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Yichang Su - One of the best experts on this subject based on the ideXlab platform.

  • using chinese Body Constitution concepts and measurable variables for assessing risk of coronary artery disease
    Evidence-based Complementary and Alternative Medicine, 2019
    Co-Authors: Yichia Huang, Shumeng Cheng, Yichang Su
    Abstract:

    Background. Identifying patients with high risk of coronary artery disease (CAD) is often difficult in outpatient clinic settings. This study aimed to explore if the measurement of Body Constitution can be adopted to predict the risk of CAD diagnosis. The objective of this study is to conduct a prospective observational study and a case-control study to answer the research question. Study Design. Part 1 (prospective observational study): a total of 143 patients with chest pain and admitted to receive cardiac catheterization were enrolled, and 108 of them were diagnosed with CAD. Part 2 (case-control study): the above 108 CAD patients and 476 healthy controls matched by age and gender from the participants of Taiwan Biobank were adopted for comparison. Main Outcome Measures. The Body Constitution of both patients and healthy controls were measured by the Body Constitution Questionnaire (BCQ). Each one received scores of Yang-Xu (Yang-deficiency), Yin-Xu (Yin-deficiency), and Stasis. These 3 scores together with demographic characteristics and CAD risk factors were used in the logistic multiple regression model to predict the risk of CAD. Results. (Part 1) No difference was found between the scores of Yang-Xu, Yin-Xu, and Stasis between the patients with and without CAD. (Part 2) The scores of Yang-Xu, Yin-Xu, and Stasis of the CAD patients were significant higher those of the healthy controls. Yang-Xu and Stasis scores were obtained with age, BMI, and hypertension in the model with prediction rate 89.0%. The area under receiver operating characteristic curve of this model was 0.896. Conclusions. This study is the first to apply Chinese Body Constitution concepts and measurable variables to assess the risk of having CAD of the patients with chest pain prior to receiving cardiac catheterization. The higher scores of Yang-Xu and Stasis were found to be risk factors. Our results revealed that BCQ has the potential to be a first-line diagnostic tool for patients with chest pain to facilitate early recognition and diagnosis of CAD.

  • The prevalence rate of deviations in Body Constitutions and related factors in follow-up stage breast cancer patients-A nationwide study.
    Complementary Therapies in Medicine, 2017
    Co-Authors: Lili Chen, Yichang Su, Shin-mae Wang
    Abstract:

    Abstract Objectives The aim of this study was to apply a rigorous traditional Chinese medicine (TCM) Body Constitution questionnaire (BCQ) to survey the prevalence rate of deviations in Body Constitution and to explore the health-related lifestyle behavior factors of deviations in Body Constitution. Design A cross-sectional study was administered through postal mail. Subjects were recruited from a national organization for breast cancer patients (Taiwan Breast Cancer Alliance). Setting/main outcome measures Data were obtained from 311 breast cancer patients by questionnaires including a demographic record sheet, lifestyle behavior scales and the BCQ (Yang-Xu, Yin-Xu, and Stasis). Differences concerning the presence of Body Constitutions were analyzed by Chi-square tests and analyses of variance, and potential predictive factors were analyzed using multivariate logistic regression. Results In total, 55.3% of the subjects had a Yang-Xu Constitution, 61.0% had a Yin-Xu Constitution, and 47.6% had a Stasis Constitution. A total of 42.8% of the patients displayed a combination of the three types of Body Constitutions. Feeling stressed, physical exercise, and favoring fried food were predictors of the combined Yang-Xu, Yin-Xu and Stasis Constitutions (p  Conclusions A high prevalence of deviations in Body Constitutions was observed in the follow-up stage of breast cancer patients. Increasing the adherence to healthy lifestyle behaviors might strengthen and balance Body Constitution, which could improve supportive care in breast cancer survivors.

