The Experts below are selected from a list of 7488 Experts worldwide ranked by ideXlab platform
Chihyun Park - One of the best experts on this subject based on the ideXlab platform.
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Construction of a photothermal Venus flytrap from conductive polymer bimorphs
NPG Asia Materials, 2017Co-Authors: Teahoon Park, Jongbeom Na, Chihyun ParkAbstract:A photothermally foldable soft bimorph was prepared by dry transfer of poly(3,4-ethylenedioxythiophene)s (PEDOT) onto poly(dimethylsiloxane) film. The reversible folding nature of the soft bimorph was programmable to convert the two-dimensional (2D) array of bimorph into complex three-dimensional (3D) architectures such as Venus flytrap under light. These 3D structures were returned reversibly to the original unfolded 2D structures under dark. The Venus flytrap could perform a task to snap and move an object within few second of near-infrared exposure. A localized heat pocket was generated inside the folding structure due to the large photothermal effect of PEDOT. A bilayer Material that behaves like a Venus flytrap when illuminated by infrared light has been created by researchers in South Korea. Biomimetic Materials – substances that replicate the behavior of biological organisms and structures – offer a route to producing engineered devices with novel functionality. The Biomimetic Material made by Eunkyoung Kim and colleagues from Yonsei University consists of two soft polymers – a spin–coated layer of polydimethylsiloxane (PDMS) on a spin-coated film of poly (3, 4–ethylenedioxythiophene) (PEDOT) doped with tosylate. PEDOT has photothermal properties, meaning that incident light leads to localized heating. This heat then changes the volume of the PDMS, which makes the bilayer fold. The team used this effect to create complex three–dimensional architectures and hot trap including a Venus flytrap, which snapped close within a few seconds of being exposed to near–infrared radiation. A photothermally foldable soft bimorph was prepared via the dry transfer of poly(3,4-ethylenedioxythiophene) (PEDOT) doped with tosylate onto a poly(dimethylsiloxane) film. The photothermal folding was optimized via reversible actuation by controlling the thickness of each layer and the temperature increase to afford large deflection and displacement up to 150° and >20 mm, respectively, upon exposure to near-infrared (NIR) light (808 nm). A two-dimensional array of the bimorph converted into complex three-dimensional architectures, such as a Venus flytrap, under light and reversibly unfolded in the dark. Taking advantage of the photothermal nature of PEDOT, a localized heat pocket was generated inside the folding structure. Thus, a Venus flytrap with a hot pocket reaching 100 °C was realized for the first time. The Venus flytrap could trap and move an object within a few seconds of NIR exposure.
Shaoyi Jiang - One of the best experts on this subject based on the ideXlab platform.
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de novo design of functional zwitterionic Biomimetic Material for immunomodulation
Science Advances, 2020Co-Authors: Zhefan Yuan, Priyesh Jain, Hsiangchieh Hung, Xiaojie Lin, Patrick Mcmullen, Shaoyi JiangAbstract:Superhydrophilic zwitterionic polymers are a class of nonfouling Materials capable of effectively resisting any nonspecific interactions with biological systems. We designed here a functional zwitterionic polymer that achieves a trade-off between nonspecific interactions providing the nonfouling property and a specific interaction for bioactive functionality. Built from phosphoserine, an immune-signaling molecule in nature, this zwitterionic polymer exhibits both nonfouling and immunomodulatory properties. Its conjugation to uricase is shown to proactively eradicate all unwanted immune response, outperforming the zwitterionic polymers. On the other hand, this polymer could significantly prolong the half-life of protein drugs in vivo, overcoming the innate drawback of phosphoserine in inducing accelerated clearance. Our demonstration of a nonfouling zwitterionic Material with built-in immunomodulatory functionality provides new insights into the fundamental design of bioMaterials, as well as far-reaching implications for broad applications such as drug delivery, implants, and cell therapy.
