The Experts below are selected from a list of 2004 Experts worldwide ranked by ideXlab platform
Vidyadhara Lakkappan - One of the best experts on this subject based on the ideXlab platform.
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Measurement of maximal respiratory static pressure in stable COPD patients and their co-rrelation with various physiological anthropometric and spirometry parpmeters and arterial Blood Gas Tension
2020Co-Authors: Pradeep Kumar Vyas, Priyanka S Bindroo, Madhavi Gondha, Rajeev S Mathur, Gaurav Ghtawat, Vidyadhara LakkappanAbstract:The strength of respiratory muscles can be evaluated from static measurement (PImax and PEmax) or inferred from dynamic measurement such as maximal voluntary ventilation. Maximal inspiratory pressure and Maximal expiratory pressure are simple, convenient and non-invasive measurement of respiratory muscle strength. Respiratory muscle strength decreases in COPD patients due to multiple factors. The primary aim of this study is to obtain mean PImax and PEmax values in Indian COPD patients and its co-rrelation with anthropomatric, physiological, spirometric parameters and arterial Blood Gas Tension.
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Measurement of maximal respiratory static pressure in stable COPD patients and their co-rrelation with various physiological anthropometric and spirometry parpmeters and arterial Blood Gas Tension
Archives of Pulmonology and Respiratory Care - Peertechz Publications, 2020Co-Authors: Pradeep Kumar Vyas, Priyanka S Bindroo, Madhavi Gondha, Rajeev S Mathur, Gaurav Ghtawat, Vidyadhara LakkappanAbstract:The strength of respiratory muscles can be evaluated from static measurement (PImax and PEmax) or inferred from dynamic measurement such as maximal voluntary ventilation. Maximal inspiratory pressure and Maximal expiratory pressure are simple, convenient and non-invasive measurement of respiratory muscle strength. Respiratory muscle strength decreases in COPD patients due to multiple factors. The primary aim of this study is to obtain mean PImax and PEmax values in Indian COPD patients and its co-rrelation with anthropomatric, physiological, spirometric parameters and arterial Blood Gas Tension. Subjects and methods: Retrospective data were collected between 2007to 2010.139 stable COPD patients of different stages according to GOLD classification were selected for this study with mean age 62.53 ± 10.36 years, out of 139 patients 104 were male and 35 were female. Results: In our study mean PImax values in male and female COPD patients were 5.93 ± 2.19 kPa and 4.87 ±2.12 kPa respectively. Mean PEmax value in male and female COPD patients were 7.84 ± 2.80 kPa and 4.89 ±2.34 kPa respectively. Conclusion: In our study PImax, PEmax were reduced in COPD patients in comparison to normal populations and significantly lower in patients with severe airflow limitations than mild airflow limitations. This can help in assessment and monitoring of the disease burden, severity of functional impairment and response to treatment. It had significant positive or negative correlation with anthropometric and spirometry parameters and arterial Blood Gas Tension.
Pradeep Kumar Vyas - One of the best experts on this subject based on the ideXlab platform.
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Measurement of maximal respiratory static pressure in stable COPD patients and their co-rrelation with various physiological anthropometric and spirometry parpmeters and arterial Blood Gas Tension
2020Co-Authors: Pradeep Kumar Vyas, Priyanka S Bindroo, Madhavi Gondha, Rajeev S Mathur, Gaurav Ghtawat, Vidyadhara LakkappanAbstract:The strength of respiratory muscles can be evaluated from static measurement (PImax and PEmax) or inferred from dynamic measurement such as maximal voluntary ventilation. Maximal inspiratory pressure and Maximal expiratory pressure are simple, convenient and non-invasive measurement of respiratory muscle strength. Respiratory muscle strength decreases in COPD patients due to multiple factors. The primary aim of this study is to obtain mean PImax and PEmax values in Indian COPD patients and its co-rrelation with anthropomatric, physiological, spirometric parameters and arterial Blood Gas Tension.
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Measurement of maximal respiratory static pressure in stable COPD patients and their co-rrelation with various physiological anthropometric and spirometry parpmeters and arterial Blood Gas Tension
Archives of Pulmonology and Respiratory Care - Peertechz Publications, 2020Co-Authors: Pradeep Kumar Vyas, Priyanka S Bindroo, Madhavi Gondha, Rajeev S Mathur, Gaurav Ghtawat, Vidyadhara LakkappanAbstract:The strength of respiratory muscles can be evaluated from static measurement (PImax and PEmax) or inferred from dynamic measurement such as maximal voluntary ventilation. Maximal inspiratory pressure and Maximal expiratory pressure are simple, convenient and non-invasive measurement of respiratory muscle strength. Respiratory muscle strength decreases in COPD patients due to multiple factors. The primary aim of this study is to obtain mean PImax and PEmax values in Indian COPD patients and its co-rrelation with anthropomatric, physiological, spirometric parameters and arterial Blood Gas Tension. Subjects and methods: Retrospective data were collected between 2007to 2010.139 stable COPD patients of different stages according to GOLD classification were selected for this study with mean age 62.53 ± 10.36 years, out of 139 patients 104 were male and 35 were female. Results: In our study mean PImax values in male and female COPD patients were 5.93 ± 2.19 kPa and 4.87 ±2.12 kPa respectively. Mean PEmax value in male and female COPD patients were 7.84 ± 2.80 kPa and 4.89 ±2.34 kPa respectively. Conclusion: In our study PImax, PEmax were reduced in COPD patients in comparison to normal populations and significantly lower in patients with severe airflow limitations than mild airflow limitations. This can help in assessment and monitoring of the disease burden, severity of functional impairment and response to treatment. It had significant positive or negative correlation with anthropometric and spirometry parameters and arterial Blood Gas Tension.
