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R P Ellwood - One of the best experts on this subject based on the ideXlab platform.

  • the anti caries efficacy of a dentifrice containing 1 5 arginine and 1450 ppm fluoride as sodium monofluorophosphate assessed using quantitative light induced fluorescence qlf
    Journal of Dentistry, 2013
    Co-Authors: Wei Yin, Yun Po Zhang, Diane Cummins, X Fan, Iain A Pretty, L R Mateo, R P Ellwood
    Abstract:

    Objective: To compare the efficacy of a new dentifrice containing 1.5% arginine, an insoluble Calcium Compound and 1450 ppm fluoride to arrest and reverse naturally occurring buccal caries lesions in children relative to a positive control dentifrice containing 1450 ppm fluoride alone. Study design: Participants from Chengdu, Sichuan Province, China tested three dentifrices: a new dentifrice containing 1.5% arginine, an insoluble Calcium Compound, and 1450 ppm fluoride, as sodium monofluorophosphate, a positive control dentifrice containing 1450 ppm fluoride, as sodium fluoride, in a silica base, and a matched negative control dentifrice without arginine and fluoride. Quantitative Light-induced Fluorescence (QLF) was used to assess buccal caries lesions at baseline and after 3 and 6 months of product use. Results: 438 participants (initial age 9‐13 years (mean 11.1 0.78) and 48.6% female) completed the study. No adverse events attributable to the products were reported during the course of the study. The subject mean DQ (mm 2 %), representing lesion volume, was 27.26 at

  • comparison of the efficacy of a dentifrice containing 1 5 arginine and 1450 ppm fluoride to a dentifrice containing 1450 ppm fluoride alone in the management of early coronal caries as assessed using quantitative light induced fluorescence
    Journal of Dentistry, 2013
    Co-Authors: Patcharawan Srisilapanan, Yun Po Zhang, Luis R Mateo, Diane Cummins, Wei Yin, Narumanas Korwanich, C Chuensuwonkul, R P Ellwood
    Abstract:

    Abstract Objective To compare the efficacy of a new dentifrice containing 1.5% arginine, an insoluble Calcium Compound, and 1450 ppm fluoride to a matched, positive control dentifrice containing 1450 ppm fluoride in arresting and reversing early coronal caries lesions in children using Quantitative Light-induced Fluorescence (QLF). Study design 331 children from Chiang Mai, Thailand, aged 7–14 years, with one or more visible early enamel caries lesions on the upper anterior teeth, completed the study. The new dentifrice contained 1.5% arginine, an insoluble Calcium Compound, and 1450 ppm fluoride, as sodium monofluorophosphate; the matched positive control contained 1450 ppm fluoride only. Subjects brushed twice daily at home and additionally once on school days under teacher's supervision. Digital images of the upper six anterior teeth were captured at the baseline, 3- and 6-month examinations using a custom apparatus for reproducible acquisition of Quantitative Light-induced Fluorescence data. Results At the 3-month examination, the Δ Q (representing lesion volume) for the test group decreased from a mean of 28.62 at baseline to 20.53 mm 2 % and for the positive control group to 23.38 mm 2 %. The difference between groups was not statistically significant ( p  = 0.055). At the 6-month examination, the Δ Q decreased for the test group to 15.85 mm 2 % and for the positive control group to 20.35 mm 2 %. The difference between groups was statistically significant ( p Conclusion A new dentifrice containing 1.5% arginine, an insoluble Calcium Compound, and 1450 ppm fluoride, as sodium monofluorophosphate, provided statistically significant superior efficacy in arresting and reversing active coronal caries lesions in children than brushing with a matched positive control dentifrice containing fluoride alone.

