The Experts below are selected from a list of 57129 Experts worldwide ranked by ideXlab platform
John T Schousboe - One of the best experts on this subject based on the ideXlab platform.
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weight loss in men in late life and Bone Strength and microarchitecture a prospective study
Osteoporosis International, 2018Co-Authors: Kristine E Ensrud, Andrew J Burghardt, Eric S Orwoll, J A Cauley, Brent C Taylor, John T Schousboe, Ne Lane, Andrew R Hoffman, Lisa LangsetmoAbstract:Weight loss in men in late life was associated with lower Bone Strength. In contrast, weight gain was not associated with a commensurate increase in Bone Strength. Future studies should measure concurrent changes in weight and parameters of Bone Strength and microarchitecture and evaluate potential causal pathways underlying these associations. Our aim was to determine associations of weight loss with Bone Strength and microarchitecture. We used data from 1723 community-dwelling men (mean age 84.5 years) who attended the MrOS study Year (Y) 14 exam and had high-resolution peripheral quantitative computed tomography (HR-pQCT) scans at ≥ 1 skeletal sites (distal tibia, distal radius, or diaphyseal tibia). Weight change from Y7 to Y14 exams (mean 7.3 years between exams) was classified as moderate weight loss (loss ≥ 10%), mild weight loss (loss 5 to < 10%), stable weight (< 5% change), or weight gain (gain ≥ 5%). Mean HR-pQCT parameters (95%CI) were calculated by weight change category using linear regression models adjusted for age, race, site, health status, body mass index, limb length, and physical activity. The primary outcome measure was estimated failure load. There was a nonlinear association of weight change with failure load at each skeletal site with different associations for weight loss vs. weight gain (p < 0.03). Failure load and total Bone mineral density (BMD) at distal sites were lower with greater weight loss with 7.0–7.6% lower failure loads and 4.3–5.8% lower BMDs among men with moderate weight loss compared to those with stable weight (p < 0.01, both comparisons). Cortical, but not trabecular, BMDs at distal sites were lower with greater weight loss. Greater weight loss was associated with lower cortical thickness at all three skeletal sites. Weight loss in men in late life is associated with lower peripheral Bone Strength and total BMD with global measures reflecting cortical but not trabecular parameters.
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high dairy protein intake is associated with greater Bone Strength parameters at the distal radius and tibia in older men a cross sectional study
Osteoporosis International, 2018Co-Authors: Lisa Langsetmo, James M Shikany, Andrew J Burghardt, P M Cawthon, Eric S Orwoll, J A Cauley, Brent C Taylor, John T SchousboeAbstract:Summary Dairy protein but not plant protein was associated with Bone Strength of the radius and tibia in older men. These results are consistent with previous results in women and support similar findings related to fracture outcomes. Bone Strength differences were largely due to thickness and area of the Bone cortex.
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high dairy protein intake is associated with greater Bone Strength parameters at the distal radius and tibia in older men a cross sectional study
Osteoporosis International, 2018Co-Authors: Lisa Langsetmo, James M Shikany, Andrew J Burghardt, P M Cawthon, Eric S Orwoll, J A Cauley, Brent C Taylor, John T SchousboeAbstract:Dairy protein but not plant protein was associated with Bone Strength of the radius and tibia in older men. These results are consistent with previous results in women and support similar findings related to fracture outcomes. Bone Strength differences were largely due to thickness and area of the Bone cortex. Our objective was to determine the association of protein intake by source (dairy, non-dairy animal, plant) with Bone Strength and Bone microarchitecture among older men. We used data from 1016 men (mean 84.3 years) who attended the Year 14 exam of the Osteoporotic Fractures in Men (MrOS) study, completed a food frequency questionnaire (500–5000 kcal/day), were not taking androgen or androgen agonists, and had high-resolution peripheral quantitative computed tomography (HR-pQCT) scans of the distal radius and distal or diaphyseal tibia. Protein was expressed as percentage of total energy intake (TEI); mean ± SD for TEI = 1548 ± 607 kcal/day and for total protein = 16.2 ± 2.9%TEI. We used linear regression with standardized HR-pQCT parameters as dependent variables and adjusted for age, limb length, center, education, race/ethnicity, marital status, smoking, alcohol intake, physical activity level, corticosteroids use, supplement use (calcium and vitamin D), and osteoporosis medications. Higher dairy protein intake was associated with higher estimated failure load at the distal radius and distal tibia [radius effect size = 0.17 (95% CI 0.07, 0.27), tibia effect size = 0.13 (95% CI 0.03, 0.23)], while higher non-dairy animal protein was associated with higher failure load at only the distal radius. Plant protein intake was not associated with failure load at any site. The association between protein intake and Bone Strength varied by source of protein. These results support a link between dairy protein intake and skeletal health, but an intervention study is needed to evaluate causality.
