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Amine Benyamina - One of the best experts on this subject based on the ideXlab platform.
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several clock genes polymorphisms are meaningful risk factors in the development and severity of Cannabis Addiction
Chronobiology International, 2019Co-Authors: Raphael Saffroy, Genevieve Lafaye, Christophe Desterke, Elisabeth Ortiztudela, Ammar Amirouche, Pasquale Innominato, Patrick Pham, Amine Benyamina, Antoinette LemoineAbstract:Circadian rhythms have been related to psychiatric diseases and regulation of dopaminergic transmission, especially in substance abusers. The relationship between them remained enigmatic and no data on the role of clock genes on Cannabis dependence have been documented. We aimed at exploring the role of clock gene genotypes as potential predisposing factor to Cannabis Addiction, using a high throughput mass spectrometry methodology that enables the large-scale analysis of the known relevant polymorphisms of the clock genes. We have conducted a case-control study on 177 Caucasians categorizing between Cannabis-addicted subjects and casual consumers based on structured interviews recorded socio-demographic data, AUDIT, Fagerstrom test, MINI, and medical examinations. Alcohol, opiates, and stimulants' consumption was as exclusion criteria. We report an association between several Single Nucleotide Polymorphism (SNP)s in main circadian genes SNPs, especially the gene locus HES7/PER1 on chromosome 17 and Cannabis consumption as well as the development of neuropsychiatric and social disorders. This SNP's signature that may represent a meaningful risk factor in the development of Cannabis dependence and its severity requires to be deeply explored in a prospective study.
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clock genes snp array identifies a key role of the per1 hes7 gene in the risk of Cannabis Addiction and psychiatric comorbidities
European Psychiatry, 2017Co-Authors: Genevieve Lafaye, Amine BenyaminaAbstract:The existence of biological rhythms disruption in addicted subjects has been described including disturbances in their sleep-wake pattern, rest-activity rhythms, and feeding schedules. Circadian rhythms have also been related to psychiatric diseases, including mood and anxiety disorders and the regulation of dopaminergic transmission, especially in reward circuitry in substance abusers. The relationship between them remained enigmatic and no data on the role of clock genes variants on Cannabis dependence have been documented. We aimed at exploring the role of clock gene genotypes as potential predisposing factor to Cannabis Addiction, using a high throughput mass spectrometry methodology that enables the large-scale analysis of all the known clinically-relevant polymorphisms of the core human clock genes. We have conducted a case-control study on 177 Caucasians categorizing between Cannabis-addicted subjects (n = 83) and casual Cannabis consumers (n = 94). We report here a strong association between the TT* genotype RS1442849 in PER1/HES7 gene and a significantly higher risk of vulnerability to be dependent to Cannabis. Moreover, this SNP was overrepresented in the subsets of Cannabis users with more severe characteristics like personal psychiatric history, unemployed status, and beginning of Cannabis use early in lifetime as well as large weekly consumption. HES7 gene is a newly described gene with a circadian expression regulated by reactive oxygen species in many cell types including neural stem cells. The HES7 TT* genotype RS1442849 gene could intervene on the dopamine reward systems. This genotype thus represents the first potential biomarker for stratification of Cannabis consumers for the risk to develop a true dependence.
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le Cannabis Addiction consequences aigues et chroniques
The Physician and Sportsmedicine, 2017Co-Authors: Laurent Karila, Genevieve Lafaye, Sarah Coscas, Lisa Blecha, Amine BenyaminaAbstract:Le Cannabis reste la drogue la plus experimentee au cours de la vie et la plus consommee en France notamment chez les adolescents, les jeunes adultes et les populations souffrant de troubles psychiatriques (schizophrenie, trouble anxieux, trouble depressif, trouble bipolaire...). Cette substance se consomme essentiellement par voie inhalee mais peut etre ingeree ou vapotee dans des cigarettes electroniques. Outre les effets psychoactifs d’une intoxication aigue, le Cannabis peut etre a l’origine de consequences psychiatriques aigues propres (pharmacopsychose, anxiete, hallucinations, troubles cognitifs...), d’un trouble de l’usage ou Addiction, d’un syndrome de sevrage, de consequences psychiatriques chroniques (depersonalisation, syndrome amotivationnel, troubles cognitifs..).
