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Michael Marmot - One of the best experts on this subject based on the ideXlab platform.
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cardiothoracic ratio and relative heart volume as predictors of coronary heart disease mortality the whitehall study 25 year follow up
European Heart Journal, 1998Co-Authors: Harry Hemingway, D Christie, Martin J Shipley, Michael MarmotAbstract:Aim To examine the association of radiographic measures of heart size with mortality from coronary heart disease. Methods and Results One thousand, one hundred and ninety-one male civil servants aged 40‐69 years were followed-up for mortality over 25 years in relation to cardiothoracic ratio and relative heart volume. A high cardiothoracic ratio and relative heart volume predicted coronary (n=196 deaths) and all-cause mortality, but not respiratory or malignant mortality. After adjustment for age, systolic and diastolic blood pressure, the highest (§0·47) compared to the lowest quintile of the cardiothoracic ratio (<0·40) was associated with a rate ratio of 1·84 (95% CI 1·14‐2·97) for the eVect on coronary heart disease mortality. Further adjustment for heart rate, smoking, cholesterol, angina and ECG ischaemia had little eVect, reducing the rate ratio to 1·65 (95% CI 1·01‐2·70). Similar rate ratios were observed for relative heart volume. Conclusions Cardiothoracic ratio within the range considered ‘normal’ in clinical practice predicted coronary heart disease mortality independent of established coronary heart disease risk factors. The relative heart volume, which uses measurements from the lateral as well as the posteroanterior chest X-ray, did not predict coronary heart disease any better than the cardiothoracic ratio. The extent to which left ventricular mass and systolic dysfunction— pathophysiological correlates of the cardiothoracic ratio and relative heart volume — are independent risk factors for coronary heart disease should be further investigated. (Eur Heart J 1998; 19: 859‐869)
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Cardiothoracic ratio and relative heart volume as predictors of coronary heart disease mortality The Whitehall study 25 year follow-up
European Heart Journal, 1998Co-Authors: Harry Hemingway, D Christie, Martin J Shipley, Michael MarmotAbstract:Aim To examine the association of radiographic measures of heart size with mortality from coronary heart disease. Methods and Results One thousand, one hundred and ninety-one male civil servants aged 40‐69 years were followed-up for mortality over 25 years in relation to cardiothoracic ratio and relative heart volume. A high cardiothoracic ratio and relative heart volume predicted coronary (n=196 deaths) and all-cause mortality, but not respiratory or malignant mortality. After adjustment for age, systolic and diastolic blood pressure, the highest (§0·47) compared to the lowest quintile of the cardiothoracic ratio (
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is cardiothoracic ratio in healthy middle aged men an independent predictor of coronary heart disease mortality whitehall study 25 year follow up
BMJ, 1998Co-Authors: Harry Hemingway, D Christie, Martin J Shipley, Michael MarmotAbstract:Aetiological studies of myocardial ischaemia have tended to concentrate on factors which influence atherothrombotic processes in the coronary arteries rather than myocardial pathophysiology.1 The commonest clinical measure of heart size—cardiothoracic ratio—was included in the original Whitehall study of healthy middle aged civil servants. Cardiothoracic ratio is associated with left ventricular mass2 and left ventricular systolic function; since left ventricular mass determined by echocardiography has been shown to predict coronary heart disease in elderly people,1 we hypothesised that increased cardiothoracic ratio would independently predict mortality from coronary heart disease. Unlike previous studies3 we did not include mortality from stroke since it may be related to heart size through different pathophysiological mechanisms. View this table: Adjusted hazard ratios (95% confidence intervals) for the effect of cardiothoracic ratio on all cause and coronary heart disease mortality We studied the 1203 male British …
Harry Hemingway - One of the best experts on this subject based on the ideXlab platform.
