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Ana Paula Simoeswust - One of the best experts on this subject based on the ideXlab platform.
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Bryophyllum pinnatum enhances the inhibitory effect of atosiban and nifedipine on human myometrial contractility an in vitro study
BMC Complementary and Alternative Medicine, 2019Co-Authors: Monica Mennet, S Santos, Christian Haslinger, Ursula Von Mandach, Matthias Hamburger, Ana Paula SimoeswustAbstract:Background The herbal medicine Bryophyllum pinnatum has been used as a tocolytic agent in anthroposophic medicine and, recently, in conventional settings alone or as an add-on medication with tocolytic agents such as atosiban or nifedipine. We wanted to compare the inhibitory effect of atosiban and nifedipine on human myometrial contractility in vitro in the absence and in the presence of B. pinnatum press juice (BPJ).
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potential of Bryophyllum pinnatum as a detrusor relaxant an in vitro exploratory study
Planta Medica, 2017Co-Authors: Simon Bachmann, Monica Mennet, Karin Furer, Olivier Potterat, Cornelia Betschart, Ursula Von Mandach, Matthias Hamburger, Julia Gerber, Ana Paula SimoeswustAbstract:An earlier prospective, randomised, placebo-controlled clinical trial had suggested that Bryophyllum pinnatum might have potential in the treatment of overactive bladder. Here we investigated the effects of B. pinnatum leaf press juice, fractions enriched in flavonoids and bufadienolides, and a flavonoid aglycon mixture and individual aglycons on detrusor contractility as a major target in overactive bladder treatment. The strength of the detrusor contractions was investigated using porcine muscle strips stimulated with KCl. B. pinnatum leaf press juice increased the contraction force of muscle strips. Treatment with the flavonoid-enriched fraction had almost no effect on contractility, while the bufadienolide-enriched fraction and flavonoid aglycons led to a concentration-dependent lowering of the contraction force. The data indicate that several components of B. pinnatum leaf press juice may contribute to the inhibitory effect on detrusor contractility, which in turn provides support to overactive bladder treatment with B. pinnatum.
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Bryophyllum pinnatum reverse engineering of an anthroposophic herbal medicine
Natural Product Communications, 2017Co-Authors: Matthias Hamburger, Karin Furer, Olivier Potterat, Ana Paula Simoeswust, Ursula Von MandachAbstract:Bryophyllum pinnatum (syn. Kalanchoe pinnata), a plant native to Madagascar, was introduced into anthroposophic medicine in the early 20th century. In recent years, a number of investigations were ...
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die anwendung von Bryophyllum pinnatum praparaten in der geburtshilfe und gynakologie eine multizentrische prospektive beobachtungsstudie
Forschende Komplementarmedizin, 2015Co-Authors: Karin Furer, Alice Winkler, Nadine Amsler, Martin Schnelle, Ana Paula Simoeswust, Ursula Von MandachAbstract:Hintergrund: Bryophyllum pinnatum wurde durch die anthroposophische Medizin in Europa eingefuhrt und wird heutzutage auch in der konventionellen
Karin Furer - One of the best experts on this subject based on the ideXlab platform.
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potential of Bryophyllum pinnatum as a detrusor relaxant an in vitro exploratory study
Planta Medica, 2017Co-Authors: Simon Bachmann, Monica Mennet, Karin Furer, Olivier Potterat, Cornelia Betschart, Ursula Von Mandach, Matthias Hamburger, Julia Gerber, Ana Paula SimoeswustAbstract:An earlier prospective, randomised, placebo-controlled clinical trial had suggested that Bryophyllum pinnatum might have potential in the treatment of overactive bladder. Here we investigated the effects of B. pinnatum leaf press juice, fractions enriched in flavonoids and bufadienolides, and a flavonoid aglycon mixture and individual aglycons on detrusor contractility as a major target in overactive bladder treatment. The strength of the detrusor contractions was investigated using porcine muscle strips stimulated with KCl. B. pinnatum leaf press juice increased the contraction force of muscle strips. Treatment with the flavonoid-enriched fraction had almost no effect on contractility, while the bufadienolide-enriched fraction and flavonoid aglycons led to a concentration-dependent lowering of the contraction force. The data indicate that several components of B. pinnatum leaf press juice may contribute to the inhibitory effect on detrusor contractility, which in turn provides support to overactive bladder treatment with B. pinnatum.
