The Experts below are selected from a list of 26460 Experts worldwide ranked by ideXlab platform

Hungyi Chuang - One of the best experts on this subject based on the ideXlab platform.

  • the association of the Blood Lead Level and serum lipid concentrations may be modified by the genetic combination of the metallothionein 2a polymorphisms rs10636 gc and rs28366003 aa
    Journal of Clinical Lipidology, 2017
    Co-Authors: Chencheng Yang, Hungyi Chuang, Chihshien Chuang, Chiai Lin, Chaoling Wang, Yungcheng Huang
    Abstract:

    Background Lead in Blood can stimulate lipid oxidation in phosphatidylcholine and increase peroxidation in lipids. Metallothionein (MT) is a cysteine-rich protein that can influence the detoxification of heavy metals and scavenge oxidative stress for free radicals. One of the most expressive functional genes in humans is the MT2A gene. Objective This study aims to determine if the association of the Blood Lead Level and lipid biomarkers was influenced by MT2A polymorphisms. Methods We recruited 677 participants after informed consent was obtained. All the samples collected were analyzed for lipid biomarkers and Blood Lead Levels and were genotyped for MT2A polymorphisms by reverse transcription polymerase chain reaction. A short questionnaire collected the medical history and alcohol and cigarette consumption information. The data were used for descriptive analyses and linear regression models. Results The investigation revealed that Lead elevated concentration increased low-density lipoprotein cholesterol and decreased high-density lipoprotein cholesterol (HDL-C) by multiple linear models. The carriers of the rs10636 GC-rs28366003 AA genetic combination may be less susceptive to Lead elevated concentration on HDL-C than other types. Conclusion In conclusion, the association of the Blood Lead Level and HDL-C may be modified by the MT2A genetic combination: the rs10636 GC-rs28366003 AA genotype could play a protective role in Lead elevated concentration on HDL-C in humans.

  • transition of cord Blood Lead Level 1985 2002 in the taipei area and its determinants after the cease of Leaded gasoline use
    Environmental Research, 2004
    Co-Authors: Yawhuei Hwang, Chiendai Chiang, Shihpenn Hsu, Yuhsiang Lee, Chuenhua Chiou, Jungder Wang, Hungyi Chuang
    Abstract:

    Abstract Lead has long been of concern for its toxicity, impairment of neurobehavioral and cognitive development, and electrophysiological deficits in children, even at Levels less than 10 μg/dL. The present study was conducted to elucidate the extent of cord Blood Lead Level decline in the Taipei area from 1985 to 2002 and to explore the factors affecting the cord Blood Lead Level after the cease of Leaded gasoline use. In the current study period of 2001–2002, 184 of 1310 newborns delivered in the Taipei Municipal Women and Children Hospital between September 2001 and August 2002 were eligible and randomly selected to participate in this study. Neither of their parents had an occupational Lead exposure history. At each delivery, a sample of 5–10 mL umbilical cord Blood was collected for Lead determination by graphite furnace atomic absorption spectrometry. The cord Blood Lead Level of the newborns in the current study period averaged 2.35±1.12 μg/dL. Together with the cord Blood Lead averages of 7.48±2.25 and 3.28±1.52 μg/dL obtained from two previous surveys conducted in 1985–1987 and 1990–1992, respectively, the cord Blood Lead Level was significantly decreased (P

Kay D Taylor - One of the best experts on this subject based on the ideXlab platform.

  • umbilical cord Blood Lead Level disparities between flint and detroit
    American Journal of Perinatology, 2020
    Co-Authors: Mona Hannaattisha, Ashweena Gonuguntla, Nadine Peart, Jenny Lachance, Kay D Taylor
    Abstract:

    Objective The Lead-in-water impact of the Flint water crisis on the youngest and most neurodevelopmentally vulnerable population was largely unknown. The objective of this study was to investigate and compare cord Blood Lead Levels (CBLLs) in newborns in Flint, Michigan, after the Flint water crisis, to a group of Detroit newborns. Study Design Mothers of 99 Flint newborns were surveyed about potential Lead exposures. These neonates were born after the recognition of population-wide Lead-in-water contamination. CBLLs were measured and maternal–fetal metrics were reviewed. CBLLs and maternal–fetal metrics were then compared with those of a retrospective cohort of 116 Detroit newborns who previously shared the same water source. Analysis involved descriptive statistics, independent t-test, and χ 2 analysis. Results CBLLs greater than or equal to 1 μg/dL (0.05 μmol/L) were more prevalent among Flint newborns (14%), as compared with Detroit newborns (2%; p = 0.001). This was a sevenfold disparity between Flint and Detroit newborns. No statistically significant differences were found in birth weight, head circumference, small for gestational age status, gestational age, or preterm status among the two groups. Conclusion The Flint water crisis potentially exposed newborns to Lead in utero, implicating maternal–fetal outcomes and future health and development. Primary prevention efforts, including identification and mitigation of Lead exposure before conception and during pregnancy, are needed. New environmental exposure detection methods and long-term neurodevelopmental follow-up will complement the findings of this study.

