Kalanchoe

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Gideon F. Smith - One of the best experts on this subject based on the ideXlab platform.

Estrela Figueiredo - One of the best experts on this subject based on the ideXlab platform.

Massó Sergi - One of the best experts on this subject based on the ideXlab platform.

Neil R. Crouch - One of the best experts on this subject based on the ideXlab platform.

Anna Stochmal - One of the best experts on this subject based on the ideXlab platform.

  • Biological activities of leaf extracts from selected Kalanchoe species and their relationship with bufadienolides content.
    Pharmaceutical biology, 2020
    Co-Authors: Justyna Stefanowicz-hajduk, Anna Stochmal, Anna Hering, Magdalena Gucwa, Rafał Hałasa, Agata Soluch, Mariusz Kowalczyk, Renata Ochocka
    Abstract:

    Kalanchoe species (Crassulaceae) are widely used in traditional medicine as remedies in infectious diseases and cancer treatment. Cytotoxic and antimicrobial activities of Kalanchoe daigremontiana ...

  • Bufadienolides of Kalanchoe species: an overview of chemical structure, biological activity and prospects for pharmacological use
    Phytochemistry Reviews, 2017
    Co-Authors: Joanna Kolodziejczyk-czepas, Anna Stochmal
    Abstract:

    Toad venom is regarded as the main source of bufadienolides; however, synthesis of these substances takes also place in a variety of other animal and plant organisms, including ethnomedicinal plants of the Kalanchoe genus. Chemically, bufadienolides are a group of polyhydroxy C-24 steroids and their glycosides, containing a six-membered lactone (α-pyrone) ring at the C-17β position. From the pharmacological point of view, bufadienolides might be a promising group of steroid hormones with cardioactive properties and anticancer activity. Most of the literature concerns bufadienolides of animal origin; however, the medicinal use of these compounds remains limited by their narrow therapeutic index and the risk of development of cardiotoxic effects. On the other hand, plants such as Kalanchoe are also a source of bufadienolides. Kalanchoe pinnata (life plant, air plant, cathedral bells), Kalanchoe daigremontiana (mother of thousands) and other Kalanchoe species are valuable herbs in traditional medicine of Asia and Africa. The present review focuses on the available data on chemical structures of 31 compounds, biological properties and prospects for therapeutic use of bufadienolides from Kalanchoe species. Furthermore, it presents some new investigational trends in research on curative uses of these substances.