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striatal and extrastriatal dopamine transporter in Cannabis and tobacco Addiction a high resolution pet study
Addiction Biology, 2012Co-Authors: Claire Leroy, Amine Benyamina, Laurent Karila, Jeanluc Martinot, Michael Lukasiewicz, Edouard Duchesnay, Claude Comtat, Frederic Dolle, Eric Artiges, Mariajoao RibeiroAbstract:The dopamine (DA) system is known to be involved in the reward and dependence mechanisms of Addiction. However, modifications in dopaminergic neurotransmission associated with long-term tobacco and Cannabis use have been poorly documented in vivo. In order to assess striatal and extrastriatal dopamine transporter (DAT) availability in tobacco and Cannabis Addiction, three groups of male age-matched subjects were compared: 11 healthy non-smoker subjects, 14 tobacco-dependent smokers (17.6 ± 5.3 cigarettes/day for 12.1 ± 8.5 years) and 13 Cannabis and tobacco smokers (CTS) (4.8 ± 5.3 Cannabis joints/day for 8.7 ± 3.9 years). DAT availability was examined in positron emission tomography (HRRT) with a high resolution research tomograph after injection of [11C]PE2I, a selective DAT radioligand. Region of interest and voxel-by-voxel approaches using a simplified reference tissue model were performed for the between-group comparison of DAT availability. Measurements in the dorsal striatum from both analyses were concordant and showed a mean 20% lower DAT availability in drug users compared with controls. Whole-brain analysis also revealed lower DAT availability in the ventral striatum, the midbrain, the middle cingulate and the thalamus (ranging from -15 to -30%). The DAT availability was slightly lower in all regions in CTS than in subjects who smoke tobacco only, but the difference does not reach a significant level. These results support the existence of a decrease in DAT availability associated with tobacco and Cannabis Addictions involving all dopaminergic brain circuits. These findings are consistent with the idea of a global decrease in cerebral DA activity in dependent subjects.
Muradiye Nacak - One of the best experts on this subject based on the ideXlab platform.
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genetic contributing factors to substance abuse an association study between enos gene polymorphisms and Cannabis Addiction in a turkish population
Australian Journal of Forensic Sciences, 2016Co-Authors: Aysun Baransel Isir, Muradiye Nacak, Sibel Oguzkan Balci, Sukru A Aynacioglu, Sacide PehlivanAbstract:It is known to be largely related to behavioural changes and neuropsychiatric disorders, and studies demonstrating the influence of eNOS gene variants in the development of depressive, aggressive and suicidal behaviours exist in the literature. Here, we investigate two polymorphisms in the eNOS gene, namely, G894T (Glu298Asp) and intron 4 VNTR, as possible genetic contributing factors to Cannabis Addiction. DNA samples used in this work were purified from the peripheral blood of 94 unrelated Turkish Cannabis-dependent subjects and 100 Turkish control subjects from the southeastern region of Turkey. The eNOS polymorphisms were characterised by the PCR and/or PCR-RFLP (Polymerase Chain Reaction-restriction fragment length polymorphism) method. The De-finetti programme, chi-square, Fisher’s exact test, odds ratio and 95% confidence intervals (CI) were used for statistical analysis. The incidence of aa and TT genotypes and the frequency of the alleles a and T were found to be significantly higher in the canna...
