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Sathya K Chinnadurai - One of the best experts on this subject based on the ideXlab platform.
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evaluation of a pressure sensitive walkway for objective gait analysis in normal and arthritic domestic ducks Cairina moschata domestica
PLOS ONE, 2019Co-Authors: Ryan S. Bailey, Julie D Sheldon, Matthew C Allender, Michael J Adkesson, Jennifer N Langan, Sathya K ChinnaduraiAbstract:Objective gait evaluation with a pressure sensitive walkway (PSW) has been used to assess welfare of poultry and to assess lameness and response to therapy in domestic mammals. Objective gait analysis of birds with lameness due to pododermatitis, osteoarthritis, and other common diseases could provide non-biased assessment and therapeutic monitoring for zoo clinicians. The objective of this study was to evaluate the use of a PSW for objective gait analysis in normal domestic ducks (Cairina moschata domestica) and those with experimentally induced arthritis. Eighteen healthy adult ducks walked across the PSW four times in each experiment at each time point. For experiment 1, gait parameters (step and stride distances and velocities, maximum force, impulse, and peak pressure) were calculated for each foot in each duck (time 0). For experiment 2, six of these ducks were randomly selected, anesthetized, and administered a unilateral intra-tarsal injection of monosodium urate solution to induce arthritis. Serial PSW trials were repeated at 1, 2, 3, 4, 8, and 24 hours post-injection. Gait parameters were calculated and compared at each time point, including baseline at time 0. Among the normal ducks, there were no significant differences between right and left feet for any gait parameter. Maximum force and impulse were significantly lower for the affected limb at the 3- and 4-hour time points in ducks with unilateral induced arthritis. This asymmetry was resolved by 8 hours post injection. This PSW transient arthritis model allows for objective assessment of lameness in domestic ducks with maximum force and impulse serving as the most sensitive gait parameters for lameness detection. This method has potential as a model to assess analgesic efficacy for zoo-housed waterfowl and other avian species.
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analgesic efficacy of tramadol compared with meloxicam in ducks Cairina moschata domestica evaluated by ground reactive forces
Journal of Avian Medicine and Surgery, 2019Co-Authors: Ryan S. Bailey, Julie D Sheldon, Matthew C Allender, Michael J Adkesson, Sathya K ChinnaduraiAbstract:The purpose of this study was to determine the efficacy of tramadol and meloxicam in an induced, temporary arthritis model in ducks as assessed by ground-reactive forces measured by a pressure-sensitive walkway (PSW) system. Twelve ducks (Cairina moschata domestica) were randomly separated into 3 equal groups of 4 birds each: water control, tramadol treatment, and meloxicam treatment. Baseline measurements were collected by having all ducks walk along a 3-m-long PSW in a custom-built corral before anesthesia and induction of arthritis. Arthritis was induced in all groups through injection, under anesthesia, of a 3% monosodium urate (MSU) solution into the intertarsal joint. One hour after MSU injection, birds were orally gavage fed 1 mL of tap water (control), tramadol (30 mg/kg), or meloxicam (1 mg/kg). After treatments, all ducks were reevaluated on the PSW at 1, 2, 3, 4, 8, and 24 hours post-MSU injection. The difference in maximum force was significantly greater in the control group than in both the tramadol- (P = .006) and meloxicam-treated (P = .03) individuals. Post hoc comparisons revealed differences between control and treated birds occurred only at the 3- and 4-hour time points after administration. No differences were found in the absolute difference in maximum force between tramadol- and meloxicam-treated birds at any time point (P > .05). Results of this study support the hypothesis that tramadol (30 mg/kg PO) and meloxicam (1 mg/kg PO) improve certain objective variables in an induced arthritis model in ducks. Our findings also support studies in other avian species that determined that both tramadol and meloxicam are effective analgesic drugs in some birds.
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Pharmacokinetics of orally administered tramadol in Muscovy ducks (Cairina moschata domestica)
Journal of Veterinary Pharmacology and Therapeutics, 2019Co-Authors: Ryan S. Bailey, Julie D Sheldon, Matthew C Allender, Mark G. Papich, Sathya K ChinnaduraiAbstract:This study documents the pharmacokinetics of oral tramadol in Muscovy ducks. Six ducks received a single 30 mg/kg dose of tramadol, orally by stomach tube, with blood collection prior to and up to 24 hr after tramadol administration. Plasma tramadol, and metabolites O-desmethyltramadol (M1), and N,O-didesmethyltramadol (M5) concentrations were determined by high-pressure liquid chromatography (HPLC) with fluorescence (FL) detection. Pharmacokinetic parameters were calculated using a one-compartment model with first-order input. No adverse effects were noted after oral administration. All ducks achieved plasma concentrations of tramadol above 0.10 μg/ml and maintained those concentrations for at least 12 hr. Elimination half-life was 3.95 hr for tramadol in ducks, which is similar to other avian species. All ducks in this study produced the M1 metabolite and maintained plasma concentrations above 0.1 μg/ml for at least 24 hr.
