Brucella canis

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Zeliang Chen - One of the best experts on this subject based on the ideXlab platform.

H I J Roest - One of the best experts on this subject based on the ideXlab platform.

  • transboundary spread of Brucella canis through import of infected dogs the netherlands november 2016 december 2018
    Emerging Infectious Diseases, 2021
    Co-Authors: Marloes A M Van Dijk, M Y Engelsma, Vanessa X N Visser, Ingrid Keur, Marjolijn E Holtslag, Nicole Willems, Bjorn P Meij, Peter Willemsen, Jaap A Wagenaar, H I J Roest
    Abstract:

    Brucella canis had not been isolated in the Netherlands until November 2016, when it was isolated from a dog imported from Romania. Including this case, 16 suspected cases were notified to the authorities during the following 25 months. Of these 16 dogs, 10 were seropositive; tracking investigations found another 8 seropositive littermates. All seropositive animals were rescue dogs imported from Eastern Europe. B. canis was cultured from urine, blood, and other specimens collected from the dogs. Genotyping of isolates revealed clustering by litter and country. Isolating B. canis in urine indicates that shedding should be considered when assessing the risk for zoonotic transmission. This case series proves introduction of B. canis into a country to which it is not endemic through import of infected dogs from B. canis-endemic areas, posing a threat to the naive autochthonous dog population and humans.

  • Transboundary Spread of Brucella canis through Import of Infected Dogs, the Netherlands, November 2016–December 2018
    'Centers for Disease Control and Prevention (CDC)', 2021
    Co-Authors: Marloes A M Van Dijk, M Y Engelsma, Vanessa X N Visser, Ingrid Keur, Marjolijn E Holtslag, Nicole Willems, Bjorn P Meij, Jaap A Wagenaar, Peter T.j. Willemsen, H I J Roest
    Abstract:

    Brucella canis had not been isolated in the Netherlands until November 2016, when it was isolated from a dog imported from Romania. Including this case, 16 suspected cases were notified to the authorities during the following 25 months. Of these 16 dogs, 10 were seropositive; tracking investigations found another 8 seropositive littermates. All seropositive animals were rescue dogs imported from Eastern Europe. B. canis was cultured from urine, blood, and other specimens collected from the dogs. Genotyping of isolates revealed clustering by litter and country. Isolating B. canis in urine indicates that shedding should be considered when assessing the risk for zoonotic transmission. This case series proves introduction of B. canis into a country to which it is not endemic through import of infected dogs from B. canis–endemic areas, posing a threat to the naive autochthonous dog population and humans

Liuyu Huang - One of the best experts on this subject based on the ideXlab platform.

  • Complete Genome Sequence of Brucella canis Strain 118, a Strain Isolated from Canine
    2016
    Co-Authors: Liuyu Huang, Dali C Wang, Zeliang B Chen, Xingran Xua
    Abstract:

    Brucella canis infects several species of animals, and canine is the preferred host. Genome sequences of strains from different hosts are valuable for comparative analysis of host adaptation andmicroevolution. Here, we report the genome sequence of Bru-cella canis strain 118, a strain isolated from canine. Brucellosis is an important infectious zoonosis epidemic in manycountries. Brucella is the etiological pathogen of brucellosis (8). According to host preferences, Brucella is divided into six classical species, four ofwhich are pathogenic for humans.Brucella canis is the causative agent of canine brucellosis, which causes contagious abor-tion, orchiepididymitis, and uveitis (6, 7). Dogs infectedwithB. canis appear to be relatively healthy, but persistent bacteremia without fe-ver or symptoms is common (7). Symptomatic human infections are rarely reported because of the low virulence of B. canis (9). Different from other Brucella species that are highly pathogenic for humans andyield smoothcolonies,B. caniscolonies arenaturally rough,mak-ingdiagnosis ofB. canisbrucellosis difficult. Pathogenic bacteria have the capability to adapt to different environments and hosts throug

  • complete genome sequence of Brucella canis strain 118 a strain isolated from canine
    Journal of Bacteriology, 2012
    Co-Authors: Guangjun Gao, Liuyu Huang, Zhengfang Zhang, Liping Wang, Xitong Yuan, Yufei Wang, Dali Wang, Zeliang Chen
    Abstract:

    Brucella canis infects several species of animals, and canine is the preferred host. Genome sequences of strains from different hosts are valuable for comparative analysis of host adaptation and microevolution. Here, we report the genome sequence of Brucella canis strain 118, a strain isolated from canine.

