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Pierre Leroux - One of the best experts on this subject based on the ideXlab platform.
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influence du ph d acides amines et de diverses substances organiques sur la fongitoxicite du pyrimethanil du glufosinate du Captafol du cymoxanil et du fenpiclonil vis a vis de certaines souches de botrytis cinerea
Agronomie, 1994Co-Authors: Pierre LerouxAbstract:L'effet du pyrimethanil, du fenpiclonil, du Captafol, du glufosinate et du cymoxanil sur l'elongation des filaments germinatifs des spores de Botrytis cinerea est etudie dans diverses conditions culturales du champignon. Si le fenpiclonil presente un niveau d'activite stable entre pH 3,6 et 7,3, en revanche les autres pesticides voient leur toxicite chuter dans des milieux acides (ex pyrimethanil) ou neutres a faiblement basiques (ex Captafol, cymoxanil, glufosinate). L'adjonction d'extrait de levure, de peptone ou d'hydrolysat de caseine reduit notablement l'activite du pyrimethanil, du Captafol, du glufosinate et du cymoxanil mais pas celle du fenpiclonil. Une analyse detaillee des acides amines indique que ceux possedant un atome de soufre sont plus ou moins antagonistes du pyrimethanil, du cymoxanil, du glufosinate et du Captafol. Si, pour les 3 premiers pesticides, cet effet protecteur pourrait etre correle avec une inhibition de la biosynthese d'acides amines soufres, en revanche, pour le Captafol c'est une detoxication par les groupements thiols qui intervient. Parmi les autres acides amines entrainant un net antagonisme il y a la glutamine vis-a-vis du glufosinate, la valine et la leucine vis-a-vis du pyrimethanil ou la glycine et la serine vis-a-vis du cymoxanil. Les relations entre les effets protecteurs des acides amines et le mode d'action de ces pesticides chez B cinerea sont evoquees. Les implications de ces resultats dans l'elaboration de methodes de surveillance de la resistance a certains nouveaux fongicides (ex fenpiclonil, pyrimethanil) sont egalement discutees
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Influence du pH, d'acides aminés et de diverses substances organiques sur la fongitoxicité du pyriméthanil, du glufosinate, du Captafol, du cymoxanil et du fenpiclonil vis-à-vis de certaines souches de Botrytis cinerea
EDP Sciences, 1994Co-Authors: Pierre LerouxAbstract:L'effet du pyriméthanil, du fenpiclonil, du Captafol, du glufosinate et du cymoxanil sur l'élongation des filaments germinatifs des spores de Botrytis cinerea est étudié dans diverses conditions culturales du champignon. Si le fenpiclonil présente un niveau d'activité stable entre pH 3,6 et 7,3, en revanche les autres pesticides voient leur toxicité chuter dans des milieux acides (ex pyriméthanil) ou neutres à faiblement basiques (ex Captafol, cymoxanil, glufosinate). L'adjonction d'extrait de levure, de peptone ou d'hydrolysat de caséine réduit notablement l'activité du pyriméthanil, du Captafol, du glufosinate et du cymoxanil mais pas celle du fenpiclonil. Une analyse détaillée des acides aminés indique que ceux possédant un atome de soufre sont plus ou moins antagonistes du pyriméthanil, du cymoxanil, du glufosinate et du Captafol. Si, pour les 3 premiers pesticides, cet effet protecteur pourrait être corrélé avec une inhibition de la biosynthèse d'acides aminés soufrés, en revanche, pour le Captafol c'est une détoxication par les groupements thiols qui intervient. Parmi les autres acides aminés entraînant un net antagonisme il y a la glutamine vis-à-vis du glufosinate, la valine et la leucine vis-à-vis du pyriméthanil ou la glycine et la sérine vis-à-vis du cymoxanil. Les relations entre les effets protecteurs des acides aminés et le mode d'action de ces pesticides chez B cinerea sont évoquées. Les implications de ces résultats dans l'élaboration de méthodes de surveillance de la résistance à certains nouveaux fongicides (ex fenpiclonil, pyriméthanil) sont également discutées.Effect of pH, amino acids and various organic compounds on the fungitoxicity of pyrimethanil, glufosinate, Captafol, cymoxanil and fenpiclonil in Botrytis cinerea. The inhibition of germ-tube elongation by pyrimethanil, fenpiclonil, Captafol, glufosinate and cymoxanil was studied in Botrytis