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Barbara Gandolfi - One of the best experts on this subject based on the ideXlab platform.
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werewolf there wolf variants in hairless associated with hypotrichia and roaning in the lykoi Cat breed
Genes, 2020Co-Authors: Reuben M Buckley, Barbara Gandolfi, Marie Abitbol, Erica K Creighton, Connor A Pyne, Delia M Bouhan, Michelle L Leroy, David A Senter, Johnny R GobbleAbstract:A variety of Cat Breeds have been developed via novelty selection on aesthetic, dermatological traits, such as coat colors and fur types. A recently developed breed, the lykoi (a.k.a. werewolf Cat), was bred from Cats with a sparse hair coat with roaning, implying full color and all white hairs. The lykoi phenotype is a form of hypotrichia, presenting as a significant reduction in the average numbers of follicles per hair follicle group as compared to domestic shorthair Cats, a mild to severe perifollicular to mural lymphocytic infiltration in 77% of observed hair follicle groups, and the follicles are often miniaturized, dilated, and dysplastic. Whole genome sequencing was conducted on a single lykoi Cat that was a cross between two independently ascertained lineages. Comparison to the 99 Lives dataset of 194 non-lykoi Cats suggested two variants in the Cat homolog for Hairless (HR) (HR lysine demethylase and nuclear receptor corepressor) as candidate causal gene variants. The lykoi Cat was a compound heterozygote for two loss of function variants in HR, an exon 3 c.1255_1256dupGT (chrB1:36040783), which should produce a stop codon at amino acid 420 (p.Gln420Serfs*100) and, an exon 18 c.3389insGACA (chrB1:36051555), which should produce a stop codon at amino acid position 1130 (p.Ser1130Argfs*29). Ascertainment of 14 additional Cats from founder lineages from Canada, France and different areas of the USA identified four additional loss of function HR variants likely causing the highly similar phenotypic hair coat across the diverse Cats. The novel variants in HR for Cat hypotrichia can now be established between minor differences in the phenotypic presentations.
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werewolf there wolf variants in hairless associated with hypotrichia and roaning in the lykoi Cat breed
bioRxiv, 2020Co-Authors: Reuben M Buckley, Barbara Gandolfi, Marie Abitbol, Erica K Creighton, Connor A Pyne, Delia M Bouhan, Michelle L Leroy, David A Senter, Johnny R Gobble, Leslie A. LyonsAbstract:A variety of Cat Breeds have been developed via novelty selection on aesthetic, dermatological traits, such as coat colors and fur types. A recently developed breed, the lykoi, was bred from Cats with a sparse hair coat with roaning, implying full color and all white hairs. The lykoi phenotype is a form of hypotrichia, presenting as significant reduction in the average numbers of follicles per hair follicle group as compared to domestic shorthair Cats, a mild to severe perifollicular to mural lymphocytic infiltration in 77% of observed hair follicle groups, and the follicles are often miniaturized, dilated, and dysplastic. Whole genome sequencing was conducted on a single lykoi Cat that was a cross between two independently ascertained lineages. Comparison to the 99 Lives dataset of 194 non-lykoi Cats suggested two variants in the Cat homolog for Hairless (HR: lysine demethylase and nuclear receptor corepressor) as candidate causal variants. The lykoi Cat was a compound heterozygote for two loss of function variants in HR, an exon 3 c.1255_1256dupGT (chrB1:36040783), which should produce a stop codon at amino acid 420 (p.Gln420Serfs*100) and, an exon 18 c.3389insGACA (chrB1:36051555), which should produce a stop codon at amino acid position 1130 (p.Ser1130Argfs*29). Ascertainment of 14 additional Cats from founder lineages from Canada, France and different areas of the USA identified four additional loss of function HR variants likely causing the highly similar phenotypic hair coat across the diverse Cats. The novel variants in HR for Cat hypotrichia can now be established between minor differences in the phenotypic presentations.
