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Candice Delcourt - One of the best experts on this subject based on the ideXlab platform.

  • degree and timing of intensive blood pressure lowering on hematoma growth in intraCerebral Hemorrhage intensive blood pressure reduction in acute Cerebral Hemorrhage trial 2 results
    Stroke, 2016
    Co-Authors: Xia Wang, Candice Delcourt, Christian Stapf, Cheryl Carcel, Shoichiro Sato, Else Charlotte Sandset
    Abstract:

    Background and Purpose— Degree and timing of blood pressure (BP) lowering treatment in relation to hematoma growth were investigated in the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial-2 (INTERACT2). Methods— INTERACT2 was an international clinical trial of intensive (target systolic BP [SBP], Results— Greater SBP reduction was associated with reduced hematoma growth (13.3, 5.0, and 3.0 mL for P trend 6 hours (5.4 mL). The smallest mean absolute hematoma growth (2.0 mL) was in those achieving target SBP 5 to 8 times versus 3 to 4 (3.1 mL) and 0 to 2 times (5.2 mL). Conclusions— Intensive BP lowering with greater SBP reduction, which is achieved quickly and maintained consistently, seems to provide protection against hematoma growth for 24 hours. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00716079.

  • prognostic significance of perihematomal edema in acute intraCerebral Hemorrhage pooled analysis from the intensive blood pressure reduction in acute Cerebral Hemorrhage trial studies
    Stroke, 2015
    Co-Authors: Hisatomi Arima, Emma Heeley, Candice Delcourt, Jie Yang
    Abstract:

    Background and Purpose—Controversy exists over the prognostic significance of perihematomal edema (PHE) in intraCerebral Hemorrhage. We aimed to determine the association of early PHE and clinical outcome among participants of the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT) studies. Methods—Pooled analyses of computed tomographic substudies in the pilot phase (INTERACT1) and main phase (INTERACT2), both international, prospective, open, blinded end point, randomized controlled trials, of patients with spontaneous intraCerebral Hemorrhage (<6 hours) and elevated systolic blood pressure, randomly assigned to intensive (target systolic blood pressure, <140 mm Hg) or guideline-based (systolic blood pressure, <180 mm Hg) blood-pressure management. Substudy participants (n=1310; 346 INTERACT1, 964 INTERACT2) had blinded central analyses of digital images from standardized baseline and 24-hour computed tomography. Predictors of death or dependency (modified Rankin scale score...

  • significance of intraventricular Hemorrhage in acute intraCerebral Hemorrhage intensive blood pressure reduction in acute Cerebral Hemorrhage trial results
    Stroke, 2015
    Co-Authors: Edward D Chan, Hisatomi Arima, Xia Wang, Emma Heeley, Craig S Anderson, Anubhav Saxena, Tom J Moullaali, Candice Delcourt
    Abstract:

    Background and Purpose—Intraventricular Hemorrhage (IVH) with spontaneous intraCerebral Hemorrhage indicates a poor prognosis but uncertainty exists over the pattern of association. We aimed to elucidate risk associations of IVH and outcome in the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2) data set. Methods—INTERACT2 was an international prospective, open-blinded end point, randomized controlled trial in 2839 patients with intraCerebral Hemorrhage (<6 hours) with elevated systolic blood pressure randomly assigned to intensive (target systolic blood pressure <140 mm Hg) or guideline-based (systolic blood pressure <180 mm Hg) blood pressure management. Associations of baseline IVH in 740 of 2613 (28%) patients and poor outcomes (death and major disability defined on the modified Rankin Scale) at 90 days were determined in linear and logistic regression models. Results—Patients with IVH were significantly older and with greater neurological impairment, history of ischem...

Xia Wang - One of the best experts on this subject based on the ideXlab platform.

  • degree and timing of intensive blood pressure lowering on hematoma growth in intraCerebral Hemorrhage intensive blood pressure reduction in acute Cerebral Hemorrhage trial 2 results
    Stroke, 2016
    Co-Authors: Xia Wang, Candice Delcourt, Christian Stapf, Cheryl Carcel, Shoichiro Sato, Else Charlotte Sandset
    Abstract:

    Background and Purpose— Degree and timing of blood pressure (BP) lowering treatment in relation to hematoma growth were investigated in the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial-2 (INTERACT2). Methods— INTERACT2 was an international clinical trial of intensive (target systolic BP [SBP], Results— Greater SBP reduction was associated with reduced hematoma growth (13.3, 5.0, and 3.0 mL for P trend 6 hours (5.4 mL). The smallest mean absolute hematoma growth (2.0 mL) was in those achieving target SBP 5 to 8 times versus 3 to 4 (3.1 mL) and 0 to 2 times (5.2 mL). Conclusions— Intensive BP lowering with greater SBP reduction, which is achieved quickly and maintained consistently, seems to provide protection against hematoma growth for 24 hours. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00716079.