  • comparing the efficacy of a dentifrice containing 1 5 arginine and 1450 ppm fluoride to a dentifrice containing 1450 ppm fluoride alone in the management of primary root caries
    Journal of Dentistry, 2013
    Co-Authors: Maria Da Luz Rosario De Souza, Yun Po Zhang, Diane Cummins, L R Mateo, Jaime Aparecido Cury, Livia Maria Andalo Tenuta, R P Ellwood
    Abstract:

    Abstract Objective To compare the efficacy of a new dentifrice containing 1.5% arginine and 1450 ppm fluoride to a positive control dentifrice containing 1450 ppm fluoride alone in arresting and reversing primary root caries lesions in adults. Study design A total of 3779 subjects from Piracicaba, Sao Paulo, Brazil were screened; 284 had at least one leathery primary root caries lesion and were eligible for the study. The new dentifrice contained 1.5% arginine, an insoluble Calcium Compound, and 1450 ppm fluoride, as sodium monofluorophosphate; the matched positive control dentifrice contained 1450 ppm fluoride. One lesion for each subject was selected for inclusion in the study and was examined at baseline, 3 and 6 months. Results A total of 253 subjects completed the study with 129 of 144 subjects included in the final statistical analysis for the test dentifrice and 124 of 140 for the positive control. The mean age of subjects was 45.7 (±9.19) years and 56.5% were female. After 6 months product use, 70.5% of root caries lesions improved for subjects using the arginine-containing dentifrice compared to 58.1% for subjects using the positive control. The difference in the number of root caries lesions becoming hard in the two groups was statistically significant (p = 0.038). Conclusion A new dentifrice containing 1.5% arginine, an insoluble Calcium Compound, and 1450 ppm fluoride, as sodium monofluorophosphate, provided statistically significantly superior efficacy in arresting and reversing active root caries lesions in adults compared to a matched positive control dentifrice containing fluoride alone.

  • a clinical investigation using quantitative light induced fluorescence qlf of the anticaries efficacy of a dentifrice containing 1 5 arginine and 1450 ppm fluoride as sodium monofluorophosphate
    The Journal of clinical dentistry, 2013
    Co-Authors: Wei Yin, Yun Po Zhang, Diane Cummins, X Fan, Iain A Pretty, L R Mateo, Y Feng, R P Ellwood
    Abstract:

    OBJECTIVE: The purpose of this study was to assess the ability of a new dentifrice containing arginine, an insoluble Calcium Compound, and fluoride to arrest or reverse naturally occurring buccal caries lesions measured using Quantitative Light-induced Fluorescence (QLF). METHODS: Three study groups used dentifrices which contained 1) 1.5% arginine and 1450 ppm fluoride as sodium monofluorophosphate (experimental), 2) 1450 ppm fluoride as sodium monofluorophosphate (positive control), and 3) no fluoride (negative control). All three dentifrices were formulated in the same Calcium base. The study participants were from three schools in the city of Chengdu, Sichuan Province, China. A total of 446 of 450 recruited subjects completed the study. Of these, 147 were in the experimental, 148 in the positive control, and 151 in the negative control groups. The initial age of the children was 10-12 years (mean 11.4 +/- 0.54); 47.5% were female. RESULTS: Using QLF, assessments of buccal caries lesions were made at baseline and after three and six months of product use. For AQ, representing lesion volume, the baseline mean value for the three groups was 27.30, and at the three-month examination the mean values were 16.76, 19.25, and 25.89 for the experimental, positive, and negative control dentifrices, respectively. This represents improvements from baseline of 38.6%, 29.5%, and 5.2%. At six months, the deltaQ values for the three groups were 13.46, 18.47, and 24.18, representing improvements from baseline of 50.7%, 32.3%, and 11.4%. For all QLF metrics, deltaF (loss of fluorescence), area, and deltaQ, the differences between the negative control and both the experimental and positive control groups were statistically significant (p < or = 0.01). The differences between the experimental and positive control groups attained statistical significance for deltaQ (p < or = 0.003) at the six-month examination. CONCLUSION: It is concluded that both of the fluoride-containing toothpastes are significantly better at arresting and reversing buccal caries lesions than the non-fluoride toothpaste. Furthermore, it is concluded that the new dentifrice containing arginine, an insoluble Calcium Compound, and fluoride provides significantly greater anticaries benefit than a dentifrice containing fluoride alone.