cinerea cultivated on various media. The activity of fenpiclonil was not influenced by pH (between 3.6 and 7.3) whereas that of the other pesticides was reduced either in acidic conditions (eg, pyrimethanil) or at pH values greater than 6 (eg, glufosinate, Captafol, cymoxanil). The addition of yeast extract, peptone or casein-hydrolysate relieved pyrimethanil, glufosinate, cymoxanil and Captafol inhibition but not that of fenpiclonil. A detailed study conducted with amino acids indicated that those containing sulphur were antagonistic towards pyrimethanil, cymoxanil, glufosinate and Captafol. For the first 3 pesticides, this reversal could be related to an inhibition in the biosynthesis of sulphur-containing amino acids whereas for Captafol it was probably due to its reaction with thiols. Among the other amino acids that exhibit alleviatory effects we can mention glutamine for glufosinate, valine and leucine for pyrimethanil or glycine, and serine for cymoxanil. The relationship between the antagonistic effects of amino acids and the biochemical mode of action of the tested pesticides in B cinerea are evoked. The consequences of the results upon the development of suitable methods for fungicide-resistance monitoring are also discussed
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Influence du pH, d'acides aminés et de diverses substances organiques sur la fongitoxicité du pyriméthanil, du glufosinate, du Captafol, du cymoxanil et du fenpiclonil vis-à-vis de certaines souches de Botrytis cinerea
Agronomie, 1994Co-Authors: Pierre LerouxAbstract:L’effet du pyriméthanil, du fenpiclonil, du Captafol, du glufosinate et du cymoxanil sur l’élongation des filaments germinatifs des spores de Botrytis cinerea est étudié dans diverses conditions culturales du champignon. Si le fenpiclonil présente un niveau d’activité stable entre pH 3,6 et 7,3, en revanche les autres pesticides voient leur toxicité chuter dans des milieux acides (ex pyriméthanil) ou neutres à faiblement basiques (ex Captafol, cymoxanil, glufosinate). L’adjonction d’extrait de levure, de peptone ou d’hydrolysat de caséine réduit notablement l’activité du pyriméthanil, du Captafol, du glufosinate et du cymoxanil mais pas celle du fenpiclonil. Une analyse détaillée des acides aminés indique que ceux possédant un atome de soufre sont plus ou moins antagonistes du pyriméthanil, du cymoxanil, du glufosinate et du Captafol. Si, pour les 3 premiers pesticides, cet effet protecteur pourrait être corrélé avec une inhibition de la biosynthèse d’acides aminés soufrés, en revanche, pour le Captafol c’est une détoxication par les groupements thiols qui intervient. Parmi les autres acides aminés entraînant un net antagonisme il y a la glutamine vis-à-vis du glufosinate, la valine et la leucine vis-à-vis du pyriméthanil ou la glycine et la sérine vis-à-vis du cymoxanil. Les relations entre les effets protecteurs des acides aminés et le mode d’action de ces pesticides chez B cinerea sont évoquées. Les implications de ces résultats dans l’élaboration de méthodes de surveillance de la résistance à certains nouveaux fongicides (ex fenpiclonil, pyriméthanil) sont également discutées.
Nobuyuki Ito - One of the best experts on this subject based on the ideXlab platform.
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Subchronic oral toxicity study of Captafol in B6C3F1 mice.
Journal of Toxicology and Environmental Health, 2009Co-Authors: Seiko Tamano, Mayumi Kawabe, Masashi Sano, Tsuneo Masui, Nobuyuki ItoAbstract:The effects of subchronic administration of Captafol were studied in B6C3F1 mice given dose levels of 0, 0.3, 0.625, and 1.25% in the diet for 12 wk. There was a dose‐related decrease in body weight gain during the 12‐wk experiment and a loss of body weight in the 1.25% group of both sexes. Whiles the mice given Captafol consumed less diet than the control mice, this was not directly dose‐related. The relative weights of liver demonstrated a tendency for dose‐dependent increase. Light‐microscopic examination revealed cytoplasmic vacuolar degeneration, depending in severity on the dosage, in the livers of both sexes given Captafol. In conclusion, the findings obtained from the present subchronic toxicity study indicated the liver to be a primary target organ.
