The Experts below are selected from a list of 13677 Experts worldwide ranked by ideXlab platform
Anna Borje - One of the best experts on this subject based on the ideXlab platform.
-
the fragrance chemical β Caryophyllene air oxidation and skin sensitization
Food and Chemical Toxicology, 2006Co-Authors: Maria Skold, Anntherese Karlberg, Mihaly Matura, Anna BorjeAbstract:Fragrances are common causes of allergic contact dermatitis. β-Caryophyllene is a sesquiterpene that is used as a fragrance chemical. Analogous to the monoterpenes R-limonene and linalool, it can be expected to autoxidize when air exposed. The aim of the present study was to investigate the autoxidation of β-Caryophyllene and to evaluate the effect on the contact allergenic activity. β-Caryophyllene started to oxidize immediately when air exposed and after 5 weeks almost 50% of the original compound was consumed. Caryophyllene oxide was found to be the major oxidation product. Hydroperoxides of β-Caryophyllene could not be detected in the oxidation mixture. Caryophyllene oxide was shown to be an allergen of moderate strength and β-Caryophyllene air exposed for 10 weeks showed a weak sensitizing capacity in the local lymph node assay. The study reveals that the allergenic activity of β-Caryophyllene is affected by autoxidation, but to a lesser extent when compared to R-limonene and linalool. The present findings support our results in clinical studies showing oxidized β-Caryophyllene to be a rather rare sensitizer compared to oxidized R-limonene and linalool.
-
the fragrance chemical β Caryophyllene air oxidation and skin sensitization
Food and Chemical Toxicology, 2006Co-Authors: Maria Skold, Anntherese Karlberg, Mihaly Matura, Anna BorjeAbstract:Fragrances are common causes of allergic contact dermatitis. beta-Caryophyllene is a sesquiterpene that is used as a fragrance chemical. Analogous to the monoterpenes R-limonene and linalool, it can be expected to autoxidize when air exposed. The aim of the present study was to investigate the autoxidation of beta-Caryophyllene and to evaluate the effect on the contact allergenic activity. beta-Caryophyllene started to oxidize immediately when air exposed and after 5 weeks almost 50% of the original compound was consumed. Caryophyllene oxide was found to be the major oxidation product. Hydroperoxides of beta-Caryophyllene could not be detected in the oxidation mixture. Caryophyllene oxide was shown to be an allergen of moderate strength and beta-Caryophyllene air exposed for 10 weeks showed a weak sensitizing capacity in the local lymph node assay. The study reveals that the allergenic activity of beta-Caryophyllene is affected by autoxidation, but to a lesser extent when compared to R-limonene and linalool. The present findings support our results in clinical studies showing oxidized beta-Caryophyllene to be a rather rare sensitizer compared to oxidized R-limonene and linalool.
Mihaly Matura - One of the best experts on this subject based on the ideXlab platform.
-
the fragrance chemical β Caryophyllene air oxidation and skin sensitization
Food and Chemical Toxicology, 2006Co-Authors: Maria Skold, Anntherese Karlberg, Mihaly Matura, Anna BorjeAbstract:Fragrances are common causes of allergic contact dermatitis. β-Caryophyllene is a sesquiterpene that is used as a fragrance chemical. Analogous to the monoterpenes R-limonene and linalool, it can be expected to autoxidize when air exposed. The aim of the present study was to investigate the autoxidation of β-Caryophyllene and to evaluate the effect on the contact allergenic activity. β-Caryophyllene started to oxidize immediately when air exposed and after 5 weeks almost 50% of the original compound was consumed. Caryophyllene oxide was found to be the major oxidation product. Hydroperoxides of β-Caryophyllene could not be detected in the oxidation mixture. Caryophyllene oxide was shown to be an allergen of moderate strength and β-Caryophyllene air exposed for 10 weeks showed a weak sensitizing capacity in the local lymph node assay. The study reveals that the allergenic activity of β-Caryophyllene is affected by autoxidation, but to a lesser extent when compared to R-limonene and linalool. The present findings support our results in clinical studies showing oxidized β-Caryophyllene to be a rather rare sensitizer compared to oxidized R-limonene and linalool.