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an information theoretical study of the epistasis between the cnr1 1359 g a polymorphism and the taq1a and taq1b drd2 polymorphisms assessing the susceptibility to Cannabis Addiction in a turkish population
Journal of Molecular Neuroscience, 2016Co-Authors: Aysun Baransel Isir, Cesur Baransel, Muradiye NacakAbstract:Addiction is a complex, multi-factorial disease, and thus, analyzing genetic variants at multiple loci and gene-gene interactions among them (epistasis) can provide crucial clues about causative factors of Addiction which cannot be detected with single-nucleotide polymorphism (SNP) association studies. In this study, we discuss the interaction between the 1359 G/A polymorphism of the CNR1 gene and the DRD2 gene polymorphisms and the net effect of any possible epistasis on the Cannabis Addiction phenotype in a Turkish population. Using bivariate synergy and mutual information concepts as a means of capturing the magnitude of interaction between marker pairs, the present study not only confirms the A1 marker allele as a risk factor but also reveals a finer-grained association between A and B markers which manifests itself both as a preventive and a risk factor. Our results indicate that the increased phenotype of cases require an individual to be either heterozygous at both loci or homozygous at locus B with homozygous risk factor A1A1 present. We hypothesize that overlapping expressions of CB1 and D2R is the cause of CB1-D2R interactions in cases of substance abuse and the different polymorphisms of CNR1 and DRD2 genes may have decisive roles in the nature of these interactions in terms of promoting or alleviating the Cannabis Addiction risk factor of the individual.
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relationship between the 1359 g a polymorphism of the central cannabinoid receptor 1 cnr1 gene and susceptibility to Cannabis Addiction in a turkish population
Australian Journal of Forensic Sciences, 2015Co-Authors: Aysun Baransel Isir, Muradiye Nacak, Sibel Oguzkan Balci, Sacide Pehlivan, Seval Kul, Necla Benlier, Sukru A AynaciogluAbstract:In this study, we investigate the existence of a possible genetic association between 1359 G/A polymorphism of the Central Cannabinoid Receptor 1 (CNR1) Gene CNR1 (p.Thr453Thr; rs1049353) single nucleotide polymorphism (SNP) and Cannabis Addiction. DNA samples used in this work are purified from venous leukocytes of 145 unrelated Turkish Cannabis-dependent subjects and 140 Turkish control subjects. No significant difference is observed in genotype or allele frequencies of CNR1 1359 G/A polymorphism between these two groups. We also compared CNR1 1359 G/A polymorphism allele frequency distribution in our healthy Turkish population with other healthy populations. The comparison of healthy Turkish subjects with the healthy subjects from English-Irish, Chinese, European-American, African-American, Italian, German and Japanese populations revealed significant differences in allele frequencies. Data indicate that the 1359 G/A CNR1 polymorphism does not contribute to susceptibility to cannabinoid Addiction in Tu...
Genevieve Lafaye - One of the best experts on this subject based on the ideXlab platform.
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several clock genes polymorphisms are meaningful risk factors in the development and severity of Cannabis Addiction
Chronobiology International, 2019Co-Authors: Raphael Saffroy, Genevieve Lafaye, Christophe Desterke, Elisabeth Ortiztudela, Ammar Amirouche, Pasquale Innominato, Patrick Pham, Amine Benyamina, Antoinette LemoineAbstract:Circadian rhythms have been related to psychiatric diseases and regulation of dopaminergic transmission, especially in substance abusers. The relationship between them remained enigmatic and no data on the role of clock genes on Cannabis dependence have been documented. We aimed at exploring the role of clock gene genotypes as potential predisposing factor to Cannabis Addiction, using a high throughput mass spectrometry methodology that enables the large-scale analysis of the known relevant polymorphisms of the clock genes. We have conducted a case-control study on 177 Caucasians categorizing between Cannabis-addicted subjects and casual consumers based on structured interviews recorded socio-demographic data, AUDIT, Fagerstrom test, MINI, and medical examinations. Alcohol, opiates, and stimulants' consumption was as exclusion criteria. We report an association between several Single Nucleotide Polymorphism (SNP)s in main circadian genes SNPs, especially the gene locus HES7/PER1 on chromosome 17 and Cannabis consumption as well as the development of neuropsychiatric and social disorders. This SNP's signature that may represent a meaningful risk factor in the development of Cannabis dependence and its severity requires to be deeply explored in a prospective study.
