The Experts below are selected from a list of 131034 Experts worldwide ranked by ideXlab platform

Michal Janitz - One of the best experts on this subject based on the ideXlab platform.

  • apoptosis screening of human chromosome 21 proteins reveals novel Cell death regulators
    Molecular Biology Reports, 2010
    Co-Authors: Michal Janitz, Hans Lehrach, Yuhui Hu
    Abstract:

    The functional analysis of chromosome 21 (Chr21) proteins is of great medical relevance. This refers, in particular, to the trisomy of human Chr21, which results in Down’s syndrome, a complex developmental and neurodegenerative disease. In a previous study we analyzed 89 human Chr21 genes for the subCellular localization of their encoded proteins using a transfected-Cell Array technique. In the present study, the results of the follow-up investigation are presented in which 52 human Chr21 genes were over-expressed in HEK Cells using the transfected-Cell Array platform, and the effect of this protein over-expression on the induction of apoptosis has been analyzed. We found that the over-expression of two Chr21 proteins (claudin-14 and -8) induced Cell death independent of the classic caspase-mediated apoptosis. Our results strongly suggest the functional involvement of claudins in the control of the Cell cycle and regulation of the Cell death induction mechanism.

  • Cell Array-based intraCellular localization screening reveals novel functional features of human chromosome 21 proteins.
    BMC genomics, 2006
    Co-Authors: Hans-jörg Warnatz, A Fiebitz, Pascal Kahlem, Dimitri Vanhecke, Marie-laure Yaspo, Sven Thamm, Hans Lehrach, F. Wagner, Michal Janitz
    Abstract:

    Trisomy of human chromosome 21 (Chr21) results in Down's syndrome, a complex developmental and neurodegenerative disease. Molecular analysis of Down's syndrome, however, poses a particular challenge, because the aneuploid region of Chr21 contains many genes of unknown function. SubCellular localization of human Chr21 proteins may contribute to further understanding of the functions and regulatory mechanisms of the genes that code for these proteins. Following this idea, we used a transfected-Cell Array technique to perform a rapid and cost-effective analysis of the intraCellular distribution of Chr 21 proteins. We chose 89 genes that were distributed over the majority of 21q, ranging from RBM11 (14.5 Mb) to MCM3AP (46.6 Mb), with part of them expressed aberrantly in the Down's syndrome mouse model. Open reading frames of these genes were cloned into a mammalian expression vector with an amino-terminal His6 tag. All of the constructs were Arrayed on glass slides and reverse transfected into HEK293T Cells for protein expression. Co-localization detection using a set of organelle markers was carried out for each Chr21 protein. Here, we report the subCellular localization properties of 52 proteins. For 34 of these proteins, their localization is described for the first time. Furthermore, the alteration in Cell morphology and growth as a result of protein over-expression for claudin-8 and claudin-14 genes has been characterized. The Cell Array-based protein expression and detection approach is a cost-effective platform for large-scale functional analyses, including protein subCellular localization and Cell phenotype screening. The results from this study reveal novel functional features of human Chr21 proteins, which should contribute to further understanding of the molecular pathology of Down's syndrome.

Taewook Kim - One of the best experts on this subject based on the ideXlab platform.

  • flexible and twistable non volatile memory Cell Array with all organic one diode one resistor architecture
    Nature Communications, 2013
    Co-Authors: David F Zeigler, Dong Su Lee, Hyejung Choi, Alex K Y Jen, Yongsung Ji, Heung Cho Ko, Taewook Kim
    Abstract:

    Flexible organic memory devices are promising candidates for data storage applications. Here, Ji et al. develop a flexible all-organic 64-bit memory Cell Array possessing one diode–one resistor architecture, which can maintain its memory characteristics even under large mechanical distortions.

  • flexible and twistable non volatile memory Cell Array with all organic one diode one resistor architecture
    Nature Communications, 2013
    Co-Authors: David F Zeigler, Dong Su Lee, Hyejung Choi, Alex K Y Jen, Taewook Kim
    Abstract:

    Flexible organic memory devices are one of the integral components for future flexible organic electronics. However, high-density all-organic memory Cell Arrays on malleable substrates without cross-talk have not been demonstrated because of difficulties in their fabrication and relatively poor performances to date. Here we demonstrate the first flexible all-organic 64-bit memory Cell Array possessing one diode-one resistor architectures. Our all-organic one diode-one resistor Cell exhibits exCellent rewritable switching characteristics, even during and after harsh physical stresses. The write-read-erase-read output sequence of the Cells perfectly correspond to the external pulse signal regardless of substrate deformation. The one diode-one resistor Cell Array is clearly addressed at the specified Cells and encoded letters based on the standard ASCII character code. Our study on integrated organic memory Cell Arrays suggests that the all-organic one diode-one resistor Cell architecture is suitable for high-density flexible organic memory applications in the future.

