The Experts below are selected from a list of 1768401 Experts worldwide ranked by ideXlab platform
Rein Willemze - One of the best experts on this subject based on the ideXlab platform.
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primary cutaneous cd8 positive epidermotropic cytotoxic t cell lymphomas a distinct clinicopathological entity with an aggressive clinical behavior
American Journal of Pathology, 1999Co-Authors: E Berti, Dario Tomasini, Maarten H Vermeer, Chris J L M Meijer, E Alessi, Rein WillemzeAbstract:Cutaneous T cell lymphomas (CTCL) generally have the phenotype of CD3+, CD4+, CD45RO+ memory T cells. CTCL expressing a CD8+ T cell phenotype are extremely rare and ill-defined. To elucidate whether these CD8+ CTCL represent a distinct disease entity, the clinical, histological, and immunophenotypical features of 17 CD8+ CTCL were reviewed. None of the 17 cases expressed markers characteristic of natural killer cells or γ/δ T cells. Nine of 17 cases showed the characteristic clinical and histological features as well as clinical behavior of well defined types of CTCL, such as mycosis fungoides (2 cases), pagetoid reticulosis (2 cases), lymphomatoid papulosis (2 cases), and CD30+ large T cell lymphoma (2 cases), all of which usually express a CD4+ T cell phenotype, and 1 case of subcutaneous panniculitis-like T cell lymphoma. The other 8 cases formed a homogeneous group showing a distinctive set of clinicopathological and immunophenotypical features, not consistent with that of other well defined types of CTCL. Clinical characteristics included presentation with generalized patches, plaques, papulonodules, and tumors mimicking disseminated pagetoid reticulosis; metastatic spread to unusual sites, such as the lung, testis, central nervous system, and oral cavity, but not to the lymph nodes; and an aggressive course (median survival, 32 months). Histologically, these lymphomas were characterized by band-like infiltrates consisting of pleomorphic T cells or immunoblasts, showing a diffuse infiltration of an acanthotic epidermis with variable degrees of spongiosis, intraepidermal blistering, and necrosis. The neoplastic cells showed a high Ki-67 proliferation index and expression of CD3, CD8, CD7, CD45RA, βF1, and TIA-1 markers, whereas CD2 and CD5 were frequently lost. Expression of TIA-1 pointed out that these lymphomas are derived from a cytotoxic T cell subset. The results of this and other studies reviewed herein suggest that these strongly epidermotropic primary cutaneous CD8+ cytotoxic T cell lymphomas represent a distinct type of CTCL with an aggressive clinical behavior.
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primary cutaneous cd8 positive epidermotropic cytotoxic t cell lymphomas a distinct clinicopathological entity with an aggressive clinical behavior
American Journal of Pathology, 1999Co-Authors: E Berti, Dario Tomasini, Maarten H Vermeer, Chris J L M Meijer, E Alessi, Rein WillemzeAbstract:Cutaneous T cell lymphomas (CTCL) generally have the phenotype of CD3+, CD4+, CD45RO+ memory T cells. CTCL expressing a CD8+ T cell phenotype are extremely rare and ill-defined. To elucidate whether these CD8+ CTCL represent a distinct disease entity, the clinical, histological, and immunophenotypical features of 17 CD8+ CTCL were reviewed. None of the 17 cases expressed markers characteristic of natural killer cells or γ/δ T cells. Nine of 17 cases showed the characteristic clinical and histological features as well as clinical behavior of well defined types of CTCL, such as mycosis fungoides (2 cases), pagetoid reticulosis (2 cases), lymphomatoid papulosis (2 cases), and CD30+ large T cell lymphoma (2 cases), all of which usually express a CD4+ T cell phenotype, and 1 case of subcutaneous panniculitis-like T cell lymphoma. The other 8 cases formed a homogeneous group showing a distinctive set of clinicopathological and immunophenotypical features, not consistent with that of other well defined types of CTCL. Clinical characteristics included presentation with generalized patches, plaques, papulonodules, and tumors mimicking disseminated pagetoid reticulosis; metastatic spread to unusual sites, such as the lung, testis, central nervous system, and oral cavity, but not to the lymph nodes; and an aggressive course (median survival, 32 months). Histologically, these lymphomas were characterized by band-like infiltrates consisting of pleomorphic T cells or immunoblasts, showing a diffuse infiltration of an acanthotic epidermis with variable degrees of spongiosis, intraepidermal blistering, and necrosis. The neoplastic cells showed a high Ki-67 proliferation index and expression of CD3, CD8, CD7, CD45RA, βF1, and TIA-1 markers, whereas CD2 and CD5 were frequently lost. Expression of TIA-1 pointed out that these lymphomas are derived from a cytotoxic T cell subset. The results of this and other studies reviewed herein suggest that these strongly epidermotropic primary cutaneous CD8+ cytotoxic T cell lymphomas represent a distinct type of CTCL with an aggressive clinical behavior.