J A Cauley - One of the best experts on this subject based on the ideXlab platform.
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weight loss in men in late life and Bone Strength and microarchitecture a prospective study
Osteoporosis International, 2018Co-Authors: Kristine E Ensrud, Andrew J Burghardt, Eric S Orwoll, J A Cauley, Brent C Taylor, John T Schousboe, Ne Lane, Andrew R Hoffman, Lisa LangsetmoAbstract:Weight loss in men in late life was associated with lower Bone Strength. In contrast, weight gain was not associated with a commensurate increase in Bone Strength. Future studies should measure concurrent changes in weight and parameters of Bone Strength and microarchitecture and evaluate potential causal pathways underlying these associations. Our aim was to determine associations of weight loss with Bone Strength and microarchitecture. We used data from 1723 community-dwelling men (mean age 84.5 years) who attended the MrOS study Year (Y) 14 exam and had high-resolution peripheral quantitative computed tomography (HR-pQCT) scans at ≥ 1 skeletal sites (distal tibia, distal radius, or diaphyseal tibia). Weight change from Y7 to Y14 exams (mean 7.3 years between exams) was classified as moderate weight loss (loss ≥ 10%), mild weight loss (loss 5 to < 10%), stable weight (< 5% change), or weight gain (gain ≥ 5%). Mean HR-pQCT parameters (95%CI) were calculated by weight change category using linear regression models adjusted for age, race, site, health status, body mass index, limb length, and physical activity. The primary outcome measure was estimated failure load. There was a nonlinear association of weight change with failure load at each skeletal site with different associations for weight loss vs. weight gain (p < 0.03). Failure load and total Bone mineral density (BMD) at distal sites were lower with greater weight loss with 7.0–7.6% lower failure loads and 4.3–5.8% lower BMDs among men with moderate weight loss compared to those with stable weight (p < 0.01, both comparisons). Cortical, but not trabecular, BMDs at distal sites were lower with greater weight loss. Greater weight loss was associated with lower cortical thickness at all three skeletal sites. Weight loss in men in late life is associated with lower peripheral Bone Strength and total BMD with global measures reflecting cortical but not trabecular parameters.
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high dairy protein intake is associated with greater Bone Strength parameters at the distal radius and tibia in older men a cross sectional study
Osteoporosis International, 2018Co-Authors: Lisa Langsetmo, James M Shikany, Andrew J Burghardt, P M Cawthon, Eric S Orwoll, J A Cauley, Brent C Taylor, John T SchousboeAbstract:Summary Dairy protein but not plant protein was associated with Bone Strength of the radius and tibia in older men. These results are consistent with previous results in women and support similar findings related to fracture outcomes. Bone Strength differences were largely due to thickness and area of the Bone cortex.