  • association between albuminuria and different Body Constitution in type 2 diabetes patients taichung diabetic Body Constitution study
    Evidence-based Complementary and Alternative Medicine, 2015
    Co-Authors: Chiai Tsai, Tsai Chung Li, Yachi Wu, Yichang Su
    Abstract:

    Objective. Albuminuria in type 2 diabetes mellitus (T2DM) patients increases the risk of diabetic nephropathy, the leading cause of end-stage renal disease worldwide. Because albuminuria is modifiable, identifying relevant risk factors could facilitate prevention and/or management. This cross-sectional study investigated whether Body Constitution (BC) independently predicts albuminuria. Method. Patients with T2DM ( ) received urinalysis, a blood test, and diabetic retinopathy examination. Albuminuria was defined by an elevated urinary albumin/creatinine ratio (≥30 μg/mg). BC type (Yang deficiency, Yin deficiency, and Phlegm stasis) was assessed using a Body Constitution questionnaire (BCQ). Traditional risk factors for albuminuria were also recorded. Odds ratios (ORs) of albuminuria for BC were estimated using multivariate logistic regression. Results. Albuminuria was more prevalent in patients with Yang deficiency or Phlegm stasis (both ). After adjustment, patients with both Yang deficiency and Phlegm stasis exhibited a significantly higher risk of albuminuria (OR = 3.037; 95% confidence interval = 1.572–5.867, and ). Conclusion. BC is strongly associated with albuminuria in T2DM patients. Using a BCQ to assess BC is noninvasive, convenient, and inexpensive and can provide information for health care professionals to identify T2DM patients who are at a high risk of albuminuria.

  • yang deficiency Body Constitution acts as a predictor of diabetic retinopathy in patients with type 2 diabetes taichung diabetic Body Constitution study
    Evidence-based Complementary and Alternative Medicine, 2015
    Co-Authors: Tsai Chung Li, Chiai Tsai, Yachi Wu, Yichang Su
    Abstract:

    Objective. Diabetic retinopathy (DR), the most common microvascular complication of diabetes mellitus (DM), can cause severe visual impairment and blindness. To prevent the development of DR, identifying the associated risk factors for patient classification is critical. We conducted a cross-sectional study to determine whether Body Constitution (BC) is an independent predictor of DR. Method. 673 type 2 DM (T2DM) patients were recruited from a medical center, all received DR examination and Body Constitution questionnaire to assess BC. Other risk factors for DR were also recorded, including life style, history of diabetes, and blood pressure, etc. Multiple logistic regression analysis was conducted to calculate the odds ratios (ORs) for DR. Results. The prevalence of DR was significantly lower in Yang deficiency patients compared with non-Yang deficiency patients (24.69% versus 38.18% P = 0.02). After adjusting for other risk factors, we observed that patients exhibiting Yang deficiency BC were less likely to present with DR (OR = 0.531; 95% confidence interval = 0.312–0.903, P = 0.018). Conclusion. In addition to traditional risk factors, Yang deficiency BC might be an independent predictor of DR among T2DM patients and the results can be used as evidence for traditional Chinese medicine patient classification.

  • measuring Body Constitution validation of the Body Constitution questionnaire bcq in hong kong
    Complementary Therapies in Medicine, 2014
    Co-Authors: Wendy Siuyi Wong, Yichang Su, Eric Ziea, Vivian Taam Wong, Andrew Ka Lun Kwan
    Abstract:

    Summary Background The Body Constitution Questionnaire (BCQ) was developed in Taiwan to classify people into Body Constitution (BC) types based on Traditional Chinese Medicine (TCM) theories. Since the culture of Hong Kong is different from Taiwan, the BCQ must be validated before a wider application can be preceded. Aim and objectives To adapt and validate the Hong Kong version of BCQ in Hong Kong Chinese population. Methods The content validity of BCQ was investigated by the cognitive debriefing with 10 patients and 10 Chinese Medicine Practitioners (CMP). A cross-sectional study of 1084 Chinese patients recruited from TCM and Western Medicine (WM) outpatient clinics to confirm the construct validity, reliability, sensitivity and responsiveness of BCQ. 225 of the patients were assessed after 2 weeks for the test-retest reliability. 404 subjects were followed up to evaluate the responsiveness after 3–6 months. Results Cognitive debriefing confirmed the content validity of the BCQ (HK version) with content validity index of all items ranged from 70 to 100%. 1084 out of 2128 patients (51%) completed the cross-sectional study. The construct validity was confirmed with scaling success rates that ranged from 87.5 to 89.5%, moderate correlations between with SF-12v2 scores, and 3-factors structure with confirmatory factor analysis. The reliability was confirmed by the Cronbach's alphas >0.8 and test-retest reliability (intra-class correlation coefficients >0.8). Conclusion BCQ was adapted and validated on Hong Kong Chinese population. Patients with imbalanced BC types had lower health-related quality of life (HRQOL) than those with balanced BC types, which supported the validity and importance of the Body Constitution under the concept of TCM.

Tsai Chung Li - One of the best experts on this subject based on the ideXlab platform.

  • association between albuminuria and different Body Constitution in type 2 diabetes patients taichung diabetic Body Constitution study
    Evidence-based Complementary and Alternative Medicine, 2015
    Co-Authors: Chiai Tsai, Tsai Chung Li, Yachi Wu, Yichang Su
    Abstract:

    Objective. Albuminuria in type 2 diabetes mellitus (T2DM) patients increases the risk of diabetic nephropathy, the leading cause of end-stage renal disease worldwide. Because albuminuria is modifiable, identifying relevant risk factors could facilitate prevention and/or management. This cross-sectional study investigated whether Body Constitution (BC) independently predicts albuminuria. Method. Patients with T2DM ( ) received urinalysis, a blood test, and diabetic retinopathy examination. Albuminuria was defined by an elevated urinary albumin/creatinine ratio (≥30 μg/mg). BC type (Yang deficiency, Yin deficiency, and Phlegm stasis) was assessed using a Body Constitution questionnaire (BCQ). Traditional risk factors for albuminuria were also recorded. Odds ratios (ORs) of albuminuria for BC were estimated using multivariate logistic regression. Results. Albuminuria was more prevalent in patients with Yang deficiency or Phlegm stasis (both ). After adjustment, patients with both Yang deficiency and Phlegm stasis exhibited a significantly higher risk of albuminuria (OR = 3.037; 95% confidence interval = 1.572–5.867, and ). Conclusion. BC is strongly associated with albuminuria in T2DM patients. Using a BCQ to assess BC is noninvasive, convenient, and inexpensive and can provide information for health care professionals to identify T2DM patients who are at a high risk of albuminuria.

  • yang deficiency Body Constitution acts as a predictor of diabetic retinopathy in patients with type 2 diabetes taichung diabetic Body Constitution study
    Evidence-based Complementary and Alternative Medicine, 2015
    Co-Authors: Tsai Chung Li, Chiai Tsai, Yachi Wu, Yichang Su
    Abstract:

    Objective. Diabetic retinopathy (DR), the most common microvascular complication of diabetes mellitus (DM), can cause severe visual impairment and blindness. To prevent the development of DR, identifying the associated risk factors for patient classification is critical. We conducted a cross-sectional study to determine whether Body Constitution (BC) is an independent predictor of DR. Method. 673 type 2 DM (T2DM) patients were recruited from a medical center, all received DR examination and Body Constitution questionnaire to assess BC. Other risk factors for DR were also recorded, including life style, history of diabetes, and blood pressure, etc. Multiple logistic regression analysis was conducted to calculate the odds ratios (ORs) for DR. Results. The prevalence of DR was significantly lower in Yang deficiency patients compared with non-Yang deficiency patients (24.69% versus 38.18% P = 0.02). After adjusting for other risk factors, we observed that patients exhibiting Yang deficiency BC were less likely to present with DR (OR = 0.531; 95% confidence interval = 0.312–0.903, P = 0.018). Conclusion. In addition to traditional risk factors, Yang deficiency BC might be an independent predictor of DR among T2DM patients and the results can be used as evidence for traditional Chinese medicine patient classification.