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Low susceptibility of the spontaneously hypertensive rat (SHR) to quinoline-induction of hepatic hemangioendothelial sarcomas.
Cancer Letters, 1996Co-Authors: Mitsuru Futakuchi, Yamamoto Atsushi, Nobuyuki Ito, Tadashi Ogiso, Ryohei Hasegawa, Lin Cui, Tomoyuki ShiraiAbstract:Effects of quinoline and Captafol, both of which are hemangiocarcinogenic agents, were investigated in spontaneously hypertensive rats (SHR). Male SHR and Wistar Kyoto rats (WKY), the parent strain of SHR, were administered quinoline (0.2%) or Captafol (0.15%) supplemented in the diet for 32 weeks. Resultant incidences of hepatic hemangioendothelial sarcomas were in animals receiving quinoline 93% for WKY and only 7% for SHR. A few hepatocellular nodules were also induced in both strains. No histopathological lesions were observed in the other organs. Thus, the SHR proved unexpectedly less susceptible to vascular carcinogenicity than its WKY counterpart.
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13-Week oral toxicity study of Captafol in F344/DuCrj rats.
Toxicological Sciences, 1991Co-Authors: Seiko Tamano, Yasushi Kurata, Tadashi Ogiso, Masaaki Shibata, Hikaru Tanaka, Nobuyuki ItoAbstract:Captafol fed at concentrations of 0, 0.075, 0.15, 0.3, and 0.6% to both sexes of F344 rats for 13 weeks produced dose-related decreases in body weight in males and females given 0.15% or higher concentrations. A dose-dependent decrease in urinary pH was observed in males receiving 0.3 or 0.6% and in females given 0.15% or higher concentrations of Captafol. The 0.3 and 0.6% doses produced slight increases in leukocyte count and glutamic-pyruvic transaminase activity in females, along with a mild increase in alkaline phosphatase activity in the 0.6% case. The liver- and kidney-to-body weight ratios were increased in both male and female rats. Histopathological changes were observed in the forestomach, liver, and kidney. Squamous cell hyperplasia and edema accompanied by polynuclear leukocyte infiltration and dilation of vessels in the lamina propria were observed in the forestomach of both sexes given 0.15% or higher concentrations. Oval cell proliferation was apparent around Glisson's sheath in the livers of females given 0.3 and 0.6% Captafol. Multifocal appearance of karyocytomegaly and tubular cell atypia in the proximal tubules of the kidney was found in the 0.3 and 0.6% groups of both sexes.
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13 week oral toxicity study of Captafol in f344 ducrj rats
Toxicological Sciences, 1991Co-Authors: Seiko Tamano, Yasushi Kurata, Tadashi Ogiso, Masaaki Shibata, Hikaru Tanaka, Nobuyuki ItoAbstract:Captafol fed at concentrations of 0, 0.075, 0.15, 0.3, and 0.6% to both sexes of F344 rats for 13 weeks produced dose-related decreases in body weight in males and females given 0.15% or higher concentrations. A dose-dependent decrease in urinary pH was observed in males receiving 0.3 or 0.6% and in females given 0.15% or higher concentrations of Captafol. The 0.3 and 0.6% doses produced slight increases in leukocyte count and glutamic-pyruvic transaminase activity in females, along with a mild increase in alkaline phosphatase activity in the 0.6% case. The liver- and kidney-to-body weight ratios were increased in both male and female rats. Histopathological changes were observed in the forestomach, liver, and kidney. Squamous cell hyperplasia and edema accompanied by polynuclear leukocyte infiltration and dilation of vessels in the lamina propria were observed in the forestomach of both sexes given 0.15% or higher concentrations. Oval cell proliferation was apparent around Glisson's sheath in the livers of females given 0.3 and 0.6% Captafol. Multifocal appearance of karyocytomegaly and tubular cell atypia in the proximal tubules of the kidney was found in the 0.3 and 0.6% groups of both sexes.