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clock genes snp array identifies a key role of the per1 hes7 gene in the risk of Cannabis Addiction and psychiatric comorbidities
European Psychiatry, 2017Co-Authors: Genevieve Lafaye, Amine BenyaminaAbstract:The existence of biological rhythms disruption in addicted subjects has been described including disturbances in their sleep-wake pattern, rest-activity rhythms, and feeding schedules. Circadian rhythms have also been related to psychiatric diseases, including mood and anxiety disorders and the regulation of dopaminergic transmission, especially in reward circuitry in substance abusers. The relationship between them remained enigmatic and no data on the role of clock genes variants on Cannabis dependence have been documented. We aimed at exploring the role of clock gene genotypes as potential predisposing factor to Cannabis Addiction, using a high throughput mass spectrometry methodology that enables the large-scale analysis of all the known clinically-relevant polymorphisms of the core human clock genes. We have conducted a case-control study on 177 Caucasians categorizing between Cannabis-addicted subjects (n = 83) and casual Cannabis consumers (n = 94). We report here a strong association between the TT* genotype RS1442849 in PER1/HES7 gene and a significantly higher risk of vulnerability to be dependent to Cannabis. Moreover, this SNP was overrepresented in the subsets of Cannabis users with more severe characteristics like personal psychiatric history, unemployed status, and beginning of Cannabis use early in lifetime as well as large weekly consumption. HES7 gene is a newly described gene with a circadian expression regulated by reactive oxygen species in many cell types including neural stem cells. The HES7 TT* genotype RS1442849 gene could intervene on the dopamine reward systems. This genotype thus represents the first potential biomarker for stratification of Cannabis consumers for the risk to develop a true dependence.
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le Cannabis Addiction consequences aigues et chroniques
The Physician and Sportsmedicine, 2017Co-Authors: Laurent Karila, Genevieve Lafaye, Sarah Coscas, Lisa Blecha, Amine BenyaminaAbstract:Le Cannabis reste la drogue la plus experimentee au cours de la vie et la plus consommee en France notamment chez les adolescents, les jeunes adultes et les populations souffrant de troubles psychiatriques (schizophrenie, trouble anxieux, trouble depressif, trouble bipolaire...). Cette substance se consomme essentiellement par voie inhalee mais peut etre ingeree ou vapotee dans des cigarettes electroniques. Outre les effets psychoactifs d’une intoxication aigue, le Cannabis peut etre a l’origine de consequences psychiatriques aigues propres (pharmacopsychose, anxiete, hallucinations, troubles cognitifs...), d’un trouble de l’usage ou Addiction, d’un syndrome de sevrage, de consequences psychiatriques chroniques (depersonalisation, syndrome amotivationnel, troubles cognitifs..).
Aysun Baransel Isir - One of the best experts on this subject based on the ideXlab platform.
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genetic contributing factors to substance abuse an association study between enos gene polymorphisms and Cannabis Addiction in a turkish population
Australian Journal of Forensic Sciences, 2016Co-Authors: Aysun Baransel Isir, Muradiye Nacak, Sibel Oguzkan Balci, Sukru A Aynacioglu, Sacide PehlivanAbstract:It is known to be largely related to behavioural changes and neuropsychiatric disorders, and studies demonstrating the influence of eNOS gene variants in the development of depressive, aggressive and suicidal behaviours exist in the literature. Here, we investigate two polymorphisms in the eNOS gene, namely, G894T (Glu298Asp) and intron 4 VNTR, as possible genetic contributing factors to Cannabis Addiction. DNA samples used in this work were purified from the peripheral blood of 94 unrelated Turkish Cannabis-dependent subjects and 100 Turkish control subjects from the southeastern region of Turkey. The eNOS polymorphisms were characterised by the PCR and/or PCR-RFLP (Polymerase Chain Reaction-restriction fragment length polymorphism) method. The De-finetti programme, chi-square, Fisher’s exact test, odds ratio and 95% confidence intervals (CI) were used for statistical analysis. The incidence of aa and TT genotypes and the frequency of the alleles a and T were found to be significantly higher in the canna...
