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John J B Allen - One of the best experts on this subject based on the ideXlab platform.
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Prefrontal Brain Asymmetry and pre-menstrual dysphoric disorder symptomatology.
Journal of affective disorders, 2010Co-Authors: Eynav E Accortt, Jennifer L Stewart, James A Coan, Rachel Manber, John J B AllenAbstract:Pre-menstrual dysphoric disorder (PMDD), a dysphoric form of pre-menstrual syndrome, is included as a diagnosis for further study in the DSM-IV-TR (APA, 2000). The present study investigated whether a marker of risk for major depressive disorder (MDD), prefrontal Brain Asymmetry, also characterizes women with PMDD. In a sample of 25 college women with PMDD symptomatology and 25 matched controls, resting frontal electroencephalographic (EEG) activity was assessed on four occasions within a two-week span. Across several frontal sites women with PMDD had relatively less left than right prefrontal Brain activity, consistent with a diathesis-stress model for menstrual-related dysphoria. The findings suggest an overlap in the risk profile for MDD and PMDD. Published by Elsevier B.V.
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Prefrontal Brain Asymmetry and pre-menstrual dysphoric disorder symptomatology
Journal of Affective Disorders, 2010Co-Authors: Eynav E Accortt, Jennifer L Stewart, James A Coan, Rachel Manber, John J B AllenAbstract:Abstract Background Pre-menstrual dysphoric disorder (PMDD), a dysphoric form of pre-menstrual syndrome, is included as a diagnosis for further study in the DSM-IV-TR (APA, 2000). The present study investigated whether a marker of risk for major depressive disorder (MDD), prefrontal Brain Asymmetry, also characterizes women with PMDD. Methods In a sample of 25 college women with PMDD symptomatology and 25 matched controls, resting frontal electroencephalographic (EEG) activity was assessed on four occasions within a two-week span. Results Across several frontal sites women with PMDD had relatively less left than right prefrontal Brain activity, consistent with a diathesis-stress model for menstrual-related dysphoria. Conclusions The findings suggest an overlap in the risk profile for MDD and PMDD.
Eynav E Accortt - One of the best experts on this subject based on the ideXlab platform.
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Prefrontal Brain Asymmetry and pre-menstrual dysphoric disorder symptomatology.
Journal of affective disorders, 2010Co-Authors: Eynav E Accortt, Jennifer L Stewart, James A Coan, Rachel Manber, John J B AllenAbstract:Pre-menstrual dysphoric disorder (PMDD), a dysphoric form of pre-menstrual syndrome, is included as a diagnosis for further study in the DSM-IV-TR (APA, 2000). The present study investigated whether a marker of risk for major depressive disorder (MDD), prefrontal Brain Asymmetry, also characterizes women with PMDD. In a sample of 25 college women with PMDD symptomatology and 25 matched controls, resting frontal electroencephalographic (EEG) activity was assessed on four occasions within a two-week span. Across several frontal sites women with PMDD had relatively less left than right prefrontal Brain activity, consistent with a diathesis-stress model for menstrual-related dysphoria. The findings suggest an overlap in the risk profile for MDD and PMDD. Published by Elsevier B.V.
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Prefrontal Brain Asymmetry and pre-menstrual dysphoric disorder symptomatology
Journal of Affective Disorders, 2010Co-Authors: Eynav E Accortt, Jennifer L Stewart, James A Coan, Rachel Manber, John J B AllenAbstract:Abstract Background Pre-menstrual dysphoric disorder (PMDD), a dysphoric form of pre-menstrual syndrome, is included as a diagnosis for further study in the DSM-IV-TR (APA, 2000). The present study investigated whether a marker of risk for major depressive disorder (MDD), prefrontal Brain Asymmetry, also characterizes women with PMDD. Methods In a sample of 25 college women with PMDD symptomatology and 25 matched controls, resting frontal electroencephalographic (EEG) activity was assessed on four occasions within a two-week span. Results Across several frontal sites women with PMDD had relatively less left than right prefrontal Brain activity, consistent with a diathesis-stress model for menstrual-related dysphoria. Conclusions The findings suggest an overlap in the risk profile for MDD and PMDD.