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Carcinogenicity of Captafol in F344/DuCrj rats.
Japanese Journal of Cancer Research, 1990Co-Authors: Seiko Tamano, Yasushi Kurata, Mayumi Kawabe, Yamamoto Atsushi, Akihiro Hagiwara, Ricardo Cabral, Nobuyuki ItoAbstract:Captafol was administered at dietary levels of 0 (control), 750 and 1,500 parts per million (ppm) to groups of 50 male and 50 female F344/DuCrj rats for 104 weeks, and then all animals were maintained without Captafol for a further 8 weeks, and killed in week 113. Renal cell carcinoma was found in eight of 50 male rats treated with 1,500 ppm and in one of 50 male rats treated with 750 ppm of Captafol. The incidences of renal adenomas, including micro-adenomas, and basophilic altered cell tubules were significantly higher in both sexes treated with Captafol than in controls, and the increases were apparently dose-dependent except that of adenomas in females. The incidences of neoplastic and preneoplastic lesions of the kidney in Captafol-treated animals were higher in males than in females. Captafol also induced hepatocellular carcinomas in four of 50 female rats in the 1,500 ppm group. The incidences of hyperplastic (neoplastic) nodules and foci of cellular alterations in the liver were also significantly increased in both sexes treated with Captafol, the increases being dose-dependent. In conclusion, Captafol induced renal cell carcinomas in male rats and hepatocellular carcinomas in female rats.
Seiko Tamano - One of the best experts on this subject based on the ideXlab platform.
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Subchronic oral toxicity study of Captafol in B6C3F1 mice.
Journal of Toxicology and Environmental Health, 2009Co-Authors: Seiko Tamano, Mayumi Kawabe, Masashi Sano, Tsuneo Masui, Nobuyuki ItoAbstract:The effects of subchronic administration of Captafol were studied in B6C3F1 mice given dose levels of 0, 0.3, 0.625, and 1.25% in the diet for 12 wk. There was a dose‐related decrease in body weight gain during the 12‐wk experiment and a loss of body weight in the 1.25% group of both sexes. Whiles the mice given Captafol consumed less diet than the control mice, this was not directly dose‐related. The relative weights of liver demonstrated a tendency for dose‐dependent increase. Light‐microscopic examination revealed cytoplasmic vacuolar degeneration, depending in severity on the dosage, in the livers of both sexes given Captafol. In conclusion, the findings obtained from the present subchronic toxicity study indicated the liver to be a primary target organ.
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13-Week oral toxicity study of Captafol in F344/DuCrj rats.
Toxicological Sciences, 1991Co-Authors: Seiko Tamano, Yasushi Kurata, Tadashi Ogiso, Masaaki Shibata, Hikaru Tanaka, Nobuyuki ItoAbstract:Captafol fed at concentrations of 0, 0.075, 0.15, 0.3, and 0.6% to both sexes of F344 rats for 13 weeks produced dose-related decreases in body weight in males and females given 0.15% or higher concentrations. A dose-dependent decrease in urinary pH was observed in males receiving 0.3 or 0.6% and in females given 0.15% or higher concentrations of Captafol. The 0.3 and 0.6% doses produced slight increases in leukocyte count and glutamic-pyruvic transaminase activity in females, along with a mild increase in alkaline phosphatase activity in the 0.6% case. The liver- and kidney-to-body weight ratios were increased in both male and female rats. Histopathological changes were observed in the forestomach, liver, and kidney. Squamous cell hyperplasia and edema accompanied by polynuclear leukocyte infiltration and dilation of vessels in the lamina propria were observed in the forestomach of both sexes given 0.15% or higher concentrations. Oval cell proliferation was apparent around Glisson's sheath in the livers of females given 0.3 and 0.6% Captafol. Multifocal appearance of karyocytomegaly and tubular cell atypia in the proximal tubules of the kidney was found in the 0.3 and 0.6% groups of both sexes.
