The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Jeyakumar Kandasamy - One of the best experts on this subject based on the ideXlab platform.
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tert-Butyl Nitrite catalyzed synthesis of benzimidazoles from o-phenylenediamine and aldehydes at room temperature
Tetrahedron Letters, 2020Co-Authors: Sadaf Azeez, Popuri Sureshbabu, Shahulhameed Sabiah, Priyanka Chaudhary, Jeyakumar KandasamyAbstract:Abstract A simple and efficient method is demonstrated for the synthesis of benzimidazoles via cyclocondensation of o-phenylenediamine with aldehydes in the presence of catalytic amount of tert-Butyl Nitrite. All the reactions were carried out at room temperature while the desired products were obtained in good to excellent yields.
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tert-Butyl Nitrite promoted transamidation of secondary amides under metal and catalyst free conditions.
Organic and Biomolecular Chemistry, 2019Co-Authors: Popuri Sureshbabu, Sadaf Azeez, Priyanka Chaudhary, Jeyakumar KandasamyAbstract:A mild and efficient method is demonstrated for the transamidation of secondary amides with various amines including primary, secondary, cyclic and acyclic amines in the presence of tert-Butyl Nitrite. The reaction proceeds through the N-nitrosamide intermediate and provides the transamidation products in good to excellent yields at room temperature. Moreover, the developed methodology does not require any catalyst or additives.
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Regioselective Nitration of N-Alkyl Anilines using tert-Butyl Nitrite under Mild Condition.
The Journal of organic chemistry, 2018Co-Authors: Priyanka Chaudhary, Shahulhameed Sabiah, Nalluchamy Muniyappan, Surabhi Gupta, Jeyakumar KandasamyAbstract:Regioselective ring nitration of N-alkyl anilines is reported using tert-Butyl Nitrite. The reactions proceed efficiently with a wide range of substrates providing synthetically useful N-nitroso N-alkyl nitroanilines in excellent yields which can be easily converted into N-alkyl phenylenediamines and N-alkyl nitroanilines using Zn-AcOH and HCl/MeOH, respectively.
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tert-Butyl Nitrite mediated nitrogen transfer reactions: synthesis of benzotriazoles and azides at room temperature.
Organic & biomolecular chemistry, 2018Co-Authors: Sadaf Azeez, Popuri Sureshbabu, Shahulhameed Sabiah, Priyanka Chaudhary, Jeyakumar KandasamyAbstract:A conversion of o-phenylenediamines into benzotriazoles was achieved at room temperature using tert-Butyl Nitrite. The optimized conditions are also well suited for the transformation of sulfonyl and acyl hydrazines into corresponding azides. This protocol does not require any catalyst or acidic medium. The desired products were obtained in excellent yields in a short span of time.
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Regioselective Nitration of N‑Alkyl Anilines using tert-Butyl Nitrite under Mild Condition
2018Co-Authors: Priyanka Chaudhary, Shahulhameed Sabiah, Nalluchamy Muniyappan, Surabhi Gupta, Jeyakumar KandasamyAbstract:Regioselective ring nitration of N-alkyl anilines is reported using tert-Butyl Nitrite. The reactions proceed efficiently with a wide range of substrates providing synthetically useful N-nitroso N-alkyl nitroanilines in excellent yields which can be easily converted into N-alkyl phenylenediamines and N-alkyl nitroanilines using Zn-AcOH and HCl/MeOH, respectively
Zhenlu Shen - One of the best experts on this subject based on the ideXlab platform.
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Visible-Light-Induced Arene C(sp2)–H Lactonization Promoted by DDQ and tert-Butyl Nitrite
Synlett, 2019Co-Authors: Wang Yiqing, Nan Sun, Liqun Jin, Shengpeng Wang, Bajin Chen, Zhenlu ShenAbstract:A visible-light photocatalytic aerobic oxidative lactonization of arene C(sp2)–H bonds proceeds in the presence of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and tert-Butyl Nitrite (TBN). Under the optimized conditions, a range of 2-arylbenzoic acids is converted into the corresponding benzocoumarin derivatives in moderate to excellent yields. This method is characterized by its atom economy, mild reaction conditions, the use of a green oxidant and metal-free catalysis.