Stephen J Rothenberg - One of the best experts on this subject based on the ideXlab platform.

  • temporal pattern in the effect of postnatal Blood Lead Level on intellectual development of young children
    Neurotoxicology and Teratology, 2000
    Co-Authors: Lourdes Schnaas, Stephen J Rothenberg, Estela Perroni, Sandra Martinez, Carmen Hernandez, Reyna M Hernandez
    Abstract:

    Abstract To determine the temporal pattern of the effect of postnatal Blood Lead Level on the General Cognitive Index (GCI) of the McCarthy Scales of Children's Abilities, we used data from 112 children of the Mexico City Prospective Lead Study with complete evaluations from 36 to 60 months of age at 6-month intervals. We measured Blood Lead Level every 6 months from 6 to 54 months. We controlled for 5-min Apgar, birth weight, birth order, sex, socioeconomic Level, maternal IQ, and maximum maternal educational Level in a repeated measures ANCOVA using child Blood Lead Level grouped by 6–18 month (geometric mean 10.1 μg/dl, range 3.5–37.0 μg/dl), 24–36 month (geometric mean 9.7 μg/dl, range 3.0–42.7 μg/dl), and 42–54 month (geometric mean 8.4 μg/dl, range 2.5–44.8 μg/dl) averages. There were significant interactions between the 6–18 month Blood Lead Level and age with GCI as the endpoint and between 24–36 month Blood Lead Level and age. The regression coefficient of Blood Lead at 6–18 months became more negative with age until 48 months, when the rate of decline moderated (linear polynomial contrast p =0.047). The regression coefficient of Blood Lead at 24–36 months with CGI became more negative as well from 36 to 48 months but then started decreasing toward zero from 48 to 60 months (quadratic polynomial contrast p =0.019). Significant between-subjects Lead effects on GCI were found for 24–36 month Blood Lead Level at 48 months ( p =0.021) and at 54 months ( p =0.073). The greatest effect (at 48 months) was a 5.8-point GCI decrease with each natural log unit increase in Blood Lead. Significant between-subjects Lead effects on GCI were found for 42–54 month Blood Lead Level at 54 months ( p =0.040) and at 60 months ( p =0.060). The effect of postnatal Blood Lead Level on GCI reaches its maximum approximately 1–3 years later, and then becomes less evident. Four to five years of age appears to be a critical period for the manifestation of the earlier postnatal Blood Lead Level effects.

  • Blood Lead Level and Blood pressure during pregnancy in south central los angeles
    Archives of Environmental Health, 1999
    Co-Authors: Stephen J Rothenberg, Mario Manalo, Jian Jiang, Rosa Cuellar, Sergio Reyes, Margarita Soler Sanchez, M T Diaz, Fuad Khan, A Aguilar, Blanca Reynoso
    Abstract:

    Abstract In many studies in which the relationship between Blood pressure and Blood Lead Level has been examined, investigators have found significant—but small—associations. There was only one previous report of a significant association of Blood Lead with Blood pressure in pregnant women. We measured Blood Lead Level and sitting Blood pressure of 1 627 women in their third trimester of pregnancy. We eliminated subjects with known causes of hypertension. Most women (98.4%) were normotensive. We controlled for body mass index, age, and stress—among other factors—and constructed multiple-regression models of Lead association with diastolic and systolic Blood pressures. Immigrants (73% of total) had significantly higher Blood Lead Levels and different Blood pressures than nonimmigrants, suggesting that analysis be stratified by “immigrant, nonimmigrant” status. Positive relationships between Blood Lead Level and Blood pressure were found only for immigrants (p ≤ .001). From the 5th to 95th Blood-Lead percen...

  • maternal Blood Lead Level during pregnancy in south central los angeles
    Archives of Environmental Health, 1999
    Co-Authors: Stephen J Rothenberg, Mario Manalo, Jian Jiang, Rosa Cuellar, Sergio Reyes, Margarita Soler Sanchez, Fuad Khan, A Aguilar, Blanca Reynoso, M T Diaz
    Abstract:

    Abstract Twenty-five years of public health efforts produced a striking reduction in Lead exposure; the Blood Lead average in the United States has decreased to less than 20% of Levels measured in the 1970s. However, poor minority groups that live in large urban centers are still at high risk for elevated Lead Levels. In this study, our data showed that pregnant immigrants (n = 1 428) who live in South Central Los Angeles–one of the most economically depressed regions of California–have significantly higher (p < .0001) Blood Lead Levels (geometric mean = 2.3 μg/dl [0.11 μmol/l]) than 504 pregnant nonimmigrants (geometric mean = 1.9 μg/dl [0.09 μmol/l]). The most important factors associated with lower Blood Lead Levels in both groups were younger age; more-recent date of Blood sampling (i.e., decreasing secular trend); and Blood sampling in mid-autumn, instead of mid-spring (i.e., seasonal trend). Blood Lead Levels of immigrants were strongly dependent on time elapsed since immigration to the United State...

Arun J Patil - One of the best experts on this subject based on the ideXlab platform.