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cardiothoracic ratio and relative heart volume as predictors of coronary heart disease mortality the whitehall study 25 year follow up
European Heart Journal, 1998Co-Authors: Harry Hemingway, D Christie, Martin J Shipley, Michael MarmotAbstract:Aim To examine the association of radiographic measures of heart size with mortality from coronary heart disease. Methods and Results One thousand, one hundred and ninety-one male civil servants aged 40‐69 years were followed-up for mortality over 25 years in relation to cardiothoracic ratio and relative heart volume. A high cardiothoracic ratio and relative heart volume predicted coronary (n=196 deaths) and all-cause mortality, but not respiratory or malignant mortality. After adjustment for age, systolic and diastolic blood pressure, the highest (§0·47) compared to the lowest quintile of the cardiothoracic ratio (<0·40) was associated with a rate ratio of 1·84 (95% CI 1·14‐2·97) for the eVect on coronary heart disease mortality. Further adjustment for heart rate, smoking, cholesterol, angina and ECG ischaemia had little eVect, reducing the rate ratio to 1·65 (95% CI 1·01‐2·70). Similar rate ratios were observed for relative heart volume. Conclusions Cardiothoracic ratio within the range considered ‘normal’ in clinical practice predicted coronary heart disease mortality independent of established coronary heart disease risk factors. The relative heart volume, which uses measurements from the lateral as well as the posteroanterior chest X-ray, did not predict coronary heart disease any better than the cardiothoracic ratio. The extent to which left ventricular mass and systolic dysfunction— pathophysiological correlates of the cardiothoracic ratio and relative heart volume — are independent risk factors for coronary heart disease should be further investigated. (Eur Heart J 1998; 19: 859‐869)
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Cardiothoracic ratio and relative heart volume as predictors of coronary heart disease mortality The Whitehall study 25 year follow-up
European Heart Journal, 1998Co-Authors: Harry Hemingway, D Christie, Martin J Shipley, Michael MarmotAbstract:Aim To examine the association of radiographic measures of heart size with mortality from coronary heart disease. Methods and Results One thousand, one hundred and ninety-one male civil servants aged 40‐69 years were followed-up for mortality over 25 years in relation to cardiothoracic ratio and relative heart volume. A high cardiothoracic ratio and relative heart volume predicted coronary (n=196 deaths) and all-cause mortality, but not respiratory or malignant mortality. After adjustment for age, systolic and diastolic blood pressure, the highest (§0·47) compared to the lowest quintile of the cardiothoracic ratio (
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is cardiothoracic ratio in healthy middle aged men an independent predictor of coronary heart disease mortality whitehall study 25 year follow up
BMJ, 1998Co-Authors: Harry Hemingway, D Christie, Martin J Shipley, Michael MarmotAbstract:Aetiological studies of myocardial ischaemia have tended to concentrate on factors which influence atherothrombotic processes in the coronary arteries rather than myocardial pathophysiology.1 The commonest clinical measure of heart size—cardiothoracic ratio—was included in the original Whitehall study of healthy middle aged civil servants. Cardiothoracic ratio is associated with left ventricular mass2 and left ventricular systolic function; since left ventricular mass determined by echocardiography has been shown to predict coronary heart disease in elderly people,1 we hypothesised that increased cardiothoracic ratio would independently predict mortality from coronary heart disease. Unlike previous studies3 we did not include mortality from stroke since it may be related to heart size through different pathophysiological mechanisms. View this table: Adjusted hazard ratios (95% confidence intervals) for the effect of cardiothoracic ratio on all cause and coronary heart disease mortality We studied the 1203 male British …
D Christie - One of the best experts on this subject based on the ideXlab platform.
