The Experts below are selected from a list of 132 Experts worldwide ranked by ideXlab platform

Nancy L. Boltz - One of the best experts on this subject based on the ideXlab platform.

  • Therapeutic donor insemination: A prospective randomized trial of fresh versus frozen sperm
    American Journal of Obstetrics and Gynecology, 1992
    Co-Authors: Leslee L. Subak, G. David Adamson, Nancy L. Boltz
    Abstract:

    Objective: We evaluated the efficacy of fresh versus frozen sperm in therapeutic donor insemination. Study Design: Fifty-seven women underwent 72 courses of treatment (a maximum of six therapeutic donor insemination cycles—three fresh and three frozen) totaling 198 cycles. Each woman served as her own control and was prospectively randomized to receive a single, timed insemination of either fresh or frozen sperm. Results: Fecundity was 20.6% for fresh sperm cycles and 9.4% for frozen ( p 2 analysis). Fresh Cervical Cap insemination fecundity was 20.3%; frozen was 7.8% ( p 2 analysis). Fresh intrauterine insemination fecundity was 21.2%; frozen was 15.8% ( p = 0.63, by χ 2 analysis). Fresh 3-month life-table pregnancy rates were 48% ± 10%; frozen rates were 22% ± 8% ( p = 0.05 by Breslow analysis). Survival analysis with fixed covariates showed a positive association with the use of fresh sperm ( p = 0.04). Conclusion: Cycle fecundity was significantly greater with fresh sperm in women undergoing Cervical Cap insemination or intrauterine insemination and in women undergoing only Cervical Cap insemination. These results have important implications for contemporary management of patients undergoing therapeutic donor insemination with frozen sperm.

  • Failure of intrauterine insemination in a refractory infertility population.
    Fertility and sterility, 1991
    Co-Authors: G. David Adamson, Leslee L. Subak, Nancy L. Boltz, Maryanne Mcnulty
    Abstract:

    Intrauterine insemination by itself for multiple and/or severe infertility factors had no benefit over Cervical Cap with whole ejaculate or coitus in this study. The PRs for IUI and Cervical Cap with whole ejaculate or coitus were similar and low, suggesting that IUI by itself has limited, if any, utility in enhancing PRs in this type of infertility population. Couples attempting IUI should be advised about the low probability of achieving pregnancy. Ovulation stimulation and/or heterologous donor insemination, IVF, or gamete intrafallopian transfer may be beneficial therapeutic options.

James Trussell - One of the best experts on this subject based on the ideXlab platform.

  • Contraceptive discontinuation attributed to method dissatisfaction in the United States.
    Contraception, 2007
    Co-Authors: Caroline Moreau, Kelly Cleland, James Trussell
    Abstract:

    BACKGROUND: This study examines contraceptive discontinuation due to method dissatisfaction among women in the United States. STUDY DESIGN: The study population, drawn from the 2002 National Survey of Family Growth, consisted of 6724 women (15-44 years of age) who had ever used a reversible contraceptive method. We first estimated the overall proportion of women who had ever discontinued their contraceptive due to dissatisfaction. We then calculated method-specific discontinuation risks due to dissatisfaction and analyzed the reasons for dissatisfaction given by women who had ever stopped using Norplant, Depo-Provera, oral contraceptives or condoms. RESULTS: Overall, 46% of women had ever discontinued at least one method because they were unsatisfied with it. Dissatisfaction-related discontinuation risks varied widely by method: the diaphragm and Cervical Cap showed the highest proportions of such discontinuation (52%), followed by long-acting hormonal methods (42%). Oral contraceptives were associated with an intermediate risk of dissatisfaction-related discontinuation (29%), while condoms had the lowest risk (12%). CONCLUSION: A broader understanding of women's concerns and experiences using contraception could help health care providers redesign counseling strategies to improve contraceptive continuation.