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AppliCations and efficiencies of the first Cat 63K DNA array
Scientific Reports, 2018Co-Authors: Barbara Gandolfi, Hasan Alhaddad, Erica K Creighton, Mona Abdi, Leslie H. Bach, Brian W. Davis, Jared E. Decker, Nicholas H. Dodman, Edward I. Ginns, Jennifer C. GrahnAbstract:The development of high throughput SNP genotyping technologies has improved the genetic dissection of simple and complex traits in many species including Cats. The properties of feline 62,897 SNPs Illumina Infinium iSelect DNA array are described using a dataset of over 2,000 feline samples, the most extensive to date, representing 41 Cat Breeds, a random bred population, and four wild felid species. Accuracy and efficiency of the array’s genotypes and its utility in performing population-based analyses were evaluated. Average marker distance across the array was 37,741 Kb, and across the dataset, only 1% (625) of the markers exhibited poor genotyping and only 0.35% (221) showed Mendelian errors. Marker polymorphism varied across Cat Breeds and the average minor allele frequency (MAF) of all markers across domestic Cats was 0.21. Population structure analysis confirmed a Western to Eastern structural continuum of Cat Breeds. Genome-wide linkage disequilibrium ranged from 50–1,500 Kb for domestic Cats and 750 Kb for European wildCats ( Felis silvestris silvestris ). Array use in trait association mapping was investigated under different modes of inheritance, selection and population sizes. The efficient array design and Cat genotype dataset continues to advance the understanding of Cat Breeds and will support monogenic health studies across feline Breeds and populations.
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Frequency of the CMAH c.364C>T polymorphism in different Cat Breeds with unknown serology.
2016Co-Authors: Barbara Gandolfi, Leslie A. Lyons, Robert A. Grahn, Nicholas A. Gustafson, Daniela Proverbio, Eva Spada, Badri Adhikari, Janling Cheng, Gordon Andrews, Chris R. HelpsAbstract:Frequency of the CMAH c.364C>T polymorphism in different Cat Breeds with unknown serology.
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extent of linkage disequilibrium in the domestic Cat felis silvestris Catus and its Breeds
PLOS ONE, 2013Co-Authors: Hasan Alhaddad, Barbara Gandolfi, Hannes Lohi, Robert A. Grahn, Razib Khan, James C Mullikin, Shelley A Cole, T J Gruffyddjones, Jens Haggstrom, M LongeriAbstract:Domestic Cats have a unique breeding history and can be used as models for human hereditary and infectious diseases. In the current era of genome-wide association studies, insights regarding linkage disequilibrium (LD) are essential for efficient association studies. The objective of this study is to investigate the extent of LD in the domestic Cat, Felis silvestris Catus, particularly within its Breeds. A custom illumina GoldenGate Assay consisting of 1536 single nucleotide polymorphisms (SNPs) equally divided over ten 1 Mb chromosomal regions was developed, and genotyped across 18 globally recognized Cat Breeds and two distinct random bred populations. The pair-wise LD descriptive measure (r(2)) was calculated between the SNPs in each region and within each population independently. LD decay was estimated by determining the non-linear least-squares of all pair-wise estimates as a function of distance using established models. The point of 50% decay of r(2) was used to compare the extent of LD between Breeds. The longest extent of LD was observed in the Burmese breed, where the distance at which r(2) ≈ 0.25 was ∼380 kb, comparable to several horse and dog Breeds. The shortest extent of LD was found in the Siberian breed, with an r(2) ≈ 0.25 at approximately 17 kb, comparable to random bred Cats and human populations. A comprehensive haplotype analysis was also conducted. The haplotype structure of each region within each breed mirrored the LD estimates. The LD of Cat Breeds largely reflects the Breeds' population history and breeding strategies. Understanding LD in diverse populations will contribute to an efficient use of the newly developed SNP array for the Cat in the design of genome-wide association studies, as well as to the interpretation of results for the fine mapping of disease and phenotypic traits.
Hasan Alhaddad - One of the best experts on this subject based on the ideXlab platform.
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Patterns of allele frequency differences among domestic Cat Breeds assessed by a 63K SNP array.