James A Coan - One of the best experts on this subject based on the ideXlab platform.
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cognitive vulnerability and frontal Brain Asymmetry common predictors of first prospective depressive episode
Journal of Abnormal Psychology, 2011Co-Authors: Robin Nusslock, James A Coan, Alexander J Shackman, Eddie Harmonjones, Lauren B Alloy, Lyn Y AbramsonAbstract:The hopelessness theory of depression proposes that individuals with a depressogenic cognitive style are more likely to become hopeless and experience depression following negative life events. Although the neurophysiological underpinnings of cognitive style remain speculative, research indicates that decreased relative left frontal Brain electrical activity holds promise as a traitlike marker of depression. This begs the question: Do measures of depressogenic cognitive style and resting frontal Brain Asymmetry index a common vulnerability? The present study provides preliminary support for this hypothesis. At baseline assessment, increased cognitive vulnerability to depression was associated with decreased relative left frontal Brain activity at rest in individuals with no prior history of, or current, depression. Following baseline assessment, participants were followed prospectively an average of 3 years with structured diagnostic interviews at 4-month intervals. Both cognitive vulnerability and asymmetric frontal cortical activity prospectively predicted onset of first depressive episode in separate univariate analyses. Furthermore, multivariate analyses indicated that cognitive vulnerability and frontal Asymmetry represented shared, rather than independent, predictors of first depression onset.
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Prefrontal Brain Asymmetry and pre-menstrual dysphoric disorder symptomatology.
Journal of affective disorders, 2010Co-Authors: Eynav E Accortt, Jennifer L Stewart, James A Coan, Rachel Manber, John J B AllenAbstract:Pre-menstrual dysphoric disorder (PMDD), a dysphoric form of pre-menstrual syndrome, is included as a diagnosis for further study in the DSM-IV-TR (APA, 2000). The present study investigated whether a marker of risk for major depressive disorder (MDD), prefrontal Brain Asymmetry, also characterizes women with PMDD. In a sample of 25 college women with PMDD symptomatology and 25 matched controls, resting frontal electroencephalographic (EEG) activity was assessed on four occasions within a two-week span. Across several frontal sites women with PMDD had relatively less left than right prefrontal Brain activity, consistent with a diathesis-stress model for menstrual-related dysphoria. The findings suggest an overlap in the risk profile for MDD and PMDD. Published by Elsevier B.V.
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Prefrontal Brain Asymmetry and pre-menstrual dysphoric disorder symptomatology
Journal of Affective Disorders, 2010Co-Authors: Eynav E Accortt, Jennifer L Stewart, James A Coan, Rachel Manber, John J B AllenAbstract:Abstract Background Pre-menstrual dysphoric disorder (PMDD), a dysphoric form of pre-menstrual syndrome, is included as a diagnosis for further study in the DSM-IV-TR (APA, 2000). The present study investigated whether a marker of risk for major depressive disorder (MDD), prefrontal Brain Asymmetry, also characterizes women with PMDD. Methods In a sample of 25 college women with PMDD symptomatology and 25 matched controls, resting frontal electroencephalographic (EEG) activity was assessed on four occasions within a two-week span. Results Across several frontal sites women with PMDD had relatively less left than right prefrontal Brain activity, consistent with a diathesis-stress model for menstrual-related dysphoria. Conclusions The findings suggest an overlap in the risk profile for MDD and PMDD.
Yaron Zalel - One of the best experts on this subject based on the ideXlab platform.
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Fetal Brain Asymmetry: in utero sonographic study of normal fetuses.
American journal of obstetrics and gynecology, 2010Co-Authors: Zvi Kivilevitch, Reuven Achiron, Yaron ZalelAbstract:The objective of the study was to evaluate the magnitude of normal fetal Brain Asymmetry. This was a prospective study. Normal fetuses between 19-28 weeks of gestation were studied. The cerebral atria, occipital cortex, and hemispheres in both sides were measured. The difference between each side was evaluated and was correlated with sex, head biometry, and estimated weight. Four hundred six fetuses were studied. Mean atrial width was larger in the males and on the left side (5.2% and 6.5%, respectively). Mean cortical width was 2.6% larger in males but 5.5% thinner on the left side. Mean hemisphere width was larger in males and on the left side (2.3% and 1.5%, respectively). The atria and the cortex presented an inverse relationship regarding fetal growth parameters. Brain Asymmetry represents normal fetal Brain developmental phenomena. It is sex dependent and lateralized in most cases to the left. Lateralization was more accentuated in males. Copyright 2010 Mosby, Inc. All rights reserved.