  • comparative contraceptive efficacy of the female condom and other barrier methods
    Family Planning Perspectives, 1994
    Co-Authors: James Trussell, K Sturgen, Jennifer Strickler, Rosalie Dominik
    Abstract:

    Because the research design for the clinical trial establishing the contraceptive efficacy of the female condom--a six-month life-table probability of failure of 15% (12% in the United States vs. 22% in Latin America)--did not include randomization with another method of contraception, no definite conclusion about its comparative efficacy is possible. Comparisons using other female barrier methods as historical controls, however, provide evidence that, among women in the United States, the contraceptive efficacy of the female condom during typical use is not significantly different from that of the diaphragm, the sponge or the Cervical Cap. The six-month probability of failure during perfect use of the female condom is 2.6% among U.S. women, similar to rates for the diaphragm and the Cervical Cap but significantly lower than that for the sponge. Meaningful comparisons with the male condom are not possible because of the lack of data from carefully controlled prospective clinical trials. Extrapolations from the results on contraceptive efficacy suggest that perfect use of the female condom may reduce the annual risk of acquiring the human immunodeficiency virus by more than 90% among women who have intercourse twice weekly with an infected male.

  • Contraceptive efficacy of the diaphragm, the sponge and the Cervical Cap.
    Family planning perspectives, 1993
    Co-Authors: James Trussell, Jennifer Strickler, Barbara Vaughan
    Abstract:

    A reanalysis of data from two clinical studies--in which 1,439 women were randomly assigned to use either the contraceptive sponge or the diaphragm and 1,394 women were randomly assigned to use either the Cervical Cap or the diaphragm--found first-year probabilities of failure during typical use of 17% for the sponge, 18% for the Cervical Cap and 13-17% for the diaphragm. The first-year probabilities of failure during perfect use are 11-12% for the sponge, 10-13% for the Cervical Cap and 4-8% for the diaphragm. The probability of failure during perfect use is significantly higher among women who have given birth than among those who have not for users of the sponge (19-21% vs. 9-10%) and users of the Cervical Cap (26-27% vs. 8-10%), but not for users of the diaphragm.

Leslee L. Subak - One of the best experts on this subject based on the ideXlab platform.

  • Therapeutic donor insemination: A prospective randomized trial of fresh versus frozen sperm
    American Journal of Obstetrics and Gynecology, 1992
    Co-Authors: Leslee L. Subak, G. David Adamson, Nancy L. Boltz
    Abstract:

    Objective: We evaluated the efficacy of fresh versus frozen sperm in therapeutic donor insemination. Study Design: Fifty-seven women underwent 72 courses of treatment (a maximum of six therapeutic donor insemination cycles—three fresh and three frozen) totaling 198 cycles. Each woman served as her own control and was prospectively randomized to receive a single, timed insemination of either fresh or frozen sperm. Results: Fecundity was 20.6% for fresh sperm cycles and 9.4% for frozen ( p 2 analysis). Fresh Cervical Cap insemination fecundity was 20.3%; frozen was 7.8% ( p 2 analysis). Fresh intrauterine insemination fecundity was 21.2%; frozen was 15.8% ( p = 0.63, by χ 2 analysis). Fresh 3-month life-table pregnancy rates were 48% ± 10%; frozen rates were 22% ± 8% ( p = 0.05 by Breslow analysis). Survival analysis with fixed covariates showed a positive association with the use of fresh sperm ( p = 0.04). Conclusion: Cycle fecundity was significantly greater with fresh sperm in women undergoing Cervical Cap insemination or intrauterine insemination and in women undergoing only Cervical Cap insemination. These results have important implications for contemporary management of patients undergoing therapeutic donor insemination with frozen sperm.

  • Failure of intrauterine insemination in a refractory infertility population.
    Fertility and sterility, 1991
    Co-Authors: G. David Adamson, Leslee L. Subak, Nancy L. Boltz, Maryanne Mcnulty
    Abstract:

    Intrauterine insemination by itself for multiple and/or severe infertility factors had no benefit over Cervical Cap with whole ejaculate or coitus in this study. The PRs for IUI and Cervical Cap with whole ejaculate or coitus were similar and low, suggesting that IUI by itself has limited, if any, utility in enhancing PRs in this type of infertility population. Couples attempting IUI should be advised about the low probability of achieving pregnancy. Ovulation stimulation and/or heterologous donor insemination, IVF, or gamete intrafallopian transfer may be beneficial therapeutic options.

