The Experts below are selected from a list of 269439 Experts worldwide ranked by ideXlab platform
Daniel Buser - One of the best experts on this subject based on the ideXlab platform.
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oc2 calcifying epithelial odontogenic tumor of the mandible with clear Cell Component treated by conservative surgery report of a case with 30 months of follow up
Oral Diseases, 2006Co-Authors: Michael M Bornstein, Yves Germanier, Edouard Stauffer, Daniel BuserAbstract:Signs and symptoms A 44-year-old Caucasian woman was referred by her dentist for evaluation and treatment of a cystic lesion in the right mandibular angle. The referring dentist identified this lesion 3 weeks earlier by way a of routine dental radiograph. Medical history and social history The patient reported a chronic swelling of the right cheek caused by a recurrent lymphangioma, which had been surgically removed four times at other institutions. A cutaneous basal Cell carcinoma located at the left side of the nose was successfully excised 7 years earlier. The patient didn't take any medication. Oral disease history Before the onset of repeated swelling and food impaction distal to the right second mandibular molar 2-months ago, the patient did not have any symptoms. On palpation there was a hard and painless induration located at the lateral border of the right angle of the mandible. A panoramic radiograph demonstrated a well-defined, multilocular radiolucency at the right mandibular angle and enclosing the crown of a deeply impacted third molar. Diagnoses Based on the clinical and radiological findings, the presumptive diagnosis was a calcifying epithelial odontogenic tumor (CEOT). The differential diagnosis included among others calcified odontogenic cyst, ameloblastic fibro-odontoma, or ossyfying fibroma. The definite, histopathologically confirmed diagnosis was calcifying epithelial odontogenic tumor with clear Cell Component (CCCEOT). Treatment The CCCEOT was treated by conservative surgery (enucleation). No recurrence was seen 30 months after treatment. This brings one more argument for a conservative surgical approach for the CEOTs/CCCEOTs of limited size.
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calcifying epithelial odontogenic pindborg tumor of the mandible with clear Cell Component treated by conservative surgery report of a case
Journal of Oral and Maxillofacial Surgery, 2005Co-Authors: Yves Germanier, Michael M Bornstein, Edouard Stauffer, Daniel BuserAbstract:The calcifying epithelial odontogenic tumor (CEOT), also known as Pindborg tumor, 1 is a benign odontogenic neoplasm that can be locally aggressive in nature and accounts for 0.4% to 3% of all odontogenic tumors. 2-5 Two topographic variants are distinguished: an intraosseous (intrabony or central) lesion
Massimo Loda - One of the best experts on this subject based on the ideXlab platform.
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distinct molecular features of colorectal carcinoma with signet ring Cell Component and colorectal carcinoma with mucinous Component
Modern Pathology, 2006Co-Authors: Shuji Ogino, Jeffrey A Meyerhardt, Mohan Brahmandam, Mami Cantor, Chungdak Namgyal, Takako Kawasaki, Gregory J Kirkner, Massimo LodaAbstract:Signet ring Cell carcinoma and mucinous carcinoma are distinct subtypes of colorectal adenocarcinoma. The morphologic and molecular spectra of colorectal carcinomas with various signet ring Cell Components and colorectal carcinomas with various mucinous Components, compared to non-mucinous adenocarcinomas, have not been examined. The study groups consisted of 39 carcinomas with various signet ring Cell Components ('the signet group'), 167 carcinomas with various mucinous Components ('the mucinous group'), and 457 nonmucinous adenocarcinoma. We visually estimated the amounts of signet ring Cell and mucinous Components in tumors, and subclassified the signet and mucinous groups according to the amount of each Component ( or = 50%). We sequenced BRAF and KRAS, analyzed for microsatellite instability (MSI) and 18q loss of heterozygosity (LOH), and performed immunohistochemistry for TP53, cyclooxygenase-2 (COX2), MLH1, O-6-methylguanine DNA methyltransferase (MGMT), p16 (CDKN2A), and fatty acid synthase (FASN). Signet ring Cell carcinoma (> or = 50% signet ring Cell tumors) and or = 50% mucinous tumors and or = 50% signet ring Cell or mucinous carcinoma, respectively. Signet ring Cell carcinoma and mucinous carcinoma are related subtypes of colorectal adenocarcinoma, but have molecular features distinct from each other.
Benedict Yan - One of the best experts on this subject based on the ideXlab platform.
