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C K Ozaki - One of the best experts on this subject based on the ideXlab platform.

  • abstract 696 surgical injury induces local and distant adipose tissue browning
    Arteriosclerosis Thrombosis and Vascular Biology, 2015
    Co-Authors: Alban Longchamp, Ming Tao, Alexander Bartelt, Kui Ding, Lydia Lynch, Christopher Hine, Jeanmarc Corpataux, Bruce S Kristal, James R Mitchell, C K Ozaki
    Abstract:

    Objective: Adipose tissue quantity and quality are strong predictors of vascular function. The adipose organ, which comprises brown, white and beige adipocytes, possesses remarkable plasticity in response to feeding and cold exposure. While surgical procedures constantly traumatize adipose tissue, its impact on adipocyte phenotypes remains to be established. Approach and Results: We studied the effect of trauma on adipocyte phenotypes one day after sham, incision control, or surgical injury to the left inguinal adipose compartment. We included caloric restriction to control for surgery-associated Body Temperature Changes and weight loss. The cellular and molecular Changes in subcutaneous, visceral, interscapular, and perivascular adipose tissue using histology, immunohistochemistry, gene expression and flow cytometry analysis. After one day, surgical trauma stimulated adipose tissue browning at the site of injury ( Figure 1 ) and, importantly, in the contralateral inguinal depot. Browning was not present after incision only, and was independent of surgery-associated Body Temperature and weight loss. Adipose trauma rapidly recruited monocytes to the injured site and promoted alternatively activated macrophages. Conversely, PDGF receptor-positive beige progenitors were reduced. Finally, eight hours after adipose injury, mice had increased levels of circulating norepinephrine, which correlated with reduced lipid content and adipocytes size. Conclusions: In this study, we identify adipose trauma as an unexpected driver of adipose tissue browning, holding important implications for the biologic response to injury.

Alban Longchamp - One of the best experts on this subject based on the ideXlab platform.

  • surgical injury induces local and distant adipose tissue browning
    Adipocyte, 2016
    Co-Authors: Alban Longchamp, Ming Tao, Alexander Bartelt, Kui Ding, Lydia Lynch, Christopher Hine, Jeanmarc Corpataux, Bruce S Kristal, James R Mitchell, Keith C Ozaki
    Abstract:

    The adipose organ, which comprises brown, white and beige adipocytes, possesses remarkable plasticity in response to feeding and cold exposure. The development of beige adipocytes in white adipose tissue (WAT), a process called browning, represents a promising route to treat metabolic disorders. While surgical procedures constantly traumatize adipose tissue, its impact on adipocyte phenotype remains to be established. Herein, we studied the effect of trauma on adipocyte phenotype one day after sham, incision control, or surgical injury to the left inguinal adipose compartment. Caloric restriction was used to control for surgery-associated Body Temperature Changes and weight loss. We characterized the trauma-induced cellular and molecular Changes in subcutaneous, visceral, interscapular, and perivascular adipose tissue using histology, immunohistochemistry, gene expression, and flow cytometry analysis. After one day, surgical trauma stimulated adipose tissue browning at the site of injury and, importantly, in the contralateral inguinal depot. Browning was not present after incision only, and was largely independent of surgery-associated Body Temperature and weight loss. Adipose trauma rapidly recruited monocytes to the injured site and promoted alternatively activated macrophages. Conversely, PDGF receptor-positive beige progenitors were reduced. In this study, we identify adipose trauma as an unexpected driver of selected local and remote adipose tissue browning, holding important implications for the biologic response to surgical injury.

  • abstract 696 surgical injury induces local and distant adipose tissue browning
    Arteriosclerosis Thrombosis and Vascular Biology, 2015
    Co-Authors: Alban Longchamp, Ming Tao, Alexander Bartelt, Kui Ding, Lydia Lynch, Christopher Hine, Jeanmarc Corpataux, Bruce S Kristal, James R Mitchell, C K Ozaki
    Abstract:

    Objective: Adipose tissue quantity and quality are strong predictors of vascular function. The adipose organ, which comprises brown, white and beige adipocytes, possesses remarkable plasticity in response to feeding and cold exposure. While surgical procedures constantly traumatize adipose tissue, its impact on adipocyte phenotypes remains to be established. Approach and Results: We studied the effect of trauma on adipocyte phenotypes one day after sham, incision control, or surgical injury to the left inguinal adipose compartment. We included caloric restriction to control for surgery-associated Body Temperature Changes and weight loss. The cellular and molecular Changes in subcutaneous, visceral, interscapular, and perivascular adipose tissue using histology, immunohistochemistry, gene expression and flow cytometry analysis. After one day, surgical trauma stimulated adipose tissue browning at the site of injury ( Figure 1 ) and, importantly, in the contralateral inguinal depot. Browning was not present after incision only, and was independent of surgery-associated Body Temperature and weight loss. Adipose trauma rapidly recruited monocytes to the injured site and promoted alternatively activated macrophages. Conversely, PDGF receptor-positive beige progenitors were reduced. Finally, eight hours after adipose injury, mice had increased levels of circulating norepinephrine, which correlated with reduced lipid content and adipocytes size. Conclusions: In this study, we identify adipose trauma as an unexpected driver of adipose tissue browning, holding important implications for the biologic response to injury.