  • reduced health related quality of life in Body Constitutions of yin xu and yang xu stasis in patients with type 2 diabetes taichung diabetic Body Constitution study
    Evidence-based Complementary and Alternative Medicine, 2014
    Co-Authors: Chiai Tsai, Yichang Su, Tsai Chung Li
    Abstract:

    Aim. To evaluate how health-related quality of life (HRQOL) and traditional Chinese medicine (TCM) Constitutions of Yin-Xu, Yang-Xu, and Stasis are related in type 2 diabetes patients. Method. Seven hundred and five subjects were recruited in 2010 for this study from a Diabetes Shared Care Network in Taiwan. Generic and disease-specific HRQOL were assessed by the short form 36 (SF-36) and the diabetes impact measurement scale (DIMS). Constitutions of Yin-Xu, Yang-Xu, and Stasis were then assessed by the Body Constitution questionnaire (BCQ), a questionnaire consisting of 44 items that evaluate the physiological state based on subjective symptoms and signs. Results. Estimated effects of the Ying-Xu and Stasis on all scales of the SF-36 were significantly negative, while estimated effects of the Yang-Xu on all scales (except for SF, RE, MH, and MCS) were significantly negative. For DIMS, the estimated effects of the Ying-Xu and Stasis on all scales were significantly negative except for Stasis on well-being, while Yang-Xu has a significantly negative effect only on symptoms. Conclusions. This study demonstrates that TCM Constitutions of Yin-Xu, Yang-Xu, and Stasis are closely related to a reduction in HRQOL. These findings support the need for further research into the impact of intervention for TCM Constitutions on HRQOL in patients with type 2 diabetes.

Chiai Tsai - One of the best experts on this subject based on the ideXlab platform.

  • association between albuminuria and different Body Constitution in type 2 diabetes patients taichung diabetic Body Constitution study
    Evidence-based Complementary and Alternative Medicine, 2015
    Co-Authors: Chiai Tsai, Tsai Chung Li, Yachi Wu, Yichang Su
    Abstract:

    Objective. Albuminuria in type 2 diabetes mellitus (T2DM) patients increases the risk of diabetic nephropathy, the leading cause of end-stage renal disease worldwide. Because albuminuria is modifiable, identifying relevant risk factors could facilitate prevention and/or management. This cross-sectional study investigated whether Body Constitution (BC) independently predicts albuminuria. Method. Patients with T2DM ( ) received urinalysis, a blood test, and diabetic retinopathy examination. Albuminuria was defined by an elevated urinary albumin/creatinine ratio (≥30 μg/mg). BC type (Yang deficiency, Yin deficiency, and Phlegm stasis) was assessed using a Body Constitution questionnaire (BCQ). Traditional risk factors for albuminuria were also recorded. Odds ratios (ORs) of albuminuria for BC were estimated using multivariate logistic regression. Results. Albuminuria was more prevalent in patients with Yang deficiency or Phlegm stasis (both ). After adjustment, patients with both Yang deficiency and Phlegm stasis exhibited a significantly higher risk of albuminuria (OR = 3.037; 95% confidence interval = 1.572–5.867, and ). Conclusion. BC is strongly associated with albuminuria in T2DM patients. Using a BCQ to assess BC is noninvasive, convenient, and inexpensive and can provide information for health care professionals to identify T2DM patients who are at a high risk of albuminuria.

