The Experts below are selected from a list of 39 Experts worldwide ranked by ideXlab platform
Xavier Munoz - One of the best experts on this subject based on the ideXlab platform.
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immunomodulatory effect of pigeon serum in an acute and chronic murine model of Bird Fanciers Lung
Environmental Research, 2020Co-Authors: Monica Sanchezortiz, Maria Jesus Cruz, Silvia Sanchezdiez, Ana Villar, Inigo Ojanguren, Xavier MunozAbstract:Abstract Introduction Since the immunopathological mechanisms of Bird fancier’s Lung (BFL) are not well known, we created two models of the disease (acute and chronic BFL) to study and compare the pathways involved in its immunopathogenesis. Materials and methods C57BL/6 mice were used. Two intraperitoneal injections of 100 μL of commercial pigeon serum (PS) or saline (SAL) were administered with an interval of 48 h in between. Subsequently, intranasal instillations of 40 μL of PS or SAL were performed three days a week, for three weeks in the acute model (AC/PS) and for twelve weeks in the chronic model (CR/PS). Total Lung capacity (TLC) was assessed. Pulmonary inflammation was evaluated in bronchoalveolar lavage (BAL), and total serum immunoglobulin (Ig) G was measured in serum samples 24 h, 7 days and 14 days after the last exposure. Histological studies of Lungs were assessed. Results A drop in TLC was observed in treated mice. This decrease was more marked in the CR/PS group (p Conclusions Bronchial inflammation is present in acute and chronic models of HP following exposure to PS. Our results support the role of neutrophils and IL-17 in the development of the disease and an evolution towards a Th-2 immune response in chronic HP. These models may serve as a tool for future studies of the pathogenesis of HP.
J. Hata - One of the best experts on this subject based on the ideXlab platform.
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Fatal Diffuse Alveolar Damage from Bird Fanciers’ Lung
Respiration; international review of thoracic diseases, 1997Co-Authors: Sadatomo Tasaka, Minoru Kanazawa, C. Kawai, K. Soejima, Kazuhiro Yamaguchi, A. Takata, Chikao Torikata, J. HataAbstract:A 68-year-old man, who had continuing exposure to budgerigars, developed fatal acute respiratory failure following years of slowly progressive pulmonary deterioration. His Lung function was characterized first by mild airflow obstruction and later by progressive loss of Lung volume. Computed tomography showed progressive development of pulmonary fibrosis and honeycombing. His serum disclosed precipitins to pigeon antigen. During his final illness his chest radiograph showed widespread patchy consolidation. At autopsy, his Lungs revealed left lower lobe bronchopneumonia, fibrosis and honeycombing at the bases and widespread evidence of diffuse alveolar damage with organized exudate in some alveoli. To our knowledge, this is the second reported fatality due to acute alveolar injury in Bird Fanciers' Lung.
Urszula Demkow - One of the best experts on this subject based on the ideXlab platform.
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Angiogenic Activity of Sera from Interstitial Lung Disease Patients in Relation to Angiotensin-Converting Enzyme Activity
Advances in experimental medicine and biology, 2012Co-Authors: Tadeusz M. Zielonka, Katarzyna Zycinska, Joanna Chorostowska-wynimko, Filewska M, B Bialas, Michael H. Obrowski, Elżbieta Radzikowska, Ewa Skopińska-różewska, Urszula DemkowAbstract:The role of angiogenesis in the pathogenesis of interstitial Lung diseases (ILD) is unknown. Angiotensin-converting enzyme (ACE) is a marker of sarcoidosis activity and may modulate angiogenesis. The aim of this study was to examine the relationship between ACE activity in ILD patients’ sera and their effect on microvessels formation in an in vivo model of leukocyte-induced angiogenesis. The study population consisted of 77 sarcoidosis patients, 22 idiopathic pulmonary fibrosis patients, 16 Bird Fanciers Lung patients, eight silicosis patients and 14 healthy donors. Serum ACE activity was assayed by spectrophotometric method. As an angiogenic test, a leukocyte-induced angiogenesis assay in an animal model was used. Sera from interstitial Lung disease patients significantly stimulated angiogenic activity of mononuclear cells compared with healthy donors (p < 0.001). The highest ACE serum activity was measured in sera from the silicosis patients, and lowest in sera from the sarcoidosis and IPF patients. A significantly lower serum ACE activity was detected in the Bird Fanciers Lung patients. Serum angiogenic activity of ILD patients measured by angiogenesis index negatively correlated with ACE serum activity (r = ;−0.52; p < 0.01). This correlation was highest in the sarcoidosis group (r = −0.6; p < ). Sera from ILD patient constitute the source of factors modulating angiogenesis.
