best experts on this subject based on the ideXlab platform.

  • intermolecular interaction and solid state characterization of abietic acid chitosan solid dispersions possessing antimicrobial and antioxidant properties
    European Journal of Pharmaceutics and Biopharmaceutics, 2018
    Co-Authors: Valentina Cuzzucoli Crucitti, Luisa Maria Migneco, Antonella Piozzi, Vincenzo Taresco, Martin C Garnett, Richard H Argent, Iolanda Francolini
    Abstract:

    The aim of this work was to prepare and characterize solid dispersions of abietic acid (AB) and chitosan (CS) to investigate how formulation of the mixture may help in the battle against microbial colonization in different areas, such as the Biomedical Field or the food industry. Solid dispersions were characterized by differential scanning calorimetry, infrared spectroscopy, Raman spectroscopy, polarized optical microscopy, zeta potential and size analysis. The data showed that the dispersion/solvent evaporation method formed solid dispersions in which abietic acid was molecularly dispersed in the carrier. A synergistic effect between the two components in terms of antioxidant and antimicrobial properties was found, especially in the formulations obtained with 1/1 AB/CS molar ratio. Interestingly, the aggregation state (amorphous/crystalline) of AB seemed to affect the antimicrobial activity of the formulation, suggesting increased bioactivity when the drug was in the amorphous state. These findings, together with the demonstrated biocompatibility of the formulations, seem to open promising perspectives for a successful application of the developed AB/CS formulations in the Biomedical Field or in the food industry.

Joao F Mano - One of the best experts on this subject based on the ideXlab platform.

  • micro nano structured superhydrophobic surfaces in the Biomedical Field part ii applications overview
    Nanomedicine: Nanotechnology Biology and Medicine, 2015
    Co-Authors: Ana Catarina Lima, Joao F Mano
    Abstract:

    The properties of surfaces define the acceptance and integration of biomaterials in vivo, as well as the material's efficiency when used at research or manufacturing levels. The presence of micro/nano-topographical structures and low surface energies could bring several advantages when highly repellent surfaces are employed in the Biomedical Field. Biomimetic superhydrophobic surfaces have been explored for diverse applications: as an intrinsic characteristic of biomaterials to be implanted; as materials that exhibit special interactions with biological entities; or to be used in ex vivo applications. This article aims to focus on the main motivations and requirements in the Biomedical Field that pushed for the utilization of superhydrophobic surfaces as suitable alternatives, as well as the great evolution of applications that have emerged in the last few years.

  • micro nano structured superhydrophobic surfaces in the Biomedical Field part i basic concepts and biomimetic approaches
    Nanomedicine: Nanotechnology Biology and Medicine, 2015
    Co-Authors: Ana Catarina Lima, Joao F Mano
    Abstract:

    Inspired by natural structures, great attention has been devoted to the study and development of surfaces with extreme wettable properties. The meticulous study of natural systems revealed that the micro/nano-topography of the surface is critical to obtaining unique wettability features, including superhydrophobicity. However, the surface chemistry also has an important role in such surface characteristics. As the interaction of biomaterials with the biological milieu occurs at the surface of the materials, it is expected that synthetic substrates with extreme and controllable wettability ranging from superhydrophilic to superhydrophobic regimes could bring about the possibility of new investigations of cell–material interactions on nonconventional surfaces and the development of alternative devices with Biomedical utility. This first part of the review will describe in detail how proteins and cells interact with micro/nano-structured surfaces exhibiting extreme wettabilities.

  • bionanocomposites from lignocellulosic resources properties applications and future trends for their use in the Biomedical Field
    Progress in Polymer Science, 2013
    Co-Authors: Emanuel M Fernandes, Joao F Mano, Ricardo A Pires, Rui L Reis
    Abstract:

    Abstract The selection, synthesis, modification and shaping of biomaterials are complex tasks within the Biomedical Field. Human and plant tissues, such as, wood, bone and cartilage are structured at the nanometer level and exhibit a hierarchical structure up to the macroscale. Their morphological similarities enable the exploitation of lignocellulosic materials in the development of nanostructured composites targeting tissue engineering and regeneration. In this review, lignocellulosic materials and their chemical constituents are highlighted as promising alternatives for the development of drug-delivery vehicles and for the engineering or regeneration of bone and cartilage. Special focus is given to the recent developments of lignocellulosic bionanocomposite supports that induce cell attachment and proliferation. Chemical modifications techniques as well as composite processing methodologies that enhance the biomaterial performance are reviewed. It is anticipated the increasing interest in nanocellulose, bacterial cellulose, hemicellulose and lignin from natural resources as added-value Biomedical materials in the near future.

Yuri B. Yurov - One of the best experts on this subject based on the ideXlab platform.

Arianna Menciassi - One of the best experts on this subject based on the ideXlab platform.

  • Assessing cytotoxicity of boron nitride nanotubes: Interference with the MTT assay.
    Biochemical and biophysical research communications, 2010
    Co-Authors: Gianni Ciofani, Serena Danti, D D’alessandro, Stefania Moscato, Arianna Menciassi
    Abstract:

    Thanks to a non-covalent wrapping with glycol-chitosan, highly biocompatible and highly concentrated dispersions of boron nitride nanotubes were obtained and tested on human neuroblastoma cells. A systematic investigation of the cytotoxicity of these nanovectors with several complementary qualitative and quantitative assays allowed a strong interference with the MTT metabolic assay to be highlighted, similar to a phenomenon already observed for carbon nanotubes, that would wrongly suggest toxicity of boron nitride nanotubes. These results confirm the high complexity of these new nanomaterials, and the needing of extensive investigations on their exciting potential applications in the Biomedical Field.

  • Boron nitride nanotubes: An innovative tool for nanomedicine
    Nano Today, 2009
    Co-Authors: Gianni Ciofani, Vittoria Raffa, Arianna Menciassi, Alfred Cuschieri
    Abstract:

    Summary Boron nitride nanotubes are structural analogues of carbon nanotubes in nature: alternating B and N atoms entirely substitute for C atoms in a graphitic like sheet with almost no change in atomic spacing. Despite their unique physical and chemical properties, their use has not yet been exploited in the nanomedicine Field. In this Opinion, the authors briefly summarize the results of their studies on the interactions between boron nitride nanotubes and living cells and outline future and realistic applications for their use in the Biomedical Field.