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Christian Joukhadar - One of the best experts on this subject based on the ideXlab platform.

  • High extracellular levels of Cefpirome in unaffected and infected lung tissue of patients
    The Journal of antimicrobial chemotherapy, 2010
    Co-Authors: Jörg Lindenmann, Sylvia A. Kugler, Veronika Matzi, Christian Porubsky, Alfred Maier, Peter Dittrich, Wolfgang Graninger, Freyja M. Smolle-jüttner, Christian Joukhadar
    Abstract:

    OBJECTIVES the objective of the present investigation was to measure the extracellular concentrations of Cefpirome in unaffected and infected lung tissue of septic patients. METHODS a single intravenous dose of 30 mg/kg total body weight of Cefpirome was administered to eight patients every 12 h prior to insertion of microdialysis probes into lung tissue. RESULTS the median (minimum, maximum) peak concentration (C(max)), time to C(max) (T(max)), area under the concentration-time curve from 0 to 4 h (AUC(0-4)) and AUC(0-∞) of unbound Cefpirome for unaffected lung were 48 (32, 107) mg/L, 0.83 (0.17, 3.17) h, 117 (60, 177) mg · h/L and 182 (80, 382) mg · h/L, respectively. The corresponding values for infected lung tissue were 45 (6, 122) mg/L, 1.17 (0.83, 2.83) h, 92 (17, 253) mg · h/L and 206 (49, 379) mg · h/L, respectively. The median apparent terminal elimination half-lives (t(½z)) of Cefpirome were 2.61, 3.05 and 3.39 h for plasma, unaffected lung and infected lung, respectively. The median ratios of the AUC(0)(-∞) for lung to the AUC(0)(-∞) for plasma were 0.63 (0.19, 1.55) and 0.46 (0.32, 0.98) for unaffected and infected lung, respectively. CONCLUSIONS we provide strong evidence that Cefpirome penetrates effectively into the extracellular space fluid of lung tissue. Under steady-state conditions, the median concentrations of Cefpirome in plasma, unaffected lung and infected lung exceeded the MICs of the majority of relevant bacteria over the entire dosing interval of up to 12 h after intravenous administration of a dose of 30 mg/kg total body weight.

  • pharmacokinetics and pharmacodynamics of Cefpirome in subcutaneous adipose tissue of septic patients
    Antimicrobial Agents and Chemotherapy, 2005
    Co-Authors: Robert Sauermann, Apostolos Georgopoulos, Georg Dellekarth, Claudia Marsik, Ilka Steiner, Markus Zeitlinger, Bernhard X Mayerhelm, Markus Muller, Christian Joukhadar
    Abstract:

    The objective of the present study was to evaluate whether Cefpirome, a member of the latest class of broad-spectrum cephalosporins, sufficiently penetrates subcutaneous adipose tissue in septic patients. After the administration of the drug at 2 g, tissue Cefpirome concentrations in septic patients (n = 11) and healthy controls (n = 7) were determined over a period of 4 h by means of microdialysis. To assess the antibacterial effect of Cefpirome at the target site, the measured pharmacokinetic profiles were simulated in vitro with select strains of Staphylococcus aureus and Pseudomonas aeruginosa. The tissue penetration of Cefpirome was significantly impaired in septic patients compared with that in healthy subjects. For subcutaneous adipose tissue, the area under the concentration-versus-time curve values from 0 to 240 min were 13.11 +/- 5.20 g . min/liter in healthy subjects and 6.90 +/- 2.56 g . min/liter in septic patients (P MIC) in tissue were greater than 60% for pathogens for which the MIC was Cefpirome is an appropriate agent for the treatment of soft tissue infections in septic patients. However, due to the high interindividual variability of the pharmacokinetics of Cefpirome in tissue, dosing intervals of not more than 8 h should be preferred to ensure that susceptible bacterial strains are killed in each patient.

  • Pharmacokinetics and Pharmacodynamics of Cefpirome in Subcutaneous Adipose Tissue of Septic Patients
    Antimicrobial agents and chemotherapy, 2005
    Co-Authors: Robert Sauermann, Apostolos Georgopoulos, Claudia Marsik, Ilka Steiner, Markus Zeitlinger, Markus Muller, Georg Delle-karth, Bernhard X. Mayer-helm, Christian Joukhadar
    Abstract:

    The objective of the present study was to evaluate whether Cefpirome, a member of the latest class of broad-spectrum cephalosporins, sufficiently penetrates subcutaneous adipose tissue in septic patients. After the administration of the drug at 2 g, tissue Cefpirome concentrations in septic patients (n = 11) and healthy controls (n = 7) were determined over a period of 4 h by means of microdialysis. To assess the antibacterial effect of Cefpirome at the target site, the measured pharmacokinetic profiles were simulated in vitro with select strains of Staphylococcus aureus and Pseudomonas aeruginosa. The tissue penetration of Cefpirome was significantly impaired in septic patients compared with that in healthy subjects. For subcutaneous adipose tissue, the area under the concentration-versus-time curve values from 0 to 240 min were 13.11 +/- 5.20 g . min/liter in healthy subjects and 6.90 +/- 2.56 g . min/liter in septic patients (P MIC) in tissue were greater than 60% for pathogens for which the MIC was

Elmar Dr Schrinner - One of the best experts on this subject based on the ideXlab platform.

