Microsatellite

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The Experts below are selected from a list of 228432 Experts worldwide ranked by ideXlab platform

Pedro E. Cruz - One of the best experts on this subject based on the ideXlab platform.

G Mendozacarrion - One of the best experts on this subject based on the ideXlab platform.

G. Mendoza‐carrión - One of the best experts on this subject based on the ideXlab platform.

Ana M. Ibarra - One of the best experts on this subject based on the ideXlab platform.

Christian Schlötterer - One of the best experts on this subject based on the ideXlab platform.

  • Survey of Microsatellite clustering in eight fully sequenced species sheds light on the origin of compound Microsatellites
    BMC Genomics, 2008
    Co-Authors: Robert Kofler, Christian Schlötterer, Evita Luschützky, Tamas Lelley
    Abstract:

    Background Compound Microsatellites are a special variation of Microsatellites in which two or more individual Microsatellites are found directly adjacent to each other. Until now, such composite Microsatellites have not been investigated in a comprehensive manner. Results Our in silico survey of Microsatellite clustering in genomes of Homo sapiens , Maccaca mulatta , Mus musculus , Rattus norvegicus , Ornithorhynchus anatinus , Gallus gallus , Danio rerio and Drosophila melanogaster revealed an unexpected high abundance of compound Microsatellites. About 4 – 25% of all Microsatellites could be categorized as compound Microsatellites. Compound Microsatellites are approximately 15 times more frequent than expected under the assumption of a random distribution of Microsatellites. Interestingly, Microsatellites do not only tend to cluster but the adjacent repeat types of compound Microsatellites have very similar motifs: in most cases (>90%) these motifs differ only by a single mutation (base substitution or indel). We propose that the majority of the compound Microsatellites originates by duplication of imperfections in a Microsatellite tract. This process occurs mostly at the end of a Microsatellite, leading to a new repeat type and a potential Microsatellite repeat track. Conclusion Our findings suggest a more dynamic picture of Microsatellite evolution than previously believed. Imperfections within Microsatellites might not only cause the "death" of Microsatellites they might also result in their "birth".

  • Drosophila virilis Has Long and Highly Polymorphic Microsatellites
    Molecular biology and evolution, 2000
    Co-Authors: Christian Schlötterer, Bettina Harr
    Abstract:

    Comparative genomics is a powerful approach to inference of the dynamics of genome evolution. Most information about the evolution of Microsatellites in the genus Drosophila has been obtained from Drosophila melanogaster. For comparison, we collected Microsatellite data for the distantly related species Drosophila virilis. Screening about 0.5 Mb of nonredundant genomic sequence from GenBank, we identified 239 dinucleotide Microsatellites. On average, D. virilis dinucleotides were significantly longer than D. melanogaster Microsatellites (7.69 repeats vs. 6.75 repeats). Similarly, direct cloning of Microsatellites resulted in a higher mean repeat number in D. virilis than in D. melanogaster (12.7 repeats vs. 12.2 repeats). Characterization of 11 Microsatellite loci mapping to division 40-49 on the fourth chromosome of D. virilis indicated that D. virilis Microsatellites are more variable than those of D. melanogaster.

  • Evolutionary dynamics of Microsatellite DNA
    Chromosoma, 2000
    Co-Authors: Christian Schlötterer
    Abstract:

    Within the past decade Microsatellites have developed into one of the most popular genetic markers. Despite the widespread use of Microsatellite analysis, an integral picture of the mutational dynamics of Microsatellite DNA is just beginning to emerge. Here, I review both generally agreed and controversial results about the mutational dynamics of Microsatellite DNA.

  • Microsatellites: Evolution and Applications
    1999
    Co-Authors: David B. Goldstein, Christian Schlötterer
    Abstract:

    1: Hancock: Microsatellites and other simple sequences 2: Kashi and Soller: Functional roles of Microsatellites and minisatellites 3: Armour et al: Microsatellites and mutation processes in tandemly repetitive DNA 4: Eisen: Mechanistic basis for Microsatellite instability 5: Estoup and Cornuet: Microsatellite evolution: inferences from population data 6: Amos: A comparative approach to the study of Microsatellite evolution 7: Rubinsztein: Trinucleotide expansion mutations cause diseases which do not conform to Mendelian expectations 8: Feldman: Mutation and migration in models of Microsatellite evolution 9: Donnelly: The coalescent and Microsatellite variability 10: Reich and Goldstein: Estimating the age of mutations using variation of linked markers 11: Chakraborty and Kimmel: Statistics of Microsatellite loci: Estimation of mutation rate and pattern of population expansion 12: Pemberton et al: Using Microsatellites to measure the fitness consequences of inbreeding and outbreeding 13: Beaumont and Bruford: Microsatellites in conservation genetics 14: Linares: Microsatellites and the reconstruction of the history of human populations 15: Balding: Forensic applications of Microsatellite markers 16: Stephens et al: Tracking linkage disequilibrium in advanced population with Microsatellite loci 17: Carrington et al: Microsatellite markers in complex disease: mapping disease - associated regions within the human MHC 18: Schlotterer and Wiehe: Microsatellites: a neutral marker to infer selective sweeps 19: Karafet et al: Y chromosome Microsatellite haplotypes and the history of Samoyed-speaking populations in N-W Siberia 20: Shibata: MS analysis of human tumours.

  • Distribution of dinucleotide Microsatellites in the Drosophila melanogaster genome.
    Molecular Biology and Evolution, 1999
    Co-Authors: Doris Bachtrog, Steven Weiss, Barbara Zangerl, Gottfried Brem, Christian Schlötterer
    Abstract:

    Microsatellites, a special class of repetitive DNA, have become one of the most popular genetic markers. The progress of various genome projects has made it possible to study the genomic distribution of Microsatellites and to evaluate the potential influence of several parameters on their genesis. We report the distribution of dinucleotide Microsatellites in the genome of Drosophila melanogaster. When considering only Microsatellites with five or more repeat units, the average length of dinucleotide repeats in D. melanogaster is 6.7 repeats. We tested a wide range of parameters which could potentially influence Microsatellite density, and we did not detect a significant influence of recombination rate, number of exons, or total length of coding sequence. In concordance with the neutral expectation for the origin of Microsatellites, a significant positive correlation between AT content and (AT/TA)n Microsatellite density was detected. While this pattern may indicate that Microsatellite genesis is a random process, we also found evidence for a nonrandom distribution of Microsatellites. Average Microsatellite density was higher on the X chromosome, but extreme heterogeneity was observed between different genomic regions. Such a clumping of Microsatellites was also evident on a more local scale, as 38.9% of the contiguous sequences analyzed showed a deviation from a random distribution of Microsatellites.