J C Raphael - One of the best experts on this subject based on the ideXlab platform.
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mechanisms underlying effects of nocturnal ventilation on daytime Blood Gases in neuromuscular diseases
European Respiratory Journal, 1999Co-Authors: Djillali Annane, M A Querasalva, Frederic Lofaso, J B Vercken, Olivier Lesieur, C Fromageot, B Clair, Philippe Gajdos, J C RaphaelAbstract:The hypothesis that, in neuromuscular and chest wall diseases, improvement in central respiratory drive explains the effects of night-time ventilation on diurnal Gas exchanges was tested. The effects at 6 months, 1, 2 and 3 yrs of intermittent positive pressure ventilation (IPPV) on arterial Blood Gas Tension, pulmonary function, muscle strength, sleep parameters, respiratory parameters during sleep and ventilatory response to CO2 were evaluated in 16 consecutive patients with neuromuscular or chest wall disorders. As compared with baseline, after IPPV daytime arterial oxygen Tension (Pa,O2) increased (+2.3 kPa at peak effect) and arterial carbon dioxide Tension (Pa,CO2) and total bicarbonate decreased (-1.8 kPa and -5 mmol x L(-1), respectively) significantly; vital capacity, total lung capacity, maximal inspiratory and expiratory pressures and alveolar-arterial oxygen gradient did not change; the apnoea-hypo-opnoea index and the time spent with an arterial oxygen saturation (Sa,O2) value <90% decreased (-24 and -101 min, respectively), sleep efficiency and mean Sa,O2 increased (+16% and +5%, respectively); and ventilatory response to CO2 increased (+4.56 L x min(-1) x kPa(-1)) significantly. The reduction in Pa,CO2 observed after IPPV correlated solely with the increase in the slope of ventilatory response to the CO2 curve (r=-0.68, p=0.008). In neuromuscular or chest wall diseases, improvement of daytime hypoventilation with nocturnal intermittent positive pressure ventilation may represent an adaptation of the central chemoreceptors to the reduction of profound hypercapnia during sleep or reflect change in the quality of sleep.
Toru Takeuchi - One of the best experts on this subject based on the ideXlab platform.
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the progression of retinopathy of prematurity and fluctuation in Blood Gas Tension
Graefes Archive for Clinical and Experimental Ophthalmology, 1993Co-Authors: Yoshihiro Saito, Tatsuya Omoto, Yoko Cho, Yoshikazu Hatsukawa, Masanori Fujimura, Toru TakeuchiAbstract:In this study, the relationship between the fluctuation in Blood oxygen and carbon dioxide Tension and the progression of acute retinopathy of prematurity (ROP) was evaluated. Eighteen extremely premature infants were selected on the basis of the following criteria: gestational age less than 26 weeks, oxygen supply or mechanical ventilation for more than 50 days, transcutaneous oxygen pressure (TcPO2) recorded almost once per hour, and arterial oxygen pressure (PaO2) and arterial carbon dioxide pressure (PaCO2) measured intermittently, for over 8 weeks after birth. All of these infants developed ROP, which ceased progressing in 7 infants (group I, stage 1 or 2 ROP, international classification), but advanced in 11 (group II, stage 3 or 3+). The fluctuations in TcPO2, PaO2, and PaCO2 are represented as coefficients of both variation (CV) and mean difference (D) in these two groups. The results demonstrate that both the CV and D values of TcPO2 are significantly elevated in group II infants compared with group I infants, in the first and second 3-weeks periods, and over the entire 9-week period after birth. The incidences of extreme hyperoxemia (TcPO2 > or = 100 mm Hg) and hypoxemia (TcPO2 < 30 mm Hg) in recorded TcPO2 time series show no significant differences between these two groups. We conclude that extremely premature infants with widely fluctuating arterial oxygen Tension may have a greater chance of developing progressive ROP.
Marco Guazzi - One of the best experts on this subject based on the ideXlab platform.
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exercise ventilation inefficiency and cardiovascular mortality in heart failure the critical independent prognostic value of the arterial co2 partial pressure
European Heart Journal, 2005Co-Authors: Gabriele Tumminello, Giuseppe Reina, Marco GuazziAbstract:Aims In chronic heart failure (CHF) patients, the ventilation (Ve) needed to eliminate metabolically produced CO2 during exercise (i.e. the Ve/Vco2 slope) is a strong prognosticator. Ve/Vco2 slope determinants are the dead space–tidal volume (Vd/Vt) ratio and the arterial CO2 partial pressure (Paco2). We aimed at defining the respective prognostic role of these two variables. Methods and results One hundred and twenty-eight stable CHF patients (average left ventricular ejection fraction 34±10%) underwent cardiopulmonary exercise testing and Blood Gas analysis. The prognostic relevance of the Ve/Vco2 slope, Vd/Vt, and Paco2 at peak exercise was evaluated by the Kaplan–Meier approach with log-rank testing and by multivariate Cox regression analysis. During a mean period of 31.3±20 months, 24 patients died from cardiac causes. In univariate analysis, predictors of death included the use of anti-aldosterone drugs, low peak Vo2, peak Ve/Vo2, peak Paco2 and high Ve/Vco2 slope, and peak Vd/Vt. Multivariate analysis identified a low peak Paco2 (<35 mmHg) as the strongest independent prognostic indicator [hazard ratio 4.65, 95% confidence interval (CI) (1.695−12.751), P =0.003] that primarily accounts for the Ve/Vco2 slope prognostic power. Conclusion These findings imply that regulatory mechanisms involved in the tight control of ventilatory command and Blood Gas Tension, rather than lung function abnormalities, play a critical pathophysiological role in the exercise ventilation inefficiency of CHF patients.