  • all organic photopatterned one diode one resistor Cell Array for advanced organic nonvolatile memory applications
    Advanced Materials, 2012
    Co-Authors: David F Zeigler, Taewook Kim, Orb Acton, Hinlap Yip, Alex K Y Jen
    Abstract:

    ONVM is one emerging technology that has been explored as the next generation data storage media. In literature, there are numerous reports regarding the switching mechanisms for ONVM devices, [ 15–18 ] as well as the development of new organic materials [ 15 , 18–21 ] and device architectures [ 22–27 ] for ONVM applications. Research on novel device architectures can potentially generate more reliable organic memory devices with higher density and improved performance, while simultaneously mitigating misreading (cross-talk) issues. For these reasons, organic one diode-one resistor (1D–1R) type devices have been demonstrated. [ 23,24 ] However, these devices exhibit irreversible switching behavior and are nonpatternable, which strongly limits their application in systems that require both an Array architecture and rewritable memory capability. Recently, we have reported a hybrid type 1T–1R and 1D–1R device architecture, which is composed of a hybrid ONVM device with Si-based transistors or Si schottky diodes. [ 25,26 ]

Kamal Sarabandi - One of the best experts on this subject based on the ideXlab platform.

  • flexible antenna integrated with an epitaxial lift off solar Cell Array for flapping wing robots
    IEEE Transactions on Antennas and Propagation, 2014
    Co-Authors: Kyusang Lee, Tyle W Hughes, Stephe R Forres, Kamal Sarabandi
    Abstract:

    We describe the integration of a flexible UHF antenna with an epitaxial lift-off thin-film III-V solar Cell Array used for power generation and wireless communication in a flapping-wing robotic platform. The antenna is configured to utilize the Cells and their interconnections as a part of the radiating element, leading to compact multifunctional antenna/solar Cell Array surface. The high junction capacitance of individual solar Cells allows RF current conduction through the Cells without an associated power penalty. Metallic interconnects in the solar Cell Array carry both the DC power as well as forming part of the UHF antenna. To suppress RF current leakage into the DC circuit used for conducting the solar Cell current, a RF choke is inserted between the antenna and the solar Cells in the DC path. The performance characteristics of the integrated antenna and solar Cell Array verify the predicted performance of the antenna for reliable communication. Further, mounting the thin film solar Cell Array on a 25 μm thick Kapton sheet is shown to be a robust power source when positioned on the flexible wings of flapping robotic platforms. Details about design procedure and performance of the proposed integrated antenna are discussed.

  • conformal structurally integrated antenna with a thin film solar Cell Array for flapping wing robots
    IEEE Antennas and Propagation Society International Symposium, 2013
    Co-Authors: Kyusang Lee, Stephe R Forres, Kamal Sarabandi
    Abstract:

    A conformal antenna structurally integrated with a thin-film solar Cell Array on wings of a flapping robotic platform is presented. The thin-film solar Cells operate as a part of radiating elements as well as power generators, leading to size/mass reduction of the antenna/solar Cell module. This configuration is possible because as frequency increases, impedance characteristic of a thin-film solar Cell gets closer to that of a high junction capacitance and thus the solar Cell works as a short circuit with a small phase shift at high frequencies. Impedance and radiation characteristics of the antenna under flat or bending conditions are discussed.

Liuling Wang - One of the best experts on this subject based on the ideXlab platform.

  • modeling and characteristic parameters analysis of a trough concentrating photovoltaic thermal system with gaas and super Cell Arrays
    International Journal of Photoenergy, 2012
    Co-Authors: Weidong Lin, Liuling Wang, Wenbo Wang, Xi Luo
    Abstract:

    The paper established the one-dimension steady models of a trough concentrating photovoltaic/thermal system with a super Cell Array and a GaAs Cell Array, respectively, and verified the models by experiments. The gaps between calculation results and experimental results were less than 5%. Utilizing the models, the paper analyzed the influences of the characteristic parameters on the performances of the TCPV/T system with a super Cell Array and a GaAs Cell Array, respectively. The reflectivity of the parabolic mirror in the TCPV/T system was an important factor to determine the utilizing efficiency of solar energy. The performances of the TCPV/T system can be optimized by improving the mirror reflectivity and the thermal solar radiation absorptivity of the lighting plate and pursuing a suitable focal line with uniform light intensity distribution. All these works will benefit to the utilization of the trough concentrating system and the combined heat/power supply.