-
the fragrance chemical β Caryophyllene air oxidation and skin sensitization
Food and Chemical Toxicology, 2006Co-Authors: Maria Skold, Anntherese Karlberg, Mihaly Matura, Anna BorjeAbstract:Fragrances are common causes of allergic contact dermatitis. beta-Caryophyllene is a sesquiterpene that is used as a fragrance chemical. Analogous to the monoterpenes R-limonene and linalool, it can be expected to autoxidize when air exposed. The aim of the present study was to investigate the autoxidation of beta-Caryophyllene and to evaluate the effect on the contact allergenic activity. beta-Caryophyllene started to oxidize immediately when air exposed and after 5 weeks almost 50% of the original compound was consumed. Caryophyllene oxide was found to be the major oxidation product. Hydroperoxides of beta-Caryophyllene could not be detected in the oxidation mixture. Caryophyllene oxide was shown to be an allergen of moderate strength and beta-Caryophyllene air exposed for 10 weeks showed a weak sensitizing capacity in the local lymph node assay. The study reveals that the allergenic activity of beta-Caryophyllene is affected by autoxidation, but to a lesser extent when compared to R-limonene and linalool. The present findings support our results in clinical studies showing oxidized beta-Caryophyllene to be a rather rare sensitizer compared to oxidized R-limonene and linalool.
Theeraphap Chareonviriyaphap - One of the best experts on this subject based on the ideXlab platform.
-
excito repellency and biological safety of β Caryophyllene oxide against aedes albopictus and anopheles dirus diptera culicidae
Acta Tropica, 2020Co-Authors: Jirod Nararak, Carole Di Giorgio, Chutipong Sukkanon, Valerie Mahiouleddet, Sylvie Manguin, Evelyne Ollivier, Theeraphap ChareonviriyaphapAbstract:Abstract The activity of β-Caryophyllene oxide as either a contact or noncontact repellent was evaluated against two laboratory strains (Aedes albopictus and Anopheles dirus) using an excito-repellency test system. N, N-Diethyl-3-methylbenzamide (DEET) was used as a standard reference baseline for comparative purposes. β-Caryophyllene oxide and DEET were tested at concentrations of 0.1, 0.25, 0.5 and 1.0% (v/v). In addition, the phototoxic and genotoxic effects of β-Caryophyllene oxide were investigated on Balb/c 3T3 mouse fibroblasts (3T3-L1) and Chinese hamster ovary cell line (CHO-K1). The results demonstrated that the higher concentrations of test compounds (0.5 and 1.0%) produced greater behavioral responses. Aedes albopictus was more sensitive to β-Caryophyllene oxide than An. dirus. Moderate avoidance response rates (25-56% escape) of Ae. albopictus at 0.5% and 1.0% β-Caryophyllene oxide were observed in contact and noncontact trials compared with low response rates from An. dirus (26-31% escape). DEET at ≤1% displayed lower irritancy and repellency (1-38%) than β-Caryophyllene oxide when tested against the two mosquito species. Knockdown responses (37%) were only observed in An. dirus exposed to 1% β-Caryophyllene oxide in the contact trial. β-Caryophyllene oxide did not show any phototoxic potential (PIF= 0.38) nor was there any significant genotoxic response as indicated by no increase in micro-nucleated cells with or without metabolic activation. β-Caryophyllene oxide could be considered as a safe repellent, effective against mosquitoes.
-
excito repellent activity of β Caryophyllene oxide against aedes aegypti and anopheles minimus
Acta Tropica, 2019Co-Authors: Jirod Nararak, Valerie Mahiouleddet, Sylvie Manguin, Sunaiyana Sathantriphop, Monthathip Kongmee, Evelyne Ollivier, Theeraphap ChareonviriyaphapAbstract:Abstract Contact irritant and non-contact repellent activities of β-Caryophyllene oxide were evaluated against laboratory strains of female Aedes aegypti (USDA strain), a major arbovirus vector and Anopheles minimus (KU strain), a major malaria parasite vector, compared with the synthetic repellent DEET, using an excito-repellency test system. β-Caryophyllene oxide and DEET were tested at concentrations of 0.1, 0.25, 0.5 and 1.0% (v/v). Anopheles minimus was found to be more sensitive to β-Caryophyllene oxide than that of Ae. aegypti and exhibited high avoidance response rates (86–96% escape) at 0.5% and 1.0% concentrations in contact and non-contact trials compared with Ae. aegypti (22–59% escape). However, at the same concentrations, DEET displayed lower irritancy and repellency capacities against these two mosquito species (range 0–54% escape) compared to β-Caryophyllene oxide. The analysis of escape responses showed significant differences between mosquito species at all concentrations (P
Asta Judzentiene - One of the best experts on this subject based on the ideXlab platform.