  • Activated Carbon Fabric Mask Reduces Lead Absorption and Improves the Heme Biosynthesis and Hematological Parameters of Battery Manufacturing Workers
    Indian Journal of Clinical Biochemistry, 2019
    Co-Authors: Jyotsna A Patil, Mandakini S. Kshirsagar, Arun J Patil
    Abstract:

    Activated carbon fabrics (ACF) mask prevents the absorption of Lead and reduce its adverse effects of human health. Aim of this study to know the Blood Lead Level and its effects on heme biosynthesis and hematological parameters after using 2 months activated carbon fabric mask of battery manufacturing workers (BMW). Blood Lead Level, heme biosynthesis and hematological parameters were measured by using standard method. Blood Lead Level ( P  

  • Effect of Vitamin C Supplementation on Blood Lead Level, Oxidative Stress and Antioxidant Status of Battery Manufacturing Workers of Western Maharashtra, India
    Journal of clinical and diagnostic research : JCDR, 2016
    Co-Authors: Ganesh H. Ghanwat, Mandakini S. Kshirsagar, Jyotsna A Patil, Arun J Patil, Ajit V Sontakke, Ram Krishna Ayachit
    Abstract:

    Introduction The high Blood Lead Level induces oxidative stress and alters the antioxidant status of battery manufacturing workers. Supplementation of vitamin C is beneficial to reduce the oxidative stress and to improve the antioxidant status of these workers.

  • effect of vitamin c supplementation on Blood Lead Level oxidative stress and antioxidant status of battery manufacturing workers of western maharashtra india
    Journal of clinical and diagnostic research : JCDR, 2016
    Co-Authors: Ganesh H. Ghanwat, Mandakini S. Kshirsagar, Jyotsna A Patil, Arun J Patil, Ajit V Sontakke, Ram Krishna Ayachit
    Abstract:

    INTRODUCTION The high Blood Lead Level induces oxidative stress and alters the antioxidant status of battery manufacturing workers. Supplementation of vitamin C is beneficial to reduce the oxidative stress and to improve the antioxidant status of these workers. AIM The main aim of this study was to observe the changes in Blood Lead Levels, oxidative stress i.e. serum lipid peroxide and antioxidant status parameters such as erythrocyte superoxide dismutase and catalase and serum nitrite after the vitamin C supplementation in battery manufacturing workers. MATERIALS AND METHODS This study included 36 battery manufacturing workers from Western Maharashtra, India, having age between 20-60 years. All study group subjects were provided vitamin C tablets (500 mg/day for one month) and a Blood sample of 10 ml each was drawn by puncturing the anterior cubital vein before and after vitamin C supplementation. The biochemical parameters were estimated by using the standard methods. RESULTS Blood Lead Levels were not significantly altered, however, serum lipid peroxide (p<0.001, -15.56%) and serum nitrite (p<0.001, -21.37%) Levels showed significant decrease and antioxidant status parameters such as erythrocyte superoxide dismutase (p<0.001, 38.02%) and catalase (p<0.001, 32.36%) revealed significant increase in battery manufacturing workers after the supplementation of vitamin C. CONCLUSION One month vitamin C supplementation in battery manufacturing workers is not beneficial to decrease the Blood Lead Levels. However, it is helpful to reduce the lipid peroxidation and nitrite formation and enhances the erythrocytes superoxide dismutase and catalase activity.

Mona Hannaattisha - One of the best experts on this subject based on the ideXlab platform.

  • umbilical cord Blood Lead Level disparities between flint and detroit
    American Journal of Perinatology, 2020
    Co-Authors: Mona Hannaattisha, Ashweena Gonuguntla, Nadine Peart, Jenny Lachance, Kay D Taylor
    Abstract:

    Objective The Lead-in-water impact of the Flint water crisis on the youngest and most neurodevelopmentally vulnerable population was largely unknown. The objective of this study was to investigate and compare cord Blood Lead Levels (CBLLs) in newborns in Flint, Michigan, after the Flint water crisis, to a group of Detroit newborns. Study Design Mothers of 99 Flint newborns were surveyed about potential Lead exposures. These neonates were born after the recognition of population-wide Lead-in-water contamination. CBLLs were measured and maternal–fetal metrics were reviewed. CBLLs and maternal–fetal metrics were then compared with those of a retrospective cohort of 116 Detroit newborns who previously shared the same water source. Analysis involved descriptive statistics, independent t-test, and χ 2 analysis. Results CBLLs greater than or equal to 1 μg/dL (0.05 μmol/L) were more prevalent among Flint newborns (14%), as compared with Detroit newborns (2%; p = 0.001). This was a sevenfold disparity between Flint and Detroit newborns. No statistically significant differences were found in birth weight, head circumference, small for gestational age status, gestational age, or preterm status among the two groups. Conclusion The Flint water crisis potentially exposed newborns to Lead in utero, implicating maternal–fetal outcomes and future health and development. Primary prevention efforts, including identification and mitigation of Lead exposure before conception and during pregnancy, are needed. New environmental exposure detection methods and long-term neurodevelopmental follow-up will complement the findings of this study.