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Calcium Binding

The Experts below are selected from a list of 177 Experts worldwide ranked by ideXlab platform

Willi Hunzlker – 1st expert on this subject based on the ideXlab platform

  • intracellular Calcium Binding proteins more sites than insights
    Trends in Biochemical Sciences, 1991
    Co-Authors: Claus W Heizmann, Willi Hunzlker

    Abstract:

    Abstract Calcium ions as biological regulators exert their effects in part via interaction with a wide variety of intracellular CalciumBinding proteins. One class of these proteins shares a common CalciumBinding motif, the EF-hand. A consensus amino acid sequence for this motif has aided the identification of new members of this family of EF-hand proteins, which now has about 170 members. A few of these proteins are present in all cells, whereas the vast majority are expressed in a tissue-specific fashion. The physiological function of a few of these proteins is known to be achieved via a Calcium-dependent interaction with other proteins, thereby regulating their activity. The elucidation of the interactions and functions of the majority of these proteins remains a challenging task for the coming years.

Jenny J. Yang – 2nd expert on this subject based on the ideXlab platform

  • Analysis and Evaluation of Rational Designed Calcium Binding Sites in CD2
    Peptides: The Wave of the Future, 2020
    Co-Authors: Wei Yang, Jenny J. Yang

    Abstract:

    Calcium functions as a second messenger. It regulates different biological systems by interaction with proteins with different affinities in different biological environments. Calcium and CalciumBinding proteins play central roles in intracellular signal transduction pathways and are associated with a wide-range of effects in health and disease [1]. To reveal the key factors for the Calcium Binding in proteins, rational design of de novo CalciumBinding proteins has been carried out to overcome the drawbacks of natural CalciumBinding proteins such as metal-metal interactions and conformational changes. Establishments of the parameters in programs and criteria in screening the output from the computer are the keys for successful design.

  • Identifying and Designing of Calcium Binding Sites in Proteins by Computational Algorithm
    Computational Studies Nanotechnology and Solution Thermodynamics of Polymer Systems, 2020
    Co-Authors: Wei Yang, Homme W. Hellinga, Michelle Pu, Jenny J. Yang

    Abstract:

    Our studies for the identification of the natural Calcium Binding sites with both classic and pseudo EF-hand motifs in three EF-hand proteins have shown that natural Calcium Binding sites can be accurately relocated with Dezymer using a set of geometric descriptions of an ideal pentagonal bipyramid. The success of each constructed site can be ranked by the relative U(p) values. The searched native-like sites in three EF-hand proteins have the smallest deviation from the target geometry. Our work indicates that a useful method for searching CalciumBinding sites in proteins has been established. It is possible to use established parameters to design novel Calcium Binding proteins.

  • Encyclopedia of Inorganic and Bioinorganic Chemistry – CalciumBinding Proteins
    Encyclopedia of Inorganic and Bioinorganic Chemistry, 2011
    Co-Authors: Jenny J. Yang, Wei Yang

    Abstract:

    Ca2+ is an important second messenger in the regulation of cell life cycle in addition to being an essential component in biomineralization. Ca2+ mediates its action in regulation by Binding to Ca2+ receptors/proteins that in turn regulate signal transduction, enzymatic activity, and protein stability. During the past few years, owing to the fast progress in genomic information and structural biological studies, our understanding of CalciumBinding proteins has been greatly expanded. Since 1991, the structures of CalciumBinding proteins have been extended to more than 1000 today and CalciumBinding proteins are found in every cellular compartment. In this article, we will first summarize the current knowledge about the common properties of CalciumBinding proteins. We then will highlight recent developments in structural biology and biological functions of CalciumBinding proteins.

    Keywords:

    CalciumBinding proteins;
    metalloproteins;
    EF-hand;
    calmodulin;
    conformational change;
    protein–protein interaction;
    extracellular CalciumBinding proteins;
    Calcium signaling, Calcium homeostasis;
    trigger proteins;
    biometals;
    signal transduction

Wei Yang – 3rd expert on this subject based on the ideXlab platform

  • Analysis and Evaluation of Rational Designed Calcium Binding Sites in CD2
    Peptides: The Wave of the Future, 2020
    Co-Authors: Wei Yang, Jenny J. Yang

    Abstract:

    Calcium functions as a second messenger. It regulates different biological systems by interaction with proteins with different affinities in different biological environments. Calcium and CalciumBinding proteins play central roles in intracellular signal transduction pathways and are associated with a wide-range of effects in health and disease [1]. To reveal the key factors for the Calcium Binding in proteins, rational design of de novo CalciumBinding proteins has been carried out to overcome the drawbacks of natural CalciumBinding proteins such as metal-metal interactions and conformational changes. Establishments of the parameters in programs and criteria in screening the output from the computer are the keys for successful design.

  • Identifying and Designing of Calcium Binding Sites in Proteins by Computational Algorithm
    Computational Studies Nanotechnology and Solution Thermodynamics of Polymer Systems, 2020
    Co-Authors: Wei Yang, Homme W. Hellinga, Michelle Pu, Jenny J. Yang

    Abstract:

    Our studies for the identification of the natural Calcium Binding sites with both classic and pseudo EF-hand motifs in three EF-hand proteins have shown that natural Calcium Binding sites can be accurately relocated with Dezymer using a set of geometric descriptions of an ideal pentagonal bipyramid. The success of each constructed site can be ranked by the relative U(p) values. The searched native-like sites in three EF-hand proteins have the smallest deviation from the target geometry. Our work indicates that a useful method for searching CalciumBinding sites in proteins has been established. It is possible to use established parameters to design novel Calcium Binding proteins.

  • Encyclopedia of Inorganic and Bioinorganic Chemistry – CalciumBinding Proteins
    Encyclopedia of Inorganic and Bioinorganic Chemistry, 2011
    Co-Authors: Jenny J. Yang, Wei Yang

    Abstract:

    Ca2+ is an important second messenger in the regulation of cell life cycle in addition to being an essential component in biomineralization. Ca2+ mediates its action in regulation by Binding to Ca2+ receptors/proteins that in turn regulate signal transduction, enzymatic activity, and protein stability. During the past few years, owing to the fast progress in genomic information and structural biological studies, our understanding of CalciumBinding proteins has been greatly expanded. Since 1991, the structures of CalciumBinding proteins have been extended to more than 1000 today and CalciumBinding proteins are found in every cellular compartment. In this article, we will first summarize the current knowledge about the common properties of CalciumBinding proteins. We then will highlight recent developments in structural biology and biological functions of CalciumBinding proteins.

    Keywords:

    CalciumBinding proteins;
    metalloproteins;
    EF-hand;
    calmodulin;
    conformational change;
    protein–protein interaction;
    extracellular CalciumBinding proteins;
    Calcium signaling, Calcium homeostasis;
    trigger proteins;
    biometals;
    signal transduction