Julie D Sheldon - One of the best experts on this subject based on the ideXlab platform.
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evaluation of a pressure sensitive walkway for objective gait analysis in normal and arthritic domestic ducks Cairina moschata domestica
PLOS ONE, 2019Co-Authors: Ryan S. Bailey, Julie D Sheldon, Matthew C Allender, Michael J Adkesson, Jennifer N Langan, Sathya K ChinnaduraiAbstract:Objective gait evaluation with a pressure sensitive walkway (PSW) has been used to assess welfare of poultry and to assess lameness and response to therapy in domestic mammals. Objective gait analysis of birds with lameness due to pododermatitis, osteoarthritis, and other common diseases could provide non-biased assessment and therapeutic monitoring for zoo clinicians. The objective of this study was to evaluate the use of a PSW for objective gait analysis in normal domestic ducks (Cairina moschata domestica) and those with experimentally induced arthritis. Eighteen healthy adult ducks walked across the PSW four times in each experiment at each time point. For experiment 1, gait parameters (step and stride distances and velocities, maximum force, impulse, and peak pressure) were calculated for each foot in each duck (time 0). For experiment 2, six of these ducks were randomly selected, anesthetized, and administered a unilateral intra-tarsal injection of monosodium urate solution to induce arthritis. Serial PSW trials were repeated at 1, 2, 3, 4, 8, and 24 hours post-injection. Gait parameters were calculated and compared at each time point, including baseline at time 0. Among the normal ducks, there were no significant differences between right and left feet for any gait parameter. Maximum force and impulse were significantly lower for the affected limb at the 3- and 4-hour time points in ducks with unilateral induced arthritis. This asymmetry was resolved by 8 hours post injection. This PSW transient arthritis model allows for objective assessment of lameness in domestic ducks with maximum force and impulse serving as the most sensitive gait parameters for lameness detection. This method has potential as a model to assess analgesic efficacy for zoo-housed waterfowl and other avian species.
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analgesic efficacy of tramadol compared with meloxicam in ducks Cairina moschata domestica evaluated by ground reactive forces
Journal of Avian Medicine and Surgery, 2019Co-Authors: Ryan S. Bailey, Julie D Sheldon, Matthew C Allender, Michael J Adkesson, Sathya K ChinnaduraiAbstract:The purpose of this study was to determine the efficacy of tramadol and meloxicam in an induced, temporary arthritis model in ducks as assessed by ground-reactive forces measured by a pressure-sensitive walkway (PSW) system. Twelve ducks (Cairina moschata domestica) were randomly separated into 3 equal groups of 4 birds each: water control, tramadol treatment, and meloxicam treatment. Baseline measurements were collected by having all ducks walk along a 3-m-long PSW in a custom-built corral before anesthesia and induction of arthritis. Arthritis was induced in all groups through injection, under anesthesia, of a 3% monosodium urate (MSU) solution into the intertarsal joint. One hour after MSU injection, birds were orally gavage fed 1 mL of tap water (control), tramadol (30 mg/kg), or meloxicam (1 mg/kg). After treatments, all ducks were reevaluated on the PSW at 1, 2, 3, 4, 8, and 24 hours post-MSU injection. The difference in maximum force was significantly greater in the control group than in both the tramadol- (P = .006) and meloxicam-treated (P = .03) individuals. Post hoc comparisons revealed differences between control and treated birds occurred only at the 3- and 4-hour time points after administration. No differences were found in the absolute difference in maximum force between tramadol- and meloxicam-treated birds at any time point (P > .05). Results of this study support the hypothesis that tramadol (30 mg/kg PO) and meloxicam (1 mg/kg PO) improve certain objective variables in an induced arthritis model in ducks. Our findings also support studies in other avian species that determined that both tramadol and meloxicam are effective analgesic drugs in some birds.
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Pharmacokinetics of orally administered tramadol in Muscovy ducks (Cairina moschata domestica)
Journal of Veterinary Pharmacology and Therapeutics, 2019Co-Authors: Ryan S. Bailey, Julie D Sheldon, Matthew C Allender, Mark G. Papich, Sathya K ChinnaduraiAbstract:This study documents the pharmacokinetics of oral tramadol in Muscovy ducks. Six ducks received a single 30 mg/kg dose of tramadol, orally by stomach tube, with blood collection prior to and up to 24 hr after tramadol administration. Plasma tramadol, and metabolites O-desmethyltramadol (M1), and N,O-didesmethyltramadol (M5) concentrations were determined by high-pressure liquid chromatography (HPLC) with fluorescence (FL) detection. Pharmacokinetic parameters were calculated using a one-compartment model with first-order input. No adverse effects were noted after oral administration. All ducks achieved plasma concentrations of tramadol above 0.10 μg/ml and maintained those concentrations for at least 12 hr. Elimination half-life was 3.95 hr for tramadol in ducks, which is similar to other avian species. All ducks in this study produced the M1 metabolite and maintained plasma concentrations above 0.1 μg/ml for at least 24 hr.