Jana Pachlopnik Schmid - One of the best experts on this subject based on the ideXlab platform.

  • neutralization of ifnγ defeats haemophagocytosis in lcmv infected perforin and rab27a deficient mice
    Embo Molecular Medicine, 2009
    Co-Authors: Jana Pachlopnik Schmid, Fabrice Chretien, Juliette M Lefebvre, Gerard Pivert, Marie Koscovilbois, Walter Ferlin, Frederic Geissmann
    Abstract:

    Hereditary haemophagocytic lymphohistiocytosis (HLH) is a fatal inflammatory disease and treatments currently may lead to serious side effects. There is a pressing need for effective, less toxic treatments for this disease. Previous reports have suggested that interferon γ (IFNγ) has a role in the pathogenesis of HLH. Here, we report that blocking IFNγ had a therapeutic effect in two different murine models of human hereditary HLH (perforin-deficient and Rab27a-deficient mice, both infected with lymphocytic choriomeningitis virus). Therapeutic administration of an anti-IFNγ antiBody induced recovery from haemophagocytosis in both genetic models, as evidenced by increased survival in perforin-deficient mice and correction of blood cytopenia, moderation of Body Temperature Changes, decreased cytokinaemia, restoration of splenic architecture and reduced haemophagocytosis in the liver of both murine models. Involvement of the central nervous system in Rab27a-deficient mice was prevented by anti-IFNγ therapy. Hepatic T-cell infiltrates and virus persisted, with no detectable harm during the time course of these studies. These data strongly suggest that neutralization of IFNγ could be used in humans to safely alleviate the clinical manifestations of haemophagocytosis.

James R Mitchell - One of the best experts on this subject based on the ideXlab platform.

  • surgical injury induces local and distant adipose tissue browning
    Adipocyte, 2016
    Co-Authors: Alban Longchamp, Ming Tao, Alexander Bartelt, Kui Ding, Lydia Lynch, Christopher Hine, Jeanmarc Corpataux, Bruce S Kristal, James R Mitchell, Keith C Ozaki
    Abstract:

    The adipose organ, which comprises brown, white and beige adipocytes, possesses remarkable plasticity in response to feeding and cold exposure. The development of beige adipocytes in white adipose tissue (WAT), a process called browning, represents a promising route to treat metabolic disorders. While surgical procedures constantly traumatize adipose tissue, its impact on adipocyte phenotype remains to be established. Herein, we studied the effect of trauma on adipocyte phenotype one day after sham, incision control, or surgical injury to the left inguinal adipose compartment. Caloric restriction was used to control for surgery-associated Body Temperature Changes and weight loss. We characterized the trauma-induced cellular and molecular Changes in subcutaneous, visceral, interscapular, and perivascular adipose tissue using histology, immunohistochemistry, gene expression, and flow cytometry analysis. After one day, surgical trauma stimulated adipose tissue browning at the site of injury and, importantly, in the contralateral inguinal depot. Browning was not present after incision only, and was largely independent of surgery-associated Body Temperature and weight loss. Adipose trauma rapidly recruited monocytes to the injured site and promoted alternatively activated macrophages. Conversely, PDGF receptor-positive beige progenitors were reduced. In this study, we identify adipose trauma as an unexpected driver of selected local and remote adipose tissue browning, holding important implications for the biologic response to surgical injury.