  • performance investigation and optimization of the trough concentrating photovoltaic thermal system
    Solar Energy, 2011
    Co-Authors: Ming Li, Guihua Li, Xu Ji, Z. M. Yang, Liuling Wang
    Abstract:

    Abstract The overall performances of a 10 m2 Trough Concentrating Photovoltaic/Thermal (TCPV/T) system with a Super Cell Array, a GaAs Cell Array and a concentrating silicon Cell Array are investigated. The experimental results show that the average electrical efficiencies of the TCPV/T system with the three types of solar Cell Arrays are 3.63%, 8.94%, and 3.67% respectively in typical synoptic condition. The thermal efficiencies of the TCPV/T system with the three types of solar Cell Arrays are 45.17%, 41.69%, and 34.53% respectively after the TCPV/T system runs over 5 h. The TCPV/T system with the three types of Cell Arrays is also evaluated based on the electricity generation costs. From the point of the performance price ratio, the concentrating silicon Cell Array is preferable for the system with a middle or low concentration ratio. In order to improve the performance of the TCPV/T system, a 2 m2 experimental system utilizing the mirrors with a higher reflectivity is built. In concentrating irradiance, when the mirror reflectivity increases from 0.69 to 0.92, even the area of the reflecting mirrors reduce, the maximum powers of the Cell Arrays increase. The electrical efficiencies of the system using a Super Cell Array, a GaAs Cell Array and a concentrating silicon Cell Array rise by 0.9%, 2.62% and 5.47% respectively. The high reflectivity of the parabolic mirror is pursued. All these works are helpful to the further study on the trough concentrating system.

Ming Li - One of the best experts on this subject based on the ideXlab platform.

  • the performance analysis of the trough concentrating solar photovoltaic thermal system
    Energy Conversion and Management, 2011
    Co-Authors: Ming Li, Guoliang Li, Xu Ji, L Xu
    Abstract:

    Abstract The electrical and thermal performance of a 2 m 2 Trough Concentrating Photovoltaic/Thermal (TCPV/T) system with an energy flux ratio 10.27 are characterized by experiments. A single crystalline silicon solar Cell Array, a polycrystalline silicon Cell Array, a Super Cell Array and a GaAs Cell Array are respectively used in the experiments. The experimental results show that the electrical performance of the system with the GaAs Cell Array is better than that of crystal silicon solar Cell Arrays. The superior output performance of the GaAs Cell Array mainly benefits from its lower series resistance. But the thermal performances of the system using the single crystal silicon solar Cell Array and the polycrystalline silicon solar Cell Array are better. It results from the widths of the two types of Cells in the system close to that of the focal line. Another 10 m 2 TCPV/T system with an energy flux ratio of 20 using the GaAs Cell Array and a concentrating silicon Cell Array are also constructed and characterized. The experimental results indicate that the photoelectric efficiency of the GaAs Cell Array is 23.83%, and the instantaneous electrical efficiency and thermal efficiency of the system are 9.88% and 49.84% respectively. While the instantaneous electrical efficiency and thermal efficiency of the system using the low-cost concentrating silicon Cell Array are 7.51% and 42.4% respectively. The economic performance analysis show the electricity generating cost of the TCPV/T system with the concentrating silicon Cell Array can catch up with flat-plate PV system, but besides electricity generation, the TCPV/T system supplies extra heat energy to users.

  • performance investigation and optimization of the trough concentrating photovoltaic thermal system
    Solar Energy, 2011
    Co-Authors: Ming Li, Guihua Li, Xu Ji, Z. M. Yang, Liuling Wang
    Abstract:

    Abstract The overall performances of a 10 m2 Trough Concentrating Photovoltaic/Thermal (TCPV/T) system with a Super Cell Array, a GaAs Cell Array and a concentrating silicon Cell Array are investigated. The experimental results show that the average electrical efficiencies of the TCPV/T system with the three types of solar Cell Arrays are 3.63%, 8.94%, and 3.67% respectively in typical synoptic condition. The thermal efficiencies of the TCPV/T system with the three types of solar Cell Arrays are 45.17%, 41.69%, and 34.53% respectively after the TCPV/T system runs over 5 h. The TCPV/T system with the three types of Cell Arrays is also evaluated based on the electricity generation costs. From the point of the performance price ratio, the concentrating silicon Cell Array is preferable for the system with a middle or low concentration ratio. In order to improve the performance of the TCPV/T system, a 2 m2 experimental system utilizing the mirrors with a higher reflectivity is built. In concentrating irradiance, when the mirror reflectivity increases from 0.69 to 0.92, even the area of the reflecting mirrors reduce, the maximum powers of the Cell Arrays increase. The electrical efficiencies of the system using a Super Cell Array, a GaAs Cell Array and a concentrating silicon Cell Array rise by 0.9%, 2.62% and 5.47% respectively. The high reflectivity of the parabolic mirror is pursued. All these works are helpful to the further study on the trough concentrating system.