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Blood Pressure Variability

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Gianfranco Parati – One of the best experts on this subject based on the ideXlab platform.

  • Blood Pressure Variability: clinical relevance and application.
    Journal of Clinical Hypertension, 2018
    Co-Authors: Gianfranco Parati, George S. Stergiou, Eamon Dolan, Grzegorz Bilo

    Abstract:

    Blood Pressure Variability is an entity that characterizes the continuous and dynamic fluctuations that occur in Blood Pressure levels throughout a lifetime. This phenomenon has a complex and yet not fully understood physiological background and can be evaluated over time spans ranging from seconds to years. The present paper provides a short overview of methodological aspects, clinical relevance, and potential therapeutic interventions related to the management of Blood Pressure Variability.

  • Arterial Stiffness and Blood Pressure Variability
    , 2015
    Co-Authors: Gianfranco Parati, Juan Eugenio Ochoa, Paolo Salvi, Giuseppe Schillaci

    Abstract:

    Epidemiological evidence has indicated that the risk of cardiovascular complications associated with hypertension may not only depend on the magnitude of Blood Pressure elevation per se, but also, on the presence of increased Blood Pressure Variability. Although the neurogenic influences to the peripheral vasculature and the heart are major determinants of Blood Pressure fluctuations (in particular in the short-term), evidence has also been provided that the degree of Blood Pressure Variability is directly related to stiffness of large arteries, that is, known to be a strong and independent predictor of cardiovascular risk. The aim of this chapter is to critically review the evidence exploring the association between large artery stiffness and different components of Blood Pressure Variability (BPV, i.e., short-term, mid-term, and long-term BPV) focusing on potential mechanisms underlying this relationship that is, alterations in carotid baroreflex and arterial mechanical properties.

  • Mechanisms of Blood Pressure Variability in man.
    Clinical and Experimental Hypertension, 2009
    Co-Authors: Giuseppe Mancia, Gianfranco Parati, M. Di Rienzo, G. Bertinieri, Anita Cavallazzi, Guido Pomidossi, Agustin J. Ramirez, Alberto Zanchetti

    Abstract:

    This paper will touch on three points derived from the studies our group has performed by means of continuous 24 hour Blood Pressure recording in humans. The first point will concern a description of the factors involved in the production of spontaneous Blood Pressure Variability and in particular of our evidence that the magnitude of this phenomenon depends on arterial baroreflexes but also, and perhaps to a larger extent, on central modulation of the cardiovascular system. The second point will deal with the differences in Blood Pressure Variability we have observed in subjects with normal and high Blood Pressure. Finally, the third point will briefly address the changes in Blood Pressure Variability that take place with ageing.

Giuseppe Mancia – One of the best experts on this subject based on the ideXlab platform.

  • Mechanisms and clinical implications of Blood Pressure Variability.
    Journal of Cardiovascular Pharmacology, 2016
    Co-Authors: Giuseppe Mancia, Guido Grassi

    Abstract:

    Several studies have unequivocally shown that the target-organ damage associated with the hypertensive condition is more closely related to 24 h average Blood Pressure values than to clinic Blood Pressure. Blood Pressure, however, is highly variable over the daytime and night-time period, and of major interest is whether average 24 h Blood Pressure values, as well as 24 h Blood Pressure Variability, correlate with, and are possibly responsible for, the hypertension-related alterations of the target-organ structure and function. This paper will address this issue by discussing the main features of Blood Pressure Variability in hypertension. It will also examine the mechanisms involved in this phenomenon, with particular emphasis on the pathogenetic role of sympathetic neural factors. The clinical relevance of Blood Pressure Variability in promoting target-organ damage, as well as its therapeutic implications, will finally be highlighted.

  • Mechanisms of Blood Pressure Variability in man.
    Clinical and Experimental Hypertension, 2009
    Co-Authors: Giuseppe Mancia, Gianfranco Parati, M. Di Rienzo, G. Bertinieri, Anita Cavallazzi, Guido Pomidossi, Agustin J. Ramirez, Alberto Zanchetti

    Abstract:

    This paper will touch on three points derived from the studies our group has performed by means of continuous 24 hour Blood Pressure recording in humans. The first point will concern a description of the factors involved in the production of spontaneous Blood Pressure Variability and in particular of our evidence that the magnitude of this phenomenon depends on arterial baroreflexes but also, and perhaps to a larger extent, on central modulation of the cardiovascular system. The second point will deal with the differences in Blood Pressure Variability we have observed in subjects with normal and high Blood Pressure. Finally, the third point will briefly address the changes in Blood Pressure Variability that take place with ageing.

  • Blood Pressure Variability and silent cerebral damage in essential hypertension.
    American Journal of Hypertension, 2004
    Co-Authors: Elisenda Gómez-angelats, Gianfranco Parati, Giuseppe Mancia, Alejandro De La Sierra, Cristina Sierra, Antonio Coca

    Abstract:

    Background It is recognized that Blood Pressure (BP) Variability has prognostic significance in determining target organ damage and cardiovascular mortality and morbidity. The aim of this study was to analyze the association between Blood Pressure Variability and the presence of silent cerebral white matter lesions in middle-aged asymptomatic essential hypertensives. Methods We studied 43 middle-aged untreated hypertensive patients. Blood Pressure variabilities (short-term and long-term) were evaluated by using both non-invasive, beat-to-beat, continuous finger 24-hour monitoring (Portapres) and oscillometric automated discontinuous ambulatory Blood Pressure monitoring. All patients underwent cerebral magnetic resonance imaging to detect the presence or not of white matter lesions. Results Hypertensive patients with cerebral white matter lesions exhibited significantly higher values of long-term systolic Blood Pressure Variability (standard deviation of 24-hour Blood Pressure) measured both by continuous beat-to-beat monitoring (16.2 ± 3.7 v 13.7 ± 3.6 mmHg; P = 0.047) and by ambulatory Blood Pressure monitoring (15.2 ± 3.8 v 12.8 ± 2.7 mmHg; P = 0.022). However, these differences were not independent on Blood Pressure elevation and did not maintain their significance after adjusting for 24-hour systolic Blood Pressure. Neither short-term systolic Blood Pressure Variability, nor short-term or long-term diastolic Blood Pressure variabilities showed differences between patients with and without white matter lesions. Conclusion The present study indicates that long-term systolic Blood Pressure Variability is significantly related to the presence of silent cerebral white matter lesions in essential hypertensive patients, although this relationship is partially dependent on absolute Blood Pressure elevation.

Johan Sundrom – One of the best experts on this subject based on the ideXlab platform.

  • prognostic impact of systolic Blood Pressure Variability in people with diabetes
    PLOS ONE, 2018
    Co-Authors: Katy J L Bell, Lamiae Azizi, Peter M Nilsson, Andrew Hayen, Les Irwig, Carl Johan Ostgren, Johan Sundrom

    Abstract:

    Objective: Blood Pressure Variability (BPV) has been associated with risk of cardiovascular events in observational studies, independently of mean BP levels. In states with higher autonomic imbalan …