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high dairy protein intake is associated with greater Bone Strength parameters at the distal radius and tibia in older men a cross sectional study
Osteoporosis International, 2018Co-Authors: Lisa Langsetmo, James M Shikany, Andrew J Burghardt, P M Cawthon, Eric S Orwoll, J A Cauley, Brent C Taylor, John T SchousboeAbstract:Dairy protein but not plant protein was associated with Bone Strength of the radius and tibia in older men. These results are consistent with previous results in women and support similar findings related to fracture outcomes. Bone Strength differences were largely due to thickness and area of the Bone cortex. Our objective was to determine the association of protein intake by source (dairy, non-dairy animal, plant) with Bone Strength and Bone microarchitecture among older men. We used data from 1016 men (mean 84.3 years) who attended the Year 14 exam of the Osteoporotic Fractures in Men (MrOS) study, completed a food frequency questionnaire (500–5000 kcal/day), were not taking androgen or androgen agonists, and had high-resolution peripheral quantitative computed tomography (HR-pQCT) scans of the distal radius and distal or diaphyseal tibia. Protein was expressed as percentage of total energy intake (TEI); mean ± SD for TEI = 1548 ± 607 kcal/day and for total protein = 16.2 ± 2.9%TEI. We used linear regression with standardized HR-pQCT parameters as dependent variables and adjusted for age, limb length, center, education, race/ethnicity, marital status, smoking, alcohol intake, physical activity level, corticosteroids use, supplement use (calcium and vitamin D), and osteoporosis medications. Higher dairy protein intake was associated with higher estimated failure load at the distal radius and distal tibia [radius effect size = 0.17 (95% CI 0.07, 0.27), tibia effect size = 0.13 (95% CI 0.03, 0.23)], while higher non-dairy animal protein was associated with higher failure load at only the distal radius. Plant protein intake was not associated with failure load at any site. The association between protein intake and Bone Strength varied by source of protein. These results support a link between dairy protein intake and skeletal health, but an intervention study is needed to evaluate causality.
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Bone Strength measured by peripheral quantitative computed tomography and the risk of nonvertebral fractures the osteoporotic fractures in men mros study
Journal of Bone and Mineral Research, 2011Co-Authors: Yahtyng Sheu, Eric S Orwoll, Joseph M Zmuda, Robert M Boudreau, Moira A Petit, Kristine E Ensrud, Douglas C Bauer, Christopher L Gordon, J A CauleyAbstract:Many fractures occur in individuals without osteoporosis defined by areal Bone mineral density (aBMD). Inclusion of other aspects of skeletal Strength may be useful in identifying at-risk subjects. We used surrogate measures of Bone Strength at the radius and tibia measured by peripheral quantitative computed tomography (pQCT) to evaluate their relationships with nonvertebral fracture risk. Femoral neck (FN) aBMD, measured by dual-energy X-ray absorptiometry (DXA), also was included. The study population consisted of 1143 white men aged 69+ years with pQCT measures at the radius and tibia from the Minneapolis and Pittsburgh centers of the Osteoporotic Fractures in Men (MrOS) study. Principal-components analysis and Cox proportional-hazards modeling were used to identify 21 of 58 pQCT variables with a major contribution to nonvertebral incident fractures. After a mean 2.9 years of follow-up, 39 fractures occurred. Men without incident fractures had significantly greater Bone mineral content, cross-sectional area, and indices of Bone Strength than those with fractures by pQCT. Every SD decrease in the 18 of 21 pQCT parameters was significantly associated with increased fracture risk (hazard ration ranged from 1.4 to 2.2) independent of age, study site, body mass index (BMI), and FN aBMD. Using area under the receiver operation characteristics curve (AUC), the combination of FN aBMD and three radius Strength parameters individually increased fracture prediction over FN aBMD alone (AUC increased from 0.73 to 0.80). Peripheral Bone Strength measures are associated with fracture risk and may improve our ability to identify older men at high risk of fracture.
Eric S Orwoll - One of the best experts on this subject based on the ideXlab platform.
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weight loss in men in late life and Bone Strength and microarchitecture a prospective study
Osteoporosis International, 2018Co-Authors: Kristine E Ensrud, Andrew J Burghardt, Eric S Orwoll, J A Cauley, Brent C Taylor, John T Schousboe, Ne Lane, Andrew R Hoffman, Lisa LangsetmoAbstract:Weight loss in men in late life was associated with lower Bone Strength. In contrast, weight gain was not associated with a commensurate increase in Bone Strength. Future studies should measure concurrent changes in weight and parameters of Bone Strength and microarchitecture and evaluate potential causal pathways underlying these associations. Our aim was to determine associations of weight loss with Bone Strength and microarchitecture. We used data from 1723 community-dwelling men (mean age 84.5 years) who attended the MrOS study Year (Y) 14 exam and had high-resolution peripheral quantitative computed tomography (HR-pQCT) scans at ≥ 1 skeletal sites (distal tibia, distal radius, or diaphyseal tibia). Weight change from Y7 to Y14 exams (mean 7.3 years between exams) was classified as moderate weight loss (loss ≥ 10%), mild weight loss (loss 5 to < 10%), stable weight (< 5% change), or weight gain (gain ≥ 5%). Mean HR-pQCT parameters (95%CI) were calculated by weight change category using linear regression models adjusted for age, race, site, health status, body mass index, limb length, and physical activity. The primary outcome measure was estimated failure load. There was a nonlinear association of weight change with failure load at each skeletal site with different associations for weight loss vs. weight gain (p < 0.03). Failure load and total Bone mineral density (BMD) at distal sites were lower with greater weight loss with 7.0–7.6% lower failure loads and 4.3–5.8% lower BMDs among men with moderate weight loss compared to those with stable weight (p < 0.01, both comparisons). Cortical, but not trabecular, BMDs at distal sites were lower with greater weight loss. Greater weight loss was associated with lower cortical thickness at all three skeletal sites. Weight loss in men in late life is associated with lower peripheral Bone Strength and total BMD with global measures reflecting cortical but not trabecular parameters.