'Public Library of Science (PLoS)', 2021Co-Authors: Hasan Alhaddad, Mona Abdi, Leslie A. LyonsAbstract:Cats are ubiquitous companion animals that have been keenly associated with humans for thousands of years and only recently have been intentionally bred for aesthetically appealing coat looks and body forms. The intense selection on single gene phenotypes and the various breeding histories of Cat Breeds have left different marks on the genomes. Using a previously published 63K Feline SNP array dataset of twenty-six Cat Breeds, this study utilized a genetic differentiation-based method (di) to empirically identify candidate regions under selection. Defined as three or more overlapping (500Kb) windows of high levels of population differentiation, we identified a total of 205 candidate regions under selection across Cat Breeds with an average of 6 candidate regions per breed and an average size of 1.5 Mb per candidate region. Using the combined size of candidate regions of each breed, we conservatively estimate that a minimum of ~ 0.1-0.7% of the autosomal genome is potentially under selection in Cats. As positive controls and tests of our methodology, we explored the candidate regions of known breed-defining genes (e.g., FGF5 for longhaired Breeds) and we were able to detect the genes within candidate regions, each in its corresponding breed. For breed specific exploration of candidate regions under selection, eleven representative candidate regions were found to encompass potential candidate genes for several phenotypes such as brachycephaly of Persian (DLX6, DLX5, DLX2), curled ears of American Curl (MCRIP2, PBX1), and body-form of Siamese and Oriental (ADGRD1), which encourages further molecular investigations. The current assessment of the candidate regions under selection is empiric and detailed analyses are needed to rigorously disentangle effects of demography and population structure from artificial selection
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AppliCations and efficiencies of the first Cat 63K DNA array
Scientific Reports, 2018Co-Authors: Barbara Gandolfi, Hasan Alhaddad, Erica K Creighton, Mona Abdi, Leslie H. Bach, Brian W. Davis, Jared E. Decker, Nicholas H. Dodman, Edward I. Ginns, Jennifer C. GrahnAbstract:The development of high throughput SNP genotyping technologies has improved the genetic dissection of simple and complex traits in many species including Cats. The properties of feline 62,897 SNPs Illumina Infinium iSelect DNA array are described using a dataset of over 2,000 feline samples, the most extensive to date, representing 41 Cat Breeds, a random bred population, and four wild felid species. Accuracy and efficiency of the array’s genotypes and its utility in performing population-based analyses were evaluated. Average marker distance across the array was 37,741 Kb, and across the dataset, only 1% (625) of the markers exhibited poor genotyping and only 0.35% (221) showed Mendelian errors. Marker polymorphism varied across Cat Breeds and the average minor allele frequency (MAF) of all markers across domestic Cats was 0.21. Population structure analysis confirmed a Western to Eastern structural continuum of Cat Breeds. Genome-wide linkage disequilibrium ranged from 50–1,500 Kb for domestic Cats and 750 Kb for European wildCats ( Felis silvestris silvestris ). Array use in trait association mapping was investigated under different modes of inheritance, selection and population sizes. The efficient array design and Cat genotype dataset continues to advance the understanding of Cat Breeds and will support monogenic health studies across feline Breeds and populations.
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Genomic landscape of selection in domestic Cat Breeds
2018Co-Authors: Hasan AlhaddadAbstract:The poster is a summary of the thesis project of Mona Abdi at Kuwait University which focuses on the signatures of selection in a large number of Cat Breeds. The study also provides a general overview of regions under selection in the domestic Cat genome
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Artificial selection and shaping the genomes of Cat Breeds 2017
2017Co-Authors: Hasan AlhaddadAbstract:The poster presents the initial analysis into investigating signatures of selection among Cat Breeds. The study uses SNP genotype data using the 63K SNP array. The poster was presented at PAG 201
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extent of linkage disequilibrium in the domestic Cat felis silvestris Catus and its Breeds
PLOS ONE, 2013Co-Authors: Hasan Alhaddad, Barbara Gandolfi, Hannes Lohi, Robert A. Grahn, Razib Khan, James C Mullikin, Shelley A Cole, T J Gruffyddjones, Jens Haggstrom, M LongeriAbstract:Domestic Cats have a unique breeding history and can be used as models for human hereditary and infectious diseases. In the current era of genome-wide association studies, insights regarding linkage disequilibrium (LD) are essential for efficient association studies. The objective of this study is to investigate the extent of LD in the domestic Cat, Felis silvestris Catus, particularly within its Breeds. A custom illumina GoldenGate Assay consisting of 1536 single nucleotide polymorphisms (SNPs) equally divided over ten 1 Mb chromosomal regions was developed, and genotyped across 18 globally recognized Cat Breeds and two distinct random bred populations. The pair-wise LD descriptive measure (r(2)) was calculated between the SNPs in each region and within each population independently. LD decay was estimated by determining the non-linear least-squares of all pair-wise estimates as a function of distance using established models. The point of 50% decay of r(2) was used to compare the extent of LD between Breeds. The longest extent of LD was observed in the Burmese breed, where the distance at which r(2) ≈ 0.25 was ∼380 kb, comparable to several horse and dog Breeds. The shortest extent of LD was found in the Siberian breed, with an r(2) ≈ 0.25 at approximately 17 kb, comparable to random bred Cats and human populations. A comprehensive haplotype analysis was also conducted. The haplotype structure of each region within each breed mirrored the LD estimates. The LD of Cat Breeds largely reflects the Breeds' population history and breeding strategies. Understanding LD in diverse populations will contribute to an efficient use of the newly developed SNP array for the Cat in the design of genome-wide association studies, as well as to the interpretation of results for the fine mapping of disease and phenotypic traits.