  • The in-vitro antibacterial activity of a combination of Cefpirome or cefoperazone with vancomycin against enterococci and Staphylococcus aureus
    Journal of Antimicrobial Chemotherapy, 1992
    Co-Authors: G. Seibert, Dieter Isert, N. Klesel, M. Limbert, Astrid Markus, Elmar Dr Schrinner
    Abstract:

    Cefpirome, cefoperazone and ceftazidime were tested for their in-vitro activity against Enterococcus faecalis and methicillin-resistant Staphylococcus aureus (MRSA) isolates. Cefpirome was the most active cephalosporin followed by cefoperazone. Ceftazidime had only very limited activity against these strains. In experiments with Cefpirome/vancomycin and cefoperazone/vancomycin combinations, synergy was detected against most MRSA strains and some enterococci. Antagonism did not occur.

  • Pharmacokinetics of Cefpirome administered intravenously or intramuscularly to rats and dogs
    Journal of Antimicrobial Chemotherapy, 1992
    Co-Authors: Dieter Isert, G. Seibert, N. Klesel, M. Limbert, Astrid Markus, Elmar Dr Schrinner
    Abstract:

    The pharmacokinetic profile of Cefpirome was evaluated in rats and dogs after a single intravenous or intramuscular dose. A two-compartment open model was used for the calculation of the pharmacokinetic parameters for both routes of administration. The elimination half-lives after intravenous and intramuscular administration of 20 mg/kg Cefpirome did not differ significantly and ranged from 0.4 h in rats to 1.1 h in dogs. Cefpirome was mainly excreted via the kidneys. After iv or im dosing of the compound, between 80% (dogs) and 90% (rats) was recovered in urine within 24 h. The bioavailability of Cefpirome in rats and dogs after both routes of administration was almost identical when calculated either by the AUC or the urinary recovery rates.

Hs Sandhu - One of the best experts on this subject based on the ideXlab platform.

  • Pharmacokinetics and Urinary Excretion of Cefpirome Following Single Intravenous Administration in Cross Bred Calves
    The Philippine Journal of Veterinary Medicine, 2015
    Co-Authors: Neetu Rajput, Vinod K. Dumka, Hs Sandhu
    Abstract:

    Pharmacokinetics and urinary excretion of Cefpirome (10 mg/kg, iv) were performed in five male cross-bred calves (Holstein Friesian X Sahiwal). Cefpirome was detected in plasma up to 14 h and rapidly distributed from blood to peripheral compartment as evidenced by high values of α and K12. Vdarea of 0.55 ± 0.02 l/kg revealed moderate drug distribution. Short elimination half-life and high body clearance indicated rapid elimination of the drug, while 62.6 % of administered dose of Cefpirome was eliminated in urine within 24 h. The study suggests that a dose of 10 mg/kg, iv at 12 h interval would be effective against bacterial pathogens with MIC values ≤1.0 μg/ml. Key words: Cefpirome, calves, pharmacokinetics, urinary excretion

  • Disposition kinetics and in vitro plasma protein binding of Cefpirome in cattle.
    Veterinarski Arhiv, 2012
    Co-Authors: Neetu Rajput, Vinod K. Dumka, Hs Sandhu
    Abstract:

    The disposition of Cefpirome after single intramuscular (i.m.) administration (10 mg.kg -1 ) was investigated in fi ve male cross-bred calves and in vitro plasma protein binding was determined. The concentration of Cefpirome in the plasma was estimated by the microbiological assay technique. Binding of Cefpirome to plasma proteins was determined at different concentration levels by the equilibrium dialysis technique. The peak plasma level of Cefpirome after i.m. administration to cattle was attained at 45 min post-dose and the drug was detected in plasma above MIC of 0.5 μg.mL -1 for up to 10 h. The drug disposition followed a one-compartment open model. The values of t 1/2Ka, t 1/2β and AUC were 0.21 ± 0.01 h, 2.06 ± 0.02 h and 31.7 ± 0.95 μg.mL -1 .h, respectively. Cefpirome was bound to the plasma proteins to the extent of 26.0 ± 2.84 percent at the concentration range of 1-100 μg.mL -1 . The binding capacity of Cefpirome to plasma proteins and the dissociation rate constant of the protein-drug complex were 3.71 ×10-8 ± 0.31 ×10-8 mole.g-1 and 3.43 ×10-7 ± 0.46 ×10-7 mole, respectively.