Rob Janssen - One of the best experts on this subject based on the ideXlab platform.
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Pneumoproteins in interstitial Lung diseases
2006Co-Authors: Rob JanssenAbstract:The interstitial Lung diseases (ILD)s are a diverse group of pulmonary disorders that are classified together because of similar clinical, roentgenographic, physiologic, or pathologic manifestations, compromising over 100 different members that have been broadly classified into several categories. The major abnormality in ILDs is disruption of the Lung parenchyma. Sarcoidosis is the commonest ILD in the western world. In our own experience, hypersensitivity pneumonitis is also quite common in the Utrecht region. The Lung epithelial cells produce surfactant, mucus and several Lung-epithelium-specific proteins. These Lung-epithelium-specific proteins can be classified in three separate groups: the mucins, CC10, and the surfactant proteins. Some proteins that are secreted by pulmonary cells are not only present at the surface of the respiratory tract, but are also detectable in the blood. Hermans and Bernard introduced the term pneumoproteins for these markers. Because these proteins are produced in the Lungs, their presence in serum can only be explained by leakage through the alveolar-capillary membrane into the vascular compartment. Biomarkers can be used to diagnose a disease, to monitor disease activity, to assess disease severity, and to predict the course of a disease. We studied these four qualities of pneumoproteins in the two most prevalent ILDs at our department (sarcoidosis and hypersensitivity pneumonitis). Although KL-6 and SP-D can help to differentiate bacterial pneumonia from ILD, pneumoproteins have little diagnostic value since these proteins are elevated in various ILDs, and, therefore, lack specificity. Pneumoproteins are for example unable to differentiate sarcoidosis from hypersensitivity pneumonitis. However, as demonstrated in this thesis, pneumoproteins can be useful to monitor ILD activity and assess disease severity. Although CC10, KL-6 and SP-D had been studied separately in sarcoidosis, we were the first to perform a comparative analysis. In sarcoidosis, CC10 and KL-6 reflected disease severity, since they both correlated with radiologic stage and pulmonary function impairment. SP-D did not seem to be useful as serum marker in sarcoidosis. In Bird Fanciers' Lung (hypersensitivity pneumonitis), KL-6 and SP-D correlated with disease activity. Some genetic polymorphisms influence regulatory mechanisms and cause interindividual differences in protein production. A correlation between serum CC10 and SP-D, and their encoding genes had already been described. We confirmed the CC10 gene-protein association in a Dutch Caucasian population of healthy controls and sarcoidosis patients. Previous studies found a similar association for CC10 in Japanese sarcoidosis patients, and Australian asthmatic children. Furthermore, we were the first to demonstrate that serum KL-6 levels are influenced by a mucin 1 gene polymorphism, and we calculated genotype-specific reference intervals. We conclude that serum pneumoproteins are useful biomarkers for the monitoring of ILD patients. Using genotype-specific reference intervals might improve their clinical value.
