The Experts below are selected from a list of 234 Experts worldwide ranked by ideXlab platform

Mira Haegman - One of the best experts on this subject based on the ideXlab platform.

  • t Cell Antigen receptor stimulation induces malt1 paracaspase mediated cleavage of the nf κb inhibitor a20
    Nature Immunology, 2008
    Co-Authors: Beatrice Coornaert, Karen Heyninck, Jens Staal, Mathijs Baens, Tine Bekaert, Mira Haegman, Peter Marynen, Zhijian J Chen, Rudi Beyaert
    Abstract:

    T Cell Antigen receptor stimulation induces MALT1 paracaspase–mediated cleavage of the NF-κB inhibitor A20

  • t Cell Antigen receptor stimulation induces malt1 paracaspase mediated cleavage of the nf κb inhibitor a20
    Nature Immunology, 2008
    Co-Authors: Karen Heyninck, Beatrice Coornaert, Mathijs Baens, Tine Bekaert, Mira Haegman
    Abstract:

    The paracaspase MALT1 mediates T Cell Antigen receptor-induced signaling to the transcription factor NF-kappaB and is indispensable for T Cell activation and proliferation. Enhanced expression of MALT1 or aberrant expression of a fusion protein of the apoptosis inhibitor API2 and MALT1 has been linked to mucosa-associated lymphoid tissue lymphoma. Despite the presence of a caspase-like domain, MALT1 proteolytic activity has not yet been demonstrated. Here we show that T Cell Antigen receptor stimulation induced recruitment of the NF-kappaB inhibitor A20 into a complex of MALT1 and the adaptor protein Bcl-10, leading to MALT1-mediated processing of A20. API2-MALT1 expression likewise resulted in cleavage of A20. MALT1 cleaved human A20 after arginine 439 and impaired its NF-kappaB-inhibitory function. Our studies identify A20 as a substrate of MALT1 and emphasize the importance of MALT1 proteolytic activity in the 'fine tuning' of T Cell Antigen receptor signaling.

Beatrice Coornaert - One of the best experts on this subject based on the ideXlab platform.

  • t Cell Antigen receptor stimulation induces malt1 paracaspase mediated cleavage of the nf κb inhibitor a20
    Nature Immunology, 2008
    Co-Authors: Beatrice Coornaert, Karen Heyninck, Jens Staal, Mathijs Baens, Tine Bekaert, Mira Haegman, Peter Marynen, Zhijian J Chen, Rudi Beyaert
    Abstract:

    T Cell Antigen receptor stimulation induces MALT1 paracaspase–mediated cleavage of the NF-κB inhibitor A20

  • t Cell Antigen receptor stimulation induces malt1 paracaspase mediated cleavage of the nf κb inhibitor a20
    Nature Immunology, 2008
    Co-Authors: Karen Heyninck, Beatrice Coornaert, Mathijs Baens, Tine Bekaert, Mira Haegman
    Abstract:

    The paracaspase MALT1 mediates T Cell Antigen receptor-induced signaling to the transcription factor NF-kappaB and is indispensable for T Cell activation and proliferation. Enhanced expression of MALT1 or aberrant expression of a fusion protein of the apoptosis inhibitor API2 and MALT1 has been linked to mucosa-associated lymphoid tissue lymphoma. Despite the presence of a caspase-like domain, MALT1 proteolytic activity has not yet been demonstrated. Here we show that T Cell Antigen receptor stimulation induced recruitment of the NF-kappaB inhibitor A20 into a complex of MALT1 and the adaptor protein Bcl-10, leading to MALT1-mediated processing of A20. API2-MALT1 expression likewise resulted in cleavage of A20. MALT1 cleaved human A20 after arginine 439 and impaired its NF-kappaB-inhibitory function. Our studies identify A20 as a substrate of MALT1 and emphasize the importance of MALT1 proteolytic activity in the 'fine tuning' of T Cell Antigen receptor signaling.

Doreen A. Cantrell - One of the best experts on this subject based on the ideXlab platform.

  • T-Cell Antigen receptor signal transduction.
    Immunology, 2002
    Co-Authors: Doreen A. Cantrell
    Abstract:

    T-Cell activation by foreign Antigen induces Antigen specific T-Cell clonal expansion and differentiation and this response is regulated by signal transduction pathways initiated by Antigen receptors and costimulatory molecules. The stimulus that drives T-Cell activation is a foreign peptide bound to major histocompatibility complex (MHC)-encoded molecules presented on the surface of professional Antigen-presenting Cells (APC) such as dendritic Cells (DC). The T-Cell Antigen receptor (TCR) comprises α/β subunits that recognize peptide–MHC and the signal transducing subunits γ, δ, e and ζ (CD3 complex). This review will cover recent progress from biochemistry, genetics and Cell biology towards understanding the signal transduction pathways that control T-Cell activation.