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Bryophyllum pinnatum – Reverse Engineering of an Anthroposophic Herbal Medicine:
Natural Product Communications, 2017Co-Authors: Matthias Hamburger, Karin Furer, Olivier Potterat, Ana Paula Simões-wüst, Ursula Von MandachAbstract:Bryophyllum pinnatum (syn. Kalanchoe pinnata), a plant native to Madagascar, was introduced into anthroposophic medicine in the early 20th century. In recent years, a number of investigations were ...
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Bryophyllum pinnatum reverse engineering of an anthroposophic herbal medicine
Natural Product Communications, 2017Co-Authors: Matthias Hamburger, Karin Furer, Olivier Potterat, Ana Paula Simoeswust, Ursula Von MandachAbstract:Bryophyllum pinnatum (syn. Kalanchoe pinnata), a plant native to Madagascar, was introduced into anthroposophic medicine in the early 20th century. In recent years, a number of investigations were ...
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die anwendung von Bryophyllum pinnatum praparaten in der geburtshilfe und gynakologie eine multizentrische prospektive beobachtungsstudie
Forschende Komplementarmedizin, 2015Co-Authors: Karin Furer, Alice Winkler, Nadine Amsler, Martin Schnelle, Ana Paula Simoeswust, Ursula Von MandachAbstract:Hintergrund: Bryophyllum pinnatum wurde durch die anthroposophische Medizin in Europa eingefuhrt und wird heutzutage auch in der konventionellen
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Bryophyllum pinnatum inhibits detrusor contractility in porcine bladder strips a pharmacological study towards a new treatment option of overactive bladder
Phytomedicine, 2012Co-Authors: V Schuler, K Suter, Karin Furer, Maya Horst, Daniel Eberli, Cornelia Betschart, Rudolf BrenneisenAbstract:Abstract Aims A broad spectrum of synthetic agents is available for the treatment of overactive bladder. Anti-cholinergic drugs show a poor compliance due to side effects. There is an increasing use of plant extracts in medicine. We have therefore investigated the inhibitory effects of leaf press juice from Bryophyllum pinnatum (Lam.) Oken (Kalanchoe pinnata L.) on bladder strips and compared the effects to that of oxybutynin. Methods Strips of porcine detrusor were prepared in Krebs solution and contractility was measured in a myograph system chamber aired with O2/CO2 at 37 °C. To induce contractions, electrical field stimulation (32 Hz, 40 V) was used for the inhibitory effect measurements, and carbachol (50 μM) for the relaxant effect measurements. Recordings were obtained in the absence and presence of increasing concentrations of Bryophyllum pinnatum leaf press juice (BPJ, 0.1–10%), and oxybutynin (10−7–10−3 M) as a reference substance. Results In inhibition experiments, BPJ as well as oxybutynin inhibited electrically induced contractions of porcine detrusor. BPJ at concentrations of 5% inhibited the contraction compared to a time matched control significantly by 74.6 ± 10.2% (p Conclusions Our investigations show that BPJ inhibits contractions induced by electrical field stimulation and relaxes carbachol-induced contractions. However, the effect was lower than that of the reference substance oxybutynin. It is important to continue in vitro experiments as well as clinical studies with BPJ that might offer a new treatment option for patients with OAB.
Ursula Von Mandach - One of the best experts on this subject based on the ideXlab platform.
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Bryophyllum pinnatum enhances the inhibitory effect of atosiban and nifedipine on human myometrial contractility an in vitro study
BMC Complementary and Alternative Medicine, 2019Co-Authors: Monica Mennet, S Santos, Christian Haslinger, Ursula Von Mandach, Matthias Hamburger, Ana Paula SimoeswustAbstract:Background The herbal medicine Bryophyllum pinnatum has been used as a tocolytic agent in anthroposophic medicine and, recently, in conventional settings alone or as an add-on medication with tocolytic agents such as atosiban or nifedipine. We wanted to compare the inhibitory effect of atosiban and nifedipine on human myometrial contractility in vitro in the absence and in the presence of B. pinnatum press juice (BPJ).
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potential of Bryophyllum pinnatum as a detrusor relaxant an in vitro exploratory study
Planta Medica, 2017Co-Authors: Simon Bachmann, Monica Mennet, Karin Furer, Olivier Potterat, Cornelia Betschart, Ursula Von Mandach, Matthias Hamburger, Julia Gerber, Ana Paula SimoeswustAbstract:An earlier prospective, randomised, placebo-controlled clinical trial had suggested that Bryophyllum pinnatum might have potential in the treatment of overactive bladder. Here we investigated the effects of B. pinnatum leaf press juice, fractions enriched in flavonoids and bufadienolides, and a flavonoid aglycon mixture and individual aglycons on detrusor contractility as a major target in overactive bladder treatment. The strength of the detrusor contractions was investigated using porcine muscle strips stimulated with KCl. B. pinnatum leaf press juice increased the contraction force of muscle strips. Treatment with the flavonoid-enriched fraction had almost no effect on contractility, while the bufadienolide-enriched fraction and flavonoid aglycons led to a concentration-dependent lowering of the contraction force. The data indicate that several components of B. pinnatum leaf press juice may contribute to the inhibitory effect on detrusor contractility, which in turn provides support to overactive bladder treatment with B. pinnatum.