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Fetal Brain Asymmetry: in utero sonographic study of normal fetuses.
American Journal of Obstetrics and Gynecology, 2010Co-Authors: Zvi Kivilevitch, Reuven Achiron, Yaron ZalelAbstract:Objective The objective of the study was to evaluate the magnitude of normal fetal Brain Asymmetry. Study Design This was a prospective study. Normal fetuses between 19–28 weeks of gestation were studied. The cerebral atria, occipital cortex, and hemispheres in both sides were measured. The difference between each side was evaluated and was correlated with sex, head biometry, and estimated weight. Results Four hundred six fetuses were studied. Mean atrial width was larger in the males and on the left side (5.2% and 6.5%, respectively). Mean cortical width was 2.6% larger in males but 5.5% thinner on the left side. Mean hemisphere width was larger in males and on the left side (2.3% and 1.5%, respectively). The atria and the cortex presented an inverse relationship regarding fetal growth parameters. Conclusion Brain Asymmetry represents normal fetal Brain developmental phenomena. It is sex dependent and lateralized in most cases to the left. Lateralization was more accentuated in males.
Eileen Daly - One of the best experts on this subject based on the ideXlab platform.
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Altered structural Brain Asymmetry in autism spectrum disorder in a study of 54 datasets
Nature Communications, 2019Co-Authors: Merel C Postema, Daan Van Rooij, Evdokia Anagnostou, Celso Arango, Guillaume Auzias, Marlene Behrmann, Geraldo Busatto Filho, Sara Calderoni, R M Calvo, Eileen DalyAbstract:Altered structural Brain Asymmetry in autism spectrum disorder (ASD) has been reported. However, findings have been inconsistent, likely due to limited sample sizes. Here we investigated 1,774 individuals with ASD and 1,809 controls, from 54 independent data sets of the ENIGMA consortium. ASD was significantly associated with alterations of cortical thickness Asymmetry in mostly medial frontal, orbitofrontal, cingulate and inferior temporal areas, and also with Asymmetry of orbitofrontal surface area. These differences generally involved reduced Asymmetry in individuals with ASD compared to controls. Furthermore, putamen volume Asymmetry was significantly increased in ASD. The largest case-control effect size was Cohen’s d = −0.13, for Asymmetry of superior frontal cortical thickness. Most effects did not depend on age, sex, IQ, severity or medication use. Altered lateralized neurodevelopment may therefore be a feature of ASD, affecting widespread Brain regions with diverse functions. Large-scale analysis was necessary to quantify subtle alterations of Brain structural Asymmetry in ASD.Changes in Brain structure Asymmetry have been reported in autism spectrum disorder. Here the authors investigate this issue using a large-scale sample consisting of 54 data sets.
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Altered structural Brain Asymmetry in autism spectrum disorder in a study of 54 datasets
Nature communications, 2019Co-Authors: Merel C Postema, Evdokia Anagnostou, Celso Arango, Guillaume Auzias, Marlene Behrmann, Geraldo Busatto Filho, Sara Calderoni, Daan Van Rooij, Rosa Calvo, Eileen DalyAbstract:Altered structural Brain Asymmetry in autism spectrum disorder (ASD) has been reported. However, findings have been inconsistent, likely due to limited sample sizes. Here we investigated 1,774 individuals with ASD and 1,809 controls, from 54 independent data sets of the ENIGMA consortium. ASD was significantly associated with alterations of cortical thickness Asymmetry in mostly medial frontal, orbitofrontal, cingulate and inferior temporal areas, and also with Asymmetry of orbitofrontal surface area. These differences generally involved reduced Asymmetry in individuals with ASD compared to controls. Furthermore, putamen volume Asymmetry was significantly increased in ASD. The largest case-control effect size was Cohen’s d = −0.13, for Asymmetry of superior frontal cortical thickness. Most effects did not depend on age, sex, IQ, severity or medication use. Altered lateralized neurodevelopment may therefore be a feature of ASD, affecting widespread Brain regions with diverse functions. Large-scale analysis was necessary to quantify subtle alterations of Brain structural Asymmetry in ASD.