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visible light induced aerobic oxidation of benzylic c sp3 h of alkylarenes promoted by ddq tert Butyl Nitrite and acetic acid
Synlett, 2019Co-Authors: Decheng Pan, Liqun Jin, Nan Sun, Yiqing Wang, Zhenlu ShenAbstract:A visible-light photocatalytic aerobic oxidation of benzylic C(sp3)–H bonds proceeded in the presence of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone, tert-Butyl Nitrite, and acetic acid. Advantages of this aerobic oxidation method include its relatively mild conditions, the use of visible-light irradiation instead of conventional thermal methods, the use of a low catalyst loading, and the ability to oxidize a range of alkylarenes, including xanthenes, thioxanthenes, and 9,10-dihydroacridines, to the corresponding ketones in excellent yields.
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aerobic oxidation of secondary alcohols in water with abno tert Butyl Nitrite kpf6 catalytic system
Tetrahedron Letters, 2017Co-Authors: Chao Hong, Nan Sun, Yan Wan, Liqun Jin, Zhenlu ShenAbstract:A green and efficient transition-metal free ABNO/tert-Butyl Nitrite/KPF6-catalyzed aerobic oxidation of secondary alcohols in water has been achieved. Under the optimal reaction conditions, a number of secondary aliphatic alcohols and secondary benzylic alcohols can be converted to their corresponding ketones in excellent yields (up to 99%).
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An efficient and convenient method for the preparation of disulfides from thiols using oxygen as oxidant catalyzed by tert-Butyl Nitrite
Chinese Chemical Letters, 2016Co-Authors: Zhenlu ShenAbstract:Abstract An efficient and convenient tert-Butyl Nitrite-catalyzed selective aerobic oxidation of thiols has been developed. Under the optimal reaction conditions, a number of thiol derivatives including aromatic thiols, heteroaromatic thiols and aliphatic thiols can be converted into their corresponding disulfides in good to excellent yields.
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ddq tert Butyl Nitrite catalyzed aerobic oxidation of diarylmethane sp3 c h bonds
ChemInform, 2015Co-Authors: Weijuan Zhao, Nan Sun, Zhenlu ShenAbstract:An efficient 2,3-dichloro-5,6-dicyano-1,4-benzoquinone/tert-Butyl Nitrite-catalyzed aerobic oxidation of diarylmethane sp3 C–H bonds in the presence of acetic acid has been developed. Under the optimal reaction conditions, a number of diarylmethanes can be directly converted to their corresponding diarylketones in good to excellent yields. In addition, a plausible reaction mechanism has been investigated.
Bhisma K. Patel - One of the best experts on this subject based on the ideXlab platform.
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tert-Butyl Nitrite Mediated Synthesis of 1,2,4-Oxadiazol-5(4H)-ones from Terminal Aryl Alkenes
Organic letters, 2019Co-Authors: Prasenjit Sau, Amitava Rakshit, Tipu Alam, Hemant Kumar Srivastava, Bhisma K. PatelAbstract:tert-Butyl Nitrite (TBN) mediated synthesis of 3-aryl-1,2,4-oxadiazol-5(4H)-ones has been accomplished using terminal aryl alkenes via a biradical reaction intermediate. Three consecutive sp2 C–H b...
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three sequential c n bond formations tert Butyl Nitrite as a n1 synthon in a three component reaction leading to imidazo 1 2 a quinolines and imidazo 2 1 a isoquinolines
Journal of Organic Chemistry, 2018Co-Authors: Prasenjit Sau, Amitava Rakshit, Anju Modi, Ahalya Behera, Bhisma K. PatelAbstract:tert-Butyl Nitrite serves the dual role of an oxidant as well as a N1 synthon in a multicomponent reaction involving quinolines, isoquinolines, and styrenes. Herein, two sp2 C-H functionalizations of styrenes and one sp2 C-H functionalization of quinolines and isoquinolines lead to the formation of fused quinolines and isoquinolines via three sequential C-N bond formations.