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Bryophyllum pinnatum reverse engineering of an anthroposophic herbal medicine
Natural Product Communications, 2017Co-Authors: Matthias Hamburger, Karin Furer, Olivier Potterat, Ana Paula Simoeswust, Ursula Von MandachAbstract:Bryophyllum pinnatum (syn. Kalanchoe pinnata), a plant native to Madagascar, was introduced into anthroposophic medicine in the early 20th century. In recent years, a number of investigations were ...
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Bryophyllum pinnatum – Reverse Engineering of an Anthroposophic Herbal Medicine:
Natural Product Communications, 2017Co-Authors: Matthias Hamburger, Karin Furer, Olivier Potterat, Ana Paula Simões-wüst, Ursula Von MandachAbstract:Bryophyllum pinnatum (syn. Kalanchoe pinnata), a plant native to Madagascar, was introduced into anthroposophic medicine in the early 20th century. In recent years, a number of investigations were ...
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die anwendung von Bryophyllum pinnatum praparaten in der geburtshilfe und gynakologie eine multizentrische prospektive beobachtungsstudie
Forschende Komplementarmedizin, 2015Co-Authors: Karin Furer, Alice Winkler, Nadine Amsler, Martin Schnelle, Ana Paula Simoeswust, Ursula Von MandachAbstract:Hintergrund: Bryophyllum pinnatum wurde durch die anthroposophische Medizin in Europa eingefuhrt und wird heutzutage auch in der konventionellen
Cornelia Betschart - One of the best experts on this subject based on the ideXlab platform.
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potential of Bryophyllum pinnatum as a detrusor relaxant an in vitro exploratory study
Planta Medica, 2017Co-Authors: Simon Bachmann, Monica Mennet, Karin Furer, Olivier Potterat, Cornelia Betschart, Ursula Von Mandach, Matthias Hamburger, Julia Gerber, Ana Paula SimoeswustAbstract:An earlier prospective, randomised, placebo-controlled clinical trial had suggested that Bryophyllum pinnatum might have potential in the treatment of overactive bladder. Here we investigated the effects of B. pinnatum leaf press juice, fractions enriched in flavonoids and bufadienolides, and a flavonoid aglycon mixture and individual aglycons on detrusor contractility as a major target in overactive bladder treatment. The strength of the detrusor contractions was investigated using porcine muscle strips stimulated with KCl. B. pinnatum leaf press juice increased the contraction force of muscle strips. Treatment with the flavonoid-enriched fraction had almost no effect on contractility, while the bufadienolide-enriched fraction and flavonoid aglycons led to a concentration-dependent lowering of the contraction force. The data indicate that several components of B. pinnatum leaf press juice may contribute to the inhibitory effect on detrusor contractility, which in turn provides support to overactive bladder treatment with B. pinnatum.
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Bryophyllum pinnatum inhibits detrusor contractility in porcine bladder strips a pharmacological study towards a new treatment option of overactive bladder
Phytomedicine, 2012Co-Authors: V Schuler, K Suter, Karin Furer, Maya Horst, Daniel Eberli, Cornelia Betschart, Rudolf BrenneisenAbstract:Abstract Aims A broad spectrum of synthetic agents is available for the treatment of overactive bladder. Anti-cholinergic drugs show a poor compliance due to side effects. There is an increasing use of plant extracts in medicine. We have therefore investigated the inhibitory effects of leaf press juice from Bryophyllum pinnatum (Lam.) Oken (Kalanchoe pinnata L.) on bladder strips and compared the effects to that of oxybutynin. Methods Strips of porcine detrusor were prepared in Krebs solution and contractility was measured in a myograph system chamber aired with O2/CO2 at 37 °C. To induce contractions, electrical field stimulation (32 Hz, 40 V) was used for the inhibitory effect measurements, and carbachol (50 μM) for the relaxant effect measurements. Recordings were obtained in the absence and presence of increasing concentrations of Bryophyllum pinnatum leaf press juice (BPJ, 0.1–10%), and oxybutynin (10−7–10−3 M) as a reference substance. Results In inhibition experiments, BPJ as well as oxybutynin inhibited electrically induced contractions of porcine detrusor. BPJ at concentrations of 5% inhibited the contraction compared to a time matched control significantly by 74.6 ± 10.2% (p Conclusions Our investigations show that BPJ inhibits contractions induced by electrical field stimulation and relaxes carbachol-induced contractions. However, the effect was lower than that of the reference substance oxybutynin. It is important to continue in vitro experiments as well as clinical studies with BPJ that might offer a new treatment option for patients with OAB.