  • Influence of experimentally induced fever on the disposition of Cefpirome in buffalo calves.
    Environmental toxicology and pharmacology, 2008
    Co-Authors: Neetu Rajput, Vinod K. Dumka, Hs Sandhu
    Abstract:

    Abstract The influence of Escherichia coli endotoxin-induced fever on the disposition of Cefpirome was investigated in five male buffalo calves following a single intravenous dose of 10 mg kg −1 . Blood samples were collected from 1 min to 24 h of drug administration. The drug concentration in plasma was estimated by microbiological assay using E. coli as a test organism. The disposition of Cefpirome followed two-compartment open model and the drug was detected above the minimum inhibitory concentration in plasma up to 12 h. The Vd area and AUC were 0.75 ± 0.01 L kg −1 and 35.1 ± 0.46 μg ml −1  h, respectively. The elimination half-life of 1.81 ± 0.009 h and Cl B of 0.29 ± 0.004 L kg −1  h −1 reflected rapid elimination and body clearance of Cefpirome in febrile buffalo calves. Based on the results, a satisfactory dosage regimen of Cefpirome in febrile buffalo calves was calculated to be 6 mg kg −1 to be repeated at 8 h intervals.

Neetu Rajput - One of the best experts on this subject based on the ideXlab platform.

  • Pharmacokinetics and Urinary Excretion of Cefpirome Following Single Intravenous Administration in Cross Bred Calves
    The Philippine Journal of Veterinary Medicine, 2015
    Co-Authors: Neetu Rajput, Vinod K. Dumka, Hs Sandhu
    Abstract:

    Pharmacokinetics and urinary excretion of Cefpirome (10 mg/kg, iv) were performed in five male cross-bred calves (Holstein Friesian X Sahiwal). Cefpirome was detected in plasma up to 14 h and rapidly distributed from blood to peripheral compartment as evidenced by high values of α and K12. Vdarea of 0.55 ± 0.02 l/kg revealed moderate drug distribution. Short elimination half-life and high body clearance indicated rapid elimination of the drug, while 62.6 % of administered dose of Cefpirome was eliminated in urine within 24 h. The study suggests that a dose of 10 mg/kg, iv at 12 h interval would be effective against bacterial pathogens with MIC values ≤1.0 μg/ml. Key words: Cefpirome, calves, pharmacokinetics, urinary excretion

  • Disposition kinetics and in vitro plasma protein binding of Cefpirome in cattle
    2013
    Co-Authors: Neetu Rajput, Vinod K. Dumka, Harpal S. S
    Abstract:

    The disposition of Cefpirome after single intramuscular (i.m.) administration (10 mg.kg-1) was investigated in five male cross-bred calves and in vitro plasma protein binding was determined. The concentration of Cefpirome in the plasma was estimated by the microbiological assay technique. Binding of Cefpirome to plasma proteins was determined at different concentration levels by the equilibrium dialysis technique. The peak plasma level of Cefpirome after i.m. administration to cattle was attained at 45 min post-dose and the drug was detected in plasma above MIC of 0.5 μg.mL-1 for up to 10 h. The drug disposition followed a one-compartment open model. The values of t t and AUC were 0.21 ± 0.01 h, 2.06 ± 0.02 h and 31.7 ± 0.95 μg.mL 1/2Ka, 1/2β-1.h, respectively. Cefpirome was bound to the plasma proteins to the extent of 26.0 ± 2.84 percent at the concentration range of 1-100 μg.mL-1. The binding capacity of Cefpirome to plasma proteins and the dissociation rate constant of the protein-drug complex were 3.71 ×10-8 ± 0.31 ×10-8 mole.g-1 and 3.43 ×10-7 ± 0.46 ×10-7 mole, respectively. Key words: calves, Cefpirome, disposition, protein bindin

  • Disposition kinetics and in vitro plasma protein binding of Cefpirome in cattle.
    Veterinarski Arhiv, 2012
    Co-Authors: Neetu Rajput, Vinod K. Dumka, Hs Sandhu
    Abstract:

    The disposition of Cefpirome after single intramuscular (i.m.) administration (10 mg.kg -1 ) was investigated in fi ve male cross-bred calves and in vitro plasma protein binding was determined. The concentration of Cefpirome in the plasma was estimated by the microbiological assay technique. Binding of Cefpirome to plasma proteins was determined at different concentration levels by the equilibrium dialysis technique. The peak plasma level of Cefpirome after i.m. administration to cattle was attained at 45 min post-dose and the drug was detected in plasma above MIC of 0.5 μg.mL -1 for up to 10 h. The drug disposition followed a one-compartment open model. The values of t 1/2Ka, t 1/2β and AUC were 0.21 ± 0.01 h, 2.06 ± 0.02 h and 31.7 ± 0.95 μg.mL -1 .h, respectively. Cefpirome was bound to the plasma proteins to the extent of 26.0 ± 2.84 percent at the concentration range of 1-100 μg.mL -1 . The binding capacity of Cefpirome to plasma proteins and the dissociation rate constant of the protein-drug complex were 3.71 ×10-8 ± 0.31 ×10-8 mole.g-1 and 3.43 ×10-7 ± 0.46 ×10-7 mole, respectively.

