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Brain Radiation

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Naokatsu Saeki – 1st expert on this subject based on the ideXlab platform

  • Gamma knife surgery for 1–10 Brain metastases without prophylactic whole-Brain Radiation therapy: analysis of cases meeting the Japanese prospective multi-institute study (JLGK0901) inclusion criteria
    Journal of Neuro-Oncology, 2010
    Co-Authors: Toru Serizawa, Yoshinori Higuchi, Shinji Matsuda, Osamu Nagano, Tatsuo Hirai, Naokatsu Saeki

    Abstract:

    We evaluated the results of stereotactic radiosurgery (SRS) alone using gamma knife (GK) for selected patients with 1–10 Brain metastases without prophylactic whole-Brain Radiation therapy (WBRT) among JLGK0901-eligible cases. Seven hundred seventy-eight consecutive cases meeting the following JLGK0901 study inclusion criteria were analyzed: (1) newly diagnosed Brain metastases, (2) 1–10 Brain lesions, (3) less than 10 cm^3 volume of the largest tumor, (4) less than 15 cm^3 total tumor volume, (5) no magnetic resonance (MR) findings of cerebrospinal fluid (CSF) dissemination, and (6) no impaired activity of daily living [

  • Gamma Knife® Radiosurgery Alone for One to Four Brain Metastases. Is Prophylactic Whole-Brain Radiation Therapy Really Necessary?
    Radiosurgery, 2010
    Co-Authors: Toru Serizawa, Yoshinori Higuchi, Shinji Matsuda, Osamu Nagano, Naokatsu Saeki

    Abstract:

    Objective: We evaluated the effectiveness of stereotactic radiosurgery alone for patients with 1–4 Brain metastases without prophylactic whole-Brain Radiation therapy (WBRT).

  • Gamma Knife Surgery for Metastatic Brain Tumors from Lung Cancer without Prophylactic Whole Brain Radiation Therapy
    Radiosurgery, 2006
    Co-Authors: Toru Serizawa, Yoshinori Higuchi, Shinji Matsuda, Toshihiko Iuchi, Osamu Nagano, Naokatsu Saeki

    Abstract:

    Objective: We retrospectively analyzed the effectiveness of Gamma Knife surgery
    (GKS) for metastatic Brain tumors from lung cancer without prophylactic whole Brain Radiation
    therapy. Methods: Six hu

Helen A. Shih – 2nd expert on this subject based on the ideXlab platform

  • Early experience with hippocampal avoidance whole Brain Radiation therapy and simultaneous integrated boost for Brain metastases
    Journal of Neuro-Oncology, 2020
    Co-Authors: Emily S. Lebow, William L. Hwang, Stephen Zieminski, Yi Wang, Andrzej Niemierko, William A. Mehan, Kevin S. Oh, Melin Khandekar, Henning Willers, Helen A. Shih

    Abstract:

    Purpose Cranial irRadiation results in cognitive decline, which is hypothesized to be partially attributable to hippocampal injury and stem cell loss. Recent advances allow for targeted reduction of Radiation dose to the hippocampi while maintaining adequate dose coverage to the Brain parenchyma and additional increasing dose to Brain metastases, a approach called hippocampal avoidance whole Brain Radiation therapy with a simultaneous integrated boost (HA-WBRT + SIB.) We review our early clinical experience with HA-WBRT + SIB. Materials and methods We evaluated treatments and clinical outcomes for patients treated with HA-WBRT + SIB between 2014 and 2018. Results A total of 32 patients (median age, 63.5 years, range 45.3–78.8 years) completed HA-WBRT + SIB. Median follow-up for patients alive at the time of analysis was 11.3 months. The most common histology was non-small cell lung cancer (n = 22). Most patients (n = 25) were prescribed with WBRT dose of 30 Gy with SIB to 37.5 Gy in 15 fractions. Volumetric modulated arc therapy reduced treatment time (p 

  • early experience with hippocampal avoidance whole Brain Radiation therapy and simultaneous integrated boost for Brain metastases
    Journal of Neuro-oncology, 2020
    Co-Authors: Emily S. Lebow, William L. Hwang, Stephen Zieminski, Yi Wang, Andrzej Niemierko, William A. Mehan, Kevin S. Oh, Melin Khandekar, Henning Willers, Helen A. Shih

    Abstract:

    PURPOSE: Cranial irRadiation results in cognitive decline, which is hypothesized to be partially attributable to hippocampal injury and stem cell loss. Recent advances allow for targeted reduction of Radiation dose to the hippocampi while maintaining adequate dose coverage to the Brain parenchyma and additional increasing dose to Brain metastases, a approach called hippocampal avoidance whole Brain Radiation therapy with a simultaneous integrated boost (HA-WBRT + SIB.) We review our early clinical experience with HA-WBRT + SIB. MATERIALS AND METHODS: We evaluated treatments and clinical outcomes for patients treated with HA-WBRT + SIB between 2014 and 2018. RESULTS: A total of 32 patients (median age, 63.5 years, range 45.3-78.8 years) completed HA-WBRT + SIB. Median follow-up for patients alive at the time of analysis was 11.3 months. The most common histology was non-small cell lung cancer (n = 22). Most patients (n = 25) were prescribed with WBRT dose of 30 Gy with SIB to 37.5 Gy in 15 fractions. Volumetric modulated arc therapy reduced treatment time (p < 0.0001). Median freedom from intracranial progression and overall survival from completion of treatment were 11.4 months and 19.6 months, respectively. Karnofsky Performance Status was associated with improved survival (p = 0.008). The most common toxicities were alopecia, fatigue, and nausea. Five patients developed cognitive impairment, including grade 1 (n = 3), grade 2 (n = 1), and grade 3 (n = 1). CONCLUSION: HA-WBRT + SIB demonstrated durable intracranial disease control with modest side effects and merits further investigation as a means of WBRT toxicity reduction while improving long-term locoregional control in the Brain.

  • NTCT-03CEREBRAL MICROBLEEDS AFTER WHOLE Brain Radiation THERAPY IN MEDULLOBLASTOMA PATIENTS
    Neuro-oncology, 2015
    Co-Authors: Duangnapa Roongpiboonsopit, Helen A. Shih, Lily L. Alstein, Hugo J. Kuijf, Andreas Charidimou, Li Xiong, Anastasia Vashkevich, Sergi Martinez-ramirez, Anand Viswanathan, Jorg Dietrich

    Abstract:

    BACKGROUND: Radiation therapy is part of the standard treatment for medulloblastoma patients. The pattern and incidence of neurovascular toxicities, such as cerebral microbleeds (CMBs) following whole Brain Radiation therapy (WBRT) is poorly characterized in long-term survivors. The aim of this study is to determine the temporal and spatial pattern of CMBs after WBRT in medulloblastoma patients. METHODS: We retrospectively identified medulloblastoma patients treated with WBRT at the Massachusetts General Hospital between 1999 and 2014. Longitudinal magnetic resonance imaging data was reviewed, and the incidence, prevalence and spatial pattern of CMBs were characterized over time. RESULTS: We identified 27 patients previously treated with WBRT for medulloblastoma and who had complete longitudinal imaging datasets available for review, including GRE, T1 and T2 imaging sequences. CMBs were found in >65% (18/27) of patients when followed for a median time of at least 4 years. Incidence of CMBs was increasing with each year from time of WBRT, and was more likely in patients treated at age of

Toru Serizawa – 3rd expert on this subject based on the ideXlab platform

  • Gamma knife surgery for 1–10 Brain metastases without prophylactic whole-Brain Radiation therapy: analysis of cases meeting the Japanese prospective multi-institute study (JLGK0901) inclusion criteria
    Journal of Neuro-Oncology, 2010
    Co-Authors: Toru Serizawa, Yoshinori Higuchi, Shinji Matsuda, Osamu Nagano, Tatsuo Hirai, Naokatsu Saeki

    Abstract:

    We evaluated the results of stereotactic radiosurgery (SRS) alone using gamma knife (GK) for selected patients with 1–10 Brain metastases without prophylactic whole-Brain Radiation therapy (WBRT) among JLGK0901-eligible cases. Seven hundred seventy-eight consecutive cases meeting the following JLGK0901 study inclusion criteria were analyzed: (1) newly diagnosed Brain metastases, (2) 1–10 Brain lesions, (3) less than 10 cm^3 volume of the largest tumor, (4) less than 15 cm^3 total tumor volume, (5) no magnetic resonance (MR) findings of cerebrospinal fluid (CSF) dissemination, and (6) no impaired activity of daily living [

  • Gamma Knife® Radiosurgery Alone for One to Four Brain Metastases. Is Prophylactic Whole-Brain Radiation Therapy Really Necessary?
    Radiosurgery, 2010
    Co-Authors: Toru Serizawa, Yoshinori Higuchi, Shinji Matsuda, Osamu Nagano, Naokatsu Saeki

    Abstract:

    Objective: We evaluated the effectiveness of stereotactic radiosurgery alone for patients with 1–4 Brain metastases without prophylactic whole-Brain Radiation therapy (WBRT).

  • Gamma Knife Surgery for Metastatic Brain Tumors from Lung Cancer without Prophylactic Whole Brain Radiation Therapy
    Radiosurgery, 2006
    Co-Authors: Toru Serizawa, Yoshinori Higuchi, Shinji Matsuda, Toshihiko Iuchi, Osamu Nagano, Naokatsu Saeki

    Abstract:

    Objective: We retrospectively analyzed the effectiveness of Gamma Knife surgery
    (GKS) for metastatic Brain tumors from lung cancer without prophylactic whole Brain Radiation
    therapy. Methods: Six hu