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ultralow fouling and functionalizable surface chemistry based on a zwitterionic polymer enabling sensitive and specific protein detection in undiluted blood plasma
Analytical Chemistry, 2008Co-Authors: Hana Vaisocherová, Gang Cheng, Marek Piliarik, Zhiqiang Cao, Zheng Zhang, Wei Yang, Jiří Homola, Shaoyi JiangAbstract:A crucial step in the development of implanted medical devices, in vivo diagnostics, and microarrays is the effective prevention of nonspecific protein adsorption from real-world complex media such as blood plasma or serum. In this work, a zwitterionic poly(carboxybetaine acrylamide) (polyCBAA) Biomimetic Material was employed to create a unique biorecognition coating with an ultralow fouling background, enabling the sensitive and specific detection of proteins in blood plasma. Conditions for surface activation, protein immobilization, and surface deactivation of the carboxylate groups in the polyCBAA coating were determined. An antibody-functionalized polyCBAA surface platform was used to detect a target protein in blood plasma using a sensitive surface plasmon resonance (SPR) sensor. A selective protein was directly detected from 100% human blood plasma with extraordinary specificity and sensitivity. The total nonspecific protein adsorption on the functionalized polyCBAA surface was very low (<3 ng/cm2 ...
Teahoon Park - One of the best experts on this subject based on the ideXlab platform.
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Construction of a photothermal Venus flytrap from conductive polymer bimorphs
NPG Asia Materials, 2017Co-Authors: Teahoon Park, Jongbeom Na, Chihyun ParkAbstract:A photothermally foldable soft bimorph was prepared by dry transfer of poly(3,4-ethylenedioxythiophene)s (PEDOT) onto poly(dimethylsiloxane) film. The reversible folding nature of the soft bimorph was programmable to convert the two-dimensional (2D) array of bimorph into complex three-dimensional (3D) architectures such as Venus flytrap under light. These 3D structures were returned reversibly to the original unfolded 2D structures under dark. The Venus flytrap could perform a task to snap and move an object within few second of near-infrared exposure. A localized heat pocket was generated inside the folding structure due to the large photothermal effect of PEDOT. A bilayer Material that behaves like a Venus flytrap when illuminated by infrared light has been created by researchers in South Korea. Biomimetic Materials – substances that replicate the behavior of biological organisms and structures – offer a route to producing engineered devices with novel functionality. The Biomimetic Material made by Eunkyoung Kim and colleagues from Yonsei University consists of two soft polymers – a spin–coated layer of polydimethylsiloxane (PDMS) on a spin-coated film of poly (3, 4–ethylenedioxythiophene) (PEDOT) doped with tosylate. PEDOT has photothermal properties, meaning that incident light leads to localized heating. This heat then changes the volume of the PDMS, which makes the bilayer fold. The team used this effect to create complex three–dimensional architectures and hot trap including a Venus flytrap, which snapped close within a few seconds of being exposed to near–infrared radiation. A photothermally foldable soft bimorph was prepared via the dry transfer of poly(3,4-ethylenedioxythiophene) (PEDOT) doped with tosylate onto a poly(dimethylsiloxane) film. The photothermal folding was optimized via reversible actuation by controlling the thickness of each layer and the temperature increase to afford large deflection and displacement up to 150° and >20 mm, respectively, upon exposure to near-infrared (NIR) light (808 nm). A two-dimensional array of the bimorph converted into complex three-dimensional architectures, such as a Venus flytrap, under light and reversibly unfolded in the dark. Taking advantage of the photothermal nature of PEDOT, a localized heat pocket was generated inside the folding structure. Thus, a Venus flytrap with a hot pocket reaching 100 °C was realized for the first time. The Venus flytrap could trap and move an object within a few seconds of NIR exposure.
Felismina T.c. Moreira - One of the best experts on this subject based on the ideXlab platform.