  • abstract 696 surgical injury induces local and distant adipose tissue browning
    Arteriosclerosis Thrombosis and Vascular Biology, 2015
    Co-Authors: Alban Longchamp, Ming Tao, Alexander Bartelt, Kui Ding, Lydia Lynch, Christopher Hine, Jeanmarc Corpataux, Bruce S Kristal, James R Mitchell, C K Ozaki
    Abstract:

    Objective: Adipose tissue quantity and quality are strong predictors of vascular function. The adipose organ, which comprises brown, white and beige adipocytes, possesses remarkable plasticity in response to feeding and cold exposure. While surgical procedures constantly traumatize adipose tissue, its impact on adipocyte phenotypes remains to be established. Approach and Results: We studied the effect of trauma on adipocyte phenotypes one day after sham, incision control, or surgical injury to the left inguinal adipose compartment. We included caloric restriction to control for surgery-associated Body Temperature Changes and weight loss. The cellular and molecular Changes in subcutaneous, visceral, interscapular, and perivascular adipose tissue using histology, immunohistochemistry, gene expression and flow cytometry analysis. After one day, surgical trauma stimulated adipose tissue browning at the site of injury ( Figure 1 ) and, importantly, in the contralateral inguinal depot. Browning was not present after incision only, and was independent of surgery-associated Body Temperature and weight loss. Adipose trauma rapidly recruited monocytes to the injured site and promoted alternatively activated macrophages. Conversely, PDGF receptor-positive beige progenitors were reduced. Finally, eight hours after adipose injury, mice had increased levels of circulating norepinephrine, which correlated with reduced lipid content and adipocytes size. Conclusions: In this study, we identify adipose trauma as an unexpected driver of adipose tissue browning, holding important implications for the biologic response to injury.

Ming Tao - One of the best experts on this subject based on the ideXlab platform.

  • surgical injury induces local and distant adipose tissue browning
    Adipocyte, 2016
    Co-Authors: Alban Longchamp, Ming Tao, Alexander Bartelt, Kui Ding, Lydia Lynch, Christopher Hine, Jeanmarc Corpataux, Bruce S Kristal, James R Mitchell, Keith C Ozaki
    Abstract:

    The adipose organ, which comprises brown, white and beige adipocytes, possesses remarkable plasticity in response to feeding and cold exposure. The development of beige adipocytes in white adipose tissue (WAT), a process called browning, represents a promising route to treat metabolic disorders. While surgical procedures constantly traumatize adipose tissue, its impact on adipocyte phenotype remains to be established. Herein, we studied the effect of trauma on adipocyte phenotype one day after sham, incision control, or surgical injury to the left inguinal adipose compartment. Caloric restriction was used to control for surgery-associated Body Temperature Changes and weight loss. We characterized the trauma-induced cellular and molecular Changes in subcutaneous, visceral, interscapular, and perivascular adipose tissue using histology, immunohistochemistry, gene expression, and flow cytometry analysis. After one day, surgical trauma stimulated adipose tissue browning at the site of injury and, importantly, in the contralateral inguinal depot. Browning was not present after incision only, and was largely independent of surgery-associated Body Temperature and weight loss. Adipose trauma rapidly recruited monocytes to the injured site and promoted alternatively activated macrophages. Conversely, PDGF receptor-positive beige progenitors were reduced. In this study, we identify adipose trauma as an unexpected driver of selected local and remote adipose tissue browning, holding important implications for the biologic response to surgical injury.

  • abstract 696 surgical injury induces local and distant adipose tissue browning
    Arteriosclerosis Thrombosis and Vascular Biology, 2015
    Co-Authors: Alban Longchamp, Ming Tao, Alexander Bartelt, Kui Ding, Lydia Lynch, Christopher Hine, Jeanmarc Corpataux, Bruce S Kristal, James R Mitchell, C K Ozaki
    Abstract:

    Objective: Adipose tissue quantity and quality are strong predictors of vascular function. The adipose organ, which comprises brown, white and beige adipocytes, possesses remarkable plasticity in response to feeding and cold exposure. While surgical procedures constantly traumatize adipose tissue, its impact on adipocyte phenotypes remains to be established. Approach and Results: We studied the effect of trauma on adipocyte phenotypes one day after sham, incision control, or surgical injury to the left inguinal adipose compartment. We included caloric restriction to control for surgery-associated Body Temperature Changes and weight loss. The cellular and molecular Changes in subcutaneous, visceral, interscapular, and perivascular adipose tissue using histology, immunohistochemistry, gene expression and flow cytometry analysis. After one day, surgical trauma stimulated adipose tissue browning at the site of injury ( Figure 1 ) and, importantly, in the contralateral inguinal depot. Browning was not present after incision only, and was independent of surgery-associated Body Temperature and weight loss. Adipose trauma rapidly recruited monocytes to the injured site and promoted alternatively activated macrophages. Conversely, PDGF receptor-positive beige progenitors were reduced. Finally, eight hours after adipose injury, mice had increased levels of circulating norepinephrine, which correlated with reduced lipid content and adipocytes size. Conclusions: In this study, we identify adipose trauma as an unexpected driver of adipose tissue browning, holding important implications for the biologic response to injury.