  • two year caries clinical study of the efficacy of novel dentifrices containing 1 5 arginine an insoluble Calcium Compound and 1 450 ppm fluoride
    Caries Research, 2013
    Co-Authors: Petcharat Kraivaphan, Luis R Mateo, R P Ellwood, Cholticha Amornchat, T Triratana, D Cummins, William Devizio, Y P Zhang
    Abstract:

    A 2-year double-blind randomized three-treatment controlled parallel-group clinical study compared the anti-caries efficacy of two dentifrices containing 1.5% arginine, an insoluble Calcium Compound (

Diane Cummins - One of the best experts on this subject based on the ideXlab platform.

  • the anti caries efficacy of a dentifrice containing 1 5 arginine and 1450 ppm fluoride as sodium monofluorophosphate assessed using quantitative light induced fluorescence qlf
    Journal of Dentistry, 2013
    Co-Authors: Wei Yin, Yun Po Zhang, Diane Cummins, X Fan, Iain A Pretty, L R Mateo, R P Ellwood
    Abstract:

    Objective: To compare the efficacy of a new dentifrice containing 1.5% arginine, an insoluble Calcium Compound and 1450 ppm fluoride to arrest and reverse naturally occurring buccal caries lesions in children relative to a positive control dentifrice containing 1450 ppm fluoride alone. Study design: Participants from Chengdu, Sichuan Province, China tested three dentifrices: a new dentifrice containing 1.5% arginine, an insoluble Calcium Compound, and 1450 ppm fluoride, as sodium monofluorophosphate, a positive control dentifrice containing 1450 ppm fluoride, as sodium fluoride, in a silica base, and a matched negative control dentifrice without arginine and fluoride. Quantitative Light-induced Fluorescence (QLF) was used to assess buccal caries lesions at baseline and after 3 and 6 months of product use. Results: 438 participants (initial age 9‐13 years (mean 11.1 0.78) and 48.6% female) completed the study. No adverse events attributable to the products were reported during the course of the study. The subject mean DQ (mm 2 %), representing lesion volume, was 27.26 at

  • the development and validation of a new technology based upon 1 5 arginine an insoluble Calcium Compound and fluoride for everyday use in the prevention and treatment of dental caries
    Journal of Dentistry, 2013
    Co-Authors: Diane Cummins
    Abstract:

    Abstract Objective This paper briefly discusses caries prevalence, the multi-factorial nature of caries etiology, caries risk and the role and efficacy of fluoride. The paper also highlights research on bacterial metabolism which provided understanding of the mouth's natural defenses against caries and the basis for the development of a new technology for the everyday prevention and treatment of caries. Finally, evidence that the technology complements and enhances the anti-caries efficacy of fluoride toothpaste is summarized. Conclusions Global data show that dental caries is a prevalent disease, despite the successful introduction of fluoride. Caries experience depends on the balance between consumption of sugars and oral hygiene and the use of fluoride. Three scientific concepts are fundamental to new measures to detect, treat and monitor caries: ( 1 ) dental caries is a dynamic process, ( 2 ) dental caries is a continuum of stages from reversible, pre-clinical to irreversible, clinically detectable lesions, and ( 3 ) the caries process is a balance of pathological and protective factors that can be modulated to manage caries. Fluoride functions as a protective factor by arresting and reversing the caries process, but fluoride does not prevent pathological factors that initiate the process. A novel technology, based upon arginine and an insoluble Calcium Compound, has been identified which targets dental plaque to prevent initiation of the caries process by reducing pathological factors. As the mechanisms of action of arginine and fluoride are highly complementary, a new dentifrice, which combines arginine with fluoride, has been developed and clinically proven to provide superior caries prevention.

  • comparison of the efficacy of a dentifrice containing 1 5 arginine and 1450 ppm fluoride to a dentifrice containing 1450 ppm fluoride alone in the management of early coronal caries as assessed using quantitative light induced fluorescence
    Journal of Dentistry, 2013
    Co-Authors: Patcharawan Srisilapanan, Yun Po Zhang, Luis R Mateo, Diane Cummins, Wei Yin, Narumanas Korwanich, C Chuensuwonkul, R P Ellwood
    Abstract:

    Abstract Objective To compare the efficacy of a new dentifrice containing 1.5% arginine, an insoluble Calcium Compound, and 1450 ppm fluoride to a matched, positive control dentifrice containing 1450 ppm fluoride in arresting and reversing early coronal caries lesions in children using Quantitative Light-induced Fluorescence (QLF). Study design 331 children from Chiang Mai, Thailand, aged 7–14 years, with one or more visible early enamel caries lesions on the upper anterior teeth, completed the study. The new dentifrice contained 1.5% arginine, an insoluble Calcium Compound, and 1450 ppm fluoride, as sodium monofluorophosphate; the matched positive control contained 1450 ppm fluoride only. Subjects brushed twice daily at home and additionally once on school days under teacher's supervision. Digital images of the upper six anterior teeth were captured at the baseline, 3- and 6-month examinations using a custom apparatus for reproducible acquisition of Quantitative Light-induced Fluorescence data. Results At the 3-month examination, the Δ Q (representing lesion volume) for the test group decreased from a mean of 28.62 at baseline to 20.53 mm 2 % and for the positive control group to 23.38 mm 2 %. The difference between groups was not statistically significant ( p  = 0.055). At the 6-month examination, the Δ Q decreased for the test group to 15.85 mm 2 % and for the positive control group to 20.35 mm 2 %. The difference between groups was statistically significant ( p Conclusion A new dentifrice containing 1.5% arginine, an insoluble Calcium Compound, and 1450 ppm fluoride, as sodium monofluorophosphate, provided statistically significant superior efficacy in arresting and reversing active coronal caries lesions in children than brushing with a matched positive control dentifrice containing fluoride alone.

  • comparing the efficacy of a dentifrice containing 1 5 arginine and 1450 ppm fluoride to a dentifrice containing 1450 ppm fluoride alone in the management of primary root caries
    Journal of Dentistry, 2013
    Co-Authors: Maria Da Luz Rosario De Souza, Yun Po Zhang, Diane Cummins, L R Mateo, Jaime Aparecido Cury, Livia Maria Andalo Tenuta, R P Ellwood
    Abstract:

    Abstract Objective To compare the efficacy of a new dentifrice containing 1.5% arginine and 1450 ppm fluoride to a positive control dentifrice containing 1450 ppm fluoride alone in arresting and reversing primary root caries lesions in adults. Study design A total of 3779 subjects from Piracicaba, Sao Paulo, Brazil were screened; 284 had at least one leathery primary root caries lesion and were eligible for the study. The new dentifrice contained 1.5% arginine, an insoluble Calcium Compound, and 1450 ppm fluoride, as sodium monofluorophosphate; the matched positive control dentifrice contained 1450 ppm fluoride. One lesion for each subject was selected for inclusion in the study and was examined at baseline, 3 and 6 months. Results A total of 253 subjects completed the study with 129 of 144 subjects included in the final statistical analysis for the test dentifrice and 124 of 140 for the positive control. The mean age of subjects was 45.7 (±9.19) years and 56.5% were female. After 6 months product use, 70.5% of root caries lesions improved for subjects using the arginine-containing dentifrice compared to 58.1% for subjects using the positive control. The difference in the number of root caries lesions becoming hard in the two groups was statistically significant (p = 0.038). Conclusion A new dentifrice containing 1.5% arginine, an insoluble Calcium Compound, and 1450 ppm fluoride, as sodium monofluorophosphate, provided statistically significantly superior efficacy in arresting and reversing active root caries lesions in adults compared to a matched positive control dentifrice containing fluoride alone.

  • a clinical investigation using quantitative light induced fluorescence qlf of the anticaries efficacy of a dentifrice containing 1 5 arginine and 1450 ppm fluoride as sodium monofluorophosphate
    The Journal of clinical dentistry, 2013
    Co-Authors: Wei Yin, Yun Po Zhang, Diane Cummins, X Fan, Iain A Pretty, L R Mateo, Y Feng, R P Ellwood
    Abstract:

    OBJECTIVE: The purpose of this study was to assess the ability of a new dentifrice containing arginine, an insoluble Calcium Compound, and fluoride to arrest or reverse naturally occurring buccal caries lesions measured using Quantitative Light-induced Fluorescence (QLF). METHODS: Three study groups used dentifrices which contained 1) 1.5% arginine and 1450 ppm fluoride as sodium monofluorophosphate (experimental), 2) 1450 ppm fluoride as sodium monofluorophosphate (positive control), and 3) no fluoride (negative control). All three dentifrices were formulated in the same Calcium base. The study participants were from three schools in the city of Chengdu, Sichuan Province, China. A total of 446 of 450 recruited subjects completed the study. Of these, 147 were in the experimental, 148 in the positive control, and 151 in the negative control groups. The initial age of the children was 10-12 years (mean 11.4 +/- 0.54); 47.5% were female. RESULTS: Using QLF, assessments of buccal caries lesions were made at baseline and after three and six months of product use. For AQ, representing lesion volume, the baseline mean value for the three groups was 27.30, and at the three-month examination the mean values were 16.76, 19.25, and 25.89 for the experimental, positive, and negative control dentifrices, respectively. This represents improvements from baseline of 38.6%, 29.5%, and 5.2%. At six months, the deltaQ values for the three groups were 13.46, 18.47, and 24.18, representing improvements from baseline of 50.7%, 32.3%, and 11.4%. For all QLF metrics, deltaF (loss of fluorescence), area, and deltaQ, the differences between the negative control and both the experimental and positive control groups were statistically significant (p < or = 0.01). The differences between the experimental and positive control groups attained statistical significance for deltaQ (p < or = 0.003) at the six-month examination. CONCLUSION: It is concluded that both of the fluoride-containing toothpastes are significantly better at arresting and reversing buccal caries lesions than the non-fluoride toothpaste. Furthermore, it is concluded that the new dentifrice containing arginine, an insoluble Calcium Compound, and fluoride provides significantly greater anticaries benefit than a dentifrice containing fluoride alone.

Tomomi Nemoto - One of the best experts on this subject based on the ideXlab platform.

  • A Novel Function of Noc2 in Agonist-Induced Intracellular Ca2+ Increase during Zymogen-Granule
    2016
    Co-Authors: Exocytosis Pancreatic, Acinar Cells, Sho Ogata, Takashi Miki, Susumu Seino, Seiichi Tamai, Haruo Kasai, Tomomi Nemoto
    Abstract:

    Noc2, a putative Rab effector, contributes to secretory-granule exocytosis in neuroendocrine and exocrine cells. Here, using two-photon excitation live-cell imaging, we investigated its role in Ca2+-dependent zymogen granule (ZG) exocytosis in pancreatic acinar cells from wild-type (WT) and Noc2-knockout (KO) mice. Imaging of a KO acinar cell revealed an expanded granular area, indicating ZG accumulation. In our spatiotemporal analysis of the ZG exocytosis induced by agonist (cholecystokinin or acetylcholine) stimulation, the location and rate of progress of ZG exocytosis did not differ significantly between the two strains. ZG exocytosis from KO acinar cells was seldom observed at physiological concentrations of agonists, but was normal (vs. WT) at high concentrations. Flash photolysis of a caged Calcium Compound confirmed the integrity of the fusion step of ZG exocytosis in KO acinar cells. The decreased ZG exocytosis present at physiological concentrations of agonists raised the possibility of impaired elicitation of Calcium spikes. When Calcium spikes were evoked in KO acinar cells by a high agonist concentration: (a) they always started at the apical portion and traveled to the basa

  • a novel function of noc2 in agonist induced intracellular ca2 increase during zymogen granule exocytosis in pancreatic acinar cells
    PLOS ONE, 2012
    Co-Authors: Sho Ogata, Takashi Miki, Susumu Seino, Seiichi Tamai, Haruo Kasai, Tomomi Nemoto
    Abstract:

    Noc2, a putative Rab effector, contributes to secretory-granule exocytosis in neuroendocrine and exocrine cells. Here, using two-photon excitation live-cell imaging, we investigated its role in Ca2+-dependent zymogen granule (ZG) exocytosis in pancreatic acinar cells from wild-type (WT) and Noc2-knockout (KO) mice. Imaging of a KO acinar cell revealed an expanded granular area, indicating ZG accumulation. In our spatiotemporal analysis of the ZG exocytosis induced by agonist (cholecystokinin or acetylcholine) stimulation, the location and rate of progress of ZG exocytosis did not differ significantly between the two strains. ZG exocytosis from KO acinar cells was seldom observed at physiological concentrations of agonists, but was normal (vs. WT) at high concentrations. Flash photolysis of a caged Calcium Compound confirmed the integrity of the fusion step of ZG exocytosis in KO acinar cells. The decreased ZG exocytosis present at physiological concentrations of agonists raised the possibility of impaired elicitation of Calcium spikes. When Calcium spikes were evoked in KO acinar cells by a high agonist concentration: (a) they always started at the apical portion and traveled to the basal portion, and (b) Calcium oscillations over the 10 µM level were observed, as in WT acinar cells. At physiological concentrations of agonists, however, sufficient Calcium spikes were not observed, suggesting an impaired [Ca2+]i-increase mechanism in KO acinar cells. We propose that in pancreatic acinar cells, Noc2 is not indispensable for the membrane fusion of ZG per se, but instead performs a novel function favoring agonist-induced physiological [Ca2+]i increases.

Takashi Miki - One of the best experts on this subject based on the ideXlab platform.

  • A Novel Function of Noc2 in Agonist-Induced Intracellular Ca2+ Increase during Zymogen-Granule
    2016
    Co-Authors: Exocytosis Pancreatic, Acinar Cells, Sho Ogata, Takashi Miki, Susumu Seino, Seiichi Tamai, Haruo Kasai, Tomomi Nemoto
    Abstract:

    Noc2, a putative Rab effector, contributes to secretory-granule exocytosis in neuroendocrine and exocrine cells. Here, using two-photon excitation live-cell imaging, we investigated its role in Ca2+-dependent zymogen granule (ZG) exocytosis in pancreatic acinar cells from wild-type (WT) and Noc2-knockout (KO) mice. Imaging of a KO acinar cell revealed an expanded granular area, indicating ZG accumulation. In our spatiotemporal analysis of the ZG exocytosis induced by agonist (cholecystokinin or acetylcholine) stimulation, the location and rate of progress of ZG exocytosis did not differ significantly between the two strains. ZG exocytosis from KO acinar cells was seldom observed at physiological concentrations of agonists, but was normal (vs. WT) at high concentrations. Flash photolysis of a caged Calcium Compound confirmed the integrity of the fusion step of ZG exocytosis in KO acinar cells. The decreased ZG exocytosis present at physiological concentrations of agonists raised the possibility of impaired elicitation of Calcium spikes. When Calcium spikes were evoked in KO acinar cells by a high agonist concentration: (a) they always started at the apical portion and traveled to the basa

  • a novel function of noc2 in agonist induced intracellular ca2 increase during zymogen granule exocytosis in pancreatic acinar cells
    PLOS ONE, 2012
    Co-Authors: Sho Ogata, Takashi Miki, Susumu Seino, Seiichi Tamai, Haruo Kasai, Tomomi Nemoto
    Abstract:

    Noc2, a putative Rab effector, contributes to secretory-granule exocytosis in neuroendocrine and exocrine cells. Here, using two-photon excitation live-cell imaging, we investigated its role in Ca2+-dependent zymogen granule (ZG) exocytosis in pancreatic acinar cells from wild-type (WT) and Noc2-knockout (KO) mice. Imaging of a KO acinar cell revealed an expanded granular area, indicating ZG accumulation. In our spatiotemporal analysis of the ZG exocytosis induced by agonist (cholecystokinin or acetylcholine) stimulation, the location and rate of progress of ZG exocytosis did not differ significantly between the two strains. ZG exocytosis from KO acinar cells was seldom observed at physiological concentrations of agonists, but was normal (vs. WT) at high concentrations. Flash photolysis of a caged Calcium Compound confirmed the integrity of the fusion step of ZG exocytosis in KO acinar cells. The decreased ZG exocytosis present at physiological concentrations of agonists raised the possibility of impaired elicitation of Calcium spikes. When Calcium spikes were evoked in KO acinar cells by a high agonist concentration: (a) they always started at the apical portion and traveled to the basal portion, and (b) Calcium oscillations over the 10 µM level were observed, as in WT acinar cells. At physiological concentrations of agonists, however, sufficient Calcium spikes were not observed, suggesting an impaired [Ca2+]i-increase mechanism in KO acinar cells. We propose that in pancreatic acinar cells, Noc2 is not indispensable for the membrane fusion of ZG per se, but instead performs a novel function favoring agonist-induced physiological [Ca2+]i increases.