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cardiothoracic ratio and relative heart volume as predictors of coronary heart disease mortality the whitehall study 25 year follow up
European Heart Journal, 1998Co-Authors: Harry Hemingway, D Christie, Martin J Shipley, Michael MarmotAbstract:Aim To examine the association of radiographic measures of heart size with mortality from coronary heart disease. Methods and Results One thousand, one hundred and ninety-one male civil servants aged 40‐69 years were followed-up for mortality over 25 years in relation to cardiothoracic ratio and relative heart volume. A high cardiothoracic ratio and relative heart volume predicted coronary (n=196 deaths) and all-cause mortality, but not respiratory or malignant mortality. After adjustment for age, systolic and diastolic blood pressure, the highest (§0·47) compared to the lowest quintile of the cardiothoracic ratio (<0·40) was associated with a rate ratio of 1·84 (95% CI 1·14‐2·97) for the eVect on coronary heart disease mortality. Further adjustment for heart rate, smoking, cholesterol, angina and ECG ischaemia had little eVect, reducing the rate ratio to 1·65 (95% CI 1·01‐2·70). Similar rate ratios were observed for relative heart volume. Conclusions Cardiothoracic ratio within the range considered ‘normal’ in clinical practice predicted coronary heart disease mortality independent of established coronary heart disease risk factors. The relative heart volume, which uses measurements from the lateral as well as the posteroanterior chest X-ray, did not predict coronary heart disease any better than the cardiothoracic ratio. The extent to which left ventricular mass and systolic dysfunction— pathophysiological correlates of the cardiothoracic ratio and relative heart volume — are independent risk factors for coronary heart disease should be further investigated. (Eur Heart J 1998; 19: 859‐869)
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Cardiothoracic ratio and relative heart volume as predictors of coronary heart disease mortality The Whitehall study 25 year follow-up
European Heart Journal, 1998Co-Authors: Harry Hemingway, D Christie, Martin J Shipley, Michael MarmotAbstract:Aim To examine the association of radiographic measures of heart size with mortality from coronary heart disease. Methods and Results One thousand, one hundred and ninety-one male civil servants aged 40‐69 years were followed-up for mortality over 25 years in relation to cardiothoracic ratio and relative heart volume. A high cardiothoracic ratio and relative heart volume predicted coronary (n=196 deaths) and all-cause mortality, but not respiratory or malignant mortality. After adjustment for age, systolic and diastolic blood pressure, the highest (§0·47) compared to the lowest quintile of the cardiothoracic ratio (
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is cardiothoracic ratio in healthy middle aged men an independent predictor of coronary heart disease mortality whitehall study 25 year follow up
BMJ, 1998Co-Authors: Harry Hemingway, D Christie, Martin J Shipley, Michael MarmotAbstract:Aetiological studies of myocardial ischaemia have tended to concentrate on factors which influence atherothrombotic processes in the coronary arteries rather than myocardial pathophysiology.1 The commonest clinical measure of heart size—cardiothoracic ratio—was included in the original Whitehall study of healthy middle aged civil servants. Cardiothoracic ratio is associated with left ventricular mass2 and left ventricular systolic function; since left ventricular mass determined by echocardiography has been shown to predict coronary heart disease in elderly people,1 we hypothesised that increased cardiothoracic ratio would independently predict mortality from coronary heart disease. Unlike previous studies3 we did not include mortality from stroke since it may be related to heart size through different pathophysiological mechanisms. View this table: Adjusted hazard ratios (95% confidence intervals) for the effect of cardiothoracic ratio on all cause and coronary heart disease mortality We studied the 1203 male British …
Martin J Shipley - One of the best experts on this subject based on the ideXlab platform.