  • yang deficiency Body Constitution acts as a predictor of diabetic retinopathy in patients with type 2 diabetes taichung diabetic Body Constitution study
    Evidence-based Complementary and Alternative Medicine, 2015
    Co-Authors: Tsai Chung Li, Chiai Tsai, Yachi Wu, Yichang Su
    Abstract:

    Objective. Diabetic retinopathy (DR), the most common microvascular complication of diabetes mellitus (DM), can cause severe visual impairment and blindness. To prevent the development of DR, identifying the associated risk factors for patient classification is critical. We conducted a cross-sectional study to determine whether Body Constitution (BC) is an independent predictor of DR. Method. 673 type 2 DM (T2DM) patients were recruited from a medical center, all received DR examination and Body Constitution questionnaire to assess BC. Other risk factors for DR were also recorded, including life style, history of diabetes, and blood pressure, etc. Multiple logistic regression analysis was conducted to calculate the odds ratios (ORs) for DR. Results. The prevalence of DR was significantly lower in Yang deficiency patients compared with non-Yang deficiency patients (24.69% versus 38.18% P = 0.02). After adjusting for other risk factors, we observed that patients exhibiting Yang deficiency BC were less likely to present with DR (OR = 0.531; 95% confidence interval = 0.312–0.903, P = 0.018). Conclusion. In addition to traditional risk factors, Yang deficiency BC might be an independent predictor of DR among T2DM patients and the results can be used as evidence for traditional Chinese medicine patient classification.

  • reduced health related quality of life in Body Constitutions of yin xu and yang xu stasis in patients with type 2 diabetes taichung diabetic Body Constitution study
    Evidence-based Complementary and Alternative Medicine, 2014
    Co-Authors: Chiai Tsai, Yichang Su, Tsai Chung Li
    Abstract:

    Aim. To evaluate how health-related quality of life (HRQOL) and traditional Chinese medicine (TCM) Constitutions of Yin-Xu, Yang-Xu, and Stasis are related in type 2 diabetes patients. Method. Seven hundred and five subjects were recruited in 2010 for this study from a Diabetes Shared Care Network in Taiwan. Generic and disease-specific HRQOL were assessed by the short form 36 (SF-36) and the diabetes impact measurement scale (DIMS). Constitutions of Yin-Xu, Yang-Xu, and Stasis were then assessed by the Body Constitution questionnaire (BCQ), a questionnaire consisting of 44 items that evaluate the physiological state based on subjective symptoms and signs. Results. Estimated effects of the Ying-Xu and Stasis on all scales of the SF-36 were significantly negative, while estimated effects of the Yang-Xu on all scales (except for SF, RE, MH, and MCS) were significantly negative. For DIMS, the estimated effects of the Ying-Xu and Stasis on all scales were significantly negative except for Stasis on well-being, while Yang-Xu has a significantly negative effect only on symptoms. Conclusions. This study demonstrates that TCM Constitutions of Yin-Xu, Yang-Xu, and Stasis are closely related to a reduction in HRQOL. These findings support the need for further research into the impact of intervention for TCM Constitutions on HRQOL in patients with type 2 diabetes.

Fangpey Chen - One of the best experts on this subject based on the ideXlab platform.

  • study on yang xu using Body Constitution questionnaire and blood variables in healthy volunteers
    Evidence-based Complementary and Alternative Medicine, 2016
    Co-Authors: Hongjhang Chen, Peichen Wu, Wanchung Hu, Trongneng Wu, Fangpey Chen
    Abstract:

    Traditional Chinese medicine (TCM) formulates treatment according to Body Constitution (BC) differentiation. Different Constitutions have specific metabolic characteristics and different susceptibility to certain diseases. This study aimed to assess the Yang-Xu Constitution using a Body Constitution questionnaire (BCQ) and clinical blood variables. A BCQ was employed to assess the clinical manifestation of Yang-Xu. The logistic regression model was conducted to explore the relationship between BC scores and biomarkers. Leave-one-out cross-validation (LOOCV) and K-fold cross-validation were performed to evaluate the accuracy of a predictive model in practice. Decision trees (DTs) were conducted to determine the possible relationships between blood biomarkers and BC scores. According to the BCQ analysis, 49% participants without any BC were classified as healthy subjects. Among them, 130 samples were selected for further analysis and divided into two groups. One group comprised healthy subjects without any BC (68%), while subjects of the other group, named as the sub-healthy group, had three BCs (32%). Six biomarkers, CRE, TSH, HB, MONO, RBC, and LH, were found to have the greatest impact on BCQ outcomes in Yang-Xu subjects. This study indicated significant biochemical differences in Yang-Xu subjects, which may provide a connection between blood variables and the Yang-Xu BC.

Wen Feng - One of the best experts on this subject based on the ideXlab platform.

  • association of tcm Body Constitution with insulin resistance and risk of diabetes in impaired glucose regulation patients
    BMC Complementary and Alternative Medicine, 2017
    Co-Authors: Tong Zhang, Wen Feng
    Abstract:

    Impaired glucose regulation (IGR) patients have increased risk of type 2 diabetes mellitus (T2DM). Identifying relevant risk factors in IGR subjects could facilitate early detection and prevention of IGR progression to diabetes. This study investigated the association between Traditional Chinese Medicine (TCM) Body Constitution and serum cytokines, and whether Body Constitution could independently predict diabetes in IGR subjects. Patients with IGR (n = 306) received a blood test and their Body Constitution type was assessed using a Body Constitution questionnaire (BCQ). Serum levels of cytokines were measured by ELISA. Patients were followed up for at least three years, and their status of diabetes were recorded. Multivariate logistic regression was used to estimate odds ratios (ORs) of diabetes for Body Constitution. Phlegm-damp, Damp-heat and Qi-deficiency were three most common unbanlenced Constitutions among IGR subjects. Phlegm-damp and Damp-heat Constitution subjects showed higher serum levels of interleukin 6 (IL-6), tumour necrosis factor-α (TNF-α), leptin and lower serum levels of adiponectin (P<0.05). Qi-deficiency Constitution subjects showed higher serum levels of leptin and lower serum levels of adiponectin, glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP) (P<0.05). Subjects with Phlegm-damp or Damp-heat Constitution demonstrated a significantly higher risk of diabetes (P<0.05). Phlegm-damp and Damp-heat TCM Body Constitution are strongly associated with abnormal serum cytokines, and could potentially serve as a predictor of diabetes in IGR subjects. Body Constitution can help to identify IGR subjects who are at a high risk of progression to diabetes.

  • Association of TCM Body Constitution with insulin resistance and risk of diabetes in impaired glucose regulation patients
    BMC Complementary and Alternative Medicine, 2017
    Co-Authors: Hong You, Tong Zhang, Wen Feng, Yun Gai
    Abstract:

    BACKGROUND: Impaired glucose regulation (IGR) patients have increased risk of type 2 diabetes mellitus (T2DM). Identifying relevant risk factors in IGR subjects could facilitate early detection and prevention of IGR progression to diabetes. This study investigated the association between Traditional Chinese Medicine (TCM) Body Constitution and serum cytokines, and whether Body Constitution could independently predict diabetes in IGR subjects. METHOD: Patients with IGR (n = 306) received a blood test and their Body Constitution type was assessed using a Body Constitution questionnaire (BCQ). Serum levels of cytokines were measured by ELISA. Patients were followed up for at least three years, and their status of diabetes were recorded. Multivariate logistic regression was used to estimate odds ratios (ORs) of diabetes for Body Constitution. RESULTS: Phlegm-damp, Damp-heat and Qi-deficiency were three most common unbanlenced Constitutions among IGR subjects. Phlegm-damp and Damp-heat Constitution subjects showed higher serum levels of interleukin 6 (IL-6), tumour necrosis factor-alpha (TNF-alpha), leptin and lower serum levels of adiponectin (P