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biphasic low grade nasopharyngeal papillary adenocarcinoma with a prominent spindle Cell Component report of a case localized to the posterior nasal septum
Head and Neck Pathology, 2011Co-Authors: Fredrik Petersson, Brendan Pang, David Loke, Li Hao, Benedict YanAbstract:A case (female, 39 years of) of thyroid-like nasopharyngeal low-grade papillary adenocarcinoma with a significant spindle Cell Component is presented. The tumor was located on the posterior nasal septum. The spindle Cells displayed nuclear features very much similar to the epithelial Component and the two Cell types merged imperceptibly. Immunohistochemically, the neoplastic Cells (including the spindle Cell Component) were strongly and diffusely positive for TTF-1, cytokeratins (AE1-3), cytokeratin 19 and vimentin. C-kit immunohistochemistry showed diffuse mild to moderate membranous positivity with focal areas displaying moderate to strong immunoreactivity. EMA was strongly positive in the epithelial Component with membranous and cytoplasmic reactivity whereas the spindle Cell Component was weakly although diffusely positive. Carcinoembryonic antigen, calcitonin, chromogranin A, S100-protein, thyroglobulin, cdx2 and p63 were negative. The proliferative activity (Mib-1/Ki-67) was low; 3–4%. In the molecular genetic study we found no mutations at position 1799 (exon 15) in the BRAF-gene, (BRAFV600E) or in exons 9 and 11 of the KIT-gene.
Brendan Pang - One of the best experts on this subject based on the ideXlab platform.
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biphasic low grade nasopharyngeal papillary adenocarcinoma with a prominent spindle Cell Component report of a case localized to the posterior nasal septum
Head and Neck Pathology, 2011Co-Authors: Fredrik Petersson, Brendan Pang, David Loke, Li Hao, Benedict YanAbstract:A case (female, 39 years of) of thyroid-like nasopharyngeal low-grade papillary adenocarcinoma with a significant spindle Cell Component is presented. The tumor was located on the posterior nasal septum. The spindle Cells displayed nuclear features very much similar to the epithelial Component and the two Cell types merged imperceptibly. Immunohistochemically, the neoplastic Cells (including the spindle Cell Component) were strongly and diffusely positive for TTF-1, cytokeratins (AE1-3), cytokeratin 19 and vimentin. C-kit immunohistochemistry showed diffuse mild to moderate membranous positivity with focal areas displaying moderate to strong immunoreactivity. EMA was strongly positive in the epithelial Component with membranous and cytoplasmic reactivity whereas the spindle Cell Component was weakly although diffusely positive. Carcinoembryonic antigen, calcitonin, chromogranin A, S100-protein, thyroglobulin, cdx2 and p63 were negative. The proliferative activity (Mib-1/Ki-67) was low; 3–4%. In the molecular genetic study we found no mutations at position 1799 (exon 15) in the BRAF-gene, (BRAFV600E) or in exons 9 and 11 of the KIT-gene.
Jeffrey A Meyerhardt - One of the best experts on this subject based on the ideXlab platform.
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prognostic significance and molecular features of signet ring Cell and mucinous Components in colorectal carcinoma
Annals of Surgical Oncology, 2015Co-Authors: Kosuke Mima, Yasutaka Sukawa, Reiko Nishihara, Mai Yamauchi, Kentaro Inamura, Sun A Kim, Mika Yasunari, Xuehong Zhang, Jeffrey A MeyerhardtAbstract:Background Colorectal carcinoma (CRC) represents a group of histopathologically and molecularly heterogeneous diseases, which may contain signet-ring Cell Component and/or mucinous Component to a varying extent under pathology assessment. However, little is known about the prognostic significance of those Components, independent of various tumor molecular features.
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distinct molecular features of colorectal carcinoma with signet ring Cell Component and colorectal carcinoma with mucinous Component
Modern Pathology, 2006Co-Authors: Shuji Ogino, Jeffrey A Meyerhardt, Mohan Brahmandam, Mami Cantor, Chungdak Namgyal, Takako Kawasaki, Gregory J Kirkner, Massimo LodaAbstract:Signet ring Cell carcinoma and mucinous carcinoma are distinct subtypes of colorectal adenocarcinoma. The morphologic and molecular spectra of colorectal carcinomas with various signet ring Cell Components and colorectal carcinomas with various mucinous Components, compared to non-mucinous adenocarcinomas, have not been examined. The study groups consisted of 39 carcinomas with various signet ring Cell Components ('the signet group'), 167 carcinomas with various mucinous Components ('the mucinous group'), and 457 nonmucinous adenocarcinoma. We visually estimated the amounts of signet ring Cell and mucinous Components in tumors, and subclassified the signet and mucinous groups according to the amount of each Component ( or = 50%). We sequenced BRAF and KRAS, analyzed for microsatellite instability (MSI) and 18q loss of heterozygosity (LOH), and performed immunohistochemistry for TP53, cyclooxygenase-2 (COX2), MLH1, O-6-methylguanine DNA methyltransferase (MGMT), p16 (CDKN2A), and fatty acid synthase (FASN). Signet ring Cell carcinoma (> or = 50% signet ring Cell tumors) and or = 50% mucinous tumors and or = 50% signet ring Cell or mucinous carcinoma, respectively. Signet ring Cell carcinoma and mucinous carcinoma are related subtypes of colorectal adenocarcinoma, but have molecular features distinct from each other.