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Biomimetic Materials assembled on a photovoltaic cell as a novel biosensing approach to cancer biomarker detection
Scientific Reports, 2018Co-Authors: Felismina T.c. Moreira, Liliana A.a.n.a. Truta, M. Goreti F. SalesAbstract:This work describes for the first time the integration of Dye Sensitized Solar Cell (DSSC) technology in biosensors and Biomimetic Materials, opening doors towards a new dimension of autonomous screening devices that may be used in point-of-care, with zero-power requirements. DSSCs are fabricated with a counter electrode (CE) of polypyrrole (PPy) that was made responsive to a specific protein by Biomimetic Material (BM) technology. Carcinogenic embryonic antigen (CEA) was selected as target protein. The resulting BM-PPy film acted as Biomimetic artificial antibody for CEA. Rebinding of CEA into this film changed its intrinsic electrical properties and the subsequent electrical output of the DSSC using it as CE. The quantity of CEA in solution was deduced by I-V and electrochemical impedance spesctroscopy (EIS). Linear responses to CEA were observed down to 0.25 pg/mL, with 0.13 pg/mL detection limit. Control films of PPy (prepared without CEA in the electropolymerization step) confirmed the ability of the BM Material to recognize the target protein. Accurate results were obtained in the analysis of urine samples. Further developments into this ground-breaking self-powered biosensor will display a huge impact in point-to-care medical applications, which may be extended to other fields of knowledge.
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Antibody Biomimetic Material Made of Pyrrole for CA 15-3 and Its Application as Sensing Material in Ion-Selective Electrodes for Potentiometric Detection
Biosensors, 2018Co-Authors: Alexandra R.t. Santos, Felismina T.c. Moreira, Luisa A Helguero, M. Goreti F. SalesAbstract:This work reports a very simple approach for creating a synthetic antibody against any protein of interest and its application in potentiometric transduction. The selected protein was Breast Cancer Antigen (CA 15-3), which is implicated in breast cancer disease and used to follow-up breast cancer patients during treatment. The new Material with antibody-like properties was obtained by molecular-imprinting technology, prepared by electropolymerizing pyrrol (Py, 5.0 × 10−3 mol/L) around Breast Cancer Antigen (CA 15-3) (100 U/mL) on a fluorine doped tin oxide (FTO) conductive glass support. Cyclic voltammetry was employed for this purpose. All solutions were prepared in 4-(2-Hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES) buffer, of pH 6.5. The biomarker was removed from the imprinted sites by chemical action of ethanol. The Biomimetic Material was then included in poly vinyl chloride (PVC) plasticized membranes to act as potentiometric ionophore, having or not a lipophilic ionic additive added. The corresponding selective electrodes were evaluated by calibration curves (in buffer and in synthetic serum) and by selectivity testing. The best analytical performance was obtained by selective electrodes including the plastic antibody and no lipophilic additive. The average limits of detection were 1.07 U/mL of CA 15-3, with a linear response from 1.44 to 13.2 U/mL and a cationic slope of 44.5 mV/decade. Overall, the lipophilic additives yielded no advantage to the overall potentiometric performance. The application of the MIP-based electrodes to the analysis of spiked synthetic serum showed precise and accurate results.
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novel Biomimetic composite Material for potentiometric screening of acetylcholine a neurotransmitter in alzheimer s disease
Materials Science and Engineering: C, 2017Co-Authors: Ana S Sacramento, Ana P M Tavares, Felismina T.c. Moreira, Joana Rafaela Lara Guerreiro, Goreti M F SalesAbstract:Abstract This work describes a novel approach to produce an antibody-like Biomimetic Material. It includes preparing composite imprinted Material never presented before, with highly conductive support nanostructures and assembling a high conductivity polymeric layer at low temperature. Overall, such highly conductive Material may enhance the final features of electrically-based devices. Acetylcholine (ACh) was selected as target analyte, a neurotransmitter of importance in Alzheimer's disease. Potentiometric transduction was preferred, allowing quick responses and future adaptation to point-of-care requirements. The Biomimetic Material was obtained by bulk polymerization, where ACh was placed in a composite matrix of multiwalled carbon nanotubes (MWCNTs) and aniline (ANI). Subsequent polymerization, initiated by radical species, yielded a polymeric structure of polyaniline (PANI) acting as physical support of the composite. A non-imprinted Material (NIM) having only PANI/MWCNT (without ACh) has been prepared for comparison of the Biomimetic-imprinted Material (BIM). RAMAN and Fourier Transform Infrared spectroscopy (FTIR), Transmission Electron microscopy (TEM), and Scanning Electron microscope (SEM) analysis characterized the structures of the Materials. The ability of this bioMaterial to rebind ACh was confirmed by including it as electroactive compound in a PVC/plasticizer mixture. The membranes with imprinted Material and anionic additive presented the best analytical characteristics, with a sensitivity of 83.86 mV decade − 1 and limit of detection (LOD) of 3.45 × 10 − 5 mol/L in HEPES buffer pH 4.0. Good selectivity was observed against creatinine, creatine, glucose, cysteine and urea. The electrodes were also applied on synthetic serum samples and seemed a reliable tool for screening ACh in synthetic serum samples. The overall performance showed fast response, reusability, simplicity and low price.