  • complete genome sequence of Brucella canis bcb018 a strain isolated from a human patient
    Journal of Bacteriology, 2012
    Co-Authors: Yufei Wang, Liuyu Huang, Xitong Yuan, Dali Wang, Qing Zhen, Yefeng Qiu, Zhoujia Wang, Zeliang Chen
    Abstract:

    Brucella canis is considered a rare cause of human brucellosis because of difficulties in presumptive diagnosis and underestimation of the incidence. Here, we report the draft genome sequence of a Brucella canis isolate, BCB018, isolated from a human patient, providing precious resources for comparative genomics analysis of Brucella field strains.

Jiyeon Kim - One of the best experts on this subject based on the ideXlab platform.

  • Complete Genome Sequence of Brucella canis Strain HSK A52141, Isolated from the Blood of an Infected Dog
    Journal of bacteriology, 2012
    Co-Authors: Jong-so Kim, Jong Wan Kim, Wooseog Jeong, Hye-young Jeoung, Jae-young Song, Hyungtae Kim, Jeong-hun Beak, Vinuselvi Parisutham, Sung Kuk Lee, Jiyeon Kim
    Abstract:

    ABSTRACT Brucella canis infection can be clinically inapparent in dogs, and when infection goes unnoticed, there is a chance for dog-to-human transmission. A new strain of B. canis was isolated from the blood of an infected dog in order to analyze the pathogenic mechanism, compare genetic properties, and develop new genetic tools for early diagnosis of canine brucellosis. Herein, we report the complete genome sequence of the strain B. canis HSK A52141. This is the second complete genome sequence and biological annotation available for a member of B. canis.

Nidia E Lucero - One of the best experts on this subject based on the ideXlab platform.

  • recent trends in human Brucella canis infection
    Comparative Immunology Microbiology and Infectious Diseases, 2013
    Co-Authors: Sandra Marzetti, Gabriela I Escobar, Cristina Carranza, Mariela Roncallo, Nidia E Lucero
    Abstract:

    There is little information in the literature regarding the clinical progress of brucellosis in patients affected by other diseases. We report Brucella canis human infection link to Gaucher's disease and Guillain Barre syndrome and discuss complications observed in a case with infective endocarditis. The three cases described came from areas of socio-economic deprivation and scarce epidemiological information where the healthcare personnel did not even consider such diagnosis. The growth of large urban populations deprived from basic services has created a new set of global health challenges. Changes in the urban environment due to slum communities’ expansion have resulted in increased dog populations in the peridomiciliary environment. Eleven laboratory employees working with the strains found and their identification were examined. Sanitary authorities should focus on the zoonotic aspect of B. canis considering the dramatic increase of canine roamers near urban centers.

  • Brucella canis causing infection in an hiv infected patient
    Vector-borne and Zoonotic Diseases, 2010
    Co-Authors: Nidia E Lucero, Gabriela I Escobar, Patricia Maldonado, Sara Kaufman, Eduardo Boeri, Nestor R Jacob
    Abstract:

    From the blood culture of an HIV-positive patient with a febrile syndrome (CD4 count 385 cells/microL and viral load nondetectable), Brucella canis was isolated. The patient was presumptively infected from his dogs, which tested positive, and showed good outcome after the therapy with doxycycline-ciprofloxacin, and the HIV infection would seem not to have been influenced by brucellosis. To our knowledge, no other case of B. canis in the setting of HIV infection has been reported in the literature, and the emerging zoonotic potential of the disease in urban areas should be considered.

