The Experts below are selected from a list of 13455 Experts worldwide ranked by ideXlab platform

Abdon Pena-francesch - One of the best experts on this subject based on the ideXlab platform.

  • Accelerating the design of Biomimetic Materials by integrating RNA-seq with proteomics and Materials science
    Nature Biotechnology, 2013
    Co-Authors: Paul A. Guerette, Shawn Hoon, Yiqi Seow, Manfred Raida, Admir Masic, Fong T. Wong, Vincent H.b. Ho, Kiat Whye Kong, Melik C. Demirel, Abdon Pena-francesch
    Abstract:

    Efforts to engineer new Materials inspired by biological structures are hampered by the lack of genomic data from many model organisms studied in Biomimetic research. Here we show that Biomimetic engineering can be accelerated by integrating high-throughput RNA-seq with proteomics and advanced Materials characterization. This approach can be applied to a broad range of systems, as we illustrate by investigating diverse high-performance biological Materials involved in embryo protection, adhesion and predation. In one example, we rapidly engineer recombinant squid sucker ring teeth proteins into a range of structural and functional Materials, including nanopatterned surfaces and photo-cross-linked films that exceed the mechanical properties of most natural and synthetic polymers. Integrating RNA-seq with proteomics and Materials science facilitates the molecular characterization of natural Materials and the effective translation of their molecular designs into a wide range of bio-inspired Materials. The engineering of Biomimetic Materials is accelerated by combining high-throughput RNA sequencing and proteomics.

  • Accelerating the design of Biomimetic Materials by integrating RNA-seq with proteomics and Materials science
    Nature Biotechnology, 2013
    Co-Authors: Paul A. Guerette, Shawn Hoon, Yiqi Seow, Manfred Raida, Admir Masic, Fong T. Wong, Vincent H.b. Ho, Kiat Whye Kong, Melik C. Demirel, Abdon Pena-francesch
    Abstract:

    The engineering of Biomimetic Materials is accelerated by combining high-throughput RNA sequencing and proteomics.

Kazunori Hoshino - One of the best experts on this subject based on the ideXlab platform.

  • Nondestructive, Label-Free Characterization of Mechanical Microheterogeneity in Biomimetic Materials.
    ACS biomaterials science & engineering, 2018
    Co-Authors: Devina Jaiswal, Min D. Tang-schomer, Disha Sood, David L. Kaplan, Kazunori Hoshino
    Abstract:

    We propose a novel nondestructive, label-free, mechanical characterization method for composite Biomimetic Materials. The method combines microscale-force measurement, bright-field microscopy based...

  • Nondestructive, label-free characterization of mechanical microheterogeneity in Biomimetic Materials.
    ACS Biomaterials Science & Engineering, 2018
    Co-Authors: Devina Jaiswal, Min D. Tang-schomer, Disha Sood, David L. Kaplan, Kazunori Hoshino
    Abstract:

    We propose a novel nondestructive, label-free, mechanical characterization method for composite Biomimetic Materials. The method combines microscale-force measurement, bright-field microscopy based deformation analysis, and finite-element methods (FEM) to study the heterogeneity in bioengineered composite Materials. The method was used to study silk fibroin protein based, donut-shaped scaffolds consisting of a shell (diameter 5 mm) and a core (diameter 2 mm) with a stiff-core or a soft-core configuration. The samples were based on our previously reported bioengineered brain tissue model. Step-wise images of sample deformation were recorded as the automated mechanical stage compressed the sample. The force–compression curves were also recorded with a load cell. A MATLAB program was used to compare and match optically measured strain distribution with that found from the FEM simulations. Iterative processes are used to determine the values that best represent the elastic moduli of the shell and the core reg...

Seeram Ramakrishna - One of the best experts on this subject based on the ideXlab platform.

  • Stem cells and Biomimetic Materials strategies for tissue engineering
    Materials Science and Engineering: C, 2008
    Co-Authors: Susan Liao, Casey K Chan, Seeram Ramakrishna
    Abstract:

    Stem cells have been recognized as a promising alternative to somatic cells in the application of cell therapy owing to their potential to renew themselves through cell division and to differentiate into a wide range of specialized cell types. In order to maintain the phenotype expression and differentiated functions of stem cells, the simulated natural environment of the Biomimetic material support has to provide the appropriate signals to the attached cells. Scaffolds with Biomimetic components and nanotexture can provide chemical, physical as well as spatial cues that are essential to mimic natural tissue growth. Moreover, the plasticity of stem cells provides the basic possibility for multiple-tissue engineering using a certain type of stem cells. Progress in the understanding of self-renewal and directed differentiation of stem cells on Biomimetic Materials will lead scientists to propose the possibility of cell-based therapies to treat diseases, including the use of stem cells in tissue engineering. In this review paper, we will discuss the current state of the art and future perspectives on stem cells and Biomimetic Materials strategies for tissue engineering.

