The Experts below are selected from a list of 243 Experts worldwide ranked by ideXlab platform
Stig Agurell - One of the best experts on this subject based on the ideXlab platform.
-
acidic in vivo metabolites of Cannabinol isolated from rat faeces
Journal of Pharmacy and Pharmacology, 2011Co-Authors: Woldeab Yisak, Martanne Widman, Stig AgurellAbstract:Six acidic metabolites were isolated from rat faeces and identified by gas chromatography-mass spectrometry and proton magnetic resonance. Cannabinol-7-oic acid was the most abundant acidic metabolite isolated. Others present in decreasing order of prominence were 1″-hydroxy-, 4”-hydroxy-, 3″-hydroxyCannabinol-7-oic acid, Cannabinol-3”-one-7-oic acid and 2″-hydroxyCannabinol-7-oic acid.
-
neutral in vivo metabolites of Cannabinol isolated from rat faeces
Journal of Pharmacy and Pharmacology, 2011Co-Authors: Woldeab Yisak, Janerik Lindgren, Stig AgurellAbstract:The in vivo transformation of Cannabinol (CBN) in the rat has been studied. Unchanged CBN and nine neutral mono-oxygenated and dioxygenated CBN metabolites have been identified. In the mono-oxygenated series the metabolites occurred in decreasing order of prominence as follows: 7-hydroxy-CBN, 4''-hydroxy-CBN, 1''-hydroxy-CBN, 2''-hydroxy-CBN, 3''-hydroxy-CBN, 5''-hydroxy-CBN and CBN-7-al. In the dihydroxylated metabolite series only 1'',7-dihydroxy-CBN and 4'',7-dihydroxy-CBN were found with the former as the more prominent metabolite.
Samir A. Ross - One of the best experts on this subject based on the ideXlab platform.
-
cannabisol a novel δ9 thc dimer possessing a unique methylene bridge isolated from cannabis sativa
Planta Medica, 2012Co-Authors: Fazila Zulfiqar, Samir A. Ross, Desmond Slade, Safwat A Ahmed, Mohamed M Radwan, Zulfiqar Ali, Ikhlas A Khan, Mahmoud A. ElsohlyAbstract:Cannabisol (1), a unique dimer of Δ9-tetrahydroCannabinol (Δ9-THC) with a methylene bridge, was isolated from Cannabis sativa. This is the first example of a C-bridged dimeric cannabinoid. The structure of 1 was unambiguously deduced by HRESIMS, GCMS, and NMR spectroscopy. A plausible biogenesis of 1 is described.
-
temperature stability and bioadhesive properties of δ9 tetrahydroCannabinol incorporated hydroxypropylcellulose polymer matrix systems
Drug Development and Industrial Pharmacy, 2006Co-Authors: Michael A Repka, Mahmoud A. Elsohly, Manish Munjal, Samir A. RossAbstract:ABSTRACTThe purpose of this study was to determine and compare the bioadhesive profiles of hydroxypropylcellulose (HPC) polymer matrices as a function of Δ9-tetrahydroCannabinol (THC) content. In addition, the effect of processing temperature on the stability of THC and its extent of degradation to Cannabinol (CBN) was investigated. A hot-melt cast molding method was used to prepare HPC polymer matrix systems incorporated with THC at 0, 4, 8, and 16 percent. Bioadhesive measurements including peak adhesive force, area under the curve, and elongation at adhesive failure were recorded utilizing the TA.XT2i Texture Analyzer™. Data obtained from these tests at various contact time intervals suggested that the incorporation of THC led to an increase in the bioadhesive strength of the HPC polymer matrices. To determine the stability of THC and the resulting CBN content in the matrices, three different processing temperatures were utilized (120, 160, and 200°C). Post-production High Performance Liquid Chromotogr...
-
Potency trends of delta9-THC and other cannabinoids in confiscated marijuana from 1980-1997.
Journal of Forensic Sciences, 2000Co-Authors: Mahmoud A. Elsohly, Zlatko Mehmedic, Rawia Arafat, Bao Yi, Samir A. Ross, Benjamin F. BanahanAbstract:The analysis of 35,312 cannabis preparations confiscated in the USA over a period of 18 years for delta-9-tetrahy-droCannabinol (Δ9-THC) and other major cannabinoids is reported. Samples were identified as cannabis, hashish, or hash oil. Cannabis samples were further subdivided into marijuana (loose material, kilobricks and buds), sinsemilla, Thai sticks and ditchweed. The data showed that more than 82% of all confiscated samples were in the marijuana category for every year except 1980 (61%) and 1981 (75%). The potency (concentration of Δ9-THC) of marijuana samples rose from less than 1.5% in 1980 to approximately 3.3% in 1983 and 1984, then fluctuated around 3% till 1992. Since 1992, the potency of confiscated marijuana samples has continuously risen, going from 3.1% in 1992 to 4.2% in 1997. The average concentration of Δ9-THC in all cannabis samples showed a gradual rise from 3% in 1991 to 4.47% in 1997. Hashish and hash oil, on the other hand, showed no specific potency trends. Other major cannabinoids [cannabidiol (CBD), Cannabinol (CBN), and cannabichromene (CBC)] showed no significant change in their concentration over the years.
Mahmoud A. Elsohly - One of the best experts on this subject based on the ideXlab platform.