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Bryophyllum pinnatum in der Geburtshilfe und Gynäkologie. Wirksamkeit und Verträglichkeit
2011Co-Authors: Ursula Von Mandach, Cornelia BetschartAbstract:Bryophyllum pinnatum lasst sich bei hyperaktiven Zustanden wie der vorzeitigen Wehentatigkeit, Unruhezustanden am Tag oder in der Nacht, der hyperaktiven Blase, sowie beim pramenstruellen Syndrom und bei klimakterischen Beschwerden einsetzen. Aus allen bisherigen klinischen Anwendungen besticht B. pinnatum durch seine extrem gute Vertraglichkeit.
Pierre Tane - One of the best experts on this subject based on the ideXlab platform.
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antimicrobial and antioxidant activity of kaempferol rhamnoside derivatives from Bryophyllum pinnatum
BMC Research Notes, 2012Co-Authors: Simplice J. N. Tatsimo, Leopold Havyarimana, Jean De Dieu Tamokou, Julesroger Kuiate, Peter Forgo, Judit Hohmann, Dezső Csupor, Pierre TaneAbstract:Background Bryophyllum pinnatum (Lank.) Oken (Crassulaceae) is a perennial succulent herb widely used in traditional medicine to treat many ailments. Its wide range of uses in folk medicine justifies its being called "life plant" or "resurrection plant", prompting researchers' interest. We describe here the isolation and structure elucidation of antimicrobial and/or antioxidant components from the EtOAc extract of B. pinnatum.
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antimicrobial and antioxidant activity of kaempferol rhamnoside derivatives from Bryophyllum pinnatum
BMC Research Notes, 2012Co-Authors: Simplice J. N. Tatsimo, Leopold Havyarimana, Jean De Dieu Tamokou, Julesroger Kuiate, Peter Forgo, Judit Hohmann, Dezső Csupor, Pierre TaneAbstract:Bryophyllum pinnatum (Lank.) Oken (Crassulaceae) is a perennial succulent herb widely used in traditional medicine to treat many ailments. Its wide range of uses in folk medicine justifies its being called "life plant" or "resurrection plant", prompting researchers' interest. We describe here the isolation and structure elucidation of antimicrobial and/or antioxidant components from the EtOAc extract of B. pinnatum. The methanol extract displayed both antimicrobial activities with minimum inhibitory concentration (MIC) values ranging from 32 to 512 μg/ml and antioxidant property with an IC50 value of 52.48 μg/ml. Its partition enhanced the antimicrobial activity in EtOAc extract (MIC = 16-128 μg/ml) and reduced it in hexane extract (MIC = 256-1024 μg/ml). In addition, this process reduced the antioxidant activity in EtOAc and hexane extracts with IC50 values of 78.11 and 90.04 μg/ml respectively. Fractionation of EtOAc extract gave seven kaempferol rhamnosides, including; kaempferitrin (1), kaempferol 3-O-α-L-(2-acetyl)rhamnopyranoside-7-O-α-L-rhamnopyranoside (2), kaempferol 3-O-α-L-(3-acetyl)rhamnopyranoside-7-O-α-L-rhamnopyranoside (3), kaempferol 3-O-α-L-(4-acetyl)rhamnopyranoside-7-O-α-L-rhamnopyranoside (4), kaempferol 3-O-α-D- glucopyranoside-7-O-α-L-rhamnopyranoside (5), afzelin (6) and α-rhamnoisorobin (7). All these compounds, except 6 were isolated from this plant for the first time. Compound 7 was the most active, with MIC values ranging from 1 to 2 μg/ml and its antioxidant activity (IC50 = 0.71 μg/ml) was higher than that of the reference drug (IC50 = 0.96 μg/ml). These findings demonstrate that Bryophyllum pinnatum and some of its isolated compounds have interesting antimicrobial and antioxidant properties, and therefore confirming the traditional use of B. pinnatum in the treatment of infectious and free radical damages.