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an information theoretical study of the epistasis between the cnr1 1359 g a polymorphism and the taq1a and taq1b drd2 polymorphisms assessing the susceptibility to Cannabis Addiction in a turkish population
Journal of Molecular Neuroscience, 2016Co-Authors: Aysun Baransel Isir, Cesur Baransel, Muradiye NacakAbstract:Addiction is a complex, multi-factorial disease, and thus, analyzing genetic variants at multiple loci and gene-gene interactions among them (epistasis) can provide crucial clues about causative factors of Addiction which cannot be detected with single-nucleotide polymorphism (SNP) association studies. In this study, we discuss the interaction between the 1359 G/A polymorphism of the CNR1 gene and the DRD2 gene polymorphisms and the net effect of any possible epistasis on the Cannabis Addiction phenotype in a Turkish population. Using bivariate synergy and mutual information concepts as a means of capturing the magnitude of interaction between marker pairs, the present study not only confirms the A1 marker allele as a risk factor but also reveals a finer-grained association between A and B markers which manifests itself both as a preventive and a risk factor. Our results indicate that the increased phenotype of cases require an individual to be either heterozygous at both loci or homozygous at locus B with homozygous risk factor A1A1 present. We hypothesize that overlapping expressions of CB1 and D2R is the cause of CB1-D2R interactions in cases of substance abuse and the different polymorphisms of CNR1 and DRD2 genes may have decisive roles in the nature of these interactions in terms of promoting or alleviating the Cannabis Addiction risk factor of the individual.
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relationship between the 1359 g a polymorphism of the central cannabinoid receptor 1 cnr1 gene and susceptibility to Cannabis Addiction in a turkish population
Australian Journal of Forensic Sciences, 2015Co-Authors: Aysun Baransel Isir, Muradiye Nacak, Sibel Oguzkan Balci, Sacide Pehlivan, Seval Kul, Necla Benlier, Sukru A AynaciogluAbstract:In this study, we investigate the existence of a possible genetic association between 1359 G/A polymorphism of the Central Cannabinoid Receptor 1 (CNR1) Gene CNR1 (p.Thr453Thr; rs1049353) single nucleotide polymorphism (SNP) and Cannabis Addiction. DNA samples used in this work are purified from venous leukocytes of 145 unrelated Turkish Cannabis-dependent subjects and 140 Turkish control subjects. No significant difference is observed in genotype or allele frequencies of CNR1 1359 G/A polymorphism between these two groups. We also compared CNR1 1359 G/A polymorphism allele frequency distribution in our healthy Turkish population with other healthy populations. The comparison of healthy Turkish subjects with the healthy subjects from English-Irish, Chinese, European-American, African-American, Italian, German and Japanese populations revealed significant differences in allele frequencies. Data indicate that the 1359 G/A CNR1 polymorphism does not contribute to susceptibility to cannabinoid Addiction in Tu...
Antoinette Lemoine - One of the best experts on this subject based on the ideXlab platform.
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several clock genes polymorphisms are meaningful risk factors in the development and severity of Cannabis Addiction
Chronobiology International, 2019Co-Authors: Raphael Saffroy, Genevieve Lafaye, Christophe Desterke, Elisabeth Ortiztudela, Ammar Amirouche, Pasquale Innominato, Patrick Pham, Amine Benyamina, Antoinette LemoineAbstract:Circadian rhythms have been related to psychiatric diseases and regulation of dopaminergic transmission, especially in substance abusers. The relationship between them remained enigmatic and no data on the role of clock genes on Cannabis dependence have been documented. We aimed at exploring the role of clock gene genotypes as potential predisposing factor to Cannabis Addiction, using a high throughput mass spectrometry methodology that enables the large-scale analysis of the known relevant polymorphisms of the clock genes. We have conducted a case-control study on 177 Caucasians categorizing between Cannabis-addicted subjects and casual consumers based on structured interviews recorded socio-demographic data, AUDIT, Fagerstrom test, MINI, and medical examinations. Alcohol, opiates, and stimulants' consumption was as exclusion criteria. We report an association between several Single Nucleotide Polymorphism (SNP)s in main circadian genes SNPs, especially the gene locus HES7/PER1 on chromosome 17 and Cannabis consumption as well as the development of neuropsychiatric and social disorders. This SNP's signature that may represent a meaningful risk factor in the development of Cannabis dependence and its severity requires to be deeply explored in a prospective study.