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high dairy protein intake is associated with greater Bone Strength parameters at the distal radius and tibia in older men a cross sectional study
Osteoporosis International, 2018Co-Authors: Lisa Langsetmo, James M Shikany, Andrew J Burghardt, P M Cawthon, Eric S Orwoll, J A Cauley, Brent C Taylor, John T SchousboeAbstract:Summary Dairy protein but not plant protein was associated with Bone Strength of the radius and tibia in older men. These results are consistent with previous results in women and support similar findings related to fracture outcomes. Bone Strength differences were largely due to thickness and area of the Bone cortex.
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high dairy protein intake is associated with greater Bone Strength parameters at the distal radius and tibia in older men a cross sectional study
Osteoporosis International, 2018Co-Authors: Lisa Langsetmo, James M Shikany, Andrew J Burghardt, P M Cawthon, Eric S Orwoll, J A Cauley, Brent C Taylor, John T SchousboeAbstract:Dairy protein but not plant protein was associated with Bone Strength of the radius and tibia in older men. These results are consistent with previous results in women and support similar findings related to fracture outcomes. Bone Strength differences were largely due to thickness and area of the Bone cortex. Our objective was to determine the association of protein intake by source (dairy, non-dairy animal, plant) with Bone Strength and Bone microarchitecture among older men. We used data from 1016 men (mean 84.3 years) who attended the Year 14 exam of the Osteoporotic Fractures in Men (MrOS) study, completed a food frequency questionnaire (500–5000 kcal/day), were not taking androgen or androgen agonists, and had high-resolution peripheral quantitative computed tomography (HR-pQCT) scans of the distal radius and distal or diaphyseal tibia. Protein was expressed as percentage of total energy intake (TEI); mean ± SD for TEI = 1548 ± 607 kcal/day and for total protein = 16.2 ± 2.9%TEI. We used linear regression with standardized HR-pQCT parameters as dependent variables and adjusted for age, limb length, center, education, race/ethnicity, marital status, smoking, alcohol intake, physical activity level, corticosteroids use, supplement use (calcium and vitamin D), and osteoporosis medications. Higher dairy protein intake was associated with higher estimated failure load at the distal radius and distal tibia [radius effect size = 0.17 (95% CI 0.07, 0.27), tibia effect size = 0.13 (95% CI 0.03, 0.23)], while higher non-dairy animal protein was associated with higher failure load at only the distal radius. Plant protein intake was not associated with failure load at any site. The association between protein intake and Bone Strength varied by source of protein. These results support a link between dairy protein intake and skeletal health, but an intervention study is needed to evaluate causality.