  • T Cell Antigen receptor signal transduction pathways.
    Cancer surveys, 1996
    Co-Authors: Doreen A. Cantrell
    Abstract:

    The T Cell Antigen receptor regulates the activation and growth of T lymphocytes. The initial membrane proximal event triggered by the TCR is activation of protein tyrosine kinases with the resultant phosphorylation of Cellular proteins. This biochemical response couples the TCR to a divergent array of signal transduction molecules, including enzymes that regulate lipid metabolism, GTP binding proteins, serine/threonine kinases and adapter molecules. The control of cytokine gene expression is one of the mechanisms that allows the TCR to control immune responses, and this chapter discusses the role of the different TCR signal transduction pathways in linking the TCR to nuclear targets-the transcription factors that control the expression of cytokine genes.

  • T Cell Antigen RECEPTOR SIGNAL TRANSDUCTION PATHWAYS
    Annual Review of Immunology, 1996
    Co-Authors: Doreen A. Cantrell
    Abstract:

    The T Cell Antigen receptor (TCR) regulates the activation and growth of T lymphocytes. The initial membrane proximal event triggered by the TCR is activation of protein tyrosine kinases with the resultant phosphorylation of Cellular proteins. This biochemical response couples the TCR to a divergent array of signal transduction molecules including enzymes that regulate lipid metabolism, GTP binding proteins, serine/threonine kinases, and adapter molecules. The ultimate aim of studies of intraCellular signaling mechanisms is to understand the functional consequences of a particular biochemical event for receptor function. The control of cytokine gene expression is one of the mechanism that allows the TCR to control immune responses. Accordingly, one object of the present review is to discuss the role of the different TCR signal transduction pathways in linking the TCR to nuclear targets: the transcription factors that control the expression of cytokine genes.

Karen Heyninck - One of the best experts on this subject based on the ideXlab platform.

  • t Cell Antigen receptor stimulation induces malt1 paracaspase mediated cleavage of the nf κb inhibitor a20
    Nature Immunology, 2008
    Co-Authors: Beatrice Coornaert, Karen Heyninck, Jens Staal, Mathijs Baens, Tine Bekaert, Mira Haegman, Peter Marynen, Zhijian J Chen, Rudi Beyaert
    Abstract:

    T Cell Antigen receptor stimulation induces MALT1 paracaspase–mediated cleavage of the NF-κB inhibitor A20

  • t Cell Antigen receptor stimulation induces malt1 paracaspase mediated cleavage of the nf κb inhibitor a20
    Nature Immunology, 2008
    Co-Authors: Karen Heyninck, Beatrice Coornaert, Mathijs Baens, Tine Bekaert, Mira Haegman
    Abstract:

    The paracaspase MALT1 mediates T Cell Antigen receptor-induced signaling to the transcription factor NF-kappaB and is indispensable for T Cell activation and proliferation. Enhanced expression of MALT1 or aberrant expression of a fusion protein of the apoptosis inhibitor API2 and MALT1 has been linked to mucosa-associated lymphoid tissue lymphoma. Despite the presence of a caspase-like domain, MALT1 proteolytic activity has not yet been demonstrated. Here we show that T Cell Antigen receptor stimulation induced recruitment of the NF-kappaB inhibitor A20 into a complex of MALT1 and the adaptor protein Bcl-10, leading to MALT1-mediated processing of A20. API2-MALT1 expression likewise resulted in cleavage of A20. MALT1 cleaved human A20 after arginine 439 and impaired its NF-kappaB-inhibitory function. Our studies identify A20 as a substrate of MALT1 and emphasize the importance of MALT1 proteolytic activity in the 'fine tuning' of T Cell Antigen receptor signaling.

Mathijs Baens - One of the best experts on this subject based on the ideXlab platform.

  • t Cell Antigen receptor stimulation induces malt1 paracaspase mediated cleavage of the nf κb inhibitor a20
    Nature Immunology, 2008
    Co-Authors: Beatrice Coornaert, Karen Heyninck, Jens Staal, Mathijs Baens, Tine Bekaert, Mira Haegman, Peter Marynen, Zhijian J Chen, Rudi Beyaert
    Abstract:

    T Cell Antigen receptor stimulation induces MALT1 paracaspase–mediated cleavage of the NF-κB inhibitor A20

  • t Cell Antigen receptor stimulation induces malt1 paracaspase mediated cleavage of the nf κb inhibitor a20
    Nature Immunology, 2008
    Co-Authors: Karen Heyninck, Beatrice Coornaert, Mathijs Baens, Tine Bekaert, Mira Haegman
    Abstract:

    The paracaspase MALT1 mediates T Cell Antigen receptor-induced signaling to the transcription factor NF-kappaB and is indispensable for T Cell activation and proliferation. Enhanced expression of MALT1 or aberrant expression of a fusion protein of the apoptosis inhibitor API2 and MALT1 has been linked to mucosa-associated lymphoid tissue lymphoma. Despite the presence of a caspase-like domain, MALT1 proteolytic activity has not yet been demonstrated. Here we show that T Cell Antigen receptor stimulation induced recruitment of the NF-kappaB inhibitor A20 into a complex of MALT1 and the adaptor protein Bcl-10, leading to MALT1-mediated processing of A20. API2-MALT1 expression likewise resulted in cleavage of A20. MALT1 cleaved human A20 after arginine 439 and impaired its NF-kappaB-inhibitory function. Our studies identify A20 as a substrate of MALT1 and emphasize the importance of MALT1 proteolytic activity in the 'fine tuning' of T Cell Antigen receptor signaling.