N L Boltz - One of the best experts on this subject based on the ideXlab platform.

  • Therapeutic donor insemination: a prospective randomized trial of fresh versus frozen sperm.
    American journal of obstetrics and gynecology, 1992
    Co-Authors: L L Subak, G D Adamson, N L Boltz
    Abstract:

    We evaluated the efficacy of fresh versus frozen sperm in therapeutic donor insemination. Fifty-seven women underwent 72 courses of treatment (a maximum of six therapeutic donor insemination cycles--three fresh and three frozen) totaling 198 cycles. Each woman served as her own control and was prospectively randomized to receive a single, timed insemination of either fresh or frozen sperm. Fecundity was 20.6% for fresh sperm cycles and 9.4% for frozen (p less than 0.03, by chi 2 analysis). Fresh Cervical Cap insemination fecundity was 20.3%; frozen was 7.8% (p less than 0.03, by chi 2 analysis). Fresh intrauterine insemination fecundity was 21.2%; frozen was 15.8% (p = 0.63, by chi 2 analysis). Fresh 3-month life-table pregnancy rates were 48% +/- 10%; frozen rates were 22% +/- 8% (p = 0.05 by Breslow analysis). Survival analysis with fixed covariates showed a positive association with the use of fresh sperm (p = 0.04). Cycle fecundity was significantly greater with fresh sperm in women undergoing Cervical Cap insemination or intrauterine insemination and in women undergoing only Cervical Cap insemination. These results have important implications for contemporary management of patients undergoing therapeutic donor insemination with frozen sperm.

G. David Adamson - One of the best experts on this subject based on the ideXlab platform.

  • Therapeutic donor insemination: A prospective randomized trial of fresh versus frozen sperm
    American Journal of Obstetrics and Gynecology, 1992
    Co-Authors: Leslee L. Subak, G. David Adamson, Nancy L. Boltz
    Abstract:

    Objective: We evaluated the efficacy of fresh versus frozen sperm in therapeutic donor insemination. Study Design: Fifty-seven women underwent 72 courses of treatment (a maximum of six therapeutic donor insemination cycles—three fresh and three frozen) totaling 198 cycles. Each woman served as her own control and was prospectively randomized to receive a single, timed insemination of either fresh or frozen sperm. Results: Fecundity was 20.6% for fresh sperm cycles and 9.4% for frozen ( p 2 analysis). Fresh Cervical Cap insemination fecundity was 20.3%; frozen was 7.8% ( p 2 analysis). Fresh intrauterine insemination fecundity was 21.2%; frozen was 15.8% ( p = 0.63, by χ 2 analysis). Fresh 3-month life-table pregnancy rates were 48% ± 10%; frozen rates were 22% ± 8% ( p = 0.05 by Breslow analysis). Survival analysis with fixed covariates showed a positive association with the use of fresh sperm ( p = 0.04). Conclusion: Cycle fecundity was significantly greater with fresh sperm in women undergoing Cervical Cap insemination or intrauterine insemination and in women undergoing only Cervical Cap insemination. These results have important implications for contemporary management of patients undergoing therapeutic donor insemination with frozen sperm.

  • Failure of intrauterine insemination in a refractory infertility population.
    Fertility and sterility, 1991
    Co-Authors: G. David Adamson, Leslee L. Subak, Nancy L. Boltz, Maryanne Mcnulty
    Abstract:

    Intrauterine insemination by itself for multiple and/or severe infertility factors had no benefit over Cervical Cap with whole ejaculate or coitus in this study. The PRs for IUI and Cervical Cap with whole ejaculate or coitus were similar and low, suggesting that IUI by itself has limited, if any, utility in enhancing PRs in this type of infertility population. Couples attempting IUI should be advised about the low probability of achieving pregnancy. Ovulation stimulation and/or heterologous donor insemination, IVF, or gamete intrafallopian transfer may be beneficial therapeutic options.