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TIMP-3 promoter gene polymorphisms in BFL
Thorax, 2005Co-Authors: Rob Janssen, Adrian Kruit, J.c. Grutters, Henk J.t. Ruven, C M H Van Moorsel, J. M. M. Van Den BoschAbstract:Bird Fanciers’ Lung (BFL) is a form of hypersensitivity pneumonitis induced by inhalation of antigens from Birds.1 Only a small percentage of Bird Fanciers will develop BFL, so it is likely that these patients have a certain genetic predisposition to the disease.1 Matrix metalloproteinases (MMP) are zinc enzymes responsible for the degradation of the extracellular matrix. The proteolytic activities of MMP are counter-regulated by tissue inhibitors of MMP (TIMP). Hill found a decreased carriership of the rare TIMP-3 −1296C and −915G promoter alleles in Mexican patients with pigeon induced BFL, suggesting a protective effect of these alleles against the development of this disease.2 Only two previously published genetic association studies to date have focused on the susceptibility to BFL and both were performed in Mexican pigeon breeders.2,3 We have undertaken a study to …
Zainab H. Saeed - One of the best experts on this subject based on the ideXlab platform.
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Factors influencing the clinical presentation of hypersensitivity pneumonitis in pigeon breeders in Minia governorate: an Egyptian experience
The Egyptian Journal of Bronchology, 2020Co-Authors: Nezar R. Mohamed, Eman Ramadan Ghazawy, Zainab H. SaeedAbstract:Bird Fanciers’ Lung (BFL) is a very famous type of hypersensitivity pneumonitis (HP) produced by airborne exposure to avian antigens. Immunological response and duration of exposure to the avian protein increase the risk of developing BFL. The current study investigates the risk factors and the clinical characteristics of BFL in pigeon breeders. This study aimed to determine the risk factors and clinical characteristics of HP in pigeon breeders. This cross-sectional observational study included 67 hypersensitivity pneumonitis patients with a history of pigeon breeding. Patients were subjected to history taking (age, smoking history and duration, and type of exposure to Birds), clinical examination, chest X-ray, high-resolution computed tomography (HRCT), oxygen saturation, and spirometry. Most of BFL patients were females (83.6%) and non-smokers (86.6%). Breathlessness, cough, fever, and crackles were the most common findings. Sweeping for Birds was associated with more reduction of forced vital capacity (FVC) (p value 0.02). Patients who were exposed in closed places had a rapid onset of symptoms (p value 0.01). In this study, most of the patients with BFL are females and non-smokers. Sweeping for Birds and exposure in closed areas are important risk factors of HP in BFL.
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Factors influencing the clinical presentation of hypersensitivity pneumonitis in pigeon breeders in Minia governorate: an Egyptian experience
The Egyptian Journal of Bronchology, 2020Co-Authors: Nezar R. Mohamed, Eman Ramadan Ghazawy, Zainab H. SaeedAbstract:Background Bird Fanciers’ Lung (BFL) is a very famous type of hypersensitivity pneumonitis (HP) produced by airborne exposure to avian antigens. Immunological response and duration of exposure to the avian protein increase the risk of developing BFL. The current study investigates the risk factors and the clinical characteristics of BFL in pigeon breeders. This study aimed to determine the risk factors and clinical characteristics of HP in pigeon breeders. Results This cross-sectional observational study included 67 hypersensitivity pneumonitis patients with a history of pigeon breeding. Patients were subjected to history taking (age, smoking history and duration, and type of exposure to Birds), clinical examination, chest X-ray, high-resolution computed tomography (HRCT), oxygen saturation, and spirometry. Most of BFL patients were females (83.6%) and non-smokers (86.6%). Breathlessness, cough, fever, and crackles were the most common findings. Sweeping for Birds was associated with more reduction of forced vital capacity (FVC) ( p value 0.02). Patients who were exposed in closed places had a rapid onset of symptoms ( p value 0.01). Conclusion In this study, most of the patients with BFL are females and non-smokers. Sweeping for Birds and exposure in closed areas are important risk factors of HP in BFL.