The Experts below are selected from a list of 10704 Experts worldwide ranked by ideXlab platform

Ming H. Zheng - One of the best experts on this subject based on the ideXlab platform.

  • Bioreactor Design for tendon ligament engineering
    Tissue Engineering Part B-reviews, 2013
    Co-Authors: Tao Wang, Bruce S. Gardiner, Zhen Lin, Jonas Rubenson, Thomas Brett Kirk, Allan Wang, David C. Smith, David G. Lloyd, Ming H. Zheng
    Abstract:

    Tendon and ligament injury is a worldwide health problem, but the treatment options remain limited. Tendon and ligament engineering might provide an alternative tissue source for the surgical replacement of injured tendon. A Bioreactor provides a controllable environment enabling the systematic study of specific biological, biochemical, and biomechanical requirements to Design and manufacture engineered tendon/ligament tissue. Furthermore, the tendon/ligament Bioreactor system can provide a suitable culture environment, which mimics the dynamics of the in vivo environment for tendon/ligament maturation. For clinical settings, Bioreactors also have the advantages of less-contamination risk, high reproducibility of cell propagation by minimizing manual operation, and a consistent end product. In this review, we identify the key components, Design preferences, and criteria that are required for the development of an ideal Bioreactor for engineering tendons and ligaments.

  • Bioreactor Design for tendon/ligament engineering.
    Tissue engineering. Part B Reviews, 2012
    Co-Authors: Tao Wang, Bruce S. Gardiner, Zhen Lin, Jonas Rubenson, Thomas Brett Kirk, Allan Wang, David C. Smith, David G. Lloyd, Ming H. Zheng
    Abstract:

    Tendon and ligament injury is a worldwide health problem, but the treatment options remain limited. Tendon and ligament engineering might provide an alternative tissue source for the surgical replacement of injured tendon. A Bioreactor provides a controllable environment enabling the systematic study of specific biological, biochemical, and biomechanical requirements to Design and manufacture engineered tendon/ligament tissue. Furthermore, the tendon/ligament Bioreactor system can provide a suitable culture environment, which mimics the dynamics of the in vivo environment for tendon/ligament maturation. For clinical settings, Bioreactors also have the advantages of less-contamination risk, high reproducibility of cell propagation by minimizing manual operation, and a consistent end product. In this review, we identify the key components, Design preferences, and criteria that are required for the development of an ideal Bioreactor for engineering tendons and ligaments.

J.m. Catchmark - One of the best experts on this subject based on the ideXlab platform.

  • Pullulan: Biosynthesis, production, and applications
    Applied Microbiology and Biotechnology, 2011
    Co-Authors: Kuan-chen Cheng, Ali Demirci, J.m. Catchmark
    Abstract:

    Pullulan is a linear glucosic polysaccharide produced by the polymorphic fungus Aureobasidium pullulans, which has long been applied for various applications from food additives to environmental remediation agents. This review article presents an overview of pullulan's chemistry, biosynthesis, applications, state-of-the-art advances in the enhancement of pullulan production through the investigations of enzyme regulations, molecular properties, cultivation parameters, and Bioreactor Design. The enzyme regulations are intended to illustrate the influences of metabolic pathway on pullulan production and its structural composition. Molecular properties, such as molecular weight distribution and pure pullulan content, of pullulan are crucial for pullulan applications and vary with different fermentation parameters. Studies on the effects of environmental parameters and new Bioreactor Design for enhancing pullulan production are getting attention. Finally, the potential applications of pullulan through chemical modification as a novel biologically active derivative are also discussed.

Tao Wang - One of the best experts on this subject based on the ideXlab platform.

  • Bioreactor Design for tendon ligament engineering
    Tissue Engineering Part B-reviews, 2013
    Co-Authors: Tao Wang, Bruce S. Gardiner, Zhen Lin, Jonas Rubenson, Thomas Brett Kirk, Allan Wang, David C. Smith, David G. Lloyd, Ming H. Zheng
    Abstract:

    Tendon and ligament injury is a worldwide health problem, but the treatment options remain limited. Tendon and ligament engineering might provide an alternative tissue source for the surgical replacement of injured tendon. A Bioreactor provides a controllable environment enabling the systematic study of specific biological, biochemical, and biomechanical requirements to Design and manufacture engineered tendon/ligament tissue. Furthermore, the tendon/ligament Bioreactor system can provide a suitable culture environment, which mimics the dynamics of the in vivo environment for tendon/ligament maturation. For clinical settings, Bioreactors also have the advantages of less-contamination risk, high reproducibility of cell propagation by minimizing manual operation, and a consistent end product. In this review, we identify the key components, Design preferences, and criteria that are required for the development of an ideal Bioreactor for engineering tendons and ligaments.

  • Bioreactor Design for tendon/ligament engineering.
    Tissue engineering. Part B Reviews, 2012
    Co-Authors: Tao Wang, Bruce S. Gardiner, Zhen Lin, Jonas Rubenson, Thomas Brett Kirk, Allan Wang, David C. Smith, David G. Lloyd, Ming H. Zheng
    Abstract:

    Tendon and ligament injury is a worldwide health problem, but the treatment options remain limited. Tendon and ligament engineering might provide an alternative tissue source for the surgical replacement of injured tendon. A Bioreactor provides a controllable environment enabling the systematic study of specific biological, biochemical, and biomechanical requirements to Design and manufacture engineered tendon/ligament tissue. Furthermore, the tendon/ligament Bioreactor system can provide a suitable culture environment, which mimics the dynamics of the in vivo environment for tendon/ligament maturation. For clinical settings, Bioreactors also have the advantages of less-contamination risk, high reproducibility of cell propagation by minimizing manual operation, and a consistent end product. In this review, we identify the key components, Design preferences, and criteria that are required for the development of an ideal Bioreactor for engineering tendons and ligaments.