Luis R Mateo - One of the best experts on this subject based on the ideXlab platform.

  • randomized clinical trial of the efficacy of dentifrices containing 1 5 arginine an insoluble Calcium Compound and 1450 ppm fluoride over two years
    The Journal of clinical dentistry, 2015
    Co-Authors: Yisi Zhong, Luis R Mateo, Xianjun Jiang, Hu Deyu, Boyce M Morrison, Yun Po Zhang
    Abstract:

    Objective A double blind, randomized, unsupervised, parallel-group clinical trial was conducted on over 5,500 children in Sichuan Province, China. This clinical trial compared the anti-caries efficacy of two test dentifrices to that of a control dentifrice. Methods The test dentifrices contained 1.5% arginine, 1450 ppm fluoride as sodium monofluorophosphate (MFP), and an insoluble Calcium Compound (either diCalcium phosphate or Calcium carbonate). The positive control dentifrice contained 1450 ppm fluoride as sodium fluoride (NaF), in a silica base. The children were randomly assigned one of the toothpastes, and children residing in the same household were assigned the same dentifrice to use at home, twice a day. Results Three calibrated dentists examined the children at baseline, as well as after one and two years of product use. After one year of product use, there were no statistically significant differences among the three groups with respect to decayed, missing, and filled teeth (DMFT) or to decayed, missing, and filled surfaces (DMFS). After two years of product use, subjects in the two test groups using the dentifrices containing 1.5% arginine, 1450 ppm fluoride as MFP, and an insoluble Calcium Compound had a statistically significant reduction in DMFT increments of 20.5% and in DMFS increments of 19.6% when compared to subjects in the group using the positive control dentifrice. After two years, there were no statistically significant differences with respect to DMFT or DMFS between the two groups using the dentifrices containing 1.5% arginine, 1450 ppm fluoride as MFP, and an insoluble Calcium Compound. Conclusion The use of the two test dentifrices demonstrated significant reductions in decayed, missing, and filled teeth and surfaces, however there was no statistically significant different between the two test dentifrices clinically after two years of using the toothpastes. The results of this two-year clinical investigation support the conclusion that dentifrices containing 1.5% arginine, an insoluble Calcium Compound, and 1450 ppm fluoride as MFP provide superior protection against caries lesion cavitation compared to a positive control dentifrice containing only 1450 ppm fluoride as NaF.

  • comparison of the efficacy of a dentifrice containing 1 5 arginine and 1450 ppm fluoride to a dentifrice containing 1450 ppm fluoride alone in the management of early coronal caries as assessed using quantitative light induced fluorescence
    Journal of Dentistry, 2013
    Co-Authors: Patcharawan Srisilapanan, Yun Po Zhang, Luis R Mateo, Diane Cummins, Wei Yin, Narumanas Korwanich, C Chuensuwonkul, R P Ellwood
    Abstract:

    Abstract Objective To compare the efficacy of a new dentifrice containing 1.5% arginine, an insoluble Calcium Compound, and 1450 ppm fluoride to a matched, positive control dentifrice containing 1450 ppm fluoride in arresting and reversing early coronal caries lesions in children using Quantitative Light-induced Fluorescence (QLF). Study design 331 children from Chiang Mai, Thailand, aged 7–14 years, with one or more visible early enamel caries lesions on the upper anterior teeth, completed the study. The new dentifrice contained 1.5% arginine, an insoluble Calcium Compound, and 1450 ppm fluoride, as sodium monofluorophosphate; the matched positive control contained 1450 ppm fluoride only. Subjects brushed twice daily at home and additionally once on school days under teacher's supervision. Digital images of the upper six anterior teeth were captured at the baseline, 3- and 6-month examinations using a custom apparatus for reproducible acquisition of Quantitative Light-induced Fluorescence data. Results At the 3-month examination, the Δ Q (representing lesion volume) for the test group decreased from a mean of 28.62 at baseline to 20.53 mm 2 % and for the positive control group to 23.38 mm 2 %. The difference between groups was not statistically significant ( p  = 0.055). At the 6-month examination, the Δ Q decreased for the test group to 15.85 mm 2 % and for the positive control group to 20.35 mm 2 %. The difference between groups was statistically significant ( p Conclusion A new dentifrice containing 1.5% arginine, an insoluble Calcium Compound, and 1450 ppm fluoride, as sodium monofluorophosphate, provided statistically significant superior efficacy in arresting and reversing active coronal caries lesions in children than brushing with a matched positive control dentifrice containing fluoride alone.