Dave C Brodbelt - One of the best experts on this subject based on the ideXlab platform.
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epidemiology of diabetes mellitus among 193 435 Cats attending primary care veterinary practices in england
Journal of Veterinary Internal Medicine, 2016Co-Authors: Dan G Oneill, Ruth Gostelow, C Orme, David B Church, S J M Niessen, K L P Verheyen, Dave C BrodbeltAbstract:Background Diabetes mellitus (DM) is a common endocrine disease of Cats. The prevalence of DM in Cats in England is not well-defined. Hypothesis/Objectives To estimate the prevalence and identify risk factors for DM in a large population of Cats attending primary-care practices. Animals A cohort of 193,563 Cats in the VetCompass Programme attending 118 primary-care practices in England. Methods Cross-sectional analysis of cohort clinical data. Data were extracted covering September 1st 2009 and August 31st 2014. Period prevalence of DM was calculated. Associations between risk factors and DM were assessed using logistic regression modelling. Results Of 1,128 DM cases were identified among 194,563 Cats (period prevalence 0.58%; 95% confidence interval [CI] 0.54–0.61). Multivariable modelling indiCated that Tonkinese (OR 4.1; 95% CI 1.8–9.6; P = .001), Norwegian Forest (odds ratio [OR] 3.5; 95% CI 1.3–9.6; P = .001) and Burmese (OR 3.0; 95% CI 2.0–4.4; P < .001) Cats had increased odds of DM compared with crossbred Cats. DM odds increased as bodyweight Categories increased above 4 kg (P < .001), as Cats aged beyond 6 years old (P < .001) and in insured Cats (OR 2.0; 95% CI 1.6–2.4; P < .001) but sex was not significantly associated with DM. Conclusions and Clinical Importance Diabetes mellitus is an important component of the primary-care practice caseload with 1-in-200 Cats affected. An increased risk of DM in certain Cat Breeds supports a genetic predisposition. These results can guide future research and preventative healthcare.
M Longeri - One of the best experts on this subject based on the ideXlab platform.