Francine M Foss - One of the best experts on this subject based on the ideXlab platform.
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cd4 primary cutaneous small medium sized pleomorphic t cell lymphoma a retrospective case series and review of literature
Leukemia & Lymphoma, 2015Co-Authors: Edward Samuel James, Joseph Sokhn, Juliet Fraser Gibson, Kacie R Carlson, Antonio Subtil, Michael Girardi, Lynn D Wilson, Francine M FossAbstract:AbstractCD4 + primary cutaneous small/medium-sized pleomorphic T-cell lymphoma (CD4 + PCSM-TCL) is a rare T-cell lymphoma associated with a favorable prognosis. A retrospective study of 23 patients with CD4 + PCSM-TCL as defined by World Health Organization–European Organisation for Research and Treatment of Cancer (WHO-EORTC) and WHO classifications was conducted. Median age was 63 years. The head and neck were the most commonly affected locations, followed by the trunk. Two patients had evidence of systemic involvement at relapse. All tumors were CD3 + and CD4+. CD5 and CD7 loss occurred in 52% and 84%, respectively. The median follow-up was 33.6 months. Eleven patients had excisional biopsy only, six had localized radiotherapy and two received excision and localized radiation. Cytotoxic chemotherapy and localized radiation were used in one patient with aggressive and invasive features. All patients had a complete remission but one developed systemic involvement. Our case series demonstrates that CD4 + ...
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cd4 primary cutaneous small medium sized pleomorphic t cell lymphoma a retrospective case series and review of literature
Leukemia & Lymphoma, 2015Co-Authors: Edward Samuel James, Joseph Sokhn, Juliet Fraser Gibson, Kacie R Carlson, Antonio Subtil, Michael Girardi, Lynn D Wilson, Francine M FossAbstract:CD4 + primary cutaneous small/medium-sized pleomorphic T-cell lymphoma (CD4 + PCSM-TCL) is a rare T-cell lymphoma associated with a favorable prognosis. A retrospective study of 23 patients with CD4 + PCSM-TCL as defined by World Health Organization-European Organisation for Research and Treatment of Cancer (WHO-EORTC) and WHO classifications was conducted. Median age was 63 years. The head and neck were the most commonly affected locations, followed by the trunk. Two patients had evidence of systemic involvement at relapse. All tumors were CD3 + and CD4+. CD5 and CD7 loss occurred in 52% and 84%, respectively. The median follow-up was 33.6 months. Eleven patients had excisional biopsy only, six had localized radiotherapy and two received excision and localized radiation. Cytotoxic chemotherapy and localized radiation were used in one patient with aggressive and invasive features. All patients had a complete remission but one developed systemic involvement. Our case series demonstrates that CD4 + PCSM-TCL is an indolent T-cell lymphoma that can be treated with local modalities and raises the question of its current classification as a lymphoma.
E Berti - One of the best experts on this subject based on the ideXlab platform.
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primary cutaneous cd8 positive epidermotropic cytotoxic t cell lymphomas a distinct clinicopathological entity with an aggressive clinical behavior
American Journal of Pathology, 1999Co-Authors: E Berti, Dario Tomasini, Maarten H Vermeer, Chris J L M Meijer, E Alessi, Rein WillemzeAbstract:Cutaneous T cell lymphomas (CTCL) generally have the phenotype of CD3+, CD4+, CD45RO+ memory T cells. CTCL expressing a CD8+ T cell phenotype are extremely rare and ill-defined. To elucidate whether these CD8+ CTCL represent a distinct disease entity, the clinical, histological, and immunophenotypical features of 17 CD8+ CTCL were reviewed. None of the 17 cases expressed markers characteristic of natural killer cells or γ/δ T cells. Nine of 17 cases showed the characteristic clinical and histological features as well as clinical behavior of well defined types of CTCL, such as mycosis fungoides (2 cases), pagetoid reticulosis (2 cases), lymphomatoid papulosis (2 cases), and CD30+ large T cell lymphoma (2 cases), all of which usually express a CD4+ T cell phenotype, and 1 case of subcutaneous panniculitis-like T cell lymphoma. The other 8 cases formed a homogeneous group showing a distinctive set of clinicopathological and immunophenotypical features, not consistent with that of other well defined types of CTCL. Clinical characteristics included presentation with generalized patches, plaques, papulonodules, and tumors mimicking disseminated pagetoid reticulosis; metastatic spread to unusual sites, such as the lung, testis, central nervous system, and oral cavity, but not to the lymph nodes; and an aggressive course (median survival, 32 months). Histologically, these lymphomas were characterized by band-like infiltrates consisting of pleomorphic T cells or immunoblasts, showing a diffuse infiltration of an acanthotic epidermis with variable degrees of spongiosis, intraepidermal blistering, and necrosis. The neoplastic cells showed a high Ki-67 proliferation index and expression of CD3, CD8, CD7, CD45RA, βF1, and TIA-1 markers, whereas CD2 and CD5 were frequently lost. Expression of TIA-1 pointed out that these lymphomas are derived from a cytotoxic T cell subset. The results of this and other studies reviewed herein suggest that these strongly epidermotropic primary cutaneous CD8+ cytotoxic T cell lymphomas represent a distinct type of CTCL with an aggressive clinical behavior.
