The Experts below are selected from a list of 84 Experts worldwide ranked by ideXlab platform

Valentyn Novosad - One of the best experts on this subject based on the ideXlab platform.

Maciej S. Lesniak - One of the best experts on this subject based on the ideXlab platform.

  • Magnetic particles with perpendicular anisotropy for mechanical Cancer Cell Destruction.
    Scientific reports, 2017
    Co-Authors: Rhodri Mansell, Maciej S. Lesniak, Tarun Vemulkar, Dorothée Petit, Yu Cheng, Jason P. Murphy, Russell P. Cowburn
    Abstract:

    We demonstrate the effectiveness of out-of-plane magnetized magnetic microdiscs for Cancer treatment through mechanical Cell disruption under an applied rotating magnetic field. The magnetic particles are synthetic antiferromagnets formed from a repeated motif of ultrathin CoFeB/Pt layers. In-vitro studies on glioma Cells are used to compare the efficiency of the CoFeB/Pt microdiscs with Py vortex microdiscs. It is found that the CoFeB/Pt microdiscs are able to damage 62 ± 3% of Cancer Cells compared with 12 ± 2% after applying a 10 kOe rotating field for one minute. The torques applied by each type of particle are measured and are shown to match values predicted by a simple Stoner-Wohlfarth anisotropy model, giving maximum values of 20 fNm for the CoFeB/Pt and 75 fNm for the Py vortex particles. The symmetry of the anisotropy is argued to be more important than the magnitude of the torque in causing effective Cell Destruction in these experiments. This work shows how future magnetic particles can be successfully designed for applications requiring control of applied torques.

  • biofunctionalized magnetic vortex microdiscs for targeted Cancer Cell Destruction
    Nature Materials, 2010
    Co-Authors: Donghyun Kim, Maciej S. Lesniak, Elena A Rozhkova, Ilya V Ulasov, Samuel D Bader, Tijana Rajh, Valentyn Novosad
    Abstract:

    Biocompatible, lithographically defined, ferromagnetic microdiscs that have a spin-vortex ground state oscillate when activated by an alternating magnetic field. This oscillation compromises the integrity of the Cell membrane and initiates programmed Cell death in ∼90% of Cancer Cells in vitro, even with a low-frequency field applied for only ten minutes.

Soonsun Hong - One of the best experts on this subject based on the ideXlab platform.

  • comparison of oxidized porous silicon with bare porous silicon as a photothermal agent for Cancer Cell Destruction based on in vitro Cell test results
    Lasers in Medical Science, 2012
    Co-Authors: Chongmu Lee, Chanseok Hong, Jungkeun Lee, Mikwon Son, Soonsun Hong
    Abstract:

    In the systematic administration of Cancer, Cancer markers are normally used to help the therapeutic agents access the Cancer Cells spontaneously. Therefore, it is essential to functionalize the surface of porous silicon (pSi) for Cancer markers to attach well to pSi in systematic administration because most Cancer markers does not attach easily to pSi. The thermal oxidation of pSi is adopted most widely as a surface functionalization technique for pSi. This study examined the photothermal properties and Cancer Cell-killing ability of oxidized pSi (pSiO). The temperature measurement and in vitro Cell tests including the annexin V-fluorescein isothiocyanate (FITC) apoptosis assay tests, MTT assay tests, and Trypan blue Cell death assay tests were performed to compare the photothermal properties and the cytotoxic effect of pSiO with those of pSi in combination with an 808-nm NIR laser. pSiO showed lower photothermal properties and a lower Cell-death rate than bare pSi. On the other hand, the pSiO treatment used in combination with an NIR laser treatment showed a cytotoxic effect high enough to kill a considerable portion of the Cancer Cells.

  • in vivo Cancer Cell Destruction using porous silicon nanoparticles
    Anti-Cancer Drugs, 2011
    Co-Authors: Chanseok Hong, Jungkeun Lee, Mikwon Son, Soonsun Hong, Chongmu Lee
    Abstract:

    In-vivo animal tests were performed to investigate the feasibility of photothermal therapy based on porous silicon nanoparticles (PSiNPs) in combination with a near-infrared (NIR) laser. The in-vivo animal test results showed that the murine colon carcinoma (CT-26) tumors were completely resorbed with minimal damage to surrounding healthy tissue within 5 days after PSiNPs and NIR laser treatments. In contrast, tumors in the groups treated only with PSiNPs or NIR and a control group continued to grow until the mice died. All of the mice treated with both PSiNPs and NIR remained healthy and free of tumors even 90 days after the treatment. In-vivo fluorescence imaging and the urine and feces tests revealed that PSiNPs injected intratumorally into mice were cleared mainly through the urine. The in-vivo animal test results suggest that thermotherapy based on porous silicon in combination with NIR laser irradiation can efficiently destroy Cancer Cells selectively without damaging the surrounding healthy Cells.