-
cannabisol a novel δ9 thc dimer possessing a unique methylene bridge isolated from cannabis sativa
Planta Medica, 2012Co-Authors: Fazila Zulfiqar, Samir A. Ross, Desmond Slade, Safwat A Ahmed, Mohamed M Radwan, Zulfiqar Ali, Ikhlas A Khan, Mahmoud A. ElsohlyAbstract:Cannabisol (1), a unique dimer of Δ9-tetrahydroCannabinol (Δ9-THC) with a methylene bridge, was isolated from Cannabis sativa. This is the first example of a C-bridged dimeric cannabinoid. The structure of 1 was unambiguously deduced by HRESIMS, GCMS, and NMR spectroscopy. A plausible biogenesis of 1 is described.
-
temperature stability and bioadhesive properties of δ9 tetrahydroCannabinol incorporated hydroxypropylcellulose polymer matrix systems
Drug Development and Industrial Pharmacy, 2006Co-Authors: Michael A Repka, Mahmoud A. Elsohly, Manish Munjal, Samir A. RossAbstract:ABSTRACTThe purpose of this study was to determine and compare the bioadhesive profiles of hydroxypropylcellulose (HPC) polymer matrices as a function of Δ9-tetrahydroCannabinol (THC) content. In addition, the effect of processing temperature on the stability of THC and its extent of degradation to Cannabinol (CBN) was investigated. A hot-melt cast molding method was used to prepare HPC polymer matrix systems incorporated with THC at 0, 4, 8, and 16 percent. Bioadhesive measurements including peak adhesive force, area under the curve, and elongation at adhesive failure were recorded utilizing the TA.XT2i Texture Analyzer™. Data obtained from these tests at various contact time intervals suggested that the incorporation of THC led to an increase in the bioadhesive strength of the HPC polymer matrices. To determine the stability of THC and the resulting CBN content in the matrices, three different processing temperatures were utilized (120, 160, and 200°C). Post-production High Performance Liquid Chromotogr...
-
Potency trends of delta9-THC and other cannabinoids in confiscated marijuana from 1980-1997.
Journal of Forensic Sciences, 2000Co-Authors: Mahmoud A. Elsohly, Zlatko Mehmedic, Rawia Arafat, Bao Yi, Samir A. Ross, Benjamin F. BanahanAbstract:The analysis of 35,312 cannabis preparations confiscated in the USA over a period of 18 years for delta-9-tetrahy-droCannabinol (Δ9-THC) and other major cannabinoids is reported. Samples were identified as cannabis, hashish, or hash oil. Cannabis samples were further subdivided into marijuana (loose material, kilobricks and buds), sinsemilla, Thai sticks and ditchweed. The data showed that more than 82% of all confiscated samples were in the marijuana category for every year except 1980 (61%) and 1981 (75%). The potency (concentration of Δ9-THC) of marijuana samples rose from less than 1.5% in 1980 to approximately 3.3% in 1983 and 1984, then fluctuated around 3% till 1992. Since 1992, the potency of confiscated marijuana samples has continuously risen, going from 3.1% in 1992 to 4.2% in 1997. The average concentration of Δ9-THC in all cannabis samples showed a gradual rise from 3% in 1991 to 4.47% in 1997. Hashish and hash oil, on the other hand, showed no specific potency trends. Other major cannabinoids [cannabidiol (CBD), Cannabinol (CBN), and cannabichromene (CBC)] showed no significant change in their concentration over the years.
Wu Pei-lin - One of the best experts on this subject based on the ideXlab platform.
-
Murrayamine-O and -P, two Cannabinol-skeletal carbazole alkaloids from Murraya euchrestifolia
Tetrahedron Letters, 1995Co-Authors: Wu Tiang-shung, Wang Meei-ling, Wu Pei-linAbstract:Two novel Cannabinol-skeletal carbazole alkaloids, murrayamine-O (1) and -P (2), were isolated from the root barks of Murraya euchrestifolia. Their structures were identified by spectroscopic analyses.
Woldeab Yisak - One of the best experts on this subject based on the ideXlab platform.
-
acidic in vivo metabolites of Cannabinol isolated from rat faeces
Journal of Pharmacy and Pharmacology, 2011Co-Authors: Woldeab Yisak, Martanne Widman, Stig AgurellAbstract:Six acidic metabolites were isolated from rat faeces and identified by gas chromatography-mass spectrometry and proton magnetic resonance. Cannabinol-7-oic acid was the most abundant acidic metabolite isolated. Others present in decreasing order of prominence were 1″-hydroxy-, 4”-hydroxy-, 3″-hydroxyCannabinol-7-oic acid, Cannabinol-3”-one-7-oic acid and 2″-hydroxyCannabinol-7-oic acid.
-
neutral in vivo metabolites of Cannabinol isolated from rat faeces
Journal of Pharmacy and Pharmacology, 2011Co-Authors: Woldeab Yisak, Janerik Lindgren, Stig AgurellAbstract:The in vivo transformation of Cannabinol (CBN) in the rat has been studied. Unchanged CBN and nine neutral mono-oxygenated and dioxygenated CBN metabolites have been identified. In the mono-oxygenated series the metabolites occurred in decreasing order of prominence as follows: 7-hydroxy-CBN, 4''-hydroxy-CBN, 1''-hydroxy-CBN, 2''-hydroxy-CBN, 3''-hydroxy-CBN, 5''-hydroxy-CBN and CBN-7-al. In the dihydroxylated metabolite series only 1'',7-dihydroxy-CBN and 4'',7-dihydroxy-CBN were found with the former as the more prominent metabolite.