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primary cutaneous cd8 positive epidermotropic cytotoxic t cell lymphomas a distinct clinicopathological entity with an aggressive clinical behavior
American Journal of Pathology, 1999Co-Authors: E Berti, Dario Tomasini, Maarten H Vermeer, Chris J L M Meijer, E Alessi, Rein WillemzeAbstract:Cutaneous T cell lymphomas (CTCL) generally have the phenotype of CD3+, CD4+, CD45RO+ memory T cells. CTCL expressing a CD8+ T cell phenotype are extremely rare and ill-defined. To elucidate whether these CD8+ CTCL represent a distinct disease entity, the clinical, histological, and immunophenotypical features of 17 CD8+ CTCL were reviewed. None of the 17 cases expressed markers characteristic of natural killer cells or γ/δ T cells. Nine of 17 cases showed the characteristic clinical and histological features as well as clinical behavior of well defined types of CTCL, such as mycosis fungoides (2 cases), pagetoid reticulosis (2 cases), lymphomatoid papulosis (2 cases), and CD30+ large T cell lymphoma (2 cases), all of which usually express a CD4+ T cell phenotype, and 1 case of subcutaneous panniculitis-like T cell lymphoma. The other 8 cases formed a homogeneous group showing a distinctive set of clinicopathological and immunophenotypical features, not consistent with that of other well defined types of CTCL. Clinical characteristics included presentation with generalized patches, plaques, papulonodules, and tumors mimicking disseminated pagetoid reticulosis; metastatic spread to unusual sites, such as the lung, testis, central nervous system, and oral cavity, but not to the lymph nodes; and an aggressive course (median survival, 32 months). Histologically, these lymphomas were characterized by band-like infiltrates consisting of pleomorphic T cells or immunoblasts, showing a diffuse infiltration of an acanthotic epidermis with variable degrees of spongiosis, intraepidermal blistering, and necrosis. The neoplastic cells showed a high Ki-67 proliferation index and expression of CD3, CD8, CD7, CD45RA, βF1, and TIA-1 markers, whereas CD2 and CD5 were frequently lost. Expression of TIA-1 pointed out that these lymphomas are derived from a cytotoxic T cell subset. The results of this and other studies reviewed herein suggest that these strongly epidermotropic primary cutaneous CD8+ cytotoxic T cell lymphomas represent a distinct type of CTCL with an aggressive clinical behavior.
Edward Samuel James - One of the best experts on this subject based on the ideXlab platform.
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cd4 primary cutaneous small medium sized pleomorphic t cell lymphoma a retrospective case series and review of literature
Leukemia & Lymphoma, 2015Co-Authors: Edward Samuel James, Joseph Sokhn, Juliet Fraser Gibson, Kacie R Carlson, Antonio Subtil, Michael Girardi, Lynn D Wilson, Francine M FossAbstract:AbstractCD4 + primary cutaneous small/medium-sized pleomorphic T-cell lymphoma (CD4 + PCSM-TCL) is a rare T-cell lymphoma associated with a favorable prognosis. A retrospective study of 23 patients with CD4 + PCSM-TCL as defined by World Health Organization–European Organisation for Research and Treatment of Cancer (WHO-EORTC) and WHO classifications was conducted. Median age was 63 years. The head and neck were the most commonly affected locations, followed by the trunk. Two patients had evidence of systemic involvement at relapse. All tumors were CD3 + and CD4+. CD5 and CD7 loss occurred in 52% and 84%, respectively. The median follow-up was 33.6 months. Eleven patients had excisional biopsy only, six had localized radiotherapy and two received excision and localized radiation. Cytotoxic chemotherapy and localized radiation were used in one patient with aggressive and invasive features. All patients had a complete remission but one developed systemic involvement. Our case series demonstrates that CD4 + ...