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IdentifiCation of feline miRNAs and evaluation of their differential expression in Abyssinian amyloidosis
2019Co-Authors: F. Genova, A. Mezzelani, E. Mosca, N. Di Nanni, F. Cupaioli, M LongeriAbstract:Introduction: Domestic felids represent one of the main species in which amyloidosis occurs. The disease is caused by the presence of protein complexes, known as amyloids, which form insoluble deposits in different organs. However, little is known about the pathogenic pathway and the genetic of the disease is still under exploration. Among Cat Breeds, amyloidosis is known to affect Abyssinian/Somali and Siamese/Oriental Cats, where the main target organs for the deposit were found to be kidneys and liver, respectively. Objective: The aim of this study is to identify feline miRNAs and to evaluate their possible differential expression in amyloidosis-affected and healthy Abyssinian Cats. The main objective is profiling miRNAs potentially involved in the disease onset or in the regulation of its pathogenesis. Materials & Methods: miRNAs were extracted from Formalin Fixed Paraffin Embedded (FFPE) samples collected from 4 healthy and 6 affected Abyssinians, using the miRNeasy Mini Kit (Qiagen). The sequencing of miRNAs was carried out using/by? XXX and its quality was assessed with FastQC. Cutadapter was used to remove the adapter sequences from the high-throughput sequencing reads. MiRDeep2 was then used to collapse the reads and map the fastq files against the reference sequence (mapper.pl function), to identify miRNAs (mirDeep2.pl function) and to determine their expression (quantifier.pl function). MiRNAs with less than 10 reads for each sample were filtered out. The TMM method (Trimmed mean of M values) was used for the normalization and data were expressed as log2 CPM (counts per million reads). The reference genome for Felis Catus was retrieved from NCBI (genome assembly vs 9.0) and miRNAs related to Cat were identified using the corresponding human miRNAs on miRbase (http://www.mirbase.org/Zp.shtml). Results: A total of 854 miRNAs were detected, and subsequently reduced to 341 after filtering. Considering the False Discovery Rate (FDR) at 5%, no miRNAs resulted differentially expressed between affected and healthy Abyssinians, whereas 22 miRNAs showed significance considering the nominal P-value. Among these 22 miRNAs, six are known to be involved in the development of Alzheimer Disease (AD), four of which with a P-value < 0.009. Suggestively, within the not significant miRNAs, miR-26a-5p (P-value 0.120) is one of the main miRNAs involved in the human light chain amyloidosis onset. Conclusions: recent studies in humans have been focusing on disclosing the potential role of miRNAs in the accumulation of amyloid fibrils, especially in the AD. It was shown that miRNAs significantly affect specific alterations rather than play a direct role in the onset and the development of the AD itself. In our study, some of the identified miRNAs were already found to be associated with AD in humans. These results are encouraging and could explain the role of these miRNAs in feline amyloidosis too. The genes directly regulated and involved in these pathways still have to be investigated. Further evidences could also be obtained using an integrative approach through a proteomic analysis
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First genome-wide CNV mapping in FELIS CatUS using next generation sequencing data
'Springer Science and Business Media LLC', 2018Co-Authors: F. Genova, M Longeri, L.a. Lyons, A. Bagnato, 99lives T. Consortium, M.g. StrillacciAbstract:Background: Copy Number Variations (CNVs) have becoming very significant variants, representing a major source of genomic variation. CNVs involvement in phenotypic expression and different diseases has been widely demonstrated in humans as well as in many domestic animals. However, genome wide investigation on these structural variations is still missing in Felis Catus. The present work is the first CNV mapping from a large data set of Next Generation Sequencing (NGS) data in the domestic Cat, performed within the 99 Lives Consortium. Results: Reads have been mapped on the reference assembly_6.2 by Maverix Biomics. CNV detection with cn.MOPS and CNVnator detected 592 CNVs. These CNVs were used to obtain 154 CNV Regions (CNVRs) with BedTools, including 62 singletons. CNVRs covered 0.26% of the total Cat genome with 129 losses, 19 gains and 6 complexes. Cluster Analysis and Principal Component Analysis of the detected CNVRs showed that Breeds tend to cluster together as well as Cats sharing the same geographical origins. The 46 genes identified within the CNVRs were annotated. Conclusion: This study has improved the genomic characterization of 14 Cat Breeds and has provided CNVs information that can be used for studies of traits in Cats. It can be considered a sound starting point for genomic CNVs identifiCation in this species
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IdentifiCation of causative mutations in Abyssinian Amyloidosis
