The Experts below are selected from a list of 327 Experts worldwide ranked by ideXlab platform
Francisco Borrego - One of the best experts on this subject based on the ideXlab platform.
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Modulating NK Cell Metabolism for cancer immunotherapy.
Seminars in hematology, 2020Co-Authors: Iñigo Terrén, Ane Orrantia, Joana Vitallé, Olatz Zenarruzabeitia, Gabirel Astarloa-pando, Francisco BorregoAbstract:Abstract Natural killer (NK) Cells are lymphocytes with potent antitumor functions and, therefore, multiple NK Cell-based cancer immunotherapies have been developed and are currently being tested. However, there is a necessity to find new means to improve these therapies, and immunoMetabolism represents an attractive target. NK Cell effector functions are intricately linked to their Metabolism, and modulating the latter could be the key to release their full potential. In this review, we have summarized how NK Cell Metabolism is regulated during some processes, such as maturation, viral infection, and cytokine stimulation. Additionally, we provide an overview of how NK Cell Metabolism is affected by current therapeutic approaches aimed to promote NK Cell expansion and/or to increase their effector functions. We have also recapitulated several strategies that could help alleviating the metabolic impairment that characterizes tumor-infiltrating NK Cells, and thus increase or restore their effector functions. Furthermore, we have reviewed several therapeutic approaches targeting cancer Metabolism that could synergize with NK Cell-based cancer immunotherapies, and thus enhance their efficacy.
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NK Cell Metabolism and Tumor Microenvironment.
Frontiers in immunology, 2019Co-Authors: Iñigo Terrén, Ane Orrantia, Joana Vitallé, Olatz Zenarruzabeitia, Francisco BorregoAbstract:Natural Killer (NK) Cells are characterized by their potential to kill tumor Cells by different means without previous sensitization and have, therefore, become a valuable tool in cancer immunotherapy. However, their efficacy against solid tumors is still poor and further studies are required to improve it. One of the major restrictions for NK Cell activity is the immunosuppressive tumor microenvironment (TME). There, tumor and other immune Cells create the appropriate conditions for tumor proliferation while, among others, preventing NK Cell activation. Furthermore, NK Cell Metabolism is impaired in the TME, presumably due to nutrient and oxygen deprivation, and the higher concentration of tumor-derived metabolic end products, such as lactate. This metabolic restriction of NK Cells limits their effector functions, and it could represent a potential target to focus on to improve the efficacy of NK Cell-based therapies against solid tumors. In this review, we discuss the potential effect of TME into NK Cell Metabolism and its influence in NK Cell effector functions.
Stephen R. Mattarollo - One of the best experts on this subject based on the ideXlab platform.
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Natural killer Cell Metabolism
Molecular immunology, 2017Co-Authors: Takumi Kobayashi, Stephen R. MattarolloAbstract:Natural killer (NK) Cells are a critical component in the innate immune response against disease. NK Cell function is tightly regulated by specific cytokine and activation/inhibitory receptor signalling, leading to diverse effector responses. Like all living Cells, energy Metabolism is a fundamental requirement for NK Cell activation and survival. There is growing evidence that distinct functional profiles of NK Cells are determined by alterations to Cellular metabolic pathways. In this review, we summarise current literature that has explored NK Cell Metabolism to provide insight into how metabolic regulation controls NK Cell function. We focus on Metabolism pathways induced by different NK Cell stimuli, metabolic regulatory proteins, and nutrient and hormonal levels in health and disease which impact on NK Cell metabolic and functional activity.
Iñigo Terrén - One of the best experts on this subject based on the ideXlab platform.
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Modulating NK Cell Metabolism for cancer immunotherapy.
Seminars in hematology, 2020Co-Authors: Iñigo Terrén, Ane Orrantia, Joana Vitallé, Olatz Zenarruzabeitia, Gabirel Astarloa-pando, Francisco BorregoAbstract:Abstract Natural killer (NK) Cells are lymphocytes with potent antitumor functions and, therefore, multiple NK Cell-based cancer immunotherapies have been developed and are currently being tested. However, there is a necessity to find new means to improve these therapies, and immunoMetabolism represents an attractive target. NK Cell effector functions are intricately linked to their Metabolism, and modulating the latter could be the key to release their full potential. In this review, we have summarized how NK Cell Metabolism is regulated during some processes, such as maturation, viral infection, and cytokine stimulation. Additionally, we provide an overview of how NK Cell Metabolism is affected by current therapeutic approaches aimed to promote NK Cell expansion and/or to increase their effector functions. We have also recapitulated several strategies that could help alleviating the metabolic impairment that characterizes tumor-infiltrating NK Cells, and thus increase or restore their effector functions. Furthermore, we have reviewed several therapeutic approaches targeting cancer Metabolism that could synergize with NK Cell-based cancer immunotherapies, and thus enhance their efficacy.
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NK Cell Metabolism and Tumor Microenvironment.
Frontiers in immunology, 2019Co-Authors: Iñigo Terrén, Ane Orrantia, Joana Vitallé, Olatz Zenarruzabeitia, Francisco BorregoAbstract:Natural Killer (NK) Cells are characterized by their potential to kill tumor Cells by different means without previous sensitization and have, therefore, become a valuable tool in cancer immunotherapy. However, their efficacy against solid tumors is still poor and further studies are required to improve it. One of the major restrictions for NK Cell activity is the immunosuppressive tumor microenvironment (TME). There, tumor and other immune Cells create the appropriate conditions for tumor proliferation while, among others, preventing NK Cell activation. Furthermore, NK Cell Metabolism is impaired in the TME, presumably due to nutrient and oxygen deprivation, and the higher concentration of tumor-derived metabolic end products, such as lactate. This metabolic restriction of NK Cells limits their effector functions, and it could represent a potential target to focus on to improve the efficacy of NK Cell-based therapies against solid tumors. In this review, we discuss the potential effect of TME into NK Cell Metabolism and its influence in NK Cell effector functions.