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13 week oral toxicity study of Captafol in f344 ducrj rats
Toxicological Sciences, 1991Co-Authors: Seiko Tamano, Yasushi Kurata, Tadashi Ogiso, Masaaki Shibata, Hikaru Tanaka, Nobuyuki ItoAbstract:Captafol fed at concentrations of 0, 0.075, 0.15, 0.3, and 0.6% to both sexes of F344 rats for 13 weeks produced dose-related decreases in body weight in males and females given 0.15% or higher concentrations. A dose-dependent decrease in urinary pH was observed in males receiving 0.3 or 0.6% and in females given 0.15% or higher concentrations of Captafol. The 0.3 and 0.6% doses produced slight increases in leukocyte count and glutamic-pyruvic transaminase activity in females, along with a mild increase in alkaline phosphatase activity in the 0.6% case. The liver- and kidney-to-body weight ratios were increased in both male and female rats. Histopathological changes were observed in the forestomach, liver, and kidney. Squamous cell hyperplasia and edema accompanied by polynuclear leukocyte infiltration and dilation of vessels in the lamina propria were observed in the forestomach of both sexes given 0.15% or higher concentrations. Oval cell proliferation was apparent around Glisson's sheath in the livers of females given 0.3 and 0.6% Captafol. Multifocal appearance of karyocytomegaly and tubular cell atypia in the proximal tubules of the kidney was found in the 0.3 and 0.6% groups of both sexes.
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Carcinogenicity of Captafol in F344/DuCrj rats.
Japanese Journal of Cancer Research, 1990Co-Authors: Seiko Tamano, Yasushi Kurata, Mayumi Kawabe, Yamamoto Atsushi, Akihiro Hagiwara, Ricardo Cabral, Nobuyuki ItoAbstract:Captafol was administered at dietary levels of 0 (control), 750 and 1,500 parts per million (ppm) to groups of 50 male and 50 female F344/DuCrj rats for 104 weeks, and then all animals were maintained without Captafol for a further 8 weeks, and killed in week 113. Renal cell carcinoma was found in eight of 50 male rats treated with 1,500 ppm and in one of 50 male rats treated with 750 ppm of Captafol. The incidences of renal adenomas, including micro-adenomas, and basophilic altered cell tubules were significantly higher in both sexes treated with Captafol than in controls, and the increases were apparently dose-dependent except that of adenomas in females. The incidences of neoplastic and preneoplastic lesions of the kidney in Captafol-treated animals were higher in males than in females. Captafol also induced hepatocellular carcinomas in four of 50 female rats in the 1,500 ppm group. The incidences of hyperplastic (neoplastic) nodules and foci of cellular alterations in the liver were also significantly increased in both sexes treated with Captafol, the increases being dose-dependent. In conclusion, Captafol induced renal cell carcinomas in male rats and hepatocellular carcinomas in female rats.
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carcinogenicity of Captafol in f344 ducrj rats
Japanese Journal of Cancer Research, 1990Co-Authors: Seiko Tamano, Yasushi Kurata, Mayumi Kawabe, Akihiro Hagiwara, Ricardo Cabral, Atsushi Yamamoto, Nobuyuki ItoAbstract:Captafol was administered at dietary levels of 0 (control), 750 and 1,500 parts per million (ppm) to groups of 50 male and 50 female F344/DuCrj rats for 104 weeks, and then all animals were maintained without Captafol for a further 8 weeks, and killed in week 113. Renal cell carcinoma was found in eight of 50 male rats treated with 1,500 ppm and in one of 50 male rats treated with 750 ppm of Captafol. The incidences of renal adenomas, including micro-adenomas, and basophilic altered cell tubules were significantly higher in both sexes treated with Captafol than in controls, and the increases were apparently dose-dependent except that of adenomas in females. The incidences of neoplastic and preneoplastic lesions of the kidney in Captafol-treated animals were higher in males than in females. Captafol also induced hepatocellular carcinomas in four of 50 female rats in the 1,500 ppm group. The incidences of hyperplastic (neoplastic) nodules and foci of cellular alterations in the liver were also significantly increased in both sexes treated with Captafol, the increases being dose-dependent. In conclusion, Captafol induced renal cell carcinomas in male rats and hepatocellular carcinomas in female rats.
Leroux Pierre - One of the best experts on this subject based on the ideXlab platform.