2017Co-Authors: F. Genova, L.a. Lyons, B. Gandolfi, A. Thomas, M LongeriAbstract:Amyloidosis is a metabolic disorder caused by the improper folding of autologous proteins that aggregate and deposit into different organs. This disease occurs in humans, chickens, wild and domestic felids and several other species. Familial forms were noticed in Abyssinian/Somali and Siamese/Oriental Cat Breeds, with liver and kidney, respectively, as main targets for the deposits. The amyloidosis pathogenic pathway is still unknown and no DNA test is available for a preventive diagnosis. The aim of this study is to identify the causative mutations of the disease in the Abyssinian Cats, using different genetic and genomic approaches. Whole genome sequences of two affected Abyssinians were used to identify mutations associated with amyloidosis, using 127 additional whole genome Cat sequences from unaffected Cats as controls for variant exclusion. Identified variants were prioritized based on a previous genome wide association study conducted on affected/healthy cohorts of Abyssinians. Significant associations on Cat chromosomes B4 and C2 were detected. Among all the genes within the two regions, two were considered good candidates for their potential role in the pathogenic pathway of the disease and showed polymorphisms only within affected individuals. Twenty-eight additional variants were found on different chromosomes and to confirm the causality link to the disorder, the polymorphisms were genotyped on a large population of affected and control Abyssinians, including 20 related Cats. Currently the genotype-phenotype association is under evaluation considering different possible modes of inheritance, including a polygenic contribution to the disease
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extent of linkage disequilibrium in the domestic Cat felis silvestris Catus and its Breeds
PLOS ONE, 2013Co-Authors: Hasan Alhaddad, Barbara Gandolfi, Hannes Lohi, Robert A. Grahn, Razib Khan, James C Mullikin, Shelley A Cole, T J Gruffyddjones, Jens Haggstrom, M LongeriAbstract:Domestic Cats have a unique breeding history and can be used as models for human hereditary and infectious diseases. In the current era of genome-wide association studies, insights regarding linkage disequilibrium (LD) are essential for efficient association studies. The objective of this study is to investigate the extent of LD in the domestic Cat, Felis silvestris Catus, particularly within its Breeds. A custom illumina GoldenGate Assay consisting of 1536 single nucleotide polymorphisms (SNPs) equally divided over ten 1 Mb chromosomal regions was developed, and genotyped across 18 globally recognized Cat Breeds and two distinct random bred populations. The pair-wise LD descriptive measure (r(2)) was calculated between the SNPs in each region and within each population independently. LD decay was estimated by determining the non-linear least-squares of all pair-wise estimates as a function of distance using established models. The point of 50% decay of r(2) was used to compare the extent of LD between Breeds. The longest extent of LD was observed in the Burmese breed, where the distance at which r(2) ≈ 0.25 was ∼380 kb, comparable to several horse and dog Breeds. The shortest extent of LD was found in the Siberian breed, with an r(2) ≈ 0.25 at approximately 17 kb, comparable to random bred Cats and human populations. A comprehensive haplotype analysis was also conducted. The haplotype structure of each region within each breed mirrored the LD estimates. The LD of Cat Breeds largely reflects the Breeds' population history and breeding strategies. Understanding LD in diverse populations will contribute to an efficient use of the newly developed SNP array for the Cat in the design of genome-wide association studies, as well as to the interpretation of results for the fine mapping of disease and phenotypic traits.
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the ascent of Cat Breeds genetic evaluations of Breeds and worldwide random bred populations
Genomics, 2008Co-Authors: Monika J Lipinski, M Longeri, Lutz Froenicke, Kathleen C Baysac, Nicholas C Billings, Christian M Leutenegger, Alon Levy, Tirri Niini, Haydar Ozpinar, Margaret R SlaterAbstract:The diaspora of the modern Cat was traced with microsatellite markers from the presumed site of domestiCation to distant regions of the world. Genetic data were derived from over 1100 individuals, representing 17 random-bred populations from five continents and 22 Breeds. The Mediterranean was reconfirmed to be the probable site of domestiCation. Genetic diversity has remained broad throughout the world, with distinct genetic clustering in the Mediterranean basin, Europe/America, Asia and Africa. However, Asian Cats appeared to have separated early and expanded in relative isolation. Most Breeds were derived from indigenous Cats of their purported regions of origin. However, the Persian and Japanese bobtail were more aligned with European/American than with Mediterranean basin or Asian clusters. Three recently derived Breeds were not distinct from their parental Breeds of origin. Pure breeding was associated with a loss of genetic diversity; however, this loss did not correlate with breed popularity or age.
Ricardo Miyasaka De ,almeida - One of the best experts on this subject based on the ideXlab platform.