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tert Butyl Nitrite mediated domino synthesis of isoxazolines and isoxazoles from terminal aryl alkenes and alkynes
Journal of Organic Chemistry, 2017Co-Authors: Prasenjit Sau, Amitava Rakshit, Sourav Kumar Santra, Bhisma K. PatelAbstract:A sequential construction of C–C, C–O, C═N, and C═O bonds from alkenes leading to the direct synthesis of isoxazolines in the presence of tert-Butyl Nitrite, quinoline, and the Sc(OTf)3 catalyst in DCE at 80 °C has been accomplished. An unprecedented three consecutive C–H functionalizations of two styrenes are involved in this isoxazoline synthesis. In this radical-mediated reaction, one-half of the aryl alkene is converted into an intermediate 2-nitroketone, which serves as a 1,3-dipolarophile and undergoes cycloaddition with the other half of the unreacted aromatic terminal alkene. The use of an alkyne in lieu of an alkene leads to the formation of isoxazole under identical reaction conditions.
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tert-Butyl Nitrite-Mediated Domino Synthesis of Isoxazolines and Isoxazoles from Terminal Aryl Alkenes and Alkynes
2017Co-Authors: Prasenjit Sau, Amitava Rakshit, Sourav Kumar Santra, Bhisma K. PatelAbstract:A sequential construction of C–C, C–O, CN, and CO bonds from alkenes leading to the direct synthesis of isoxazolines in the presence of tert-Butyl Nitrite, quinoline, and the Sc(OTf)3 catalyst in DCE at 80 °C has been accomplished. An unprecedented three consecutive C–H functionalizations of two styrenes are involved in this isoxazoline synthesis. In this radical-mediated reaction, one-half of the aryl alkene is converted into an intermediate 2-nitroketone, which serves as a 1,3-dipolarophile and undergoes cycloaddition with the other half of the unreacted aromatic terminal alkene. The use of an alkyne in lieu of an alkene leads to the formation of isoxazole under identical reaction conditions
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Three Sequential C–N Bond Formations: tert-Butyl Nitrite as a N1 Synthon in a Three Component Reaction Leading to Imidazo[1,2‑a]quinolines and Imidazo[2,1‑a]isoquinolines
2017Co-Authors: Prasenjit Sau, Amitava Rakshit, Anju Modi, Ahalya Behera, Bhisma K. PatelAbstract:tert-Butyl Nitrite serves the dual role of an oxidant as well as a N1 synthon in a multicomponent reaction involving quinolines, isoquinolines, and styrenes. Herein, two sp2 C–H functionalizations of styrenes and one sp2 C–H functionalization of quinolines and isoquinolines lead to the formation of fused quinolines and isoquinolines via three sequential C–N bond formations
Rulong Yan - One of the best experts on this subject based on the ideXlab platform.
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tert-Butyl Nitrite Promoted Oxidative Intermolecular Sulfonamination of Alkynes to Synthesize Substituted Sulfonyl Pyrroles from the Alkynylamines and Sulfinic Acids.
The Journal of organic chemistry, 2018Co-Authors: Yong Jiang, Yanyan Wang, Rulong YanAbstract:tert-Butyl Nitrite promoted oxidative intermolecular sulfonamination of alkynes to synthesize substituted sulfonyl pyrroles from the alkynylamines and sulfinic acids via tandem addition/cyclization was developed. This reaction is performed well by employing tert-Butyl Nitrite as the oxidant, and various substituted sulfonyl pyrroles are formed in moderate to good yields with no requirement of metal catalysis.
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tert-Butyl Nitrite Promoted Oxidative Intermolecular Sulfonamination of Alkynes to Synthesize Substituted Sulfonyl Pyrroles from the Alkynylamines and Sulfinic Acids
2018Co-Authors: Yong Jiang, Yanyan Wang, Rulong YanAbstract:tert-Butyl Nitrite promoted oxidative intermolecular sulfonamination of alkynes to synthesize substituted sulfonyl pyrroles from the alkynylamines and sulfinic acids via tandem addition/cyclization was developed. This reaction is performed well by employing tert-Butyl Nitrite as the oxidant, and various substituted sulfonyl pyrroles are formed in moderate to good yields with no requirement of metal catalysis
Prasenjit Sau - One of the best experts on this subject based on the ideXlab platform.