-
Caryophyllene oxide rich essential oils of lithuanian artemisia campestris ssp campestris and their toxicity
Natural Product Communications, 2010Co-Authors: Asta Judzentiene, Jurga Budiene, Rita Butkiene, Eugenija Kupcinskiene, Isabelle Laffontschwob, Veronique MasottiAbstract:: The chemical composition of the essential oils of aerial parts of Artemisia campestris ssp. campestris, collected from ten different locations in Lithuania is detailed in this paper. The major component in all the oils was Caryophyllene oxide (8.5-38.8%), whereas compounds with the caryophyllane skeleton ranged from 10.2 to 44.5%. Other representative constituents were germacrene D (< or = 15.0%), humulene epoxide II (< or = 8.1%), beta-ylangene (< or = 7.7%), spathulenol (< or = 6.8%), beta-elemene (< or = 6.8%), beta-Caryophyllene (< or = 6.2%), junenol (< or = 6.1%) and alpha- or beta-pinene (< or = 5.5%). Eighty-seven compounds were identified, comprising 73.6-92.3% of the oils. The chemical composition was highly variable depending on the sample location. Toxicity of A. campestris oils was determined using the brine shrimp (Artemia sp.) assay. LC50 values ranging to 20 microg/mL were obtained for three of the oils after 24 hours of exposure. Data of this test revealed that A. campestris ssp. campestris essential oils with dominant Caryophyllene oxide are notably toxic.
-
The essential oil of Origanum vulgare L. ssp. vulgare growing wild in vilnius district (Lithuania).
Phytochemistry, 2001Co-Authors: Danute Mockute, Genovaite Bernotiene, Asta JudzentieneAbstract:The plants of wild Origanum vulgare L. ssp. vulgare were collected in 10 localities of Vilnius district (Lithuania) in 1995-1999. The main constituents of the essential oils from 8 localities were beta-ocimene (14.9-21.6%), germacrene D (10.0-16.2), beta-Caryophyllene (10.8- 15.7%) and sabinene (6.6- 4.2%). The essential oils from two localities contained only three above compounds as major components: germacrene D, beta-ocimene and sabinene or beta-Caryophyllene, beta-ocimene and germacrene D. Three chemotypes of essential oils were identified. The main chemotype was beta-ocimene germacrene D-beta-Caryophyllene. The terpenic hydrocarbons made up 52.8-80.6% of the essential oils. The 42 identified components made up 85.6-98.0% of the essential oil.
Maria Skold - One of the best experts on this subject based on the ideXlab platform.
-
the fragrance chemical β Caryophyllene air oxidation and skin sensitization
Food and Chemical Toxicology, 2006Co-Authors: Maria Skold, Anntherese Karlberg, Mihaly Matura, Anna BorjeAbstract:Fragrances are common causes of allergic contact dermatitis. β-Caryophyllene is a sesquiterpene that is used as a fragrance chemical. Analogous to the monoterpenes R-limonene and linalool, it can be expected to autoxidize when air exposed. The aim of the present study was to investigate the autoxidation of β-Caryophyllene and to evaluate the effect on the contact allergenic activity. β-Caryophyllene started to oxidize immediately when air exposed and after 5 weeks almost 50% of the original compound was consumed. Caryophyllene oxide was found to be the major oxidation product. Hydroperoxides of β-Caryophyllene could not be detected in the oxidation mixture. Caryophyllene oxide was shown to be an allergen of moderate strength and β-Caryophyllene air exposed for 10 weeks showed a weak sensitizing capacity in the local lymph node assay. The study reveals that the allergenic activity of β-Caryophyllene is affected by autoxidation, but to a lesser extent when compared to R-limonene and linalool. The present findings support our results in clinical studies showing oxidized β-Caryophyllene to be a rather rare sensitizer compared to oxidized R-limonene and linalool.
-
the fragrance chemical β Caryophyllene air oxidation and skin sensitization
Food and Chemical Toxicology, 2006Co-Authors: Maria Skold, Anntherese Karlberg, Mihaly Matura, Anna BorjeAbstract:Fragrances are common causes of allergic contact dermatitis. beta-Caryophyllene is a sesquiterpene that is used as a fragrance chemical. Analogous to the monoterpenes R-limonene and linalool, it can be expected to autoxidize when air exposed. The aim of the present study was to investigate the autoxidation of beta-Caryophyllene and to evaluate the effect on the contact allergenic activity. beta-Caryophyllene started to oxidize immediately when air exposed and after 5 weeks almost 50% of the original compound was consumed. Caryophyllene oxide was found to be the major oxidation product. Hydroperoxides of beta-Caryophyllene could not be detected in the oxidation mixture. Caryophyllene oxide was shown to be an allergen of moderate strength and beta-Caryophyllene air exposed for 10 weeks showed a weak sensitizing capacity in the local lymph node assay. The study reveals that the allergenic activity of beta-Caryophyllene is affected by autoxidation, but to a lesser extent when compared to R-limonene and linalool. The present findings support our results in clinical studies showing oxidized beta-Caryophyllene to be a rather rare sensitizer compared to oxidized R-limonene and linalool.