  • significance of intraventricular Hemorrhage in acute intraCerebral Hemorrhage intensive blood pressure reduction in acute Cerebral Hemorrhage trial results
    Stroke, 2015
    Co-Authors: Edward D Chan, Hisatomi Arima, Xia Wang, Emma Heeley, Craig S Anderson, Anubhav Saxena, Tom J Moullaali, Candice Delcourt
    Abstract:

    Background and Purpose—Intraventricular Hemorrhage (IVH) with spontaneous intraCerebral Hemorrhage indicates a poor prognosis but uncertainty exists over the pattern of association. We aimed to elucidate risk associations of IVH and outcome in the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2) data set. Methods—INTERACT2 was an international prospective, open-blinded end point, randomized controlled trial in 2839 patients with intraCerebral Hemorrhage (<6 hours) with elevated systolic blood pressure randomly assigned to intensive (target systolic blood pressure <140 mm Hg) or guideline-based (systolic blood pressure <180 mm Hg) blood pressure management. Associations of baseline IVH in 740 of 2613 (28%) patients and poor outcomes (death and major disability defined on the modified Rankin Scale) at 90 days were determined in linear and logistic regression models. Results—Patients with IVH were significantly older and with greater neurological impairment, history of ischem...

Hisatomi Arima - One of the best experts on this subject based on the ideXlab platform.

Emma Heeley - One of the best experts on this subject based on the ideXlab platform.

Yandan Yao - One of the best experts on this subject based on the ideXlab platform.

  • A case of Cardiobacterium valvarum endocarditis with Cerebral Hemorrhage after MVR, TVP and vegetation removal operation.
    Annals of clinical microbiology and antimicrobials, 2018
    Co-Authors: Xiaoying Xie, Nengyong Ouyang, Baiji Chen, Dongye Wang, Xiaoqiang Liu, Jiajian Guo, Yandan Yao
    Abstract:

    Cardiobacterium is a fastidious Gram-negative bacillus, and is a rare human pathogen in clinical settings. Herein, we describe a case of Cardiobacterium valvarum (C. valvarum) endocarditis with a rare complication of Cerebral Hemorrhage after mitral valve replacement (MVR), tricuspid valve prosthesis (TVP) and vegetation removal operation. A 41-year-old woman who had a history of gingivitis developed into infective endocarditis due to the infection of C. valvarum. Then, she was hospitalized to receive MVR, TVP and vegetation removal operation. The indicators of patient tended to be normal until the abrupt Cerebral Hemorrhage occurred on day 15 after operation. This is the first well-described case of C. valvarum infection in China, and the first report of C. valvarum endocarditis with Cerebral Hemorrhage after MVR, TVP and vegetation removal operation worldwide. We reported the first case of C. valvarum infection in China clinically, with a rare complication of Cerebral Hemorrhage after MVR, TVP and vegetation removal operation.

  • A case of Cardiobacterium valvarum endocarditis with Cerebral Hemorrhage after MVR, TVP and vegetation removal operation
    BMC, 2018
    Co-Authors: Xiaoying Xie, Nengyong Ouyang, Baiji Chen, Dongye Wang, Xiaoqiang Liu, Jiajian Guo, Yandan Yao
    Abstract:

    Abstract Background Cardiobacterium is a fastidious Gram-negative bacillus, and is a rare human pathogen in clinical settings. Herein, we describe a case of Cardiobacterium valvarum (C. valvarum) endocarditis with a rare complication of Cerebral Hemorrhage after mitral valve replacement (MVR), tricuspid valve prosthesis (TVP) and vegetation removal operation. Case presentation A 41-year-old woman who had a history of gingivitis developed into infective endocarditis due to the infection of C. valvarum. Then, she was hospitalized to receive MVR, TVP and vegetation removal operation. The indicators of patient tended to be normal until the abrupt Cerebral Hemorrhage occurred on day 15 after operation. This is the first well-described case of C. valvarum infection in China, and the first report of C. valvarum endocarditis with Cerebral Hemorrhage after MVR, TVP and vegetation removal operation worldwide. Conclusions We reported the first case of C. valvarum infection in China clinically, with a rare complication of Cerebral Hemorrhage after MVR, TVP and vegetation removal operation