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Doença renal policística em felinos com abordagem terapêutica em acupuntura veterinária : revisão bibliográfica
2012Co-Authors: Ricardo Miyasaka De ,almeidaAbstract:A doença renal policística (DRP) autossômica dominante, importante desordem hereditária que acomete principalmente gatos da raça Persa e raças aparentadas, é caracterizada pela substituição do parênquima renal por múltiplos cistos. Ela possui alta prevalência e é de natureza progressiva, decorrendo em insuficiência renal crônica irreversível com o passar dos anos. Considerando que a DRP ainda não possui tratamento específico que impeça o seu curso clínico, é essencial para a eliminação da doença na população felina a realização de programas de triagem dos animais portadores para que estes possam ser retirados da reprodução. Uma vez que a incidência de gatos com insuficiência renal crônica decorrente da DRP ainda é alta para animais portadores e na rotina clínica, é ideal que sejam estudadas alternativas terapêuticas preventivas do progresso da doença, pois mesmo havendo relatos do tratamento por instilação percutânea de agentes esclerosantes dos cistos para controle do seu crescimento e dos sintomas decorrentes, ainda há poucos estudos nesse sentido. Por isso, com a ascensão de novas especialidades, como a Acupuntura Veterinária, diversas possibilidades complementares e menos invasivas de manutenção desses pacientes podem ser exploradas. _________________________________________________________________________________ ABSTRACTAutosomal dominant polycystic kidney disease (PKD), a significant inherited disease that primarily affects Persians and related Cat Breeds, is characterized by the replacement of renal parenchyma by multiple cysts. PKD has high prevalence and a progressive nature, thus resulting in irreversible chronic renal failure over the years. Having regard that the PKD does not have specific treatment to prevent the clinical course, it is essential for the elimination of the disease in feline population to implement screening programs so that PDK-positives Cats can be diagnosed by ultrasound, to be removed from breeding. Since the incidence of Cats with chronic renal failure caused by PKD is still high, it is ideal to consider alternative therapies in order to prevent the disease progression. Even though there are reports of treatment by percutaneous instillation of sclerosing agents for the control of cysts growth and resulting symptoms, there are few studies in this direction. Therefore, with the rise of new specialties, such as Veterinary Acupuncture, several less invasive and complementary, possibilities may be explored to improve the maintenance of these patients
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Doença renal policística em felinos com abordagem terapêutica em acupuntura veterinária : revisão bibliográfica
2011Co-Authors: Ricardo Miyasaka De ,almeidaAbstract:Monografia (graduação)—Universidade de Brasília, Faculdade de Agronomia e Medicina Veterinária, 2011.A doença renal policística (DRP) autossômica dominante, importante desordem hereditária que acomete principalmente gatos da raça Persa e raças aparentadas, é caracterizada pela substituição do parênquima renal por múltiplos cistos. Ela possui alta prevalência e é de natureza progressiva, decorrendo em insuficiência renal crônica irreversível com o passar dos anos. Considerando que a DRP ainda não possui tratamento específico que impeça o seu curso clínico, é essencial para a eliminação da doença na população felina a realização de programas de triagem dos animais portadores para que estes possam ser retirados da reprodução. Uma vez que a incidência de gatos com insuficiência renal crônica decorrente da DRP ainda é alta para animais portadores e na rotina clínica, é ideal que sejam estudadas alternativas terapêuticas preventivas do progresso da doença, pois mesmo havendo relatos do tratamento por instilação percutânea de agentes esclerosantes dos cistos para controle do seu crescimento e dos sintomas decorrentes, ainda há poucos estudos nesse sentido. Por isso, com a ascensão de novas especialidades, como a Acupuntura Veterinária, diversas possibilidades complementares e menos invasivas de manutenção desses pacientes podem ser exploradas. _________________________________________________________________________________ ABSTRACTAutosomal dominant polycystic kidney disease (PKD), a significant inherited disease that primarily affects Persians and related Cat Breeds, is characterized by the replacement of renal parenchyma by multiple cysts. PKD has high prevalence and a progressive nature, thus resulting in irreversible chronic renal failure over the years. Having regard that the PKD does not have specific treatment to prevent the clinical course, it is essential for the elimination of the disease in feline population to implement screening programs so that PDK-positives Cats can be diagnosed by ultrasound, to be removed from breeding. Since the incidence of Cats with chronic renal failure caused by PKD is still high, it is ideal to consider alternative therapies in order to prevent the disease progression. Even though there are reports of treatment by percutaneous instillation of sclerosing agents for the control of cysts growth and resulting symptoms, there are few studies in this direction. Therefore, with the rise of new specialties, such as Veterinary Acupuncture, several less invasive and complementary, possibilities may be explored to improve the maintenance of these patients