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electrochemical biosensor based on Biomimetic Material for myoglobin detection
Electrochimica Acta, 2013Co-Authors: Felismina T.c. Moreira, João Paulo Noronha, Rosa F. Dutra, Goreti M F SalesAbstract:a b s t r a c t A novel reusable molecularly imprinted polymer (MIP) assembled on a polymeric layer of carboxylated poly(vinyl chloride) (PVC COOH) for myoglobin (Myo) detection was developed. This polymer was casted on the gold working area of a screen printed electrode (Au-SPE), creating a novel disposable device relying on plastic antibodies. Electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV) and Fourier transform infrared spectroscopy (FTIR) studies confirmed the surface modification. The MIP/Au-SPE devices displayed a linear behaviour in EIS from 0.852 to 4.26 g mL−1, of positive slope 6.50 ± 1.48 (kmL g
Jongbeom Na - One of the best experts on this subject based on the ideXlab platform.
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Construction of a photothermal Venus flytrap from conductive polymer bimorphs
NPG Asia Materials, 2017Co-Authors: Teahoon Park, Jongbeom Na, Chihyun ParkAbstract:A photothermally foldable soft bimorph was prepared by dry transfer of poly(3,4-ethylenedioxythiophene)s (PEDOT) onto poly(dimethylsiloxane) film. The reversible folding nature of the soft bimorph was programmable to convert the two-dimensional (2D) array of bimorph into complex three-dimensional (3D) architectures such as Venus flytrap under light. These 3D structures were returned reversibly to the original unfolded 2D structures under dark. The Venus flytrap could perform a task to snap and move an object within few second of near-infrared exposure. A localized heat pocket was generated inside the folding structure due to the large photothermal effect of PEDOT. A bilayer Material that behaves like a Venus flytrap when illuminated by infrared light has been created by researchers in South Korea. Biomimetic Materials – substances that replicate the behavior of biological organisms and structures – offer a route to producing engineered devices with novel functionality. The Biomimetic Material made by Eunkyoung Kim and colleagues from Yonsei University consists of two soft polymers – a spin–coated layer of polydimethylsiloxane (PDMS) on a spin-coated film of poly (3, 4–ethylenedioxythiophene) (PEDOT) doped with tosylate. PEDOT has photothermal properties, meaning that incident light leads to localized heating. This heat then changes the volume of the PDMS, which makes the bilayer fold. The team used this effect to create complex three–dimensional architectures and hot trap including a Venus flytrap, which snapped close within a few seconds of being exposed to near–infrared radiation. A photothermally foldable soft bimorph was prepared via the dry transfer of poly(3,4-ethylenedioxythiophene) (PEDOT) doped with tosylate onto a poly(dimethylsiloxane) film. The photothermal folding was optimized via reversible actuation by controlling the thickness of each layer and the temperature increase to afford large deflection and displacement up to 150° and >20 mm, respectively, upon exposure to near-infrared (NIR) light (808 nm). A two-dimensional array of the bimorph converted into complex three-dimensional architectures, such as a Venus flytrap, under light and reversibly unfolded in the dark. Taking advantage of the photothermal nature of PEDOT, a localized heat pocket was generated inside the folding structure. Thus, a Venus flytrap with a hot pocket reaching 100 °C was realized for the first time. The Venus flytrap could trap and move an object within a few seconds of NIR exposure.