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Bone Strength measured by peripheral quantitative computed tomography and the risk of nonvertebral fractures the osteoporotic fractures in men mros study
Journal of Bone and Mineral Research, 2011Co-Authors: Yahtyng Sheu, Eric S Orwoll, Joseph M Zmuda, Robert M Boudreau, Moira A Petit, Kristine E Ensrud, Douglas C Bauer, Christopher L Gordon, J A CauleyAbstract:Many fractures occur in individuals without osteoporosis defined by areal Bone mineral density (aBMD). Inclusion of other aspects of skeletal Strength may be useful in identifying at-risk subjects. We used surrogate measures of Bone Strength at the radius and tibia measured by peripheral quantitative computed tomography (pQCT) to evaluate their relationships with nonvertebral fracture risk. Femoral neck (FN) aBMD, measured by dual-energy X-ray absorptiometry (DXA), also was included. The study population consisted of 1143 white men aged 69+ years with pQCT measures at the radius and tibia from the Minneapolis and Pittsburgh centers of the Osteoporotic Fractures in Men (MrOS) study. Principal-components analysis and Cox proportional-hazards modeling were used to identify 21 of 58 pQCT variables with a major contribution to nonvertebral incident fractures. After a mean 2.9 years of follow-up, 39 fractures occurred. Men without incident fractures had significantly greater Bone mineral content, cross-sectional area, and indices of Bone Strength than those with fractures by pQCT. Every SD decrease in the 18 of 21 pQCT parameters was significantly associated with increased fracture risk (hazard ration ranged from 1.4 to 2.2) independent of age, study site, body mass index (BMI), and FN aBMD. Using area under the receiver operation characteristics curve (AUC), the combination of FN aBMD and three radius Strength parameters individually increased fracture prediction over FN aBMD alone (AUC increased from 0.73 to 0.80). Peripheral Bone Strength measures are associated with fracture risk and may improve our ability to identify older men at high risk of fracture.
Lisa Langsetmo - One of the best experts on this subject based on the ideXlab platform.
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weight loss in men in late life and Bone Strength and microarchitecture a prospective study
Osteoporosis International, 2018Co-Authors: Kristine E Ensrud, Andrew J Burghardt, Eric S Orwoll, J A Cauley, Brent C Taylor, John T Schousboe, Ne Lane, Andrew R Hoffman, Lisa LangsetmoAbstract:Weight loss in men in late life was associated with lower Bone Strength. In contrast, weight gain was not associated with a commensurate increase in Bone Strength. Future studies should measure concurrent changes in weight and parameters of Bone Strength and microarchitecture and evaluate potential causal pathways underlying these associations. Our aim was to determine associations of weight loss with Bone Strength and microarchitecture. We used data from 1723 community-dwelling men (mean age 84.5 years) who attended the MrOS study Year (Y) 14 exam and had high-resolution peripheral quantitative computed tomography (HR-pQCT) scans at ≥ 1 skeletal sites (distal tibia, distal radius, or diaphyseal tibia). Weight change from Y7 to Y14 exams (mean 7.3 years between exams) was classified as moderate weight loss (loss ≥ 10%), mild weight loss (loss 5 to < 10%), stable weight (< 5% change), or weight gain (gain ≥ 5%). Mean HR-pQCT parameters (95%CI) were calculated by weight change category using linear regression models adjusted for age, race, site, health status, body mass index, limb length, and physical activity. The primary outcome measure was estimated failure load. There was a nonlinear association of weight change with failure load at each skeletal site with different associations for weight loss vs. weight gain (p < 0.03). Failure load and total Bone mineral density (BMD) at distal sites were lower with greater weight loss with 7.0–7.6% lower failure loads and 4.3–5.8% lower BMDs among men with moderate weight loss compared to those with stable weight (p < 0.01, both comparisons). Cortical, but not trabecular, BMDs at distal sites were lower with greater weight loss. Greater weight loss was associated with lower cortical thickness at all three skeletal sites. Weight loss in men in late life is associated with lower peripheral Bone Strength and total BMD with global measures reflecting cortical but not trabecular parameters.
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high dairy protein intake is associated with greater Bone Strength parameters at the distal radius and tibia in older men a cross sectional study
Osteoporosis International, 2018Co-Authors: Lisa Langsetmo, James M Shikany, Andrew J Burghardt, P M Cawthon, Eric S Orwoll, J A Cauley, Brent C Taylor, John T SchousboeAbstract:Summary Dairy protein but not plant protein was associated with Bone Strength of the radius and tibia in older men. These results are consistent with previous results in women and support similar findings related to fracture outcomes. Bone Strength differences were largely due to thickness and area of the Bone cortex.