  • human Brucella canis outbreak linked to infection in dogs
    Epidemiology and Infection, 2010
    Co-Authors: Nidia E Lucero, Gabriela I Escobar, Eduardo Boeri, R Corazza, Marisa Almuzara, E Reynes, Sandra M Ayala
    Abstract:

    SUMMARY The zoonotic risk of Brucella canis has been considered fairly high for persons who handle breeding dogs in kennels or are exposed to infected animals. Transmission to humans in other circumstances has been thought to be rare. We describe an uncommon outbreak of brucellosis caused by B. canis which, to the best of our knowledge, is the first reported in the literature. This outbreak involved six persons (three children and three adults), a bitch and three puppies which had close daily contact with the family. The clinical symptoms of the index case led to an erroneous diagnosis and the infection would have gone undiagnosed if culture had not been positive. This report aims to increase awareness of medical personnel of the need to order screening tests for children, immunodeficient persons or pregnant women presenting with fever of unknown origin, unexplained spleen or liver enlargement or other systemic signs. The emerging zoonotic potential of this disease in urban areas and the need to coordinate canine brucellosis surveillance systems should be evaluated.

  • unusual clinical presentation of brucellosis caused by Brucella canis
    Journal of Medical Microbiology, 2005
    Co-Authors: Nidia E Lucero, Nestor O Jacob, Sandra M Ayala, Gabriela I Escobar, Patricia Tuccillo, Isabelle Jacques
    Abstract:

    Brucella canis is considered a rare cause of human brucellosis. The clinical importance of this infection may have been underestimated so far because of difficulties with presumptive diagnosis. The case described here presented symptoms compatible with brucellosis but the routine tests using Brucella abortus antigen were negative. The infection would have remained undiagnosed if culture had not been positive. This case illustrates the potential for a favourable outcome in Brucella canis diagnosis and supports recommendations for the use of B. canis serology. The infection should be suspected in patients with compatible symptoms and negative serology for B. abortus antigen.

  • diagnosis of human brucellosis caused by Brucella canis
    Journal of Medical Microbiology, 2005
    Co-Authors: Nidia E Lucero, Sandra M Ayala, Gabriela I Escobar, Nestor R Jacob
    Abstract:

    The transmission of Brucella canis to man commonly occurs through contact with infected dogs or their secretions, or through direct laboratory exposure. The disease is underdiagnosed due to a general lack of serological testing facilities and misconceptions concerning its prevalence. This report shows the potential use of an indirect ELISA (IELISA) for the diagnosis of human brucellosis caused by B. canis in a population of patients negative by smooth-Brucella antigen tests but positive by rapid slide agglutination test (RSAT). One hundred and ten sera from asymptomatic people found negative by tests using smooth Brucella abortus antigen and by RSAT showed an IELISA specificity of 100 % when a cut-off value of 27 % positivity (%P) was selected. For 17 sera from patients with positive B. canis culture or in close contact with culture-positive dogs, the IELISA sensitivity was 100 % with the same cut-off value. The positive patients presented clinical symptoms similar to brucellosis caused by other species of Brucella and some of them received antibiotic treatment and made good progress. Using this cut-off value, we studied 35 patients with negative blood cultures but positive RSATs, and IELISA detected 18 as positive; of the 17 IELISA-negative, two were RSAT-positive at dilution 1 : 2 and 15 were weakly positive with pure serum. These samples were probably from patients at an early stage of infection or indicate false-positive results. No cross-reaction was observed among the sera from nine cases with a diagnosis other than brucellosis, but cross-reactivity was evident in sera from patients infected with smooth-Brucella species. Since routine brucellosis diagnosis does not include B. canis investigation, infection with this species may be more widespread than is currently suspected. The RSAT could be a suitable screening test for the diagnosis of B. canis human brucellosis, and a supplementary technique, such as IELISA, performed on all positive RSAT samples that were negative by B. abortus antigen could ensure diagnostic specificity and confirm the diagnosis.

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