Ane Orrantia - One of the best experts on this subject based on the ideXlab platform.
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Modulating NK Cell Metabolism for cancer immunotherapy.
Seminars in hematology, 2020Co-Authors: Iñigo Terrén, Ane Orrantia, Joana Vitallé, Olatz Zenarruzabeitia, Gabirel Astarloa-pando, Francisco BorregoAbstract:Abstract Natural killer (NK) Cells are lymphocytes with potent antitumor functions and, therefore, multiple NK Cell-based cancer immunotherapies have been developed and are currently being tested. However, there is a necessity to find new means to improve these therapies, and immunoMetabolism represents an attractive target. NK Cell effector functions are intricately linked to their Metabolism, and modulating the latter could be the key to release their full potential. In this review, we have summarized how NK Cell Metabolism is regulated during some processes, such as maturation, viral infection, and cytokine stimulation. Additionally, we provide an overview of how NK Cell Metabolism is affected by current therapeutic approaches aimed to promote NK Cell expansion and/or to increase their effector functions. We have also recapitulated several strategies that could help alleviating the metabolic impairment that characterizes tumor-infiltrating NK Cells, and thus increase or restore their effector functions. Furthermore, we have reviewed several therapeutic approaches targeting cancer Metabolism that could synergize with NK Cell-based cancer immunotherapies, and thus enhance their efficacy.
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NK Cell Metabolism and Tumor Microenvironment.
Frontiers in immunology, 2019Co-Authors: Iñigo Terrén, Ane Orrantia, Joana Vitallé, Olatz Zenarruzabeitia, Francisco BorregoAbstract:Natural Killer (NK) Cells are characterized by their potential to kill tumor Cells by different means without previous sensitization and have, therefore, become a valuable tool in cancer immunotherapy. However, their efficacy against solid tumors is still poor and further studies are required to improve it. One of the major restrictions for NK Cell activity is the immunosuppressive tumor microenvironment (TME). There, tumor and other immune Cells create the appropriate conditions for tumor proliferation while, among others, preventing NK Cell activation. Furthermore, NK Cell Metabolism is impaired in the TME, presumably due to nutrient and oxygen deprivation, and the higher concentration of tumor-derived metabolic end products, such as lactate. This metabolic restriction of NK Cells limits their effector functions, and it could represent a potential target to focus on to improve the efficacy of NK Cell-based therapies against solid tumors. In this review, we discuss the potential effect of TME into NK Cell Metabolism and its influence in NK Cell effector functions.
Joana Vitallé - One of the best experts on this subject based on the ideXlab platform.
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Modulating NK Cell Metabolism for cancer immunotherapy.
Seminars in hematology, 2020Co-Authors: Iñigo Terrén, Ane Orrantia, Joana Vitallé, Olatz Zenarruzabeitia, Gabirel Astarloa-pando, Francisco BorregoAbstract:Abstract Natural killer (NK) Cells are lymphocytes with potent antitumor functions and, therefore, multiple NK Cell-based cancer immunotherapies have been developed and are currently being tested. However, there is a necessity to find new means to improve these therapies, and immunoMetabolism represents an attractive target. NK Cell effector functions are intricately linked to their Metabolism, and modulating the latter could be the key to release their full potential. In this review, we have summarized how NK Cell Metabolism is regulated during some processes, such as maturation, viral infection, and cytokine stimulation. Additionally, we provide an overview of how NK Cell Metabolism is affected by current therapeutic approaches aimed to promote NK Cell expansion and/or to increase their effector functions. We have also recapitulated several strategies that could help alleviating the metabolic impairment that characterizes tumor-infiltrating NK Cells, and thus increase or restore their effector functions. Furthermore, we have reviewed several therapeutic approaches targeting cancer Metabolism that could synergize with NK Cell-based cancer immunotherapies, and thus enhance their efficacy.
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NK Cell Metabolism and Tumor Microenvironment.
Frontiers in immunology, 2019Co-Authors: Iñigo Terrén, Ane Orrantia, Joana Vitallé, Olatz Zenarruzabeitia, Francisco BorregoAbstract:Natural Killer (NK) Cells are characterized by their potential to kill tumor Cells by different means without previous sensitization and have, therefore, become a valuable tool in cancer immunotherapy. However, their efficacy against solid tumors is still poor and further studies are required to improve it. One of the major restrictions for NK Cell activity is the immunosuppressive tumor microenvironment (TME). There, tumor and other immune Cells create the appropriate conditions for tumor proliferation while, among others, preventing NK Cell activation. Furthermore, NK Cell Metabolism is impaired in the TME, presumably due to nutrient and oxygen deprivation, and the higher concentration of tumor-derived metabolic end products, such as lactate. This metabolic restriction of NK Cells limits their effector functions, and it could represent a potential target to focus on to improve the efficacy of NK Cell-based therapies against solid tumors. In this review, we discuss the potential effect of TME into NK Cell Metabolism and its influence in NK Cell effector functions.