  • Influence of experimentally induced fever on the disposition of Cefpirome in buffalo calves.
    Environmental toxicology and pharmacology, 2008
    Co-Authors: Neetu Rajput, Vinod K. Dumka, Hs Sandhu
    Abstract:

    Abstract The influence of Escherichia coli endotoxin-induced fever on the disposition of Cefpirome was investigated in five male buffalo calves following a single intravenous dose of 10 mg kg −1 . Blood samples were collected from 1 min to 24 h of drug administration. The drug concentration in plasma was estimated by microbiological assay using E. coli as a test organism. The disposition of Cefpirome followed two-compartment open model and the drug was detected above the minimum inhibitory concentration in plasma up to 12 h. The Vd area and AUC were 0.75 ± 0.01 L kg −1 and 35.1 ± 0.46 μg ml −1  h, respectively. The elimination half-life of 1.81 ± 0.009 h and Cl B of 0.29 ± 0.004 L kg −1  h −1 reflected rapid elimination and body clearance of Cefpirome in febrile buffalo calves. Based on the results, a satisfactory dosage regimen of Cefpirome in febrile buffalo calves was calculated to be 6 mg kg −1 to be repeated at 8 h intervals.

Robert Sauermann - One of the best experts on this subject based on the ideXlab platform.

  • pharmacokinetics and pharmacodynamics of Cefpirome in subcutaneous adipose tissue of septic patients
    Antimicrobial Agents and Chemotherapy, 2005
    Co-Authors: Robert Sauermann, Apostolos Georgopoulos, Georg Dellekarth, Claudia Marsik, Ilka Steiner, Markus Zeitlinger, Bernhard X Mayerhelm, Markus Muller, Christian Joukhadar
    Abstract:

    The objective of the present study was to evaluate whether Cefpirome, a member of the latest class of broad-spectrum cephalosporins, sufficiently penetrates subcutaneous adipose tissue in septic patients. After the administration of the drug at 2 g, tissue Cefpirome concentrations in septic patients (n = 11) and healthy controls (n = 7) were determined over a period of 4 h by means of microdialysis. To assess the antibacterial effect of Cefpirome at the target site, the measured pharmacokinetic profiles were simulated in vitro with select strains of Staphylococcus aureus and Pseudomonas aeruginosa. The tissue penetration of Cefpirome was significantly impaired in septic patients compared with that in healthy subjects. For subcutaneous adipose tissue, the area under the concentration-versus-time curve values from 0 to 240 min were 13.11 +/- 5.20 g . min/liter in healthy subjects and 6.90 +/- 2.56 g . min/liter in septic patients (P MIC) in tissue were greater than 60% for pathogens for which the MIC was Cefpirome is an appropriate agent for the treatment of soft tissue infections in septic patients. However, due to the high interindividual variability of the pharmacokinetics of Cefpirome in tissue, dosing intervals of not more than 8 h should be preferred to ensure that susceptible bacterial strains are killed in each patient.

  • Pharmacokinetics and Pharmacodynamics of Cefpirome in Subcutaneous Adipose Tissue of Septic Patients
    Antimicrobial agents and chemotherapy, 2005
    Co-Authors: Robert Sauermann, Apostolos Georgopoulos, Claudia Marsik, Ilka Steiner, Markus Zeitlinger, Markus Muller, Georg Delle-karth, Bernhard X. Mayer-helm, Christian Joukhadar
    Abstract:

    The objective of the present study was to evaluate whether Cefpirome, a member of the latest class of broad-spectrum cephalosporins, sufficiently penetrates subcutaneous adipose tissue in septic patients. After the administration of the drug at 2 g, tissue Cefpirome concentrations in septic patients (n = 11) and healthy controls (n = 7) were determined over a period of 4 h by means of microdialysis. To assess the antibacterial effect of Cefpirome at the target site, the measured pharmacokinetic profiles were simulated in vitro with select strains of Staphylococcus aureus and Pseudomonas aeruginosa. The tissue penetration of Cefpirome was significantly impaired in septic patients compared with that in healthy subjects. For subcutaneous adipose tissue, the area under the concentration-versus-time curve values from 0 to 240 min were 13.11 +/- 5.20 g . min/liter in healthy subjects and 6.90 +/- 2.56 g . min/liter in septic patients (P MIC) in tissue were greater than 60% for pathogens for which the MIC was