C. Diot - One of the best experts on this subject based on the ideXlab platform.
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Quantitative real-time PCR primer design, cDNA amplification and sequence analysis from 22 genes mainly associated with lipid metabolism in Pekin (Anas platyrhynchos) and Muscovy (Cairina moschata) ducks.
Animal Genetics, 2008Co-Authors: Frédéric Herault, E. Robert, C. DiotAbstract:Few genomic tools are available in ducks. To produce some new resources, we have designed Pekin (Anas platyrhynchos) and Muscovy (Cairina moschata) duck-specific primers for 22 genes involved mainly in lipid metabolism, and to a lesser extent in carbohydrate metabolism and other functions. Primers were designed according to duck sequences when available and otherwise from the corresponding conserved regions in chicken and human sequences. These primers allowed quantitative RT-PCR amplification of RNA from Pekin and Muscovy ducks. Amplified cDNA products from both species were sequenced and were found to be very similar to chicken sequences (about 94%). This work provides additional genomic resources and polymorphism information for some genes in duck species and represents a first step towards gene expression analyses in Pekin and Muscovy ducks.
Rosario Martin - One of the best experts on this subject based on the ideXlab platform.
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quantitation of mule duck in goose foie gras using taqman real time polymerase chain reaction
Journal of Agricultural and Food Chemistry, 2004Co-Authors: Miguel A. Rodríguez, Teresa Garcia, Luis Asensio, Pablo E Hernandez, Isabel Gonzalez, Rosario MartinAbstract:A real-time quantitative Polymerase Chain Reaction (PCR) method has been developed for the quantitation of mule duck (Anas platyrhynchos × Cairina moschata) in binary duck/goose foie gras mixtures. The method combines the use of real-time PCR with duck-specific and endogenous control “duck + goose” primers to measure duck content and total foie gras content, respectively. Both PCR systems (duck-specific and duck + goose) were designed on the mitochondrial 12S ribosomal RNA gene (rRNA). The duck-specific system amplifies a 96 bp fragment from duck DNA, whereas the duck + goose system amplifies a 120 bp fragment from duck and goose DNA. The method measures PCR product accumulation through a FAM-labeled fluorogenic probe (TaqMan). The Ct (threshold cycle) values obtained from the duck + goose system are used to normalize the ones obtained from the duck-specific system. Analysis of experimental duck/goose foie gras binary mixtures demonstrated the suitability of the assay for the detection and quantitation of...
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identification of goose mule duck chicken turkey and swine in foie gras by species specific polymerase chain reaction
Journal of Agricultural and Food Chemistry, 2003Co-Authors: Miguel A. Rodríguez, Teresa Garcia, Luis Asensio, Belen Mayoral, Ines Lopezcalleja, Pablo E Hernandez, Isabel Gonzalez, Rosario MartinAbstract:A specific Polymerase Chain Reaction (PCR) has been developed for the identification of goose (Anser anser), mule duck (Anas platyrhynchos × Cairina moschata), chicken (Gallus gallus), turkey (Mele...
Franco Mutinelli - One of the best experts on this subject based on the ideXlab platform.
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first report of parasitic esophagitis by streptocara incognita in muscovy ducks Cairina moschata domesticus in italy
Avian Diseases, 2005Co-Authors: Luca Bano, Franco Mutinelli, Alda Natale, Marta Vascellari, Damiano Comin, Fabrizio AgnolettiAbstract:This work describes the first outbreak of streptocariasis by Streptocara incognita reported from Italy. The disease was observed in a backyard flock of 62 ducks (Cairina moschata domesticus) located in Treviso, northeastern Italy. Fifteen birds died in a period of 2 wk, showing debilitation and emaciation. Two ducks were submitted for postmortem examination and an esophagitis associated with nematodes was observed. The nematodes were identified as Streptocara incognita.
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mortality in muscovy ducks Cairina moschata and domestic geese anser anser var domestica associated with natural infection with a highly pathogenic avian influenza virus of h7n1 subtype
Avian Pathology, 2001Co-Authors: Ilaria Capua, Franco MutinelliAbstract:Among the 413 outbreaks of highly pathogenic avian influenza (HPAI) caused by a virus of the H7N1 subtype, which occurred in Italy during 1999 and 2000, an outbreak diagnosed in a backyard flock was characterized by mortality and nervous signs in ducks and geese. Dead geese (Anser anser var. domestica) and Muscovy ducks (Cairina moschata) were submitted to the laboratory for bacteriological, virological, histological and immunohistochemical investigations. Routine bacteriological tests resulted negative, while a HPAI virus of the H7N1 subtype was isolated from the geese. Pancreatic damage was observed in both the geese and the ducks, and the pancreas was also positive by immunohistochemistry for avian influenza in the geese. Histopathological lesions were observed in the central nervous system of both species, and this result was supported by positive immunohistochemical findings for the presence of the virus.