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Influence du pH, d'acides aminés et de diverses substances organiques sur la fongitoxicité du pyriméthanil, du glufosinate, du Captafol, du cymoxanil et du fenpiclonil vis-à-vis de certaines souches de Botrytis cinerea
1994Co-Authors: Leroux PierreAbstract:L’effet du pyriméthanil, du fenpiclonil, du Captafol, du glufosinate et du cymoxanil sur l’élongation des filaments germinatifs des spores de Botrytis cinerea est étudié dans diverses conditions culturales du champignon. Si le fenpiclonil présente un niveau d’activité stable entre pH 3,6 et 7,3, en revanche les autres pesticides voient leur toxicité chuter dans des milieux acides (ex pyriméthanil) ou neutres à faiblement basiques (ex Captafol, cymoxanil, glufosinate). L’adjonction d’extrait de levure, de peptone ou d’hydrolysat de caséine réduit notablement l’activité du pyriméthanil, du Captafol, du glufosinate et du cymoxanil mais pas celle du fenpiclonil. Une analyse détaillée des acides aminés indique que ceux possédant un atome de soufre sont plus ou moins antagonistes du pyriméthanil, du cymoxanil, du glufosinate et du Captafol. Si, pour les 3 premiers pesticides, cet effet protecteur pourrait être corrélé avec une inhibition de la biosynthèse d’acides aminés soufrés, en revanche, pour le Captafol c’est une détoxication par les groupements thiols qui intervient. Parmi les autres acides aminés entraînant un net antagonisme il y a la glutamine vis-à-vis du glufosinate, la valine et la leucine vis-à-vis du pyriméthanil ou la glycine et la sérine vis-à-vis du cymoxanil. Les relations entre les effets protecteurs des acides aminés et le mode d’action de ces pesticides chez B cinerea sont évoquées. Les implications de ces résultats dans l’élaboration de méthodes de surveillance de la résistance à certains nouveaux fongicides (ex fenpiclonil, pyriméthanil) sont également discutées.The inhibition of germ-tube elongation by pyrimethanil, fenpiclonil, Captafol, glufosinate and cymoxanil was studied in Botrytis cinerea cultivated on various media. The activity of fenpiclonil was not influenced by pH (between 3.6 and 7.3) whereas that of the other pesticides was reduced either in acidic conditions (eg, pyrimethanil) or at pH values greater than 6 (eg, glufosinate, Captafol, cymoxanil). The addition of yeast extract, peptone or casein-hydrolysate relieved pyrimethanil, glufosinate, cymoxanil and Captafol inhibition but not that of fenpiclonil. A detailed study conducted with amino acids indicated that those containing sulphur were antagonistic towards pyrimethanil, cymoxanil, glufosinate and Captafol. For the first 3 pesticides, this reversal could be related to an inhibition in the biosynthesis of sulphur-containing amino acids whereas for Captafol it was probably due to its reaction with thiols. Among the other amino acids that exhibit alleviatory effects we can mention glutamine for glufosinate, valine and leucine for pyrimethanil or glycine, and serine for cymoxanil. The relationship between the antagonistic effects of amino acids and the biochemical mode of action of the tested pesticides in B cinerea are evoked. The consequences of the results upon the development of suitable methods for fungicide-resistance monitoring are also discussed
F. Grossmann - One of the best experts on this subject based on the ideXlab platform.
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Abbauverhalten von Captafol nach Langjähriger anwendung in einer Weizenmonokultur
Journal of Environmental Science and Health Part B-pesticides Food Contaminants and Agricultural Wastes, 1990Co-Authors: J.‐e. Garcia‐g., J. Kirchhoff, F. GrossmannAbstract:Summary In a 4‐year study, the behaviour of the residues of the fungicide Captafol in different plant parts of winter wheat and in the soil was investigated. The fungicide Bayleton DF (Captafol + triadimefon) was applied at the beginning of earing. Captafol residues clearly showed a high dependence on weather conditions in all examined aerial parts of the plant. After a 9‐year application of Captafol, there was no evidence of an enrichment of residues in the soil. At harvest, Captafol residues in grains always were below the maximum residue limits of 0,5 mg/kg established in West Germany.