  • two year caries clinical study of the efficacy of novel dentifrices containing 1 5 arginine an insoluble Calcium Compound and 1 450 ppm fluoride
    Caries Research, 2013
    Co-Authors: Petcharat Kraivaphan, Luis R Mateo, R P Ellwood, Cholticha Amornchat, T Triratana, D Cummins, William Devizio, Y P Zhang
    Abstract:

    A 2-year double-blind randomized three-treatment controlled parallel-group clinical study compared the anti-caries efficacy of two dentifrices containing 1.5% arginine, an insoluble Calcium Compound (

  • a clinical investigation of the efficacy of a dentifrice containing 1 5 arginine and 1450 ppm fluoride as sodium monofluorophosphate in a Calcium base on primary root caries
    The Journal of clinical dentistry, 2013
    Co-Authors: Wei Yin, Yun Po Zhang, Luis R Mateo, Y Feng, D Cummins, R P Ellwood
    Abstract:

    OBJECTIVE The purpose of this six-month study was to assess the ability of a new dentifrice containing 1.5% arginine, an insoluble Calcium Compound, and 1450 ppm fluoride, as sodium monofluorophosphate, to arrest and reverse primary root caries lesions in adults. METHODS Three test groups used dentifrices which contained either: 1) 1.5% arginine and 1450 ppm fluoride as sodium monofluorophosphate in a Calcium base (experimental); 2) 1450 ppm fluoride as sodium fluoride in a silica base (positive control); or 3) no fluoride in a Calcium base (negative control). The study participants were residents of the city of Chengdu, Sichuan Province, China. In order to take part, subjects had to have at least one non-cavitated primary root caries lesion. A total of 412 subjects completed the study. They were aged from 50 to 70 years (mean age 64 +/- 4.1 years) and 53.6% were female. Efficacy for arresting and reversal of primary root caries was assessed by clinical hardness measures and through the use of the Electrical Caries Monitor. RESULTS After three months of product use, clinical hardness measures showed that 27.7%, 24.6%, and 13.1% of lesions had improved in the experimental, positive, and negative control groups, respectively, and 0.7%, 4.5%, and 16.8% had become worse, respectively. The differences in the distribution of lesion change between the negative control group and both the experimental (p < 0.001) and positive control (p = 0.001) were statistically significant. The Electrical Caries Monitor was also used as an objective measure of lesion severity. The end values increased from baseline to the three-month examinations, but none of the differences between the groups attained statistical significance. After six months, clinical hardness measures showed that only one lesion (0.7%) was worse than at the baseline examination-in the experimental group compared to 9.0% and 18.2% in the positive and negative control groups, respectively. In addition, 61.7%, 56.0%, and 27.0%, respectively, showed improvement for the three groups. The differences in the distribution of lesion change scores between the negative control group and both the experimental (p < 0.001) and positive control (p < 0.001) were statistically significant, as was the difference between the experimental group and the positive control (p = 0.006). The Electrical Caries Monitor end values for the experimental, positive, and negative control groups at the six-month examination were 7.9, 1.9 mega omega(s), and 387 kilo omegas(s), respectively. The differences between the negative control group and both the experimental (p < 0.001) and positive control (p < 0.001) were statistically significant. The difference between the experimental and positive control groups was also statistically significant (p = 0.03). CONCLUSION It is concluded that the new toothpaste containing 1.5% arginine and 1450 ppm fluoride, as sodium monofluorophosphate in a Calcium base, provided greater anticaries benefits than a conventional toothpaste containing 1450 ppm fluoride. Both fluoride toothpastes demonstrated greater benefits than non-fluoride toothpaste.