Wayne R. Curtis - One of the best experts on this subject based on the ideXlab platform.

  • Encyclopedia of Industrial Biotechnology - Hairy Roots, Bioreactor Growth
    Encyclopedia of Industrial Biotechnology, 2010
    Co-Authors: Wayne R. Curtis
    Abstract:

    Introduction Influence of Product Recovery on Bioreactor Design and Operation Bioreactors for Recovery of Intracellular Metabolites Bioreactors for Recovery of Extracellular Metabolites Principles of Bioreactor Operation Growth Kinetics Biomass Yield—Reactor Monitoring and Control Influence of Root Morphology on Reactor Design Principles for Bioreactor Design and Scaleup Submerged Reactor Environment Liquid-Dispersed Reactor Environment Acknowledgments List of Variables References Keywords: biomass; mist reactor

  • Encyclopedia of Cell Technology - Hairy Roots, Bioreactor Growth
    Encyclopedia of Industrial Biotechnology, 2010
    Co-Authors: Wayne R. Curtis
    Abstract:

    Introduction Influence of Product Recovery on Bioreactor Design and Operation Bioreactors for Recovery of Intracellular Metabolites Bioreactors for Recovery of Extracellular Metabolites Principles of Bioreactor Operation Growth Kinetics Biomass Yield—Reactor Monitoring and Control Influence of Root Morphology on Reactor Design Principles for Bioreactor Design and Scaleup Submerged Reactor Environment Liquid-Dispersed Reactor Environment Acknowledgments List of Variables References Keywords: biomass; mist reactor

  • Application of Bioreactor Design principles to plant micropropagation
    Plant Cell Tissue and Organ Culture, 2005
    Co-Authors: Wayne R. Curtis
    Abstract:

    Principles of oxygen consumption, oxygen transport, suspension, and mixing are discussed in the context of propagating aggregates of plant tissue in liquid suspension Bioreactors. Although micropropagated plants have a relatively low biological oxygen demand (BOD), the relatively large tissue size and localization of BOD in meristematic regions will typically result in oxygen mass transfer limitations in liquid culture. In contrast to the typical focus of Bioreactor Design on gas–liquid mass transfer, it is shown that media-solid mass transfer limitations limit oxygen available for aerobic plant tissue respiration. Approaches to improve oxygen availability through gas supplementation and Bioreactor pressurization are discussed. The influence of media components on oxygen availability are also quantified for plant culture media. Experimental studies of polystyrene beads in suspension in a 30-l air-lift and stirred Bioreactors are used to illustrate Design principles for circulation and mixing. Potential limitations to the use of liquid suspension culture due to plant physiological requirements are acknowledged.

  • Hairy Roots, Bioreactor Growth
    Encyclopedia of Cell Technology, 2003
    Co-Authors: Wayne R. Curtis
    Abstract:

    Introduction Influence of Product Recovery on Bioreactor Design and Operation Bioreactors for Recovery of Intracellular Metabolites Bioreactors for Recovery of Extracellular Metabolites Principles of Bioreactor Operation Growth Kinetics Biomass Yield—Reactor Monitoring and Control Influence of Root Morphology on Reactor Design Principles for Bioreactor Design and Scaleup Submerged Reactor Environment Liquid-Dispersed Reactor Environment Acknowledgments List of Variables Bibliography Keywords: biomass; mist reactor

  • Hairy Roots, Bioreactor Growth
    Encyclopedia of Cell Technology, 2003
    Co-Authors: Wayne R. Curtis
    Abstract:

    Introduction Influence of Product Recovery on Bioreactor Design and Operation Bioreactors for Recovery of Intracellular Metabolites Bioreactors for Recovery of Extracellular Metabolites Principles of Bioreactor Operation Growth Kinetics Biomass Yield—Reactor Monitoring and Control Influence of Root Morphology on Reactor Design Principles for Bioreactor Design and Scaleup Submerged Reactor Environment Liquid-Dispersed Reactor Environment Acknowledgments List of Variables Bibliography Keywords: biomass; mist reactor

Kuan-chen Cheng - One of the best experts on this subject based on the ideXlab platform.

  • Pullulan: Biosynthesis, production, and applications
    Applied Microbiology and Biotechnology, 2011
    Co-Authors: Kuan-chen Cheng, Ali Demirci, J.m. Catchmark
    Abstract:

    Pullulan is a linear glucosic polysaccharide produced by the polymorphic fungus Aureobasidium pullulans, which has long been applied for various applications from food additives to environmental remediation agents. This review article presents an overview of pullulan's chemistry, biosynthesis, applications, state-of-the-art advances in the enhancement of pullulan production through the investigations of enzyme regulations, molecular properties, cultivation parameters, and Bioreactor Design. The enzyme regulations are intended to illustrate the influences of metabolic pathway on pullulan production and its structural composition. Molecular properties, such as molecular weight distribution and pure pullulan content, of pullulan are crucial for pullulan applications and vary with different fermentation parameters. Studies on the effects of environmental parameters and new Bioreactor Design for enhancing pullulan production are getting attention. Finally, the potential applications of pullulan through chemical modification as a novel biologically active derivative are also discussed.