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high dairy protein intake is associated with greater Bone Strength parameters at the distal radius and tibia in older men a cross sectional study
Osteoporosis International, 2018Co-Authors: Lisa Langsetmo, James M Shikany, Andrew J Burghardt, P M Cawthon, Eric S Orwoll, J A Cauley, Brent C Taylor, John T SchousboeAbstract:Dairy protein but not plant protein was associated with Bone Strength of the radius and tibia in older men. These results are consistent with previous results in women and support similar findings related to fracture outcomes. Bone Strength differences were largely due to thickness and area of the Bone cortex. Our objective was to determine the association of protein intake by source (dairy, non-dairy animal, plant) with Bone Strength and Bone microarchitecture among older men. We used data from 1016 men (mean 84.3 years) who attended the Year 14 exam of the Osteoporotic Fractures in Men (MrOS) study, completed a food frequency questionnaire (500–5000 kcal/day), were not taking androgen or androgen agonists, and had high-resolution peripheral quantitative computed tomography (HR-pQCT) scans of the distal radius and distal or diaphyseal tibia. Protein was expressed as percentage of total energy intake (TEI); mean ± SD for TEI = 1548 ± 607 kcal/day and for total protein = 16.2 ± 2.9%TEI. We used linear regression with standardized HR-pQCT parameters as dependent variables and adjusted for age, limb length, center, education, race/ethnicity, marital status, smoking, alcohol intake, physical activity level, corticosteroids use, supplement use (calcium and vitamin D), and osteoporosis medications. Higher dairy protein intake was associated with higher estimated failure load at the distal radius and distal tibia [radius effect size = 0.17 (95% CI 0.07, 0.27), tibia effect size = 0.13 (95% CI 0.03, 0.23)], while higher non-dairy animal protein was associated with higher failure load at only the distal radius. Plant protein intake was not associated with failure load at any site. The association between protein intake and Bone Strength varied by source of protein. These results support a link between dairy protein intake and skeletal health, but an intervention study is needed to evaluate causality.
P M Cawthon - One of the best experts on this subject based on the ideXlab platform.
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high dairy protein intake is associated with greater Bone Strength parameters at the distal radius and tibia in older men a cross sectional study
Osteoporosis International, 2018Co-Authors: Lisa Langsetmo, James M Shikany, Andrew J Burghardt, P M Cawthon, Eric S Orwoll, J A Cauley, Brent C Taylor, John T SchousboeAbstract:Summary Dairy protein but not plant protein was associated with Bone Strength of the radius and tibia in older men. These results are consistent with previous results in women and support similar findings related to fracture outcomes. Bone Strength differences were largely due to thickness and area of the Bone cortex.
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high dairy protein intake is associated with greater Bone Strength parameters at the distal radius and tibia in older men a cross sectional study
Osteoporosis International, 2018Co-Authors: Lisa Langsetmo, James M Shikany, Andrew J Burghardt, P M Cawthon, Eric S Orwoll, J A Cauley, Brent C Taylor, John T SchousboeAbstract:Dairy protein but not plant protein was associated with Bone Strength of the radius and tibia in older men. These results are consistent with previous results in women and support similar findings related to fracture outcomes. Bone Strength differences were largely due to thickness and area of the Bone cortex. Our objective was to determine the association of protein intake by source (dairy, non-dairy animal, plant) with Bone Strength and Bone microarchitecture among older men. We used data from 1016 men (mean 84.3 years) who attended the Year 14 exam of the Osteoporotic Fractures in Men (MrOS) study, completed a food frequency questionnaire (500–5000 kcal/day), were not taking androgen or androgen agonists, and had high-resolution peripheral quantitative computed tomography (HR-pQCT) scans of the distal radius and distal or diaphyseal tibia. Protein was expressed as percentage of total energy intake (TEI); mean ± SD for TEI = 1548 ± 607 kcal/day and for total protein = 16.2 ± 2.9%TEI. We used linear regression with standardized HR-pQCT parameters as dependent variables and adjusted for age, limb length, center, education, race/ethnicity, marital status, smoking, alcohol intake, physical activity level, corticosteroids use, supplement use (calcium and vitamin D), and osteoporosis medications. Higher dairy protein intake was associated with higher estimated failure load at the distal radius and distal tibia [radius effect size = 0.17 (95% CI 0.07, 0.27), tibia effect size = 0.13 (95% CI 0.03, 0.23)], while higher non-dairy animal protein was associated with higher failure load at only the distal radius. Plant protein intake was not associated with failure load at any site. The association between protein intake and Bone Strength varied by source of protein. These results support a link between dairy protein intake and skeletal health, but an intervention study is needed to evaluate causality.