Chongmu Lee - One of the best experts on this subject based on the ideXlab platform.

  • comparison of oxidized porous silicon with bare porous silicon as a photothermal agent for Cancer Cell Destruction based on in vitro Cell test results
    Lasers in Medical Science, 2012
    Co-Authors: Chongmu Lee, Chanseok Hong, Jungkeun Lee, Mikwon Son, Soonsun Hong
    Abstract:

    In the systematic administration of Cancer, Cancer markers are normally used to help the therapeutic agents access the Cancer Cells spontaneously. Therefore, it is essential to functionalize the surface of porous silicon (pSi) for Cancer markers to attach well to pSi in systematic administration because most Cancer markers does not attach easily to pSi. The thermal oxidation of pSi is adopted most widely as a surface functionalization technique for pSi. This study examined the photothermal properties and Cancer Cell-killing ability of oxidized pSi (pSiO). The temperature measurement and in vitro Cell tests including the annexin V-fluorescein isothiocyanate (FITC) apoptosis assay tests, MTT assay tests, and Trypan blue Cell death assay tests were performed to compare the photothermal properties and the cytotoxic effect of pSiO with those of pSi in combination with an 808-nm NIR laser. pSiO showed lower photothermal properties and a lower Cell-death rate than bare pSi. On the other hand, the pSiO treatment used in combination with an NIR laser treatment showed a cytotoxic effect high enough to kill a considerable portion of the Cancer Cells.

  • in vivo Cancer Cell Destruction using porous silicon nanoparticles
    Anti-Cancer Drugs, 2011
    Co-Authors: Chanseok Hong, Jungkeun Lee, Mikwon Son, Soonsun Hong, Chongmu Lee
    Abstract:

    In-vivo animal tests were performed to investigate the feasibility of photothermal therapy based on porous silicon nanoparticles (PSiNPs) in combination with a near-infrared (NIR) laser. The in-vivo animal test results showed that the murine colon carcinoma (CT-26) tumors were completely resorbed with minimal damage to surrounding healthy tissue within 5 days after PSiNPs and NIR laser treatments. In contrast, tumors in the groups treated only with PSiNPs or NIR and a control group continued to grow until the mice died. All of the mice treated with both PSiNPs and NIR remained healthy and free of tumors even 90 days after the treatment. In-vivo fluorescence imaging and the urine and feces tests revealed that PSiNPs injected intratumorally into mice were cleared mainly through the urine. The in-vivo animal test results suggest that thermotherapy based on porous silicon in combination with NIR laser irradiation can efficiently destroy Cancer Cells selectively without damaging the surrounding healthy Cells.

Xuexiang Weng - One of the best experts on this subject based on the ideXlab platform.

  • carbon nanotubes as a protein toxin transporter for selective her2 positive breast Cancer Cell Destruction
    Molecular BioSystems, 2009
    Co-Authors: Xuexiang Weng, Meiyan Wang, Baohong Liu, Jiang Zhong, Jilie Kong
    Abstract:

    The recombined ricin A chain protein (RTA) was transported into living Cells by multiwalled carbon nanotubes (MWNTs) as a Cellular carrier, as performed by natural ricin B chain protein (RTB). The conjugate of the toxinprotein RTA and MWNT was found to translocate to the cytoplasm of various Cell lines and performed biological functions, as evidenced by the induction of Cell death. The delivery of RTA into the Cells viananotube carriers was directly visualized by transmission electron microscopy (TEM) and confocal microscopy. About three times higher Cell death rates for L-929, HL7702, MCF-7, HeLa and COS-7 Cells were demonstrated induced by MWNT–RTA conjugates, compared to those achieved by RTA alone. Especially for HeLa Cells, the Cell mortality reached ∼75%. In addition, obvious selective Destruction of Cancer Cells was achieved by coupling MWNTs–RTA–HER2, which selectively recognize the HER2/neu receptor on certain breast Cancer Cells. This is the first example of recombined proteintoxin (RTA)-induced targeting Destruction for tumor Cells viacarbon nanotube molecular transporters. The transporting capabilities of carbon nanotubes combined with functional proteins may open exciting new venues for drug delivery and Cancer therapy.