Devina Jaiswal - One of the best experts on this subject based on the ideXlab platform.

  • Nondestructive, Label-Free Characterization of Mechanical Microheterogeneity in Biomimetic Materials.
    ACS biomaterials science & engineering, 2018
    Co-Authors: Devina Jaiswal, Min D. Tang-schomer, Disha Sood, David L. Kaplan, Kazunori Hoshino
    Abstract:

    We propose a novel nondestructive, label-free, mechanical characterization method for composite Biomimetic Materials. The method combines microscale-force measurement, bright-field microscopy based...

  • Nondestructive, label-free characterization of mechanical microheterogeneity in Biomimetic Materials.
    ACS Biomaterials Science & Engineering, 2018
    Co-Authors: Devina Jaiswal, Min D. Tang-schomer, Disha Sood, David L. Kaplan, Kazunori Hoshino
    Abstract:

    We propose a novel nondestructive, label-free, mechanical characterization method for composite Biomimetic Materials. The method combines microscale-force measurement, bright-field microscopy based deformation analysis, and finite-element methods (FEM) to study the heterogeneity in bioengineered composite Materials. The method was used to study silk fibroin protein based, donut-shaped scaffolds consisting of a shell (diameter 5 mm) and a core (diameter 2 mm) with a stiff-core or a soft-core configuration. The samples were based on our previously reported bioengineered brain tissue model. Step-wise images of sample deformation were recorded as the automated mechanical stage compressed the sample. The force–compression curves were also recorded with a load cell. A MATLAB program was used to compare and match optically measured strain distribution with that found from the FEM simulations. Iterative processes are used to determine the values that best represent the elastic moduli of the shell and the core reg...

Fu-zhen Xuan - One of the best experts on this subject based on the ideXlab platform.

  • A modified analysis for thermal–mechanical properties of staggered structure in Biomimetic Materials ☆
    Journal of The Mechanical Behavior of Biomedical Materials, 2012
    Co-Authors: Fu-zhen Xuan, Shan-tung Tu
    Abstract:

    The thermal–mechanical stress distributions and equivalent coefficient of thermal expansion (CTE) of the staggered arrangement of mineral platelets wrapped by soft matrix are analyzed, which exist in numerous natural biological and Biomimetic Materials. Two analytical models, ‘Stress model’ and ‘Displacement model’, were established from the ways of stress and displacement solution based on the modification of classical shear-lag model. Complementary finite element analysis (FEA) was used to verify the analytical models. Results reveal that, compared to ‘Displacement model’, ‘Stress model’ gives a better prediction of the stress distributions within the staggered structure referring to FEA. The equivalent CTE predicted by both models reach constant as the aspect ratio and volume fraction of platelets exceeding the critical values. Nevertheless, the relative error between the results from different models increases with the increase of the ratio of overlap to length of platelets. These provide a benchmark to the optimum design of micro/nanostructure in bio-inspired Materials suffering to temperature fluctuation and applied loading. & 2012 Elsevier Ltd. All rights reserved.

  • A modified analysis for thermal-mechanical properties of staggered structure in Biomimetic Materials.
    Journal of the Mechanical Behavior of Biomedical Materials, 2012
    Co-Authors: Yun-fei Jia, Fu-zhen Xuan
    Abstract:

    The thermal-mechanical stress distributions and equivalent coefficient of thermal expansion (CTE) of the staggered arrangement of mineral platelets wrapped by soft matrix are analyzed, which exist in numerous natural biological and Biomimetic Materials. Two analytical models, 'Stress model' and 'Displacement model', were established from the ways of stress and displacement solution based on the modification of classical shear-lag model. Complementary finite element analysis (FEA) was used to verify the analytical models. Results reveal that, compared to 'Displacement model', 'Stress model' gives a better prediction of the stress distributions within the staggered structure referring to FEA. The equivalent CTE predicted by both models reach constant as the aspect ratio and volume fraction of platelets exceeding the critical values. Nevertheless, the relative error between the results from different models increases with the increase of the ratio of overlap to length of platelets. These provide a benchmark to the optimum design of micro/nano-structure in bio-inspired Materials suffering to temperature fluctuation and applied loading.