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cd4 primary cutaneous small medium sized pleomorphic t cell lymphoma a retrospective case series and review of literature
Leukemia & Lymphoma, 2015Co-Authors: Edward Samuel James, Joseph Sokhn, Juliet Fraser Gibson, Kacie R Carlson, Antonio Subtil, Michael Girardi, Lynn D Wilson, Francine M FossAbstract:CD4 + primary cutaneous small/medium-sized pleomorphic T-cell lymphoma (CD4 + PCSM-TCL) is a rare T-cell lymphoma associated with a favorable prognosis. A retrospective study of 23 patients with CD4 + PCSM-TCL as defined by World Health Organization-European Organisation for Research and Treatment of Cancer (WHO-EORTC) and WHO classifications was conducted. Median age was 63 years. The head and neck were the most commonly affected locations, followed by the trunk. Two patients had evidence of systemic involvement at relapse. All tumors were CD3 + and CD4+. CD5 and CD7 loss occurred in 52% and 84%, respectively. The median follow-up was 33.6 months. Eleven patients had excisional biopsy only, six had localized radiotherapy and two received excision and localized radiation. Cytotoxic chemotherapy and localized radiation were used in one patient with aggressive and invasive features. All patients had a complete remission but one developed systemic involvement. Our case series demonstrates that CD4 + PCSM-TCL is an indolent T-cell lymphoma that can be treated with local modalities and raises the question of its current classification as a lymphoma.
Iloeje, Michael Uwaezuoke - One of the best experts on this subject based on the ideXlab platform.
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Effect of neem (Azadirachta indica) leaf meal on serum metabolite profiles of male rabbits | Efecto de la harina de hojas de neem (Azadirachta indica) en los perfiles metabólicos séricos de conejos machos
UDO Agrícola, 2018Co-Authors: Ogbuewu, Ifeanyi Princewill, Okoli, Ifeanyi Charles, Iloeje, Michael UwaezuokeAbstract:This study was undertaken to determine the effect of neem leaf meal (NLM) supplementation on metabolic of male rabbits. Male rabbits (36) with mean body weights of 2025 g were randomly allotted to four treatment groups (n = 9/group). Rabbits in CD1, CD2, CD3 and CD4 groups were fed diets containing 0% (control), 5%, 10% and 15% NLM, respectively in a completely randomized design.. The feeding trial lasted 16 weeks inclusive of a two week acclimatization period. At the end of the trial, the animals were starved for 12 hours and blood samples taken from the marginal ear vein. The serum globulin values of bucks on CD2 and CD3 groups were significantly (p
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Efecto de la harina de hojas de neem (Azadirachta indica) en los perfiles metabólicos séricos de conejos machos
Universidad de Oriente Press, 2011Co-Authors: Ogbuewu, Ifeanyi Princewill, Okoli, Ifeanyi Charles, Iloeje, Michael UwaezuokeAbstract:This study was undertaken to determine the effect of neem leaf meal (NLM) supplementation on metabolic of male rabbits. Male rabbits (36) with mean body weights of 2025 g were randomly allotted to four treatment groups (n = 9/group). Rabbits in CD1, CD2, CD3 and CD4 groups were fed diets containing 0% (control), 5%, 10% and 15% NLM, respectively in a completely randomized design.. The feeding trial lasted 16 weeks inclusive of a two week acclimatization period. At the end of the trial, the animals were starved for 12 hours and blood samples taken from the marginal ear vein. The serum globulin values of bucks on CD2 and CD3 groups were significantly (p
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Effect of neem (Azadirachta indica) leaf meal on serum metabolite profiles of male rabbits
Universidad de Oriente, 2009Co-Authors: Ogbuewu, Ifeanyi Princewill, Okoli, Ifeanyi Charles, Iloeje, Michael UwaezuokeAbstract:This study was undertaken to determine the effect of neem leaf meal (NLM) supplementation on metabolic of male rabbits. Male rabbits (36) with mean body weights of 2025 g were randomly allotted to four treatment groups (n = 9/group). Rabbits in CD1, CD2, CD3 and CD4 groups were fed diets containing 0% (control), 5%, 10% and 15% NLM, respectively in a completely randomized design.. The feeding trial lasted 16 weeks inclusive of a two week acclimatization period. At the end of the trial, the animals were starved for 12 hours and blood samples taken from the marginal ear vein. The serum globulin values of bucks on CD2 and CD3 groups were significantly (p