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cardiothoracic ratio and relative heart volume as predictors of coronary heart disease mortality the whitehall study 25 year follow up
European Heart Journal, 1998Co-Authors: Harry Hemingway, D Christie, Martin J Shipley, Michael MarmotAbstract:Aim To examine the association of radiographic measures of heart size with mortality from coronary heart disease. Methods and Results One thousand, one hundred and ninety-one male civil servants aged 40‐69 years were followed-up for mortality over 25 years in relation to cardiothoracic ratio and relative heart volume. A high cardiothoracic ratio and relative heart volume predicted coronary (n=196 deaths) and all-cause mortality, but not respiratory or malignant mortality. After adjustment for age, systolic and diastolic blood pressure, the highest (§0·47) compared to the lowest quintile of the cardiothoracic ratio (<0·40) was associated with a rate ratio of 1·84 (95% CI 1·14‐2·97) for the eVect on coronary heart disease mortality. Further adjustment for heart rate, smoking, cholesterol, angina and ECG ischaemia had little eVect, reducing the rate ratio to 1·65 (95% CI 1·01‐2·70). Similar rate ratios were observed for relative heart volume. Conclusions Cardiothoracic ratio within the range considered ‘normal’ in clinical practice predicted coronary heart disease mortality independent of established coronary heart disease risk factors. The relative heart volume, which uses measurements from the lateral as well as the posteroanterior chest X-ray, did not predict coronary heart disease any better than the cardiothoracic ratio. The extent to which left ventricular mass and systolic dysfunction— pathophysiological correlates of the cardiothoracic ratio and relative heart volume — are independent risk factors for coronary heart disease should be further investigated. (Eur Heart J 1998; 19: 859‐869)
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Cardiothoracic ratio and relative heart volume as predictors of coronary heart disease mortality The Whitehall study 25 year follow-up
European Heart Journal, 1998Co-Authors: Harry Hemingway, D Christie, Martin J Shipley, Michael MarmotAbstract:Aim To examine the association of radiographic measures of heart size with mortality from coronary heart disease. Methods and Results One thousand, one hundred and ninety-one male civil servants aged 40‐69 years were followed-up for mortality over 25 years in relation to cardiothoracic ratio and relative heart volume. A high cardiothoracic ratio and relative heart volume predicted coronary (n=196 deaths) and all-cause mortality, but not respiratory or malignant mortality. After adjustment for age, systolic and diastolic blood pressure, the highest (§0·47) compared to the lowest quintile of the cardiothoracic ratio (
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is cardiothoracic ratio in healthy middle aged men an independent predictor of coronary heart disease mortality whitehall study 25 year follow up
BMJ, 1998Co-Authors: Harry Hemingway, D Christie, Martin J Shipley, Michael MarmotAbstract:Aetiological studies of myocardial ischaemia have tended to concentrate on factors which influence atherothrombotic processes in the coronary arteries rather than myocardial pathophysiology.1 The commonest clinical measure of heart size—cardiothoracic ratio—was included in the original Whitehall study of healthy middle aged civil servants. Cardiothoracic ratio is associated with left ventricular mass2 and left ventricular systolic function; since left ventricular mass determined by echocardiography has been shown to predict coronary heart disease in elderly people,1 we hypothesised that increased cardiothoracic ratio would independently predict mortality from coronary heart disease. Unlike previous studies3 we did not include mortality from stroke since it may be related to heart size through different pathophysiological mechanisms. View this table: Adjusted hazard ratios (95% confidence intervals) for the effect of cardiothoracic ratio on all cause and coronary heart disease mortality We studied the 1203 male British …
David A Harrison - One of the best experts on this subject based on the ideXlab platform.
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The Assessment of Risk in Cardiothoracic Intensive Care (ARCtIC): prediction of hospital mortality after admission to cardiothoracic critical care
Anaesthesia, 2016Co-Authors: Jason Shahin, Paloma Ferrando-vivas, G. S. Power, S. Biswas, Stephen T. Webb, Kathy Rowan, David A HarrisonAbstract:Summary The models used to predict outcome after adult general critical care may not be applicable to cardiothoracic critical care. Therefore, we analysed data from the Case Mix Programme to identify variables associated with hospital mortality after admission to cardiothoracic critical care units and to develop a risk-prediction model. We derived predictive models for hospital mortality from variables measured in 17,002 patients within 24 h of admission to five cardiothoracic critical care units. The final model included 10 variables: creatinine; white blood count; mean arterial blood pressure; functional dependency; platelet count; arterial pH; age; Glasgow Coma Score; arterial lactate; and route of admission. We included additional interaction terms between creatinine, lactate, platelet count and cardiac surgery as the admitting diagnosis. We validated this model against 10,238 other admissions, for which the c index (95% CI) was 0.904 (0.89–0.92) and the Brier score was 0.055, while the slope and intercept of the calibration plot were 0.961 and −0.183, respectively. The discrimination and calibration of our model suggest that it might be used to predict hospital mortality after admission to cardiothoracic critical care units.