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altered structural Brain Asymmetry in autism spectrum disorder large scale analysis via the enigma consortium
bioRxiv, 2019Co-Authors: Merel C Postema, Daan Van Rooij, Evdokia Anagnostou, Celso Arango, Guillaume Auzias, Marlene Behrmann, Geraldo Busatto Filho, Sara Calderoni, Rossa Calvo, Eileen DalyAbstract:Abstract Background Left-right Asymmetry is an important organizing feature of the healthy Brain. Various studies have reported altered structural Brain Asymmetry in autism spectrum disorder (ASD). However, findings have been inconsistent, likely due to limited sample sizes and low statistical power. Methods We investigated 1,774 subjects with ASD and 1,809 controls, from 54 datasets, for differences in the Asymmetry of thickness and surface area of 34 cerebral cortical regions. We also examined global hemispheric measures of cortical thickness and area Asymmetry, and volumetric asymmetries of subcortical structures. Data were obtained via the ASD Working Group of the ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) consortium. T1-weighted MRI data were processed with a single protocol using FreeSurfer and the Desikan-Killiany atlas. Results ASD was significantly associated with reduced leftward Asymmetry of total hemispheric average cortical thickness, compared to controls. Eight regional thickness asymmetries, distributed over the cortex, also showed significant associations with diagnosis after correction for multiple comparisons, for which Asymmetry was again generally lower in ASD versus controls. In addition, the medial orbitofrontal surface area was less rightward asymmetric in ASD than controls, and the putamen volume was more leftward asymmetric in ASD than controls. The largest effect size had Cohen’s d = 0.15. Most effects did not depend on age, sex, IQ, or disorder severity. Conclusion Altered lateralized neurodevelopment is suggested in ASD, affecting widespread cortical regions with diverse functions. Large-scale analysis was necessary to reliably detect, and accurately describe, subtle alterations of structural Brain Asymmetry in this disorder.
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The influence of sex chromosome aneuploidy on Brain Asymmetry.
American Journal of Medical Genetics, 2008Co-Authors: Roozbeh Rezaie, William J Cutter, Declan G M Murphy, Dene M W Robertson, Lynn E Delisi, Clare E Mackay, Thomas R Barrick, Timothy J Crow, Eileen Daly, Neil RobertsAbstract:The cognitive deficits present in individuals with sex chromosome aneuploidies suggest that hemispheric differentiation of function is determined by an X–Y homologous gene [Crow (1993); Lancet 342:594–598]. In particular, females with Turner's syndrome (TS) who have only one X-chromosome exhibit deficits of spatial ability whereas males with Klinefelter's syndrome (KS) who possess a supernumerary X-chromosome are delayed in acquiring words. Since spatial and verbal abilities are generally associated with right and left hemispheric function, such deficits may relate to anomalies of cerebral Asymmetry. We therefore applied a novel image analysis technique to investigate the relationship between sex chromosome dosage and structural Brain Asymmetry. Specifically, we tested Crow's prediction that the magnitude of the Brain torque (i.e., a combination of rightward frontal and leftward occipital Asymmetry) would, as a function of sex chromosome dosage, be respectively decreased in TS women and increased in KS men, relative to genotypically normal controls. We found that Brain torque was not significantly different in TS women and KS men, in comparison to controls. However, TS women exhibited significantly increased leftward Brain Asymmetry, restricted to the posterior of the Brain and focused on the superior temporal and parietal–occipital association cortex, while KS men showed a trend for decreased Brain Asymmetry throughout the frontal lobes. The findings suggest that the number of sex chromosomes influences the development of Brain Asymmetry not simply to modify the torque but in a complex pattern along the antero-posterior axis. © 2008 Wiley-Liss, Inc.