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tert-Butyl Nitrite Mediated Synthesis of 1,2,4-Oxadiazol-5(4H)-ones from Terminal Aryl Alkenes
Organic letters, 2019Co-Authors: Prasenjit Sau, Amitava Rakshit, Tipu Alam, Hemant Kumar Srivastava, Bhisma K. PatelAbstract:tert-Butyl Nitrite (TBN) mediated synthesis of 3-aryl-1,2,4-oxadiazol-5(4H)-ones has been accomplished using terminal aryl alkenes via a biradical reaction intermediate. Three consecutive sp2 C–H b...
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three sequential c n bond formations tert Butyl Nitrite as a n1 synthon in a three component reaction leading to imidazo 1 2 a quinolines and imidazo 2 1 a isoquinolines
Journal of Organic Chemistry, 2018Co-Authors: Prasenjit Sau, Amitava Rakshit, Anju Modi, Ahalya Behera, Bhisma K. PatelAbstract:tert-Butyl Nitrite serves the dual role of an oxidant as well as a N1 synthon in a multicomponent reaction involving quinolines, isoquinolines, and styrenes. Herein, two sp2 C-H functionalizations of styrenes and one sp2 C-H functionalization of quinolines and isoquinolines lead to the formation of fused quinolines and isoquinolines via three sequential C-N bond formations.
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tert Butyl Nitrite mediated domino synthesis of isoxazolines and isoxazoles from terminal aryl alkenes and alkynes
Journal of Organic Chemistry, 2017Co-Authors: Prasenjit Sau, Amitava Rakshit, Sourav Kumar Santra, Bhisma K. PatelAbstract:A sequential construction of C–C, C–O, C═N, and C═O bonds from alkenes leading to the direct synthesis of isoxazolines in the presence of tert-Butyl Nitrite, quinoline, and the Sc(OTf)3 catalyst in DCE at 80 °C has been accomplished. An unprecedented three consecutive C–H functionalizations of two styrenes are involved in this isoxazoline synthesis. In this radical-mediated reaction, one-half of the aryl alkene is converted into an intermediate 2-nitroketone, which serves as a 1,3-dipolarophile and undergoes cycloaddition with the other half of the unreacted aromatic terminal alkene. The use of an alkyne in lieu of an alkene leads to the formation of isoxazole under identical reaction conditions.
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tert-Butyl Nitrite-Mediated Domino Synthesis of Isoxazolines and Isoxazoles from Terminal Aryl Alkenes and Alkynes
2017Co-Authors: Prasenjit Sau, Amitava Rakshit, Sourav Kumar Santra, Bhisma K. PatelAbstract:A sequential construction of C–C, C–O, CN, and CO bonds from alkenes leading to the direct synthesis of isoxazolines in the presence of tert-Butyl Nitrite, quinoline, and the Sc(OTf)3 catalyst in DCE at 80 °C has been accomplished. An unprecedented three consecutive C–H functionalizations of two styrenes are involved in this isoxazoline synthesis. In this radical-mediated reaction, one-half of the aryl alkene is converted into an intermediate 2-nitroketone, which serves as a 1,3-dipolarophile and undergoes cycloaddition with the other half of the unreacted aromatic terminal alkene. The use of an alkyne in lieu of an alkene leads to the formation of isoxazole under identical reaction conditions
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Three Sequential C–N Bond Formations: tert-Butyl Nitrite as a N1 Synthon in a Three Component Reaction Leading to Imidazo[1,2‑a]quinolines and Imidazo[2,1‑a]isoquinolines
2017Co-Authors: Prasenjit Sau, Amitava Rakshit, Anju Modi, Ahalya Behera, Bhisma K. PatelAbstract:tert-Butyl Nitrite serves the dual role of an oxidant as well as a N1 synthon in a multicomponent reaction involving quinolines, isoquinolines, and styrenes. Herein, two sp2 C–H functionalizations of styrenes and one sp2 C–H functionalization of quinolines and isoquinolines lead to the formation of fused quinolines and isoquinolines via three sequential C–N bond formations
